Interfacial oxygen nanobubble for mitigating the methane emissions from aquatic ecosystems: A review by Qingnan Chu, Xiangyu Liu, Detian Li, Shuai Yin, Ping He, Wenjuan Li, Chengrong Chen, Zhimin Sha

“…Despite their potential, challenges remain in optimizing oxygen-loading capacity, assessing long-term ecological impacts, and scaling up production. …”
Get full text

Insight into the management of patients with melanoma in times of the COVID-19 pandemic: A single-center experience by Nikolić Jelena, Marinković Marija, Jovanović Mladen, Mijatov Ivana, Leković-Stojanov Dragana, Kecman Stefan

“…Thin melanoma percentage as a measurement of successful screening programs decreased significantly during the COVID-19 pandemic (11.57% vs. 24.01%), while median Breslow thickness remained stable. The distribution of different histological types was consistent across both periods. …”
Get full text

Effect of Head Rotation on Cerebral Blood Velocity in the Prone Position by Jakob Højlund, Marie Sandmand, Morten Sonne, Teit Mantoni, Henrik L. Jørgensen, Bo Belhage, Johannes J. van Lieshout, Frank C. Pott

“…Prone positioning with rotated head affects both CBF and cerebrovenous drainage indicating that optimal brain perfusion requires head centering.…”
Get full text

Simulation-free cone beam CT-based online adaptive radiotherapy for metastatic spinal cord compression by Lisette Sandt, Evangelos Giannoulis, Laura Ann Rechner, Lina Åström, Anna Mann Nielsen, Jens Morgenthaler Edmund, Gitte Fredberg Persson

“…Patient/material and methods: Diagnostic CT scans from patients diagnosed with MSCC were used for treatment planning, while CBCT scans from their first treatment session were retrospectively used to emulate the treatments. …”
Get full text

Management of immune-related adverse events under PD-1/PD-L1 inhibitors: Insights from a Moroccan real-world experience by Inès Cherradi, Mohamed Ichou, Mohammed Squalli Houssaini, Nabil Ismaili

“…Most toxicities were grade 1-2, while 2 patients developed severe grade 3 pneumonitis and colitis, requiring hospitalization. …”
Get full text

Enhancing Specificity in Predicting Axillary Lymph Node Metastasis in Breast Cancer through an Interpretable Machine Learning Model with CEM and Ultrasound Integration by Weimin Xu PhD, Bowen Zheng MS, Chanjuan Wen PhD, Hui Zeng MS, Sina Wang MS, Zilong He PhD, Xin Liao MS, Weiguo Chen MS, Yingjia Li PhD, Genggeng Qin PhD

“…Among these, the LightGBM achieved the highest AUC (0.762) and specificity (86.67%, while the ensemble model using RF as the meta-model had an AUC (0.754) and specificity (83.33%. …”
Get full text

Machine learning-based integration develops relapse related signature for predicting prognosis and indicating immune microenvironment infiltration in breast cancer by Junyi Li, Shixin Li, Dongpo Zhang, Yibing Zhu, Yue Wang, Xiaoxiao Xing, Juefei Mo, Yong Zhang, Daixiang Liao, Jun Li

“…Abstract Breast cancer is the most common type of cancer in women, and while current treatments can cure the majority of early-stage primary BC cases, recurrence remains a significant challenge. …”
Get full text

Platelet response following dexamethasone in obese vs nonobese patients with primary, acute immune-mediated thrombocytopenia by Tyler Everhardt, Kelley Julian, Russell Benefield, Aaron Wilson, Nathan Wilson, Charles J. Parker, Anna Parks, Jeffrey A. Gilreath

“…Objectives: We aimed to evaluate if body weight altered the response rates to dexamethasone (DEX) in the treatment of ITP. Methods: We conducted a retrospective review to evaluate the effects of body weight on response to DEX in ITP. …”
Get full text

