Risk of disease progression after discontinuing immunotherapy in 105 patients with Merkel cell carcinoma who responded to PD-1 pathway blockade by Shailender Bhatia, Daniel S Hippe, Paul T Nghiem, Candice Church, Tomoko Akaike, Kristina Lachance, Lisa Tachiki, Thomas Pulliam, Song Y Park, Coley Doolittle-Amieva, Lisa Zaba, Nora A Alexander, Emily Gong, Lauren Zawacki, Allison J Remington, Yasman Moshiri, Alex Fu, Emily Huynh, Nikhil Harikrishnan, Marika Bierma

“…Background Immune checkpoint inhibitors (ICIs) are the preferred systemic therapy for most patients with advanced Merkel cell carcinoma (MCC). However, the optimal duration of treatment for patients responding to ICI is unclear. …”
Get full text

High-throughput screening of monoclonal antibodies against carbapenemases using a multiplex protein microarray platform by Sascha D. Braun, Sascha D. Braun, Martin Reinicke, Martin Reinicke, Celia Diezel, Celia Diezel, Elke Müller, Elke Müller, Katrin Frankenfeld, Thomas Schumacher, Hugo Arends, Stefan Monecke, Stefan Monecke, Ralf Ehricht, Ralf Ehricht, Ralf Ehricht

“…However, the development of such assays is often hindered by the time-consuming process of identifying high-affinity antibody pairs.MethodsTo accelerate this process, we evaluated a protein microarray platform as a high-throughput screening tool to identify optimal monoclonal antibody (mAb) pairs targeting the most clinically relevant carbapenemases. …”
Get full text

Knowledge, attitudes, and practices toward ticks and tick-borne diseases: a cross-sectional study in Rwanda by Abakundana Nsenga Ariston Gabriel, Xiao-Yang Wang, Guo-Yao Zu, Laila Jamil, Blaise Iraguha, Methode Ngabo Gasana, Bing-Bing Gu, Ntakirutimana Theoneste, Lin Zhao, Wu-Chun Cao

“…This study aimed to assess the knowledge, attitudes, and practices toward ticks and tick-borne diseases among adults in Rwanda. Methods The sample size was determined using a single-population proportion formula. …”
Get full text

Epidemiological characteristics of acute viral and mycoplasma respiratory infections in Yongzhou, China: a retrospective descriptive study by Ying Jiang, Ying Jiang, Junyan Lu, Junyan Lu, Zhengrong Tan, Zhengrong Tan, Hanmei Wan, Hanmei Wan, Min Tang, Min Tang, Jiani Li, Jiani Li, Tao Zhou, Tao Zhou, Wenlong Tang, Wenlong Tang

“…RSV primarily affected children under 5 years (38.63% of RSV cases), while SARS-CoV-2 showed higher detection rates in older adult populations (64.81% of COVID-19 cases). …”
Get full text

Impact of semen extenders, storage duration, and insemination timing on semen quality and reproductive performance in Palestinian Assaf sheep by Wael Halawa, Samia Khnissi, Ikram Bensouf, Bochra Bejaoui, Hela Chalouati, Muayad Salman, Naceur M’Hamdi

“…Pregnancy rates were not significantly influenced by the extender type but were optimized by insemination at both 48 and 52 h post-eCG injection. …”
Get full text

Perceived effects of accreditation on education quality and health-related job outcomes: scales validation and correlates in Lebanon by Deema Rahme, Daniele Saade, Hala Sacre, Chadia Haddad, Samah Tawil, Samar Merhi, Randa Aoun, Aline Hajj, Fouad Sakr, Jihan Safwan, Marwan Akel, Rony M. Zeenny, Pascale Salameh

“…Multivariate analysis of covariance (MANCOVA) adjusted for sociodemographic and university-related factors, while multiple regression explored predictors of time to employment for graduates. …”
Get full text

Dihydroartemisinin-sodium taurocholate-PLGA nanoparticles: a novel therapeutic approach against cystic echinococcosis by Aierpati Moheteer, Aierpati Moheteer, Jiang Zhu, Jiang Zhu, Dongming Pang, Dongming Pang, Xue Rao, Xue Rao, Nijiati Aini, Nijiati Aini, Kalibixiati Aimulajiang, Zhenping Zhang, Zhenping Zhang, Saifuding Abula, Saifuding Abula, Adelijiang Wusiman, Adelijiang Wusiman

