Risk Factors and Prognostic Models in Acute Large Vessel Occlusion Stroke: Insights From ASPECTS‐Net Water Uptake by Hongru Ou, Huanhua Wu, Shuolong Wu, Qian Cao, Xiaozheng Cao, Guanye Zhang, Jiabin Mo, Youzhu Hu

“…ABSTRACT Background The outcomes of endovascular reperfusion in acute large vessel occlusion stroke (ALVOS) vary, with some patients recovering fully while others face disability or mortality despite recanalization. …”
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Adaptation and validation of the Washington group/unicef child functioning module in a nationally representative sample of Canadian children and youth by Emma Nolan, Katherine Cost, Ryan Miller, Li Wang, Chen Yun-Ju, Jordan Edwards, Eric Duku, Stelios Georgiades, Peter Szatmari, Harriet MacMillian, Charlotte Waddell, Katholiki Georgiades

“…Factor one represented Cognitive, Behavioural and Interpersonal Functional Difficulties; while Factor two represented Emotional Functional Difficulties. …”
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Development and Evaluation of Trans-Resveratrol-Loaded Transfersomes: Role of Cholesterol in Formulation Design for Dermal Delivery by Sarotsumpan P, Chiu IH, Wu PC, Khong NMH, Liew CV, Chutoprapat R

“…Notably, formulation F3, with a hydrogenated lecithin to cholesterol to Tween 60 ratio of 6:0:4, emerged as the optimal candidate, achieving the highest release rate (80.24% over 24 hours) while maintaining favorable permeation compared to control.Conclusion: These findings feature the potential of transfersomal systems, particularly cholesterol-free variants, as promising carriers for the effective and safe dermal delivery of trans-resveratrol. …”
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Intrathecal hydromorphone vs. transversus abdominis plane block for upper abdominal surgery: a propensity score-matching study by Yue-xin Huang, Yu Chen, Wei Wang, Ting-ting Li, Lin Ding, Fang Gao, Xiao-chuan Zou, Fei Liu

“…Abstract Background Multimodal analgesia is vital for enhanced recovery after upper-abdominal surgery. While both Intrathecal hydromorphone (ITH) and transversus abdominis plane (TAP) block are widely applied in upper-abdominal surgery, evidence comparing the two techniques remains limited. …”
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Analysis of mitochondrial-targeted antioxidant SkQ1 effectiveness on myocardial ischemia-reperfusion injury in a rat model: Focus on morphological and ultrastructural tissue study by E. A. Senokosova, E. A. Velikanova, R. A. Mukhamadiyarov, O. D. Sidorova, E. O. Krivkina, L. V. Antonova, E. V. Grigoriev

“…The quantitative data were processed using GraphPad Prism 7 (Graph Pad Software, USA).Results. The optimal myocardial preservation was discovered while using 12 ng/mL of SkQ1: the lowest concentrations of MDA (49.5 [41.1; 58.9] mmol/g), Troponin-I (22.3 [20.3; 23.9] pg/mL) and H-FABP (0.8 [0.6; 16.0] ng/mL) were associated with extensive areas of tissues with preserved transverse dark and light bands and a moderate interstitial edema. …”
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Exploring the Impact of Backward and Forward Locomotor Treadmill Training in Chronic Stroke Survivors with Severe Post-Stroke Walking Impairment: A Single-Center Pilot Randomized C... by Saiprasad Naidu, Khwahish Singh, Tamiel Murray, Colin Drury, Erin Palermo, Heidi J. Sucharew, Changchun Xie, Pierce Boyne, Kari Dunning, Oluwole O. Awosika

“…Future well-powered dosing trials and mechanistically driven studies are needed to optimize and identify predictors of training response.…”
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Clinical management and analysis of immune-related adverse events in neoadjuvant immunotherapy for locally advanced rectal cancer by AN Yang, WANG Chentong, QIU Xiaoyuan, ZHOU Jiaolin, LIN Guole