A newly modified nerve-sparing radical hysterectomy technique with analysis of short-term oncologic, surgical, and functional outcomes by Shichao Han, Shichao Han, Xinyou Wang, Xinyou Wang, Jinming Zhu, Ya Li, Ya Li, Jing Na, Jing Na, Jun Wang, Jun Wang

“…In clinical practice, utilizing the three-plane structure of the paracolpium and medially lifting the vascular plane facilitated safe, reliable dissection, exposure, and preservation of pelvic autonomic nerve function.Through clinical practice, follow-up, and analysis of 55 cases, it was observed that combining the concept of membrane anatomy with the three-plane anatomical structure of the paracolpium not only enables nerve-sparing radical hysterectomy as a bloodless surgical procedure but also ensures optimal nerve preservation, favorable oncological outcomes, and a significant reduction in perioperative complications.ConclusionGuided by the principles of membrane anatomy and the three-plane theory of the paracolpium, nerve-sparing radical hysterectomy facilitates precise preservation of pelvic autonomic nerve function in a bloodless manner, while achieving favorable oncological outcomes.…”
Get full text

Updating the Brazilian clinical practice guidelines for sickle cell disease: Recommendations and development process by Ludmila Peres Gargano, Mariana Millan Fachi, Layssa Andrade Oliveira, Clarisse Lobo, Katharina Nelly Tobos Melnikoff, Selma Soriano, Marta da Cunha Lobo Souto Maior, Meline Rossetto Kron-Rodrigues, Dalila Fernandes Gomes, Haliton Alves Oliveira Junior, Rosa Camila Lucchetta

“…Dissemination and integration aim to enhance healthcare delivery, while future assessments should optimize real-world implementation.…”
Get full text

Validation of the EVendo score for assessing high-risk varices in Western European patients with cirrhosis by Julian Müller-Kühnle, Christian Benignus, Severin Schricker, Moritz Schanz, Julia Todoroff, Jörg Latus, Wolfram Zoller, Dominik Marschner

“…Background : Gastroesophageal varices (GEV) and associated bleeding are serious complications of cirrhosis, leading to considerable morbidity and mortality. While esophagogastroduodenoscopy (EGD) remains the gold standard for detecting GEV, it is an invasive procedure. …”
Get full text

Development and validation of an interpretable multi-task model to predict outcomes in patients with rhabdomyolysis: a multicenter retrospective cohort studyResearch in context by Chunli Liu, Jie Shi, Fengjuan Wang, Duo Li, Yu Luo, Bofan Yang, Yunlong Zhao, Li Zhang, Dingwei Yang, Heng Jin, Jie Song, Xiaoqin Guo, Haojun Fan, Qi Lv

“…Data from eICU-CRD and MIMIC-IV were combined to form the derivation cohort for model training and internal validation, while data from the Chinese hospitals served as the external validation cohort. …”
Get full text

Calculation Model of Multi-roll Straightening Process Based on Bilinear Hardening and Power Hardening by ZHU Xiaoyu, CHENG Zixing, WANG Xiaogang, HAN Peisheng

“…The goal is to support the development of straightening techniques for new materials and provide a theoretical basis for intelligent straightening and optimal design of straightening machines.MethodsThree material models—ideal elastic-plastic, bilinear hardening, and power hardening—were selected, and the curvature-moment (M‒K) relationships for these materials during bending were derived. …”
Get full text

MicroRNAs in anthracycline cardiotoxicity: biomarkers, mechanisms, and therapeutic advances by Hongyun Mao, Hongyun Mao, Jing Hu, Chenshuo Yu, Sicong Xie, Cheng Chang, Juanjuan Peng, Yang Zhang

“…MicroRNAs (miRNAs), as key post-transcriptional regulators of gene expression, play a pivotal role in the pathophysiology of cardiovascular disease, but their specific functions in anthracycline-induced cardiotoxicity (AIC) require systematic elucidation.PurposeThis review aims to systematically summarize current research on the key miRNAs, their molecular targets, and associated signaling pathways that regulate AIC, while also exploring their potential as biomarkers for early diagnosis and as therapeutic targets for intervention.MethodsA comprehensive literature search was conducted in PubMed, Web of Science, and Scopus databases for relevant studies published up to April 2025. …”
Get full text

