Comparative efficacy assessment for various insulin regimens in patients with type 2 diabetes mellitus, ischaemic heart disease and frequent hypoglycemic events by Vladimir Ivanovich Kudinov, Maria Sergeevna Nichitenko, Anna Ivanovna Chesnikova, Natalya Vladimirovna Zolotareva

“…To study influence of combined treatment with human insulin analogues (insulin aspart and insulin detemir) on glycemic control,insulin resistance and development of ischaemic heart disease (IHD) in patients with type 2 diabetes mellitus (T2DM) and frequenthypoglycemic events in comparison with that of human insulins (soluble and isophane). Materials and methods. 54 patients (mean age 61.2?0.7) with T2DM and IHD participated in this study. …”
Get full text

Comprehensive dosimetric comparison of halcyon 3.0 versus truebeam for breast cancer volumetric modulated arc therapy plans by Anyan Gu, Mengyuan Wang, Zhenyu Pan, Ran Tang, Yaotao Li, Yu Wu, Guozi Yang, Xingru Sun

“…This study aimed to compare the dosimetric performance of Halcyon 3.0 and TrueBeam in Volumetric Modulated Arc Therapy (VMAT) planning for breast cancer.MethodsThirty post-operative breast cancer patients were included. …”
Get full text

Risk Factors for Acute Exacerbation in Patients with COPD Group E in Ningbo: Risk Analysis of Irregular Review, Cardiovascular Complications, and Lung Function Decline by Qian Y, Sun C, Zhang L, Cai C, Sun M, Zhang J, Huang J, Ma H, Tan L, Zhao Y, Wang S, Lv D

“…These results may reduce medical resource utilization and AE frequency while improving quality of life, thereby informing evidence-based COPD management strategies and optimizing chronic disease care and resource allocation.Keywords: COPD, intervention management, risk factors, regular review, acute exacerbation, high risk…”
Get full text

Unraveling the role of GPCR signaling in metabolic reprogramming and immune microenvironment of lung adenocarcinoma: a multi-omics study with experimental validation by Zhaoxuan Wang, Cheng Wang, Cheng Wang, Shilei Zhao, Chundong Gu

“…BackgroundLung adenocarcinoma (LUAD) is characterized by metabolic and immune heterogeneity, driving tumor progression and therapy resistance. While G protein-coupled receptors (GPCR) signaling is known to regulate metabolism and immunity in cancers, its role in LUAD remains poorly defined. …”
Get full text

Impact of obesity on proteomic profiles of follicular fluid-derived small extracellular vesicles: A comparison between PCOS and non-PCOS women by Qiyuan Chang, Senlan Wang, Qingyun Mai, Canquan Zhou

“…Correlation analysis revealed significant associations between specific differentially expressed proteins and IVF/ICSI outcomes, while a protective role for Heat Shock Protein 90 Beta Family Member 1 (HSP90B1) protein was observed in the non-PCOS group. …”
Get full text

Performance evaluation of a medium axial field-of-view sparse PET system based on flat panels of monolithic LYSO detectors: a simulation study by Maya Abi-Akl, Jens Maebe, Boris Vervenne, Othmane Bouhali, Christian Vanhove, Stefaan Vandenberghe

“…We simulate the performance of two flat-panel PET configurations: one with a fully populated 106 cm AFOV and another cost-efficient design featuring a reduced AFOV with axial gaps and vertical panel motion optimized for head and torso imaging. Methods Both configurations consist of two monolithic LYSO-based flat panels placed 50 cm apart. …”
Get full text

Adjuvants and rebound pain following peripheral nerve block in adult surgical patients: a systematic review and network meta-analysis of randomized controlled trials by Xiaodan Yang, Bin Su, Yupei Chen, Jianjun Yang, He Huang, Bing Chen, Pain Group of the Chinese Society of Anesthesiology

“…Conclusion Current evidence, albeit of low quality, indicates that IV dexamethasone is the most effective adjuvant for the prevention of rebound pain, while PN dexamethasone is optimal for delaying its onset. …”
Get full text

Identification of Th1-polarized Th17 cells: solving the problem by E. M. Kuklina, N. S. Glebezdina

“…However, the development of this direction is complicated by the weak comparability of data on the size of such a population. The analysis of methods for determining Th1-polarized Th17 in vivo and in vitro, carried out in this work, made it possible to resolve these contradictions and develop optimal approaches to identifying this population. …”
Get full text

Improved clinical outcomes with a modified warming protocol in donor oocyte cycles by Chun-I Lee, Hsiu-Hui Chen, Shu-Hui Lin, Chun-Chia Huang, Pin-Yao Lin, Tsung-Hsien Lee, Ming-Jer Chen, Maw-Sheng Lee, Chien-Hong Chen

“…Abstract Background Recent studies have attempted to improve laboratory efficiency while preserving clinical outcomes by shortening the time to warm cryopreserved embryos, though it is still unclear for oocytes. …”
Get full text

The role of Pan-Immune inflammation value and systemic Immune-Inflammation index as potential biomarkers in predicting infectious complications following retrograde intrarenal surg... by Bedreddin Kalyenci, Ferhat Çoban, Hasan Sulhan, Mehmet Özgür Yücel, Can Benlioğlu, Gazi Kaz, Tayfun Şahinkanat, Ali Çift

