Optimization of selection agent concentrations and expanding G418 utility for gentamicin resistance in Marchantia polymorpha by Andisheh Poormassalehgoo, Elżbieta Kaniecka, Mohamadreza Mirzaei, Shino Goto-Yamada

“…Abstract Genetic transformation of plants is pivotal for advancing biotechnology, with success depending largely on effective selection methods. Marchantia polymorpha has emerged as a model plant due to its evolutionary importance, ease of manipulation, and simple genetic structure. …”
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Optimizing antimicrobial routes: risk factor analysis for intravenous therapy in children with preseptal orbital cellulitis by Roberto Privato, Emanuela Inserra, Francesco Pezzoli, Alessia Nucci, Stefano Masi, Elena Chiappini, Giuseppe Indolfi, Sandra Trapani, Luisa Galli, Elisabetta Venturini

“…Abstract Background The optimal route of antimicrobial administration for preseptal orbital cellulitis (OC) in children remains uncertain. …”
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OPTIMIZATION STRATEGIES AND COMPUTATIONAL MODELING IN THE DESIGN AND PERFORMANCE EVALUATION OF GREEN POROUS OIL ADSORBENT MATERIALS by Haoran Zhang, Sagdat Mederbekovna Tazhibayeva

“… This study optimizes green porous oil adsorbent material design and selection to improve adsorption efficiency, cost-effectiveness, and sustainability to address the growing environmental challenge of oil spill remediation. …”
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Optimization of Extraction Parameters for Phenolics Recovery from Avocado Peels Using Ultrasound and Microwave Technologies by Lorena Martínez-Zamora, María Carmen Bueso, Mathieu Kessler, Rosa Zapata, Perla A. Gómez, Francisco Artés-Hernández

“…Total antioxidant capacity (TAC) and total phenolic compounds (TPC) were measured, while individual phenolics were analyzed via HPLC/MS. …”
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Directed Fuzzy Edge Graphs Under q-ROF Environment: A Framework for Optimal Pathfinding by Nazia Nazir, Tanzeela Shaheen, Wajid Ali, Md Rafiul Hassan, Mohammad Mehedi Hassan

“…This structure captures the uncertainty in edge relationships while retaining deterministic node identities, making it ideal for applications in uncertain environments such as social networks, supply chains, healthcare systems, and recommendation systems. …”
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Modelling the Accommodation Preferences of Tourists by Combining Fuzzy-AHP and GIS Methods by Ali Mahdi, Domokos Esztergár-Kiss

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Large language models versus traditional textbooks: optimizing learning for plastic surgery case preparation by Chandler Hinson, Cybil Sierra Stingl, Rahim Nazerali

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Investigating the effect of optimal cytoreduction in the context of platinum sensitivity in high‐grade serous ovarian cancer by Nicholas Cardillo, Eric Devor, Christian Calma, Silvana Pedra Nobre, Sofia Gabrilovich, David P. Bender, Michael Goodheart, Jesus Gonzalez‐Bosquet

“…We sought to answer whether surgical cytoreduction independently improves overall survival when controlling for chemotherapy outcome. Material and Methods We performed a retrospective case–control study using our institution's ovarian cancer database to evaluate the effect of optimal cytoreduction on advanced stage, high‐grade serous ovarian cancer. …”
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Characterization of “sweet spots” and optimization of volume fracturing parameters in deep tight reservoirs of Subei Basin by TANG Jiandong, ZHANG Shunkang, LIN Shiwei, GE Zhengjun, LIN Bo

“…To optimize development strategies, well types, production methods, fracturing parameters, and well pattern designs were systematically refined to ensure stable production. …”
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An explainable AI-based framework for predicting and optimizing blast-induced ground vibrations in surface mining by Charan Kumar Ala, Zefree Lazarus Mayaluri, Aman Kaushik, Nikhat Parveen, Surabhi Saxena, Abu Taha Zamani, Debendra Muduli

“…This study proposes a novel hybrid artificial intelligence (AI) framework that integrates physics informed neural networks (PINNs) with conventional machine learning (ML) algorithms for the accurate prediction and optimization of BIGV. Unlike empirical equations that lack generalizability or black box ML models with limited transparency, the proposed approach embeds domain specific physical laws while leveraging data driven learning to improve both predictive accuracy and interpretability. …”
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Optimizing Routine Educational Tasks through Prompt Engineering: A Comparative Study of AI Chatbots by Svitlana Skvortsova, Tetiana Symonenko, Kira Hnezdilova