Comparative Pharmacological Assessment of Amoxicillin in Five Cultured Fish Species: Implications for Off-Label Use in Aquaculture by Jun Sung Bae, Chae Won Lee, Chan Yeong Yang, Eun Ha Jeong, Bosung Kim, Kwan Ha Park, Jung Soo Seo, Mun-Gyeong Kwon, Ji-Hoon Lee

“…<b>Results</b>: AMOX, at 40 mg/kg, significantly reduced bacterial loads in olive flounder, rainbow trout, and Japanese eel (<i>p</i> < 0.05), while Israeli carp exhibited a limited response (<i>p</i> = 0.54). …”
Get full text

Discovery of Small Molecules Against Foot-and-Mouth Disease Virus Replication by Targeting 2C Helicase Activity by Saisai Zhou, Suyu Mu, Shuqi Yu, Yang Tian, Sijia Lu, Zhen Li, Hao Wu, Jiaying Zhao, Huanchun Chen, Shiqi Sun, Yunfeng Song

“…Background: The 2C protein of foot-and-mouth disease virus (FMDV), a member of helicase superfamily 3 (SF3), drives viral genome replication and serves as a critical target for antiviral drug development. Methods: A fluorescence resonance energy transfer (FRET)-based high-throughput screening (HTS) platform was developed to identify 2C helicase inhibitors. …”
Get full text

Risk Factors of Ankle Sprain in Soccer Players: A Systematic Review and Meta-Analysis by Amir Human Hoveidaei, Amir Reza Moradi, Amin Nakhostin-Ansari, Mohammad Mehdi Mousavi Nasab, Seyed Pouya Taghavi, Shayan Eghdami, Bijan Forogh, Masumeh Bagherzadeh Cham, Christopher J. Murdock

“…BMI emerged as a risk factor in three out of seven studies, while age and height were significant in one out of six studies each. …”
Get full text

The association between acute kidney injury and dysglycaemia in critically ill patients with and without diabetes mellitus: a retrospective single-center study by Chong Zhang, Meng Ning, Weiru Liang, Wei Su, Yi Chen, Tingting Guo, Kun Hu, Wenjin Peng, Yingwu Liu

“…Further research is needed to develop optimal glycemic control strategies for AKI patients.…”
Get full text

Characteristics of adenomyosis in secondary infertility patients on MRI and factors associated with fertility recovery after HIFU by Zhiyun Yang, Jinfeng Lin, Tao Tan, Yuan Li, Ying Chen, Meijie Yang, Zhibo Xiao, Jinyun Chen

“…Objective To study the MRI characteristics of adenomyosis in secondary infertility patients, and to analyze the factors affecting pregnancy after High-intensity focused ultrasound (HIFU).Methods Clinical data of 388 patients with adenomyosis were selected from January 2014 to December 2019 treated with HIFU They were divided into the infertility group and the control group by the presence of secondary infertility. …”
Get full text

Determinants of patient satisfaction among outpatients with chronic illnesses in the region of medina, Saudi Arabia: a cross-sectional study by Mustafa S. Alhasan, Ibrahim M. Alahmadi, Hassan F. Alhilali, Nawaf M. Alyoubi, Nasser A. Alkhoriji, Ahmad M. Aljazairi, Basil M. Othman, Abdulrahim M. Alshehri, Mohammad O. Alhejaili, Baraa Alhejaili, Omar I. Alanazi, Ahmed Y. Azzam, Ayman S. Alhasan

“…Accessibility and convenience scored lowest (60% satisfaction), while interpersonal manner, communication, and financial aspects achieved highest scores (70% satisfaction). …”
Get full text