Proactive strategies to optimize engagement of Black, Hispanic/Latinx, transgender, and nonbinary individuals in a trial of a novel agent for HIV pre-exposure prophylaxis (PrEP). by Michelle Cespedes, Moupali Das, J Carlo Hojilla, Jill Blumenthal, Karam Mounzer, Moti Ramgopal, Theo Hodge, Thiago S Torres, Charles Peterson, Senzokuhle Shibase, Ayana Elliott, A C Demidont, Larkin Callaghan, C Chauncey Watson, Christoph Carter, Alex Kintu, Jared M Baeten, Onyema Ogbuagu

“…Here we describe strategic approaches undertaken in the PURPOSE 2 trial to optimize engagement of underrepresented individuals.…”
Get full text

Microplate Reader–TLC–HPLC–UPLC-MS: A Rapid Screening Strategy for Isoliquiritigenin-Transforming Bacteria by Chuanhong Nie, Ruiqi Liu, Songhao Yang, Panpan Li, Jing Zhang

“…This study demonstrates that the optimized MTHM method is efficient and reliable, capable of rapidly detecting subtle structural changes in flavonoids before and after microbial transformation. …”
Get full text

Optimizing Physical Fitness Before Colorectal Cancer Surgery (CANOPTIPHYS): The Effect of Preoperative Exercise on Pre- and Postoperative Physical Fitness in Older people – A Rando... by Johanna Danielsson, Julia Engström Sid, Mikael Andersson, Malin Nygren-Bonnier, Monika Egenvall, Maria Hagströmer, Laura E. Vossen, Ing-Mari Dohrn, Elisabeth Rydwik

“…Our objective was to evaluate the effect of preoperative exercise on physical fitness in older patients with low physical fitness scheduled for colorectal cancer surgery. Methods: In this randomized, controlled trial, patients ≥65 years of age, who were scheduled for colorectal cancer surgery were included if they had a low maximal walking speed. …”
Get full text

A Comparison of Water Flooding and CO₂-EOR Strategies for the Optimization of Oil Recovery: A Case Study of a Highly Heterogeneous Sandstone Formation by Dung Bui, Son Nguyen, William Ampomah, Samuel Appiah Acheampong, Anthony Hama, Adewale Amosu, Abdul-Muaizz Koray, Emmanuel Appiah Kubi

“…This study presents a comparative analysis of CO₂-EOR and water flooding scenarios to optimize oil recovery in a geologically heterogeneous reservoir with a dome structure and partial aquifer support. …”
Get full text

qBiCo: a method to assess global DNA conversion performance in epigenetics via single-copy genes and repetitive elements by Faidra Karkala, Roy B. Simons, Floor Claessens, Vivian Kalamara, Manfred Kayser, Athina Vidaki

“…However, despite the popularity of this approach, it is known to cause DNA fragmentation and loss affecting standardization, while incomplete conversion may result in potential misinterpretation of methylation-based outcomes. …”
Get full text

HPLC-UV method development and validation for anticancer drug sorafenib and the co-prescribed drug dexamethasone: application to pharmacokinetic evaluation of sorafenib nanoformula... by Abdul Mateen, Abad Khan, Ismail Khan, Saifullah Khan Khalil, Lateef Ahmad, Muhammad Junaid, Saqib Jehan, Muhammad Sohail Anwar, Muhammad Faheem, Abdul Salam

“…The analytes were extracted with acetonitrile using the protein precipitation method. The chromatographic parameters were optimized, and the method was validated as per the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines. …”
Get full text

Optimizing the utilization of winged bean (Psophocarpus tetragonolobus (L.) DC.) tubers as a replacement for cassava chips in ruminant diets through pelleting: an in vitro gas tech... by Anusorn Cherdthong, Napudsawun Sombuddee, Saowalak Lukbun, Natdanai Kanakai, Pachara Srichompoo, Winai Jaikan, Perapong Phaengphairee, Theerachai Haitook, Sompong Chankaew, Chanon Suntara

Get full text

Characteristics associated with optimal blood sugar in individuals living with type 2 diabetes in hard-to-reach rural communities: results of a cross-sectional study in Esmeraldas,... by Marta Puig-García, Cintia Caicedo-Montaño, Mónica Márquez-Figueroa, Elisa Chilet-Rosell, Blanca Lumbreras, Abraham Beltrán-Pérez, Lucy Anne Parker

“…Furthermore, older age (aOR = 1.03, 95%CI: 1.01–1.05, p = 0.006), living in an urbanised setting (aOR = 2.04, 95%CI: 1.22–3.40, p = 0.006) and unemployment (aOR = 0.48, 95%CI: 0.25–0.94, p = 0.031) were also linked to optimal blood glucose levels. While perceived social support in this population was moderate (median = 2.33, on a scale of 1 to 4), high family support appeared to reduce optimal glycaemic levels (aOR = 0.35, 95%CI: 0.18–0.70, p = 0.003). …”
Get full text