“…To overcome these limitations and enhance hepatic targeting, the DHA was encapsulated in poly (lactic-co-glycolic acid) (PLGA) nanoparticles, and using sodium taurocholate (STC) as the surface modifier, a novel composite nanoparticle designated as DHA-STC-PLGA nanoparticles (DSP nanoparticles).MethodsThe formulation was optimized using response surface methodology, and its targeting efficiency was confirmed through in-vivo fluorescence imaging. …”
Get full text

Gender and sex differences in the outcomes of modern coronary surgery: the main results of the Coronary Revascularization Outcomes Within Necessary Sex And Gender Aspects (CROWN-SA... by S. Kh. Lilothia, R. N. Komarov, V. B. Arutyunyan, V. A. Belov

“…Predictor of long-term MACCE and death for women was use of composite grafts, while for men — ejection fraction (EF) £40%, age >70 years, and off-pump CABG. …”
Get full text

Frequency and Prognostic Value of Acute Periprocedural Myocardial Injury in Elective Percutaneous Coronary Interventions by E. O. Nalesnik, A. N. Repin

“…PMI was diagnosed with an increase in the level of creatine phosphokinase MB fraction (CK-MB) or or cardiac troponin I (cTn I) >1×99 percentile URL (Upper Reference Limit), while the level of increase in biomarkers >1, 2, 3, 4 or >5×99 percentile URL was recorded. …”
Get full text

Brain tumor segmentation using deep learning: high performance with minimized MRI data by Jacky Huang, Banu Yagmurlu, Powell Molleti, Richard Lee, Abigail VanderPloeg, Humaira Noor, Rohan Bareja, Yiheng Li, Michael Iv, Haruka Itakura

“…However, this data-intensive approach is time-consuming. We aimed to optimize the process by using a deep learning (DL) based model while minimizing the number of MRI sequences required to segment gliomas.MethodsWe trained a 3D U-Net DL model using the annotated 2018 MICCAI BraTS dataset (training dataset, n = 285), focusing on sub-segmenting enhancing tumor (ET) and tumor core (TC). …”
Get full text

Prediction of sinus rhythm maintenance after radiofrequency ablation in patients with atrial fibrillation using speckle tracking echocardiography and dynamics of left atrial struct... by T. I. Musin, Z. A. Bagmanova, D. A. Gareev, V. G. Rudenko, N. Sh. Zagidullin

“…To evaluate the dynamics of left atrial volume (LAV), strain (S) during the reservoir phase and strain rate (SR) in patients with paroxysmal and persistent atrial fibrillation (AF), scheduled for catheter radiofrequency ablation (RFA), as well as to compare the predictive value of S and SR as a marker of maintaining sinus rhythm.Material and methods. A total of 19 patients (men, 11; women, 8) aged 62±10,7 years with AF were included in the study, 13 (67%) of whom had persistent AF, while 6 patients (33%) had paroxysmal AF Two-dimensional and speckle tracking N. …”
Get full text

Immunohistochemical analysis of PD-L1, CD4, CD8, CD20, and PU.1 expression in a dedifferentiated chondrosarcoma: the clinical and prognostic value by Olga V. Kovaleva, Irena V. Boulytcheva, Dmitrii V. Rogozhin, Alexei N. Gratchev, Polina L. Prishchep, Nikolay E. Kushlinskii

“…Median survival of the PD-L1 non-expressing patients was 68.6 months, while of those with the expression 7.7 months (p = 0.096). …”
Get full text

Impact of tumor diameter on post-radiofrequency ablation survival and local progression risk in patients with colorectal cancer lung metastasis by YING Leilei, LI Kening, CHEN Chao, WANG Ying, HUANG Haozhe, WANG Biao, LI Wentao, HE Xinhong

“…A tumor diameter of 3 cm can serve as a critical threshold for selecting RFA indications, and combining preoperative CEA levels can optimize patient stratification.…”
Get full text

Development and validation of a machine learning-based risk prediction model for stroke-associated pneumonia in older adult hemorrhagic stroke by Yi Cao, Yi Cao, Haipeng Deng, Shaoyun Liu, Xi Zeng, Yangyang Gou, Weiting Zhang, Yixinyuan Li, Hua Yang, Min Peng

“…Model performance was compared using Delong's test or Bootstrap test, while sensitivity, specificity, accuracy, precision, recall, and F1-score evaluated predictive efficacy. …”
Get full text

Inflammatory and Nutritional Biomarker in Different Subtypes of Early Stage Diffuse Large B-Cell Lymphoma: Towards a Diagnostic Model by Oehadian A, Gunadi SV, Mersiana L, Susandi E, Wijaya I, Martha JW, Supriyadi R, Prihatni D

