Options for postoperative radiation therapy in patients with de novo metastatic breast cancer by Chaofan Li, Yusheng Wang, Biyun Fang, Mengjie Liu, Shiyu Sun, Jingkun Qu, Shuqun Zhang, Chong Du

“…Background: Although meta-analyses have demonstrated survival benefits associated with primary tumor resection in MBC, guidelines lack consensus on the survival benefit of postoperative radiation therapy (RT). Methods: In this study, we included 1392 patients with de novo metastatic breast cancer (dnMBC) by integrating data from the SEER database (2010–2019) to systematically assess the efficacy of postoperative RT and develop a machine learning-driven prognostic tool. …”
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Primary cardiac sarcoma: insights from two decades of multimodal management at LMU Munich by Anton Burkhard-Meier, Dorit Di Gioia, Vindi Jurinovic, Michael Hoberger, Sinan E. Güler, Michael Völkl, Stefanie Corradini, Aurélie V. Gaasch, Annabel H. S. Alig, Thomas Knösel, Christian Hagl, Christian Schneider, Wulf Sienel, Wolfgang G. Kunz, Caspar Burkhard-Meier, Michael von Bergwelt-Baildon, Lars H. Lindner, Luc M. Berclaz

“…Methods Thirty-three patients diagnosed with PCS between 2002 and 2024 were retrospectively reviewed. …”
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Re-sperm collection with a short abstinence time: a strategy for successful cryopreservation in cryptozoospermia by Wen-Rui Zhao, Bo Liu, Xue-Feng Luo, Jin-Yan Xu, Chen Luo, Yuan Liu, Yang Xian, Fu-Ping Li

“…Conclusions: These findings indicate that short-interval sperm collection enhances cryopreservation feasibility for cryptozoospermic patients without compromising post-thaw viability, potentially reducing reliance on invasive testicular sperm extraction. While larger prospective studies are needed to confirm these reproductive outcome benefits, this dual-collection protocol offers a cost-effective strategy to optimize sperm availability for intracytoplasmic sperm injection cycles in cases of severe male factor infertility. …”
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Machine learning for detection of diffusion abnormalities-related respiratory changes among normal, overweight, and obese individuals based on BMI and pulmonary ventilation paramet... by Xin-Yue Song, Xin-Peng Xie, Wen-Jing Xu, Yu-Jia Cao, Bin-Miao Liang

“…We evaluated the effectiveness of various supervised ML algorithms and identified the optimal configurations for these applications. Methods We conducted a retrospective analysis of data from 440 individuals who underwent pulmonary function tests between January 1, 2021, and April 1, 2024. …”
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Key Considerations for Ovarian Preservation during Radiotherapy for Cervical Carcinoma by Xiaolong Cheng, Jiping Liu, Xiaojuan Lv, Long Sun

“…Following serum hormone level tests, 73 patients presented normal ovarian function prior to radiotherapy, while 4 demonstrated signs of impaired function. …”
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Effects of resistance exercise on patients with post-stroke dysphagia based on ACSM recommendations: a systematic review of randomized controlled trials by Yu Ye, Kairui Wu, Yingquan Liu, Hongjie Ji, Hongtao Li, Bo Jiang, Fangyuan Xu, Xuejun Li, Peijia Hu, Hongliang Cheng

“…BackgroundResistance exercise shows potential for improving swallowing function in post-stroke dysphagia (PSD), though optimal dose-response parameters remain unclear. While the American College of Sports Medicine (ACSM) framework effectively guides exercise prescriptions in healthy populations, its application to PSD rehabilitation lacks meta-analytical validation. …”
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Pathophysiological Significance of Urea in Glomerular Filtration Dysregulation in Hepatorenal Syndrome: An Integrative Review by Anatoliy Gozhenko, Walery Zukow, Olena Gozhenko, Olga Kvasnytska

