RNAi delivery mediated by milk extracellular vesicles in colon cancer by Jessie Santoro, Silvia Nuzzo, Andrea Soricelli, Marco Salvatore, Anna Maria Grimaldi

“…These EVs offer advantages such as low immunogenicity, biocompatibility, and the ability to cross biological barriers. Here, we optimized methods for loading siRNA into milk-derived EVs (mEVS) and assessed their ability to protect siRNA from degradation while preserving its gene-silencing efficacy. …”
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Advancements in Plant Diagnostic and Sensing Technologies by Shalini Krishnamoorthi, Sally Shuxian Koh, Mervin Chun‐Yi Ang, Mark Ju Teng Teo, Randall Ang Jie, U. S. Dinish, Michael S. Strano, Daisuke Urano

“…Abstract Recent advancements in plant sensing technologies have significantly improved agricultural productivity while reducing resource inputs, resulting in higher yields by enabling early disease detection, precise diagnostics, and optimized fertilizer and pesticide applications. …”
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Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects by Nadezhda A. Pechnikova, Kalliopi Domvri, Konstantinos Porpodis, Maria S. Istomina, Aleksandra V. Iaremenko, Alexey V. Yaremenko

“…However, challenges such as optimizing synthesis, ensuring long‐term stability, and addressing safety concerns in biological environments remain critical hurdles. …”
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Extracorporeal Cytokine Adsorption in Sepsis: Current Evidence and Future Perspectives by Matteo Guarino, Anna Costanzini, Francesco Luppi, Martina Maritati, Carlo Contini, Roberto De Giorgio, Michele Domenico Spampinato

“…<b>Conclusions</b>: Extracorporeal cytokine adsorption is a potential adjunctive therapy in sepsis management, offering improvements in organ function and inflammatory control. While the mortality benefit remains uncertain, ongoing research and large-scale clinical trials are essential to define its clinical role and optimize its application.…”
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No evidence for PAPE-induced jumping performance enhancement following isometric and treadmill warm-ups in team sport athletes by Artur TERBALYAN, Anna ŚCISŁOWSKA-CZARNECKA, Adam MASZCZYK, Robert ROCZNIOK

“…The primary focus was on assessing neuromuscular activation and performance indicators such as jump height and force asymmetry. Materials and Methods: Fifty-three athletes from basketball, volleyball, handball, and soccer participated in a controlled, parallel-group experiment. …”
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Hybrid framework for improved PM2.5 prediction based on seasonal-trend decomposition and tailored component processing by Dongbao Jia, Wenjun Ruan, Rui Ma, Shiwei Zhao, Yichen Wang, Wei Xu, Weijie Zhou, Xinxin Ge, Zhongxun Xu

“…However, accurately forecasting PM2.5 levels presents significant challenges due to the complex, non-linear, and non-stationary characteristics inherent in the PM2.5 concentration data, which are influenced by diverse meteorological conditions, emission sources, and atmospheric transport dynamics. Existing prediction methods often struggle to adequately capture these multifaceted patterns simultaneously; single models may fail to address both long-term trends and seasonal variations as well as short-term stochastic fluctuations, while many hybrid decomposition approaches may not optimally utilize techniques suited to the distinct nature of each decomposed component, thereby limiting potential accuracy improvements. …”
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Catalytic Approaches for CO2 Conversion to Value‐Added Products: An Overview of Life Cycle Assessment Studies by Anastasia Pappa, Cuong Pham‐Huu, Spiros Papaefthimiou, Spyridon Zafeiratos

“…It is highlighted that despite the widely recognized advantages of CO2‐based processes, the environmental benefits cannot be guaranteed, while the carbon intensity of the electricity source used significantly affects the outcomes. …”
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Research trends between acquired immune deficiency syndrome and hematological malignancies: a bibliometric analysis by Qiwen Zhou, Hao Sun, Shanshan Fan, Lan Luo, Jianhua Ji, Zejiao Jiang, Haiyan Min

“…Blood is the most influential journal in this field, while authors Elie Azoulay and Hans-Peter Kiem were noted as influential figures. …”
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Lung Delivery of Lactose-Free Microparticles Loaded with Azithromycin for the Treatment of Bacterial Infections by Gracia Molina, Dolores R. Serrano, María Auxiliadora Dea-Ayuela, Carmina Rodriguez, Elena González-Burgos, Brayan J. Anaya

“…This study aimed to develop a lactose-free dry powder inhaler (DPI) formulation containing azithromycin (AZM) microparticles for enhanced pulmonary delivery. <b>Methods:</b> Using a quality-by-design approach, an optimized formulation (4% AZM, 20% leucine, and 76% mannitol) was achieved. …”
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Palytoxin Signal in LC-MS and UV: Preliminary Investigation on the Effect of Solvent and Temperature by Chiara Melchiorre, Michela Varra, Valeria Tegola, Valentina Miele, Carmela Dell’Aversano

“…OVTX-producing algae have been linked to dermatitis and respiratory distress in Mediterranean beachgoers, while serious public health concerns are related to PLTX accumulation in seafood. …”
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Microbial Fermentation Assisted by Pulsed Electric Fields, Magnetic Fields and Cold Atmospheric Plasma: State of the Art by Nahed Yousfi, Nofel Merbahi, Jalloul Bouajila, Patricia Taillandier, Mohamed Debouba

