Dasatinib Dose Optimization Based on Therapeutic Drug Monitoring in Patients with Chronic-Phase Chronic Myeloid Leukemia by Cheng F, Cui Z, Li Q, Wang L, Zhang Y, Li W

“…Fang Cheng,1,2 Zheng Cui,1,2 Qiang Li,1,2 Liu Wang,1,2 Yu Zhang,1,2 Weiming Li3 1Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan, 430022, People’s Republic of China; 3Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of ChinaCorrespondence: Yu Zhang, Email zhangwkp@163.com Weiming Li, Email lee937@126.comBackground: Although a dosage decrease regimen for chronic phase chronic myeloid leukemia (CML-CP) has been suggested, there is a marked lack of guidance on individualizing medication dosages for patients.Methods: Our aim was to explore the application of therapeutic drug monitoring (TDM) as a strategy for optimizing dasatinib dosage in patients with CML-CP.Results: It was observed that patients administered a dosage of 100 mg exhibited significantly higher concentrations than those given 50 mg, with no marked difference in concentration between branded and generic drugs. …”
Get full text

Nutritional status and barriers to optimal nutrition among pediatric patients with cancer in tanzania: a quantitative analysis by Deogratias M. Katabalo, Yadurshini Raveendran, Anthony Cuthbert Liwa, Benson R. Kidenya, Kristin Schroeder

“…Methods Two study populations were recruited: pediatric patients with cancer and their primary caregivers. …”
Get full text

Topical Nitroglycerin for Radial Access Optimization: Supporting Vascular Access in Patients at Risk for Acute Heart Failure by Adrian Sebastian Zus, Simina Crișan, Silvia Luca, Daniel Nișulescu, Mihaela Valcovici, Oana Pătru, Mihai-Andrei Lazăr, Cristina Văcărescu, Dan Gaiță, Constantin-Tudor Luca

“…<i>Background and Objectives</i>: Radial artery spasm (RAS) is a frequent complication during invasive angiography using the transradial approach, leading to patient discomfort and procedural challenges. While intra-arterial nitroglycerine (NTG) effectively reduces RAS after sheath insertion, preprocedural prevention strategies are limited. …”
Get full text

Optimizing blood management in arthroplasty: a meta-analysis of carbazochrome sodium sulfonate and Tranexamic acid combination by Mohamed A. Alsaied, Omnia Samy El-Sayed, Shahd Alqato, Abdelrahman M. Elettreby, Ahmed A. Abo Elnaga

Get full text

Structural Optimization Design of the Dual-Layer CMUT with Low Power Consumption and High Ultrasonic Reception Performance by Jie Li, Zhaohui Xiao, Zutang Wu, Xiong Hu, Zhikang Li, Yihe Zhao, Min Li, Jiawei Yuan, Shaohui Qin, Libo Zhao

“…This design increases the total deflection and reduces the stiffness, making the membrane more susceptible to deformation under external forces, thereby achieving low power consumption and high reception performance. The finite element method (FEM) results showed that, compared with conventional CMUTs, the structural optimization design of the dual-layer CMUT had a 13.7% reduction in collapse voltage. …”
Get full text

Characterizing the Optimal Diversity Training Programs for Physicians: A Survey sponsored by Pacific Spine and Pain Society by Gendreau JL, Bauman MMJ, Brown NJ, Alfonzo Horowitz M, Chakravarti S, Mehkri Y, Grovey B, Lee E, Lee G, Cornidez E, Bhandal HS, Pope JE

“…In this paper, we attempt to describe trends in the Pacific Spine and Pain Society (PSPS) membership to help discover optimal diversity education paradigms for pain management providers by performing a survey on behalf PSPS.Methods: A survey was disseminated to all members of the PSPS at the 2022 annual meeting. …”
Get full text

Potency-optimized CD28-activating bispecific antibody for the targeted treatment of Nectin-4 positive cancers by Manpreet Kaur, Starlynn C Clarke, Katherine E Harris, Nathan D Trinklein, Elaine C Chen, Katja Rüger, Udaya S Rangaswamy, Laura M Davison, Sebastian Moreno Arteaga, Imani Smith, Ruth Chu, Soumili Chattopadhyay, Mathias Rickert, Shelley Force Aldred

Get full text

Optimizing blood-brain barrier permeability in KRAS inhibitors: A structure-constrained molecular generation approach by Xia Sheng, Yike Gui, Jie Yu, Yitian Wang, Zhenghao Li, Xiaoya Zhang, Yuxin Xing, Yuqing Wang, Zhaojun Li, Mingyue Zheng, Liquan Yang, Xutong Li