“…Accurate subtyping is crucial due to differences in prognosis and treatment response. While gene expression profiling is the gold standard, it is often unavailable in low-resource settings. …”
Get full text

CPAP modulation of sleep microstructure (N2-SSD and REM-AHI) as predictors of neurological recovery in ischemic stroke patients with moderate-to-severe OSA by Tianyu Jing, Tianyu Jing, Tianyu Jing, Liwen Xu, Liwen Xu, Shutong Sun, Wenyi Yu, Wenyi Yu, Yixi Zheng, Yixi Zheng, Gang Xu, Xinhao Shen, Tieyu Tang, Cheng Chu, Cheng Chu

“…The findings are expected to optimize treatment strategies and improve overall patient outcomes.MethodsA total of 141 patients with IS combined with moderate-to-severe OSA admitted to the Affiliated Hospital of Yangzhou University from October 2022 to August 2024 were enrolled. …”
Get full text

Evaluation of the hypercholesterolemia care cascade and compliance with NCEP-ATP III guidelines in Iran based on the WHO STEPS survey by Shirin Djalalinia, Sepehr Khosravi, Moein Yoosefi, Sarvenaz Salahi, Zahra Shokri Varniab, Ali Golestani, Nazila Rezaei, Ameneh Kazemi, Arezou Dilmaghani-Marand, Negar Rezaei, Erfan Ghasemi, Naser Ahmadi, Mohammad-Mahdi Rashidi, Yosef Farzi, Kamyar Rezaee, Maryam Nasserinejad, Sina Azadnajafabad, Elham Abdolhamidi, Rosa Haghshenas, Arefeh Alipour Derouei, Azadeh Momen Nia Rankohi, Farshad Farzadfar

“…Of those receiving treatment, 52.85% (females) and 53.93% (males) achieved optimal LDL, while 76.98% (females) and 81.06% (males) attained total cholesterol < 200 mg/dL. …”
Get full text

Trends in inpatient antibiotic use in Indonesia and the Philippines during the COVID-19 pandemic by Amara Z. Fazal, Olivia L. McGovern, Garrett W. Mahon, Fernanda C. Lessa, Maria Tarcela Gler, Jemelyn Garcia, Mark John Festin, Kuntaman Kuntaman, Ida Parwati, Cherry Siregar, Jay Christian D. Muere, Gina De Guzman Betito, Maya Montemayor, Arleen De Leon, Emmeline Borillo, Mark Ramon Victor Llanes, Regina Berba, Musofa Rusli, Mariyatul Qibtiyah, Bambang Pujo Semedi, Rosantia Sarassari, Leonardus Widyatmoko, Basti Andriyoko, Adhi Kristianto Sugianli MD, Dewi Kartika Turbawaty, Ivo Dhanitri Ranita, Franciscus Ginting, Rahmadania Marita Joesoef, Made Ananda Krisna, Twisha S. Patel

“…We assessed changes in AU during the COVID-19 pandemic in Indonesia and the Philippines. Methods: We evaluated hospital-wide AU over 36 months in six hospitals, 3 in Indonesia and 3 in the Philippines. …”
Get full text

What Changes are Mandatory in Breast Surgery Training? An International Survey and Recommendations of the French Academy of Surgery and the Senologic International Society by Tolga Ozmen, Caroline Bouche, Megane Buttignol, Bolivar Arboleda-Osorio, Mauricio Magalhaes Costa, Henry Coudane, Darius Dian, Xishan Hao, Shigeru Imoto, Olivier Jardé, Hubert Johanet, Esther Meka, Alexander Mundinger, Ruben Orda, Vahit Ozmen, Tadeusz Pienkowski, Schlomo Schneebaum, Charlotte Vaysse, Susie Brousse, Atilla Soran, Carole Mathelin

“…Most respondents (66%) had over 15 years of experience, and 75% were male. While 50% reported that breast surgery fellowships were not mandatory, countries with requirements often stipulated a one or two-year experience and a minimum cases number. …”
Get full text

VENETOCLAX-BASED VERSUS 7+3 INDUCTION THERAPY IN FIT YOUNGER ADULTS WITH NEWLY DIAGNOSED NON-CBF AML by Dmitrii Zhogolev, Nikita Pastukhov, Bella Aybova, Anna Smirnova, Ivan Moiseev, Sergey Bondarenko, Alexander Kulagin

“…Survival analysis was conducted using the Kaplan-Meier method and log-rank test. Cumulative incidences of relapse and NRM were assessed using competing risk models with Gray’s test. …”
Get full text