Asymmetric Double-Sideband Composite Signal and Dual-Carrier Cooperative Tracking-Based High-Precision Communication–Navigation Convergence Positioning Method by Zhongliang Deng, Zhenke Ding, Xiangchuan Gao, Peijia Liu

“…By organically integrating an embedded signal into the original positioning signal, the code loop is optimized via fuzzy control, while the ADCLS signal is processed as an asymmetric double-sideband signal for joint signal extraction. …”
Get full text

Comparative analysis of phytochemicals and antioxidant activities in seeds and sprouts of different varieties of radish (Raphanus sativus L.): TOPSIS-entropy weight method by Caihui Guo, Yi Zhu

“…The ultimate goal was to identify the optimal radish variety with these beneficial properties through the TOPSIS-entropy weight method. …”
Get full text

Study of mechanical and physical properties of pineapple leaf fiber and coffee husk filler reinforced polymer composite using response surface method by Kinisa Wareso Abesho, Moera Gutu Jiru, Hirpa G. Lemu, Mohammed Abdulkedir Alfeki

“…This study fabricates composite samples using the hand layup method, and the Response Surface Methodology is used to optimize the experimental design. …”
Get full text

A novel two-stage feature selection method based on random forest and improved genetic algorithm for enhancing classification in machine learning by Junyao Ding, Jianchao Du, Hejie Wang, Song Xiao

“…Then, the improved genetic algorithm is used to search for the global optimal feature subset further. This process introduces a multi-objective fitness function to guide the feature subset, minimizing the number of features in the subset while enhancing classification accuracy. …”
Get full text

Scientific basis for design low-speed synchronous permanent magnet generators for wind power plants by A. A. Tatevosyan

“…However, engineering approaches to the design of individual components of the WPP indicate the difficulties of developing a scientifically based methodology for optimizing the parameters of the WPP as a whole taking into account the mutual influence of individual components on each other. …”
Get full text

Solving Power Supply Stability Issues in Remote Agricultural Areas Based on an Improved Sliding-Mode Active Disturbance Rejection Control Method by Boyan Huang, Kai Song, Tao Zhang, Zihui Lian, Hongxu Li, Dezhi Jin, Runjin Wang

“…Traditional power supply methods often struggle to meet demand due to significant fluctuations in solar irradiance and load. …”
Get full text

A Simple Real-Time Method for Detecting Low Performance in Wet High-Intensity Magnetic Separators (WHIMSs) Due to Coil Malfunction by Ricardo B. Ventura, Alan K. Rêgo Segundo, Thiago A. M. Euzébio

“…Wet High-Intensity Magnetic Separators (WHIMSs) have become well established in mineral processing operations by efficiently separating particles based on their magnetic properties. While the existing literature extensively discusses WHIMS performance under varying operational conditions, there is a notable absence of attention to the degradation of coils over time and methods for its detection. …”
Get full text

Reduced duration and dosage of venetoclax is efficient in newly diagnosed patients with acute myeloid leukemia by Jingying Cui, Xuexing Chen, Chunfang Li, Qiong Yan, Guolin Yuan

“…After a median follow-up of 15 (range 4–29) months, the median overall survival (OS) and progression-free survival (PFS) for the whole cohort were 17 (4–29) months and 12 (1–28) months, respectively. …”
Get full text

Adoption of virtual and augmented reality in the architecture, engineering, construction, and facilities management (AEC-FM): mixed method analysis of trends, gaps, and solutions by Sahand Fathi, Sepehr Sabeti, Omidreza Shoghli, Arsalan Heydarian, Vahid Balali

“…While adoption has been led by commercial and institutional sectors, recent growth in the industrial sector reflects AR/VR’s value in large-scale, complex projects. …”
Get full text

Evaluating integrated development environments using the TOPSIS method and Schweizer-Sklar power aggregation operator: implications for university students’ psychological managemen... by Lijun Ma, Fengyu Guo, Zeeshan Ali, Shi Yin

“…Finally, numerical examples are presented to compare the proposed ranking results with existing ones, demonstrating the effectiveness of these methods in optimizing IDE selection and supporting students' psychological well-being.…”
Get full text

Method for limiting the peak factor using an additional compensation signal in a system with orthogonal frequency division multiplexing for a Gaussian channel by Th. T. Pham, O. V. Tikhonova

“…Statistical radio engineering and computer modeling methods are used according to optimal signal reception theory.Results. …”
Get full text

Greens assessment of RP-UPLC method for estimating Triamcinolone Acetonide and its degraded products compared to Box-Behnken and Six Sigma designs by Hossam M. Nassef, Hoda A. Ahmed, Mohamed A. El-Atawy, Tahani Y. A. Alanazi, Mahmoud A. Mohamed

“…The Box-Behnken design was developed to efficiently determine the optimal chromatographic conditions while minimizing the required trials. …”
Get full text