Pembrolizumab-axitinib versus nivolumab-cabozantinib as first-line therapy in patients with metastatic renal cell carcinoma: a retrospective real-world comparison (ARON-1) by Matteo Santoni, Giandomenico Roviello, Enrique Grande, Ugo De Giorgi, Ondrej Fiala, Emmanuel Seront, Javier Molina-Cerrillo, Renate Pichler, Zin W. Myint, Jakub Kucharz, Ravindran Kanesvaran, Thomas Büttner, Martin Pichler, Umberto Basso, Jindrich Kopecky, Maria T. Bourlon, Linda Cerbone, Tomas Buchler, Alvaro Pinto, Alfonso Gómez de Liaño, Caterina Gianni, Anca Zgura, Pasquale Rescigno, Jawaher Ansari, Orazio Caffo, Zsófia Küronya, Maria Giuseppa Vitale, Dipen Bhuva, Martina Catalano, Nuno Vau, Ray Manneh Kopp, Sebastiano Buti, Aristotelis Bamias, Camillo Porta, Kaisa Sunela, Francesco Massari

“…Abstract Background The optimal first-line therapy for metastatic renal cell carcinoma (mRCC) remains uncertain, despite recent advancements in immune-based combinations. …”
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Efficacy test of a Mycoplasma hyorhinis mRNA-LNP vaccine candidate by Eszter Zsófia Nagy, Levente Szeredi, Hiromi Muramatsu, Noémi Nagy, Dénes Grózner, Zsuzsa Kreizinger, Kinga M. Sulyok, Bandana Pangabam, Lilla Tóth, Rachel H.J. Jun, Dorottya Földi, Enikő Wehmann, Miklós Tenk, Norbert Pardi, Miklós Gyuranecz

“…Therefore, the present study aimed to develop a M. hyorhinis mRNA-LNP vaccine candidate. Materials and methods: The selected antigens were highly conserved proteins involved in bacterial adhesion. …”
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Enhancing fermentation quality and fiber decomposition of Phragmites australis silage by introducing Bacillus subtilis and lactic acid bacteria consortia by Yong Liu, Songbai Zhang, Junrui Liao, Nazir Ahmad Khan, Shaoxun Tang, Chuanshe Zhou, Zhiliang Tan, Asmaa Elnagar, Ibrahim F. Rehan, Ibrahim F. Rehan, Ibrahim F. Rehan, František Zigo, Abdelfattah Z. M. Salem, Abdelfattah Z. M. Salem

“…Acetic and butyric acid concentrations were significantly reduced (p < 0.05), while neutral detergent fiber (NDF) decreased by 5.9% compared to the Control. …”
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Expression characteristics and functional identification of PpD2 gene in peach (Prunus persica) by XIE Hefang, ZHANG Yajia, ZHANG Junjie, LIAN Xiaodong, ZHANG Haipeng, CHENG Jun, WANG Wei, HOU Nan, WANG Lei, ZHENG Xianbo, FENG Jiancan, WANG Xiaobei, TAN Bin

“…These challenges highlight the emergent need to optimize tree architecture and develop labor-saving cultivars to address the developmental bottlenecks in the peach industry. …”
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Rapid laboratory confirmation of the 2025 Sudan Virus Disease (Svd) index case in Uganda by Andrew Nsawotebba, Susan Nabadda, Valeria Nakintu, Isaac Ssewanyana, Misaki Wayengera, Jonathan Kabazzi, Stephen Balinandi, Godfrey Pimundu, Tonny Muyigi, Alisen Ayitewala, Samuel Gidudu, Morgan Otita, Ibrahim Mugerwa, Moses Rubangakene, Sulaiman Ikoba, Sam Kalungi, Rhoda Wanyenze, Kevin K. Ariën, Eunice Namboozo, Benedict Kanamwanji, Steven Ssekyondwa, Ronald Kasujja, Derrick Kitwe, Catherine Dambya, Innocent Morunyanga, Reginald Rony Bahatungire, Francis Kakooza, Moses Joloba, Atek Kagirita, Allan Muruta, Pontiano Kaleebu, Henry Kyobe, Charles Olaro, Diana Atwine, Jane Ruth Aceng

