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    Analgesic action of hexaazaisowurtzitane derivative in somatic pain models caused by TRPA1 and TRPV1 Ion channels activation by S. G. Krylova, K. A. Lopatina, E. P. Zueva, E. A. Safonova, T. N. Povet’eva, Yu. V. Nesterova, O. G. Afanas’eva, P. V. Kul’pin, N. I. Suslov, D. A. Kulagina, S. V. Sysolyatin, V. V. Zhdanov

    Published 2021-01-01
    “…The reference drugs were diclofenac sodium in a preventive single per os dose of 10 mg/kg in 1% starch gel in a volume of 0.2 ml/mouse, and ketorolac in a dose of 6 mg/kg in the same solvent, volume and route of administration.Results. Thiowurtzine, when administered in per os doses of 100 and 200 mg/kg, was found to effectively block nociceptive reactions caused by activation of TRPA1 and TRPV1 ion channels. …”
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