“…This study aimed to investigate the characteristics, clinical management strategies, and outcomes of irAEs during neoadjuvant immunotherapy for rectal cancer, providing a basis for optimizing irAEs monitoring and intervention. Methods: We retrospectively analyzed clinical data from LARC patients who developed irAEs after receiving neoadjuvant immunotherapy at Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, between July 2022 and June 2024. …”
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Pharmacokinetic Properties and Therapeutic Effectiveness of Remimazolam in ICU Patients With Mechanical Ventilation: A Preliminary Study by Jing Hu, Yuhan Zhao, Litao Shao, Wenhui Zhang, Han Wang, Yun Liu, Mengxiang Su, Xiangrong Zuo

“…ABSTRACT The pharmacokinetic (PK) profile of remimazolam, a ultra‐short‐acting benzodiazepine, has been investigated for procedural sedation and anesthesia, but its pharmacokinetics, pharmacodynamics, and optimal dosing for ICU sedation are still unclear. …”
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Augmenting Naïve Bayes Classifiers with <i>k</i>-Tree Topology by Fereshteh R. Dastjerdi, Liming Cai

“…In such cases, however, the selection of the <i>k</i> parent features for each variable is often made through heuristic search methods (such as sorting), which do not guarantee an optimal approximation of network topology. …”
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Edge-Deployed Band-Split Rotary Position Encoding Transformer for Ultra-Low-Signal-to-Noise-Ratio Unmanned Aerial Vehicle Speech Enhancement by Feifan Liu, Muying Li, Luming Guo, Hao Guo, Jie Cao, Wei Zhao, Jun Wang

“…Addressing the significant challenge of speech enhancement in ultra-low-Signal-to-Noise-Ratio (SNR) scenarios for Unmanned Aerial Vehicle (UAV) voice communication, particularly under edge deployment constraints, this study proposes the Edge-Deployed Band-Split Rotary Position Encoding Transformer (Edge-BS-RoFormer), a novel, lightweight band-split rotary position encoding transformer. While existing deep learning methods face limitations in dynamic UAV noise suppression under such constraints, including insufficient harmonic modeling and high computational complexity, the proposed Edge-BS-RoFormer distinctively synergizes a band-split strategy for fine-grained spectral processing, a dual-dimension Rotary Position Encoding (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>RoPE</mi></semantics></math></inline-formula>) mechanism for superior joint time–frequency modeling, and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>FlashAttention</mi></semantics></math></inline-formula> to optimize computational efficiency, pivotal for its lightweight nature and robust ultra-low-SNR performance. …”
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Dual Role of Quercetin in Promoting Early Wound Healing via Inhibiting Inflammatory Factors and Attenuating Scar Formation by Suppressing Myofibroblast Differentiation by Dan Wu, Mengyuan Jiang, Jing Zhang

“…Further efforts should focus on optimizing its bioavailability to enhance clinical translation.…”
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Randomized, controlled trial comparing the efficacy of intercostal nerve block in thoracoscopic surgery by timing: study protocol for a randomized clinical trial by Yasuharu Sekine, Hideo Ichimura, Sho Ueda, Shinsuke Kitazawa, Naohiro Kobayashi, Yuya Murata, Kumiko Yamada, Shinichi Inomata, Kazushi Maruo, Yukio Sato

“…Abstract Background Even minimally invasive thoracic surgeries carry a postoperative cost in pain. While regional anesthesia may alleviate this anticipated pain, especially intercostal nerve blocks (ICNB), the timing of block administration for optimal effect (at the beginning of surgery vs. before wound closure) remains controversial. …”
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Clinical and Demographic Characteristics of Hospitalized Pediatric Measles Cases; The 2023 Outbreak in Northern Jordan by Alsulaiman JW, Kheirallah KA, Alrawashdeh A, Abu Sanad Z, Al-Mnayyis AM, Yassin A, Rawabdeh MI, Alzoubi H