“…The 50 µL sample had the lowest Ct values for the Orthoebolavirus target, while the 30 µL sample had the lowest Ct values for the internal control target. …”
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Serum Concentrations of Matrix Metalloproteinase‐1 and Procollagen Type I Carboxy Terminal Propeptide Discriminate Infarct‐Like Myocarditis and Non−ST‐Segment−Elevation Myocardial... by Lucas Bacmeister, Ersin Cavus, Sebastian Bohnen, Enver Tahir, Hanna Wolf, Annette Buellesbach, Adrian Heidenreich, Virginia K. Haacke, Susanne Weber, Ingo Hilgendorf, Tanja Zeller, Francisco Ojeda, Ulf K. Radunski, Gunnar K. Lund, Gerhard Adam, Stefan Blankenberg, Dirk Westermann, Kai Muellerleile, Diana Lindner

“…Compared with healthy controls, subjects with myocarditis had higher serum concentrations of MMP‐1 and PICP, while no difference was observed in individuals with myocardial infarction. …”
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Isolation and identification of strawberry anthracnose and fungicide screening in Henan province by SUN Wenbin, ZHANG Jingjing, SONG Yanhong, ZHAO Xia, LI Gang, ZHOU Houcheng, LIU Lifeng

“…Inoculated leaves with strain ZG-2 displayed rot after one week, while the lesion areas caused by the other strains were less than 50%, indicating a lower pathogenicity in comparison to ZG-2. …”
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Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8+ T cells by Kyungwha Lee, Jung-Yun Lee, Ji-Hyun Kim, Min Park, Junsik Park, Young Min Oh, Wonjae Lee, Myoung Ho Jang, Young Jun Koh, Sanghee Lee, Jisoo Kim, Kayoung Shin, Seoho Kim, Haejong Lee, Yuseong Lee, Chong Woo Park, Yaein Amy Shim, Young-Gyu Cho, Jongil Kim, Suyoun Park, Eun-Jin Lee, Hyuckjun Mok, Sung-Man Oh, Kook Hwan Kim

“…To optimize targeting to CD73-expressing cells and reinvigorate the antitumor effect of IL-2 in adenosine-rich microenvironment, we engineered a novel bifunctional GI-αCD73/IL-2v fusion protein. …”
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Analysis of the humoral and cell-mediated immune response in heterologous and homologous SARS-CoV-2 revaccination by O. M. Drapkina, M. G. Chashchin, S. A. Berns, A. Yu. Gorshkov, O. V. Zhdanova, L. N. Ryzhakova, O. A. Litinskaya

“…Studying and selecting optimal revaccination regimens will allow for long-term protection against coronavirus disease 2019 (COVID-19).Aim. …”
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Comparative outcomes of revision total knee arthroplasty: a systematic review and meta-Analysis of high tibial osteotomy vs. unicompartmental knee arthroplasty by Peijie Li, Yongjie Qiao, Yingjia Zhou, Jiahuan Li, Zhiqiang Lin, Yafei Cao, Fei Tan, Jiankang Zeng, Xiaoyang Song, Peng Liu, Shuo Ye, Kaipeng Zhuang, Qiuming Gao, Shenghu Zhou

“…The findings are intended to offer valuable insights for optimizing treatment strategies for patients with knee osteoarthritis in clinical practice. …”
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The median Effective Dose (ED50) and the 95% Effective Dose (ED95) of alfentanil in inhibiting responses to cervical dilation when combined with ciprofol during hysteroscopic proce... by Run Gao, Shu-Xi Li, Yan-Hong Zhou, Li Xing, Jin-Peng Fu, Jian-Jun Shen, Xin-Zhong Chen, Li-Li Xu