“…Most recent research studies are currently devoted to the implementation of innovative technological processes in order to increase fermentation effectiveness while consuming less energy and processing time. …”
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Quantitative and Qualitative Symmetry Analysis of Open Reduction and Fixation of Zygomatic Complex Fractures by Frederic Van der Cruyssen, Mathilda Wylde, Anthony Campbell, Ali Reza Pourkarim, Zeeshan Ahmad, Nabeel Bhatti, Simon Holmes

“…The study underscores the need for enhanced imaging and standardized evaluation methods to optimize surgical precision and outcomes in craniofacial trauma care.…”
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Evaluating Interaction Techniques in XR Environments Through the Prism of Four EduGames by Ilias Logothetis, Vasiliki Eirini Chatzea, Iraklis Katsaris, Alexandros Papadakis, Vasileios Kontoulis, Dimitris Pirpiris, Myron Sfyrakis, Antonios Stamatakis, Nikolaos Vidakis

“…Performed analysis determines the context in which each technique is most effective, how different techniques can be combined, and how integration can be improved for optimal impact. Additionally, methods for transitioning from traditional interaction techniques to modern XR approaches utilizing 3D space and interaction requirements are proposed. …”
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Alkaline Amino Acids for Salt Reduction in Surimi: A Review by Tong Shi, Guxia Wang, Yu Xie, Wengang Jin, Xin Wang, Mengzhe Li, Yuanxiu Liu, Li Yuan

“…However, traditional processing methods rely on high concentrations of salt (2–3%) to maintain texture and stability, contributing to excessive sodium intake. …”
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Removal of methylene blue dye from textile industry wastewater using green synthesized Teff straw assisted ZnO nanoparticle by Getachew L. Rorissa, Ermias A. Tesema, Reddy Prasad D.M., Abdisa R. Hunde, Sirno Y. Beyena, Meron A. Biru, Dereje T. Mekonnen, Tebelay L. Adnualem

“…Adsorption experiments analyzed the impact of pH, adsorbent dose, contact time, and initial dye concentration, while Response Surface Methodology (RSM) with a Central Composite Design (CCD) optimized conditions, achieving 99.77% removal efficiency at pH 6.9, 68.5 mg/L dye concentration, 0.265 g adsorbent dose, and 77.87 min contact time, fitting the Freundlich isotherm model (R² = 0.99). …”
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Dispersive X-ray absorption spectroscopy using independent grazing-incidence focusing and convexly bent Bragg-crystal dispersing optics by Juanjuan Huang, Adam P. Tornheim, Xianbo Shi, Mark Wolfman, Yanna Chen, Steve M. Heald, Shelly D. Kelly, George E. Sterbinsky

“…Theoretical calculations are performed to determine optimal instrument operating parameters and demonstrate that an energy resolution better than the K-edge core-hole lifetime broadening can be maintained while providing a sufficient bandwidth for X-ray absorption near-edge structure spectroscopy through the full operating range of 5–11 keV. …”
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Quantitative assessment of fixation strength in combined thread lifting: Comparative analysis of bidirectional-multidirectional versus double bidirectional thread combinations by Kyu-Ho Yi, Soo Yeon Park, Jovian Wan, Jong Keun Song, Jin-Hyun Kim, Erik Koppert, Jae Young Kim

“…., Ltd.) threads versus double bidirectional threads. Methods: Ex vivo testing was conducted on fresh cadaver tissue specimens (n = 30 per group). …”
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In Situ Forming Hypoxia‐Induced Exosome‐Loaded Hydrogel for Enhanced Diabetic Wound Healing by Yong‐fei Wang, Gang Zhao, Sigen A, Qian Xu, Xiao‐li Wu, Wen‐Xin Wang, Yong‐jun Rui

“…Through systematic screening of Exo‐hydrogel formulations, it is demonstrated that the encapsulated Exo retained their bioactivity, exhibits therapeutic efficacy in vitro via scratch and tube formation assays. Further, the optimal Exo‐hydrogel promotes accelerated wound healing while preventing scar formation in a diabetic rat wound model. …”
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Evaluation of tramadol/paracetamol 75 mg/650 mg combination therapy for early-stage knee osteoarthritis: a retrospective observational study by Alessandro Conforti, Cosimo Ruggiero, Nastasja Palombi, Filippo Messina, Marco Bonifacio, Linda Lucchetti, Marco Ruggiero, Giuseppe La Cava, Roberto Piazza, Mario Mangrella

“…Efficacy was consistent across demographic and clinical subgroups, possibly suggesting broad treatment applicability. Conclusions. While the findings could support tramadol/paracetamol as a safe and effective first-line therapy for KOA, reinforcing its role in optimizing KOA management strategies, limitations such as the small sample size and lack of a control group highlight the need for further research. …”
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Multiphysics modeling and validation of a microwave applicator with a three-stub tuner for the continuous flow pasteurization of fruit juices with low reflection by Guilherme Russo, Jorge A. W. Gut, Jorge A. W. Gut, Dorin Boldor

“…Using the principles of electromagnetism and the Monte Carlo method, the stub heights in the tuner were optimized to minimize power reflection, quantified by the scattering parameter (S11). …”
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