What is the best first-line combination regimen for advanced EGFR-mutated non-small cell lung cancer: a network meta-analysis and systemic review by Chuang Yang, Yunfei Wang, Yiyong Sun, Ying Sun, Rongyu Zhang, Chengjun Wang, Yanan Song, Wen Zhao, Jisheng Li

“…In patients with brain metastases, osimertinib plus chemotherapy appeared to offer clinical benefits over other treatment strategies, although statistical significance was only observed in comparison with osimertinib monotherapy.ConclusionThis network meta-analysis suggests osimertinib plus pemetrexed-based chemotherapy as the only regimen demonstrating PFS benefits in the whole cohort and almost all the subgroup analyses, making it the optimal treatment for patients with advanced EGFR-mutated NSCLC. …”
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Leveraging ultrasonic-derived phenotypes and estimated breeding value to improve abdominal fat weight prediction in chickens throughout the egg laying period by Penghao Li, Zhengda Li, Fan Ying, Dan Zhu, Dawei Liu, Xianyi Song, Jie Wen, Guiping Zhao, Bingxing An

“…When incorporating EBVs of AFW as extra independent variables, all methods’ predictive ability had increased by an average of 15.71 %, especially KNN (27.2 %). …”
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The application of PET/CT with 18F-FDG in the differential diagnosis of lung solitary lesions by G. V. Afonin, A. E. Glukhareva, E. I. Smolenov, I. V. Kolobaev, E. E. Beketov, L. O. Petrov, S. A. Ivanov

“…The study was aimed to investigate the effectiveness of PET / CT with 18 fluoro‑2 deoxy-D-glucose (18F-FDG) in the differential diagnosis of focal lung neoplasms.Materials and methods. Patients (n = 108) with newly diagnosed lung focal lesions were enrolled in the study. …”
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CT-based radiomics model to predict platinum sensitivity in epithelial ovarian carcinoma: a multicentre study by Mengge He, Rahul Singh, Mandi Wang, Grace Ho, Esther M. F. Wong, Keith W. H. Chiu, Anthony K. T. Leung, Ka Yu Tse, Philip P. C. Ip, Andy Hwang, Lujun Han, Elaine Y. P. Lee

“…The whole tumour volume was manually segmented on the baseline ceCT. …”
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Advantages, applications, and future directions of in vivo aptamer SELEX: A review by Minchuan Lyu, Chi Ho Chan, Ziqi Chen, Yumeng Liu, Yuanyuan Yu

“…Unlike traditional in vitro methods that often fail to capture the complexity of biological interactions in physiological environments, in vivo SELEX leverages whole living organisms as selection targets. …”
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The Circular Kitchen by Bas Jansen

“…The research goals were designed to support the development of the CIK while also generating valuable methods and knowledge. …”
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The role of supine imaging in assessing failure of pelvic compensation and its impact on surgical outcomes in patients with adult spinal deformity by Dongfan Wang, Wei Wang, Yu Wang, Chao Kong, Shuaikang Wang, Xiaolong Chen, Shibao Lu

“…Abstract Aims This study aims to investigate the impacts of failure of pelvic compensation (FPC), as determined by variations in spinopelvic alignment during the transition from the supine to the upright position, on surgical outcomes in patients with adult spinal deformity (ASD). Methods A total of 125 ASD patients who underwent posterior correction surgery with a minimum follow-up of two years were enrolled. …”
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Effects of light intensity and nitrogen supply on the dynamic characteristics of leaf SPAD value of rice canopy by He Junjun, Yang Jingping, Yang Hu, Zhao Xing, Ye Xinyi

“…And the feasibility of applying chlorophyll meter on nitrogen nutrition diagnosis was investigated.This article studied the methods to optimize nitrogen nutrition diagnosis of rice leaves under low-light stress condition with SPAD meter.Pot experiments were conducted to study the distributing characteristics of canopy SPAD and the distributional difference at tillering, booting and heading stages. …”
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Comprehensive evaluation of the MeltPro MTB/PZA assay for prediction of pyrazinamide resistance in multidrug-resistant tuberculosis by Guiqing He, Chunxia Tu, Yelei Zhu, Qingyong Zheng, Qiulong Zhou, Wenzhen Zhou, Ouyang Huang, Bin Chen, Zhengwei Liu, Ye Xu, Xiangao Jiang

“…WGS demonstrated 97.30% sensitivity and 84.31% specificity compared to pDST, while MeltPro MTB/PZA showed 91.89% sensitivity and 86.27% specificity. …”
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Immunomodulatory gene networks predict treatment response and survival to de-escalated, anthracycline-free neoadjuvant chemotherapy in triple-negative breast cancer in the WSG-ADAP... by Darren Korbie, Clare Stirzaker, Oleg Gluz, Christine zu Eulenburg, Ulrike Nitz, Matthias Christgen, Sherko Kuemmel, Eva-Maria Grischke, Helmut Forstbauer, Michael Braun, Mathias Warm, John Hackmann, Christoph Uleer, Bahriye Aktas, Claudia Schumacher, Rachel Wuerstlein, Enrico Pelz, Hans Heinrich Kreipe, Susan J. Clark, Matt Trau, Monika Graeser, Nadia Harbeck

“…Methods eTNBC patients (cT1c-cT4c, cN +) were randomized to 12 weeks of nab-paclitaxel + gemcitabine (n = 182) or nab-paclitaxel + carboplatin (n = 154). …”
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Сombat wounds microflora in modern warfare by V. P. Kovalchuk, N. S. Fomina, V. M. Kondratiuk, О. О. Fomin, Y. V. Lazarenko, K. V. Gumenyuk

“…Analysis of the clonal characteristics and antibiotic resistance of the most prevalent wound pathogens among individuals injured in the Russian-Ukrainian war to support microbiota surveillance of combat wounds and optimize treatment strategies. Materials and Methods. …”
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Application of a high-resolution melt assay for monitoring SARS-CoV-2 variants in Burkina Faso and Kenya by Caitlin Greenland-Bews, Sonal Shah, Morine Achieng, Emilie S. Badoum, Yaya Bah, Hellen C. Barsosio, Helena Brazal-Monzó, Jennifer Canizales, Anna Drabko, Alice J. Fraser, Luke Hannan, Sheikh Jarju, Jean-Moise Kaboré, Mariama A. Kujabi, Cristina Leggio, Maia Lesosky, Jarra Manneh, Tegwen Marlais, Julian Matthewman, Issa Nebié, Eric Onyango, Alphonse Ouedraogo, Kephas Otieno, Samuel S. Serme, Sodiomon Sirima, Ben Soulama, Brian Tangara, Alfred Tiono, William Wu, Emily R. Adams, Abdul Karim Sesay, Chris Drakeley, Feiko O. ter Kuile, Issiaka Soulama, Simon Kariuki, David J. Allen, Thomas Edwards

“…We show through comparison to sequencing that our assay can generate highly similar data on the different variants circulating in a population, therefore showing the effectiveness of our tool. While not a replacement for sequencing, we present a method of screening and prioritizing samples for further investigation and reduce overburdening sequencing capacity. …”
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