Galactomannan detection in sputum samples of patients with chronic obstructive pulmonary disease: A promising marker for diagnosis of chronic pulmonary aspergillosis? by Sabrieh Asadi Shahi Sarae, Masoud Aliyali, Vida Mortezaee, Hamidreza Jamaati, Hossein Asgarian Omran, Siavash Abedi, Hossein Mehravaran, Jamshid Yazdani Charati, Maryam Sadat Mirenayat, Mihan Pourabdollah, Kosar Najmi, Sabah Mayahi, Mona Ghazanfari, Ahmed Al-Harrasi, Mahdi Abastabar, Mohammad T. Hedayati, Abdullah M.S. Al Hatmi

“…Background and purpose: Diagnosing chronic pulmonary aspergillosis (CPA) is challenging due to nonspecific symptoms, variable radiological findings, and limited mycological evidences. While galactomannan (GM) testing has been validated in serum and bronchoalveolar lavage fluid (BAL) for invasive pulmonary aspergillosis (IPA), its usefulness in sputum samples for CPA remains unclear. …”
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Impact of Storage Conditions on Bronchoalveolar Lavage Fluid Analysis: A Human Study by Yu Shionoya, Kanae Maruyama, Takeshi Kawasaki, Mayumi Ono, Yushi Murai, Ryutaro Hirama, Dai Horiuchi, Noriko Sakuma, Shinsuke Kitahara, Shun Sato, Kohei Takahashi, Yoshihito Ozawa, Takuji Suzuki

“…This study aimed to evaluate how different storage conditions impact BALF cell counts and differentials to guide optimal sample handling practices. <b>Methods</b>: Forty patients who underwent BAL at Chiba University Hospital from June to December 2024 were included. …”
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Increased autophagy activity regulated by LC3B gene promoter DNA methylation is associated with progression to active pulmonary tuberculosis disease by Yung-Che Chen, Ying-Tang Fang, Chao-Chien Wu, Tung-Ying Chao, Yi-Hsi Wang, Chia-Cheng Tseng, Sum-Yee Leung, Chiu-Ping Lee, Ting-Ya Wang, Po-Yuan Hsu, Jen-Chieh Chang, Meng-Chih Lin, Chang-Chun Hsiao

“…Conclusions Increased LC3B expression and LC3B gene promoter hypermethylation may serve as biomarkers for progression of M. tb infection, while use of de-methylation agent may be a potential approach to host-directed immunotherapy in active TB disease.…”
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Impacts of Traditional Warm-Up and Post-Activation Potentiation on Muscle Endurance During the Back Squat: Response of Blood Lactate, Perceived Effort, and Time Under Tension by Taianda M. Amorim, Alexandre V. Gurgel, Viviane Faleiro, Thiago T. Guimarães, Estêvão R. Monteiro, Felipe G. Teixeira, Bruno Jotta, Tiago C. Figueiredo, Raquel C. Castiglione, Silvio R. Marques-Neto

“…Background: Warm-up strategies are essential for optimizing strength-training performance. Traditional warm-ups improve neuromuscular readiness, whereas post-activation potentiation (PAP) has been proposed to acutely enhance muscular output. …”
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Assessment of salt tolerance in peas using machine learning and multi-sensor data by Zehao Liu, Qiyan Jiang, Yishan Ji, Rong Liu, Hongquan Liu, Xiuxiu Ya, Zhenxing Liu, Zhirui Wang, Xiuliang Jin, Tao Yang

“…The results show that: 1) multi-source data fusion significantly improved the accuracy of AGB and SPAD estimation; 2) the CatBoost algorithm achieved the highest performance for AGB estimation (R² = 0.70, RMSE = 1.59 t/hm2, NRMSE = 13.94 %), while the LightGBM algorithm performed best for SPAD estimation (R² = 0.60, RMSE = 2.33, NRMSE = 14.53 %); and 3) The PSTS established based on the optimal estimation data exhibits a strong consistency with the ground-measured data. …”
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Clinical features of non-compaction cardiomyopathy across age groups: a retrospective study of 415 patients by Ying Li, Jimei Chen, Min Qiu, Miao Tian, Ziqin Zhou, Ruyue Zhang, Jiazichao Tu, Linjiang Han, Shuheng Zhou, Xinming Li, Jian Zhuang, Shusheng Wen

“…Notably, heart failure was most prevalent in adult patients (54.6%, n=53), while cardiac murmur was the primary presenting symptom in both infant and child/adolescent groups (19.5%, n=33 and 17.4%, n=26, respectively). …”
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Longitudinal analysis of hsa-miR-3163, hsa-miR-124-3p, hsa-miR-548c-3p, and hsa-miR-27a-3p as prognostic biomarkers in HIV-infected patients by Ilker Inanç Balkan, Ilker Inanç Balkan, Ilker Inanç Balkan, Andleeb Shahzadi, Haktan Sönmez, Burhaneddin Oktan, Muhammad Ihtisham Umar, Bilgül Mete, Fehmi Tabak, Günnur Deniz, Umut Can Küçüksezer