“…Elevated urea levels above 35 mmol/L associate with a 3.42-fold increased mortality risk, while reductions exceeding 30% correlate with improved clinical outcomes, emphasizing the need for randomized trials targeting urea correction in HRS.   …”
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Comparative pharmacogenetic study of disulfiram or cyanamide efficacy for alcohol dependence: the key role of dopamine neurotransmission gene polymorphisms by A. O. Kibitov, K. V. Rybakova, V. M. Brodyansky, V. A. Berntsev, E. P. Skurat, E. M. Krupitsky

“…Materials and methods. A pharmacogenetic study was conducted on the basis of a double-blind, randomized, comparative, placebo-controlled clinical study of the efficacy and tolerability of disulfiram and cyanamide in the treatment of alcohol dependence syndrome. …”
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Construction and application of a drought classification model for tea plantations based on multi-source remote sensing by Yang Xu, Yilin Mao, He Li, Xiaojiang Li, Litao Sun, Kai Fan, Zhipeng Li, Shuting Gong, Zhaotang Ding, Yu Wang

“…In the backdrop of global climate change, drought is identified as a major natural hazard, posing a severe threat to tea production. Traditional methods for assessing drought stress in tea plants rely on manual investigation. …”
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Does prioritization of COVID vaccine distribution to communities with the highest COVID burden reduce health inequity? by Hae-Young Kim, Anna Bershteyn, Rienna Russo, Jessica Mcgillen, Julia Sisti, Charles Ko, Jaimie Shaff, Remle Newton-Dame, R. Scott Braithwaite

“…We evaluated the impact of vaccine prioritization strategies on COVID-19 infections and mortality in New York City (NYC). Methods: We used a susceptible-exposed-infected-recovered COVID-19 transmission model calibrated to NYC neighborhood-level data to compare three vaccine distribution strategies: 1) uniform across neighborhoods (no prioritization); 2) prioritizing hardest-hit neighborhoods (exposure-based prioritization); and 3) prioritizing hardest-hit neighborhoods while maintaining mitigation measures in other neighborhoods (exposure-based prioritization plus mitigation). …”
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Efficacy and safety comparison of CAR-T and blinatumomab immunotherapy as bridge-to-transplant strategies in relapsed/refractory B cell acute lymphoblastic leukemia by Wenyue Cao, Ningwen Li, Gaoxiang Wang, Hao Xu, Yang Yang, Jue Wang, Jinhuan Xu, Yun Li, Yicheng Zhang, Yang Cao, Na Wang

“…Further studies are needed to optimize these treatment strategies.…”
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ChatGPT-o1 Preview Outperforms ChatGPT-4 as a Diagnostic Support Tool for Ankle Pain Triage in Emergency Settings by Pooya Hosseini-Monfared, Shayan Amiri, Alireza Mirahmadi, Amirhossein Shahbazi, Aliasghar Alamian, Mohammad Azizi, Seyed Morteza Kazemi

“… Introduction: ChatGPT, a general-purpose language model, is not specifically optimized for medical applications. This study aimed to assess the performance of ChatGPT-4 and o1-preview in generating differential diagnoses for common cases of ankle pain in emergency settings. …”
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Implementing intranasal povidone-iodine in the orthopedic trauma surgery setting to prevent surgical site infections: a qualitative study of healthcare provider perspectives by AM Racila, Erin C. Balkenende, Loreen A. Herwaldt, Michael C. Willey, Linda D. Boyken, Jean G. Pottinger, Brennan S. Ayres, Kimberly C. Dukes, Melissa A. Ward, Marin L. Schweizer

“…Before implementing the PVI intervention, we conducted a human factors task analysis to determine the optimal time and hospital location to perform PVI decolonization for patients receiving these orthopedic fixation procedures. …”
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Comparative efficacy and safety of non-pharmacological interventions on treatment-induced xerostomia in head and neck cancer patients: a systematic review and network meta-analysis by Jingyu Tai, Aimin Guo, Juntong Chen, Haoyu Li, Qian Dong, Wumei Hao, Wenjing Wang, Zunzhu Li, Jianshu Ye, Jinbang Liu, Chengwu Yang