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Differential Diagnosis of Peripheral Lung Lesions: Capabilities and Limitations of Current Methods by R. N. Islamov, R. A. Sharipov, M. A. Bagirov, R. K. Tukfatullin, G. V. Chitorelidze, E. V. Pavlova, R. K. Yagafarova

“…It is recommended that a comprehensive approach combining CT, characterized by high informative value, and PET scan, characterized by high sensitivity and specificity for nodules >10 mm, with invasive methods be used. VATS proves effective for lesions below 3 cm, while thoracotomy is applied to large lesions. …”
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Optimal exercise interventions for enhancing cognitive function in older adults: a network meta-analysis by Han Han, Jinhao Zhang, Fan Zhang, Fanghui Li, Zhijian Wu

“…Background: Cognitive decline poses a significant challenge to healthy aging. While exercise is widely recognized for its cognitive benefits, the comparative efficacy of different exercise modalities and optimal intervention protocols for specific cognitive domains in older adults remains unclear.Objective: This network meta-analysis aimed to systematically compare the effects of five exercise modalities—resistance training, aerobic exercise, mind-body exercise, multicomponent exercise, and high-intensity interval training (HIIT)—on global cognitive function and major cognitive domains in cognitively healthy older adults, and to identify optimal intervention protocols and population subgroups most likely to benefit.Methods: A total of 58 randomized controlled trials (RCTs) were included, encompassing 4,349 healthy older adults from diverse geographical regions. …”
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Optimizing IoT intrusion detection with cosine similarity based dataset balancing and hybrid deep learning by Arvind Prasad, Wael Mohammad Alenazy, Naved Ahmad, Gauhar Ali, Hanaa A. Abdallah, Sadique Ahmad

“…The proposed model achieved an F1-score of 0.9758 on RT-IoT2022 and 0.9275 on UNSW Bot-IoT, outperforming SMOTE-based methods in accuracy and computational efficiency. …”
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Optimizing pediatric preoperative fasting management: a survey of practices and real durations in Chinese hospitals by Bin Zhang, Shoudong Pan, Jijian Zheng, Bo Li, Yi Miao, Guohua Liu

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Enhanced Fault Diagnosis in Milling Machines Using CWT Image Augmentation and Ant Colony Optimized AlexNet by Niamat Ullah, Muhammad Umar, Jae-Young Kim, Jong-Myon Kim

“…The proposed method provides significant improvements in fault classification while outperforming state-of-the-art methods. …”
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Defatting strategies for chia protein production: effects on physicochemical properties by Simon Dirr, Ozlem Ozmutlu Karslioglu, Elif Gokcen Ates, Mecit H. Oztop

“…This study evaluates protein extraction efficiency and functional properties across two types of chia product: organic partially defatted flour (O) and conventional whole full-fat seeds (C). Defatting methods included mechanical cold pressing (O_PD), hexane extraction (O_HEX, C_HEX), supercritical CO₂ with ethanol (C_SCF), and a non-defatted control (C_ND). …”
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Role conflict, satisfaction, and performance in administrative staff at public universities: The role of optimism and sex differences. by Pedro Antonio Díaz-Fúnez, Francisco Gabriel Martín-Martín, Ana Martínez-Díaz, Carmen Salvador-Ferrer, Chiara Consiglio, Miguel Ángel Mañas-Rodríguez

“…<h4>Conclusions</h4>It is concluded that role conflict negatively affects the perception of one's own performance among administrative employees. However, while in the men group this relationship is mediated by job satisfaction and moderated by optimism, in women, role conflict directly affects performance. …”
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Propionyl Carnitine Metabolic Profile: Optimizing the Newborn Screening Strategy Through Customized Cut-Offs by Maria Lucia Tommolini, Maria Concetta Cufaro, Silvia Valentinuzzi, Ilaria Cicalini, Mirco Zucchelli, Alberto Frisco, Simonetta Simonetti, Michela Perrone Donnorso, Sara Moccia, Ines Bucci, Maurizio Aricò, Vincenzo De Laurenzi, Luca Federici, Damiana Pieragostino, Claudia Rossi

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Optimizing equine standing sedation: continuous infusion of detomidine and butorphanol enhances stability but prolongs ataxia by Julia de Assis Arantes, Isabela Peixoto Rabelo, Lucas Bermudes, Milena Domingues Lacerenza, Rubens Peres Mendes, Rodrigo Romero Corrêa, Diego Iwao Yamada, Carlos Augusto de Araújo Valadão, Renata Gebara Sampaio Dória

“…Future studies should explore alternative drug combinations to optimize sedation quality while minimizing ataxia and cardiorespiratory effects.…”
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