“…The incidence of intraoperative hypotension was lower in patients given 8 µg·kg−1, 10 µg·kg−1, 12 µg·kg−1 alfentanil, and 14 µg·kg−1 alfentanil than those given 0.15 µg·kg−1 sufentanil (P = 0.044), while the incidence of intraoperative desaturation was higher in patients given 14 µg·kg−1 alfentanil than those given 8 µg·kg−1, 10 µg·kg−1, and 12 µg·kg−1 alfentanil, and 0.15 µg·kg−1 sufentanil (P < 0.001). …”
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Novel perceptions and insights into the rare hematologic malignancy of acute megakaryocytic leukemia: a multicenter clinical retrospective study by Yuan Liu, Yanquan Liu, Xiaojun Chen, Yue Yin, Zhenyuan Xu, Jiachen Xie, Jianzhen Shen, He Huang, Huidong Guo

“…Clinical trials of new drugs should be prioritized, while close monitoring of measurable residual disease (MRD) should be implemented. …”
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Treatment with intravenous immunoglobulin modulates coagulation- and complement-related pathways in COVID-19 patients by Dominic McGrosso, Dominic McGrosso, Jessica Raygoza, Jessica Raygoza, Avnee J. Kumar, Avnee J. Kumar, Michael T. Y. Lam, Michael T. Y. Lam, Laura A. Barnes, Laura A. Barnes, Sophia Karandashova, Alexia Perryman, Alexia Perryman, Matthew Geriak, Mazen F. Odish, Nicole G. Coufal, Nicole G. Coufal, Nicole G. Coufal, Brian Lichtenstein, George Sakoulas, George Sakoulas, Angela Meier, Victor Nizet, Victor Nizet, Jorge A. Masso-Silva, Jorge A. Masso-Silva

“…IntroductionIntravenous immunoglobulin (IVIG) is a therapy that uses pooled immunoglobulins from thousands of different donors. While it is primarily used to treat immunodeficiency and autoimmune diseases due to its immunomodulatory properties, IVIG has also been used as an off-label therapy for respiratory infections, including COVID-19. …”
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Effects of temperature on the pollination biology of Luntai Xiaobai apricot by XIE Lixing, TIAN Baolian, TANG Zhanghu, ZHU Zongcai, Abulaike Niyazi, ZHANG Dahai, LUO Shudong

“…[Methods] The dynamic flowering of Luntai Xiaobai apricot was observed and recorded from March to April 2024. …”
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Understanding patient pathways to Mother and Baby Units: a longitudinal retrospective service evaluation in the UK by Nikolina Jovanović, Žan Lep, Giles Berrisford, Aysegul Dirik, Julia Barber, Bukola Kelani, Olivia Protti

“…The simple pathway entailed contact with one clinician/service prior to admission to the Mother and Baby Unit, while the complex pathway involved interactions with two or more clinicians/services before Mother and Baby Unit admission. …”
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The role of immunochemotherapy maintenance in metastatic nasopharyngeal carcinoma: insights from a cohort study in an endemic region by Zhuoying Luo, Yue Xia, Yuping Zhao, Haoyang Huang, Ying Deng, Zejiang Zhan, Yingying Huang, Xun Cao, Xi Chen, Jiayu Zhou, Chixiong Liang, Weixiong Xia, Liangru Ke, Xuehua Wei, Jinling Duan, Xing Lv, Hu Liang