“…The average hospital stay was 4.4 days.Conclusion: The measles outbreak in Northern Jordan predominantly affected unvaccinated children, particularly those under nine months of age. While vaccination reduced the risk of severe complications (eg, pneumonia occurred in 75% of unvaccinated vs 25% of vaccinated cases), breakthrough infections in vaccinated children underscore the need for optimized immunization strategies. …”
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Diagnostic accuracy of the A-test and cutoff points for assessing outcomes and planning acute and post-acute rehabilitation of patients surgically treated for hip fractures and ost... by Vukomanović Aleksandra, Đurović Aleksandar, Brdareski Zorica

“…On the second and the third day A-test had two cutoff points, the lower point safely separated the patients with functional disability, while the upper point ruled out functional disability. …”
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Accuracy of 7 intraocular lens power calculation formulas in primary angle-closure glaucoma eyes, according to axial length and anterior chamber depth by Han Xu, Yuanjin Zheng, Xinlei Lu, Longyuan Liu, Rui Wan, Shaodan Zhang, Guoxing Li, Rongrong Le, Yuanbo Liang

“…Design Retrospective, consecutive case series. Methods Patients who underwent cataract surgery diagnosed with PACG or not were included. …”
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Intraoperative titration of positive end-expiratory pressure in urological patients undergoing laparoscopic procedures under lateral position: a randomized controlled trial by Lili Pan, Xing Wu, Lingling Gao, Zhanqi Zhao, Li Yang, Jun Zhang

“…Abstract Objective The study aimed to investigate the role of electrical impedance tomography (EIT)-guided individualized positive end-expiratory pressure (PEEP) in surgical patients under lateral position. Methods The urological patients undergoing elective laparoscopic surgery were randomly allocated to either the PEEPEIT (titrated with EIT) or PEEP5 (fixed PEEP = 5cmH₂O) groups. …”
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Direct comparison of cardioprotective effects of necroptosis inhibitors against global ischemia-reperfusion in the isolated rat heart by Yu. V. Dmitriev, S. M. Minasian, V. K. Bayrasheva, E. A. Demchenko, M. M. Galagudza

“…The study was aimed at comparative assessment of cardioprotective properties of various necroptosis inhibitors in the isolated perfused rat heart subjected to global ischemia-reperfusion.Materials and Methods. The study was performed on 38 male Wistar rats weighting 250–300 g. …”
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A nomogram for predicting malnutrition risk in patients with chronic heart failure and correlation study between GHRL, MSTN, CRP, Hs-CRP by Yuling Zha, Chengshuai Liu, Yuping Zhou, Miao Kong, Jinlei Liu, Lu Jing, Hailati Gulimila

“…Additionally, MSTN was positively correlated with CRP and Hs-CRP, while GHRL was negatively correlated with MSTN, CRP, and Hs-CRP. …”
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Effect of metabolic syndrome on patient-reported outcome measures following lumbar fusion surgery: a longitudinal study with 24-month follow-up by Xuan Zhao, Wei Wang, Xiaolong Chen, Shibao Lu

“…Among them, 74 (31.1%) patients had MetS, while 164 (68.9%) did not. In patients without MetS, NASS distribution improved gradually until 6-month follow-up, and then plateaued. …”
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Efficacy of Tuina Therapy Based on Hip-Knee-Ankle Synergy in the Lower Extremity Kinematic Chain in Patients With Knee Osteoarthritis: Protocol for a Randomized Controlled Trial by Zonglin Wen, Ruoyun Lyu, Shuaipan Zhang, Yifeng Yu, Jianwei Wang, Lingjun Kong, Min Fang

“…Thus, the therapeutic efficacy may not be optimal in these instances. ObjectiveThis study aims to evaluate the clinical efficacy of Tuina therapy based on hip-knee-ankle synergy combined with conventional treatment in patients with KOA. …”
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