“…AimTo comprehensively evaluate the efficacy and safety of non-pharmacological interventions for radiotherapy-induced xerostomia in patients with head and neck cancer.MethodsA systematic literature search was conducted in PubMed, Embase, the Cochrane Library, and Web of Science for articles published up to March 1, 2025. …”
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Distinct infectivity and neutralization antibody responses in the highly homologous AAV Go.1 and AAV5 by Mei Li, Haixiao Ma, Yang Wu, Yunling Gao, Jie Wang, Jie Wang, Hanbing Wang

“…However, their therapeutic potential and biological properties remain underexplored.MethodsIn this study, we developed a recombinant AAV (rAAV) Go.1 by replacing the goat AAV rep gene with the standard AAV2-rep gene to improve packaging efficiency. …”
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Hydrogel and scalp/skin conductivities impact dose from tumor treating fields by Edwin Lok, Edwin Lok, Olivia Liang, Olivia Liang, Monika Haack, Eric T. Wong, Eric T. Wong, Eric T. Wong

“…GTV hotspots decreased by +17% in E5% at 1 S/m.ConclusionTTFields delivery can be modulated by the conductivity of hydrogel and scalp/skin at the transducer-scalp or transducer-skin interface. Optimizing this aspect of TTFields delivery may increase tumor control while minimizing toxicity at the scalp or skin.…”
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Emerging Therapies in the Treatment of Prurigo Nodularis: Biological Therapy and Systematic Review of Literature by Gaetano Licata, Mariachiara Arisi, Caterina Mariarosaria Giorgio, Cesare Ariasi, Cesare Tomasi, Simone Soglia, Sara Mezzana, Benedetta Galli, Grazia Linda Artelli, Mariateresa Rossi, Cecilia Catapano

“…Dupilumab and nemolizumab emerge as first-line therapies with favorable safety profiles, while JAK inhibitors provide rapid relief for refractory cases. …”
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Time to replace the oral glucose tolerance test for cystic fibrosis related diabetes first-step screening? Establishing glycemic tools relevant to cystic fibrosis by Mathew P. Estey, Shelby Sissons, Heather Sharpe, Michelle Doll-Shankaruk, Dan Beriault, Julie Gilmour, Kathleen Lee, Winnie Leung, Michael D. Parkins, Bradley S. Quon, Elizabeth Tullis, Jie Zheng, Grace Y. Lam

“…However, this is a cumbersome test with poor adherence, and emerging evidence suggests that HbA1c or serum fructosamine might be viable alternative screening tools.Research Design and Methods A multi-center study across four Canadian adult CF centers was conducted to determine the ability of HbA1c and serum fructosamine levels to predict screening OGTT results. …”
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Study on Soil Nutrients and Microbial Community Diversity in Ancient Tea Plantations of China by Jiaxin Li, Wei Huang, Xinyuan Lin, Waqar Khan, Hongbo Zhao, Binmei Sun, Shaoqun Liu, Peng Zheng

“…Sustained excess of AN and SOM may lead to over-proliferation of dominant microorganisms, inhibition of other functional microbial communities, and disruption of ecological balance. Therefore, optimizing nutrient input methods during fertilization is recommended.…”
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Associations between exercise and university students’ depression during the COVID-19 pandemic and lockdown: the mediating role of relative deprivation and subjective exercise expe... by Chao Chen, Jie Ma, Jinzhuang Song, Chuang Yan, Minghao Yan

“…Exercise frequency demonstrates a significant association with RD, which appears to alleviate depressive symptoms. To optimize the depression-alleviating benefits of exercise, students should engage in moderate exercise to avoid excessive fatigue while maintaining positive exercise experiences.…”
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