“…RT-qPCR and ELISA techniques were used to analyze miRNA expression levels while immunological markers (CD4 count and ratio) were assessed by flow cytometry.ResultsmiR-27a-3p expression was significantly increased at 2nd and 6th months of ART (p&lt;0.001). miR-548ac-3p was upregulated at 6th month compared to healthy individuals and ART-naive subjects (p&lt;0.05). miR-124-3p expression was significantly elevated in ART-naive subjects in comparison with healthy controls (p&lt;0.001). …”
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The effect of taurine supplementation on markers of muscle damage and muscle pain in an athletic population: A systematic review and meta-analysis of randomized controlled trials a... by Elaheh Dehghani, Fatemeh Naeini, Sakineh Shab Bidar, Mohammad Beba, Erfan Mortezapour, Ruhollah Nourian, Khashayar Danandeh, Zahra Gohari Dezfuli, Kurosh Djafarian

“…Conclusion: TS may support post-exercise muscle recovery by reducing CK and LDH levels, but its effect on muscle pain remains unclear. While it shows potential as a recovery aid for athletes, further research is needed to optimize dosing and practical applications in sports performance and rehabilitation.…”
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Cerebrospinal Fluid Aβ Biomarkers Predict Recurrent Hemorrhage and Identify Cerebral Amyloid Angiopathy in Patients With Lobar Hemorrhage by Philipp Arndt, Malte Pfister, Frank Schreiber, Valentina Perosa, Hendrik Mattern, Jose Bernal, Berkant Bay, Marc Dörner, Marwa Al‐Dubai, Vanessa Swiatek, Belal Neyazi, Erol Sandalcioglu, Cornelia Garz, Sven G. Meuth, Michael Goertler, Stefan Vielhaber, Katja Neumann, Stefanie Schreiber

“…Biomarker levels were compared between patients with and without recurrent hemorrhage, and optimal cutoff values were derived from receiver operating characteristic analysis to define high and low biomarker groups. …”
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Construction of a risk prediction model for pulmonary infection in patients with spontaneous intracerebral hemorrhage during the recovery phase based on machine learning by Jixiang Xu, Yuan Li, Fumin Zhu, Fumin Zhu, Xiaoxiao Han, Liang Chen, Yinliang Qi, Yinliang Qi, Xiaomei Zhou, Xiaomei Zhou

“…Accurate prediction of PI risk is crucial for early intervention and optimized clinical management. The aim of this study was to develop a machine learning (ML) model for predicting PI risk in patients during the recovery phase of deep SICH and to investigate the contributions of individual risk factors through explainable artificial intelligence techniques.MethodsWe conducted a retrospective study involving 649 patients diagnosed with PI during the recovery phase of deep SICH between 2021 and 2023. …”
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Macular epiretinal membrane in high myopia: timing and prognosis of pars plana vitrectomy surgery by Yu-Tong Xia, Jia-Yun Ge, Zong-Chan Zhang, Li-Yue Zhang, Ying-Ying Wen, Ying Xie, Ye Shen, Jian-Ping Tong

“…AIM: To investigate the outcomes and prognosis of macular epiretinal membrane (ERM) after pars plana vitrectomy (PPV) in patients with high myopia (HM), focusing on the optimal timing of surgery and its impact on prognosis. …”
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Subnational introduction of the RTS,S/AS01E malaria vaccine into routine immunization: experience and lessons from the three pilot countries by Rose Jalang’o, Kwame Amponsa-Achiano, Mike Chisema, Keziah Malm, Lydiah Khalayi, Brenda Mhone, Wahjib Mohammed, Franklin Asiedu-Bekoe, Adam Haji, Josephine Njoroge, Boston Zimba, Esther Chirwa, Peter O. Tweneboah, Jackson Sillah, Mgaywa G. M. D. Magafu, Cynthia Bergstrom, Tracey Goodman, Jenny Walldorf, Kristen Kelleher, Eliane Pellaux-Furrer, Mary J. Hamel, Michael R. Adjei, Rafiq N. A. Okine

“…RTS,S was initially introduced in randomly selected areas, while other areas served as comparators until the four-dose schedule vaccine was scaled up following the WHO recommendation in 2021. …”
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Effect of repetitive transcranial magnetic stimulation with different stimulation parameters on post-stroke dysphagia: a systematic review and meta-analysis of randomized controlle... by Xu-Miao Peng, Xu-Miao Peng, Cheng Gong, Mei-Xia Xiao, Liang-Sheng Chen, Liang-Sheng Chen, Yi Li, Yi Li, Jie Chen, Mao-Yuan Wang, Mao-Yuan Wang, Mao-Yuan Wang, Yun Luo, Yun Luo, Yun Luo