“…Abstract Objectives Metastatic nasopharyngeal carcinoma (mNPC) following palliative chemotherapy has high incidence and mortality rates. While maintenance therapy shows promising potential, the optimal strategy remains undefined. …”
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Clinical and economic impact of the availability of innovative therapies for advanced lung cancer in men in Latin America: a population-based secondary data studyResearch in contex... by Andrés F. Cardona, Natalia Sánchez, Liliana Gutiérrez-Babativa, Leonardo Rojas, Jairo Zuluaga, Stella Martínez, Lucia Viola, Carlos Carvajal, Juliana Bogoya, Laura Prieto-Pinto, Daniel Samacá-Samacá, Antonio Robles, Joshua Kock, Claudio Martín, Luis Corrales, Luis E. Raez, Vladmir Cordeiro de Lima, Suraj Samtani, Oscar Arrieta

“…Accelerating the introduction of innovative therapies for advanced lung cancer in Latin America represents a significant opportunity to enhance survival rates, instilling hope and optimism while also avoiding substantial PL. Funding: This study was conducted as a research partnership between Roche and CTIC. …”
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Deep Learning-Based Cardiac Chamber Segmentation in Magnetic Resonance-Guided Adaptive Radiation Therapy by Xinru Chen, PhD, Yao Ding, PhD, Julius Weng, MD, Carol C. Wu, MD, Yao Zhao, PhD, Angela Sobremonte, BS, Mustefa Mohammedsaid, MS, Zhan Xu, PhD, Xiaodong Zhang, PhD, Joshua S. Niedzielski, PhD, Sanjay S. Shete, PhD, Laurence E. Court, PhD, Zhongxing Liao, MD, Jihong Wang, PhD, Ergys Subashi, PhD, Percy P. Lee, MD, Jinzhong Yang, PhD

“…Adaptive plan greatly reduced individual cardiac chamber dose while maintaining similar target coverage. Conclusions: This study demonstrated the feasibility of using bFFE-SPAIR and T1 mDixon sequences to accurately segment cardiac chambers on a 1.5-T MR-Linac. …”
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Bronchoalveolar lavage cell percentages as diagnostic markers of immune checkpoint inhibitor pneumonitis by Mahnoor Mir, Felipe Soto, Pedro Antonio Amezcua Gomez, Rodrigo Del Rio Arroyo, Adarsh Suresh, Amber Su, Qiong Gan, John Stewart, Roberto Adachi, Diwakar D. Balachandran, Lara Bashoura, Roberto F. Casal, Burton F. Dickey, George A. Eapen, Scott E. Evans, Horiana Grosu, Carlos A. Jimenez, Julie Lin, David E. Ost, Bruce F. Sabath, Vickie R. Shannon, Aung Naing, Jianjun Gao, Jia Wu, Karthik Suresh, Saadia A. Faiz, Mehmet Altan, Ajay Sheshadri

“…The AUROC for BAL lymphocytes to diagnose ICIP was 0.62 (95% CI 0.57–0.67, optimal cutoff 15.5%, sensitivity 69%, and specificity 52%) and the AUROC for eosinophils was 0.61 (95% CI 0.56–0.66, optimal cutoff 1%, sensitivity 58%, and specificity 62%). …”
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Effective cellular and neutralizing immunity against SARS-CoV-2 after mRNA booster vaccination is associated with pDC and B cell activation by Dorit Fabricius, Carolin Ludwig, Carolin Ludwig, Matthias Proffen, Matthias Proffen, Janina Hägele, Janina Hägele, Judith Scholz, Judith Scholz, Christiane Vieweg, Christiane Vieweg, Immanuel Rode, Immanuel Rode, Simone Hoffmann, Simone Hoffmann, Sixten Körper, Sixten Körper, Hubert Schrezenmeier, Hubert Schrezenmeier, Bernd Jahrsdörfer, Bernd Jahrsdörfer

“…This study aimed to elucidate the immune responses, including B cell, plasmacytoid dendritic cell (pDC), and T cell activation, following mRNA booster vaccination.MethodsIn a longitudinal cohort study, 136 individuals received three different vaccination regimens: homologous mRNA, heterologous vector-mRNA-mRNA, or heterologous vector-vector-mRNA vaccinations. …”
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