“…Abstract Background To predict postoperative infectious complications by utilizing hemogram parameters and derived inflammation indices and to analyze patient-related risk factors to propose a nomogram. Methods The data of patients who underwent retrograde intrarenal surgery were reviewed. …”
Get full text

Is cooperation better than competition? Evidence from patient mobility before and after the COVID-19 pandemic in Tuscany, Italy by Giovanni Guarducci, Davide Golinelli, Luca Spadea, Giuliana Fabbri, Nicola Nante, Nicola Nante

“…Tuscan patients were more likely to escape to non-border regions for HS DRGs while for Musculoskeletal Diseases (in 2019 OR: 0.76; 95%CI: 0.68–0.84; in 2022 OR: 0.83; 95%CI: 0.72–0.89) they were less likely to be admitted to non-border regions for HS DRGs (p < 0.05).ConclusionThe findings highlight the need to implement interregional agreements to optimize patient mobility, avoid duplication of services, reduce costs and improve access to care.…”
Get full text

Contribution of inflammation to heart failure development in human immunodeficiency virus-infected patients by N. A. Koziolova, O. G. Goryacheva, I. F. Litsinger

“…The first group included 37 HIV-infected patients with HF and blood CRP <15 mg/l, while the second group — 63 HIV-infected patients with HF and CRP concentration ≥15 mg/l. …”
Get full text

Antibiotic treatment for 7 days versus 14 days in patients with uncomplicated bloodstream infections: a Systematic review and meta-analysis of randomized controlled trials and tria... by Changyun Zhao, Changqin Chen, Difan Lu, Kailun Cai, Weihang Hu, Wenchao Mao

“…BackgroundThe optimal duration of antibiotic therapy for bloodstream infections (BSI) remains a topic of ongoing debate. …”
Get full text

Reevaluating Backup Monitor Chamber Tolerances for Stereotactic Body Radiotherapy Treatments using Volumetric-modulated Arc Therapy by Yong Sang, Jun Dang, Jianan Wu, Enzhuo Quan

“…In addition, minor variations in gantry angles (up to 0.2%) slightly affected MU2 readings, while field size had no significant impact. Conclusions: The current 2% constancy tolerance may not be optimal for SBRT treatments on the Elekta Infinity accelerator. …”
Get full text

Multi-scenario dynamic analysis of demand for critical minerals in China’s new energy vehicles under “dual carbon” goals by ZHENG Linchang, BAO Wenqi, CHEN Ge, GENG Aomiao

“…Under identical “dual carbon” policy scenarios, new energy vehicles adopting high-nickel and nickel-cobalt-aluminum battery technologies had higher demand for nickel, while those using low-nickel alternatives had higher demand for cobalt. …”
Get full text

Effects of adding dietary bakery waste to corn on broiler growth performance, carcass traits, and feed costs by Wilaiwan Sirirotjanaput, Jeerasak Chobtang, Auraiwan Isuwan, Supawadee Chimtomg, Janjira Sittiya

“…Future research should optimize bakery waste inclusion levels to ensure economic feasibility while maintaining meat quality.…”
Get full text

Electrochemical performance and behavior of nickel pig Iron anodic electrolysis for enhanced sulfuric acid leaching by Namhun Kwon, Myungsuk Kim, Soongju Oh, Jae Hong Shin, Kyoung-Tae Park

“…This study presents an innovative electrochemical method for producing ultra-fine Nickel Pig Iron (NPI) powders through anodically induced overpotential electrolysis, achieving a significantly high surface area and exceptional sulfuric acid leaching efficiency. …”
Get full text

Effect of Temperature on the Physiological Response of Enhalus acoroides Seedlings by Aditya Hikmat Nugraha, Rika Anggraini, Ramona Desrica, Jelita Rahma Hidayati, Indri Addini, Muhamad Halim

“…The highest anatomical size of leaf tissue in the upper and lower epidermis was observed at 31°C, while the most extensive mesophyll tissue was observed at 35°C. …”
Get full text

Analysis of surface roughness and machining performance of AZ91 magnesium alloy cut by WEDM by Levent Urtekin, Faik Yılan, İbrahim Baki Şahin, Kadir Gök

“…For this purpose, an analysis of variance (ANOVA) and Grey Relational Analysis (GRA) were performed to find the optimal settings. Findings indicate that pulse-on time (Ton) significantly affects both MRR and SR: higher Ton increases MRR but worsens SR, while shorter Ton improves SR but reduces MRR. …”
Get full text

Enhancement of Phytochemicals and Antioxidant Activity of Thai Fermented Soybean Using Box–Behnken Design Guided Microwave-Assisted Extraction by Piya Temviriyanukul, Woorawee Inthachat, Ararat Jaiaree, Jirarat Karinchai, Pensiri Buacheen, Supachai Yodkeeree, Tanongsak Laowanitwattana, Teera Chewonarin, Uthaiwan Suttisansanee, Arisa Imsumran, Ariyaphong Wongnoppavich, Pornsiri Pitchakarn

“…In this study, an initial non-optimized TFS extract (TFSE) was prepared using a conventional triplicate 80% ethanol extraction method and evaluated for its biological activity. …”
Get full text