“…However, consensus on optimal clinical protocols for rTMS remains unclear. …”
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Modification of the Cardiac Renal Angina Index for Predicting Adverse Kidney Events After Pediatric Cardiac Surgery by Katherine F. Melink, Natalja L. Stanski, Emily Gorrell, Jeffrey A. Alten, Kevin A. Pettit, Stuart L. Goldstein, Huaiyu Zang, Nicholas J. Ollberding, Rajit K. Basu, Shina Menon, Megan SooHoo, Katja M. Gist

“…Patients who were cRAI positive had worse outcomes, while the composite outcome was effectively ruled out in patients who were cRAI negative. …”
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Evaluating and Forecasting the Probability of Lightning Occurrence in Rasht City by Afsaneh Ghasemi, Jamil Amanollahi

“…The main purpose of this study was to use recorded ground data from the occurrence and non-occurrence of lightning (binary data) and the effect of related meteorological parameters (temperature, relative humidity, cloudy, wind speed, wind direction, pressure air and previous day's lightning) to estimate the probability of lightning occurrence in future using data mining (trees and neural network models) and evaluate and determine the optimal model to reduce future damage. 2-Materials and Methods In this study, binary data of lightning and atmospheric parameters (temperature, relative humidity, cloudy, wind speed, wind direction, pressure air and previous day's lightning) were obtained from Rasht Meteorological Station during the years 2012-2018. …”
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Integration of Network Pharmacology, Transcriptomics, and Metabolomics Strategies to Uncover the Mechanism of Chaihuang Qingfu Pill in Treating Sepsis-Induced Liver Injury by Zhang C, Chen F, Jiang Y, Deng J, Yan X, Yin X, Su B, Liu W

“…This study aims to systematically investigate the molecular basis of CHQF in the mitigation of sepsis-associated liver damage.Purpose: To explore the mechanism of CHQF for the treatment of sepsis-induced liver injury.Methods: A sepsis mouse model was established via cecal ligation and puncture (CLP). …”
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The impact of early vs. delayed surgery on outcomes in cervical spinal cord injury without fracture or dislocation by Sirui Xiao, Hui Yan, Beixi Bao, Yuxuan Wu, Xiaokang Cheng, Chunyang Xu, Jiaguang Tang

“…ObjectiveThis study aims to retrospectively analyze 104 patients diagnosed with cervical spinal cord injury without fracture or dislocation (CSCIwoFD) who underwent surgical treatment, in order to compare the effects of early vs. delayed surgical intervention on neurological functional recovery.MethodsPatients diagnosed with CSCIwoFD and treated surgically at our institution between August 2020 and January 2023 were retrospectively reviewed. …”
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UMI-77 targets MCL-1 to activate mitophagy and ameliorate periodontitis in mice by Dalei Sun, Shu Ouyang, Xiaoxuan Xu, Jingjing Yan, Heqian Wang, Chenkai Lan, Wubin Ouyang, Liangjun Zhong, Jun Lin

“…Western blot confirmed downregulation of MCL-1 expression to near-normal levels in Group Ba, while TEM detected autolysosomes in both Group Ba and Group Ca, indicating mitophagy activation. …”
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A multi-dimensional performance evaluation of large language models in dental implantology: comparison of ChatGPT, DeepSeek, Grok, Gemini and Qwen across diverse clinical scenarios by Xing Wu, Guofei Cai, Bin Guo, Leizi Ma, Siqi Shao, Jun Yu, Yuchen Zheng, Linhong Wang, Fan Yang

“…Mixed-effects models showed Gemini-2.0-flash-thinking superiority over ChatGPT-o3-mini, while Qwen2.5-max exhibited a decline in performance. …”
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Risk factors of low bone mass in young patients with transfusion-dependent beta-thalassemia by Wei Zhang, Wei Zhang, Rongrong Liu, Rongrong Liu, Rongrong Liu, Siping He, Jihua Huang, Liting Wu, Cuifeng Huang, Yuzhen Liang, Yongrong Lai, Yongrong Lai, Yongrong Lai

“…ObjectiveTo determine the prevalence of low bone mass and associated risk factors among children and adolescents suffering from transfusion-dependent beta-thalassemia (TDT).MethodsIn this study, a total of 389 children and adolescents with TDT (236 males and 153 females), treated between January 2015 and December 2024 in the Department of Hematology at the First Affiliated Hospital of Guangxi Medical University, were selected. …”
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