“…Our approach utilizes a variational autoencoder (VAE) generative model integrated with reinforcement learning for multi-objective optimization. This method specifically aims to enhance BBB permeability (BBBp) while maintaining high-affinity substructures of KRAS inhibitors. …”
Get full text

BBSNet: An Intelligent Grading Method for Pork Freshness Based on Few-Shot Learning by Chao Liu, Jiayu Zhang, Kunjie Chen, Jichao Huang

Get full text

Microbiological Assessment of the Different Hand Drying Methods and Washroom Environment Cross-Contamination by Fayza Kouadri

“…This research compared the effectiveness of three different hand drying methods—paper towels, the use of warm air dryers in stationary hands position, and the use of air drying while hand rubbing—and their potential for cross-contamination of other users and the surrounding environment. …”
Get full text

Practical and cost-effective method for the isolation of pollen grains from various sources by Ozge S. Kuddar, Benjamin J. Callahan, Christopher Bernhardt, Kelly A. Meiklejohn

“…Mock standards, with known concentrations and varied characteristics, when analyzed alongside unknown samples, can provide evaluation, optimization, and validation of scientific methods. Due to the scarcity of commercially available pollen grains, this study introduces a practical and cost-effective method for isolating pollen grains from various sources to be used in a mock pollen standard. …”
Get full text

Research on Lightweighting Methods for 3D Building Models Based on Semantic Constraints by J. Wu, T. Shen, L. Huo

“…Experimental results demonstrate that the proposed method significantly reduces the model's storage requirements while effectively preserving its semantic information.…”
Get full text

Development of Green Method for Trace Determination of Bendiocarb in Real Samples Using Emerson by Baghdad Science Journal

“…The most important parameters affecting the extraction and determination of BC are conducted via a classical optimization. Under the optimum conditions established , Beer’s law is obeyed in the range of 0.1-4 µg mL-1 while the optimum concentration ranges estimated by Ringbom’s plot was of 0.4-2.12 µg mL-1. …”
Get full text

Research on aerodynamic characteristics and control method of rigid-flexible variable camber wing by Tao Xin, Bin Li

“…In the wing configuration design, the optimal lift-to-drag ratio is used as the optimization objective, and the wing section mean line is parameterized to obtain the optimal rigid-flexible hybrid deformation configuration. …”
Get full text

Taguchi Method for Tribological Excellence: Insights into Copper-Based Metal Matrix Composites by S.S. Kallesh, Rajaneesh N. Marigoudar

Get full text

Multistage Training and Fusion Method for Imbalanced Multimodal UAV Remote Sensing Classification by Shihao Wang, Zhengwei Xu, Yun Lin

“…However, during the process of multimodal learning, the effectiveness of fusion is severely affected by modality imbalance caused by inconsistent gradient directions when integrating heterogeneous information. Existing methods predominantly focus on parameter tuning and gradient modulation, failing to resolve inherent conflicts from divergent modality optimization trajectories. …”
Get full text

Electricity pinch analysis method for flexibility supply-demand matching in power systems by Yaling Mao, Tiejiang Yuan, Xueqin Tian, Yue Teng

“…Leveraging the theoretical framework of pinch technology from process engineering, this paper proposes an Electricity Pinch Analysis (EPA) method for flexibility assessment. First, the net-load profile is decomposed by successive variational mode decomposition (SVMD) optimized with the Red-billed Blue Magpie Optimization (RBMO) algorithm to construct a flexibility demand model. …”
Get full text

Modeling and Simulation of Insulin Pump Set Failures Based on the Power Flow Method by Weijie Wang, Dinghui Guo, Long Quan, Shiwei Liu

“…Conversely, as blockage approach the flow source, the impact on reducing flow rate diminishes, while their influence on increasing chamber pressure becomes more pronounced. …”
Get full text

Enhancing Privacy in IoT Networks: A Comparative Analysis of Classification and Defense Methods by Ahmet Emre Ergun, Ozgu Can, Murat Kantarcioglu

“…As a defense mechanism, DP is applied using the Fourier Perturbation Algorithm (FPA) to optimize padding strategies while maintaining network efficiency. …”
Get full text

Exploring biomass pretreatment methods for sustainable biofuel production: a bibliometric analysis by Muhammad Usman, Muhammad Faisal Afridi, Uzair Ahmad Khan

“…Abstract Biofuels offer a sustainable alternative to fossil fuels, utilizing renewable biomass feedstocks to meet the growing energy demand while reducing environmental impact. However, the efficiency of biofuel production heavily depends on the pretreatment methods used for conversion of biomass. …”
Get full text