The role of early weight bearing in the aftertreatment of unilateral displaced intraarticular calcaneal fractures: a systematic review and pooled analysis by Coen Verstappen, Mitchell L. S. Driessen, Lloyd Brandts, Michael J. R. Edwards, Martijn Poeze, Erik Hermans, Pishtiwan H. S. Kalmet

“…Abstract Background Displaced intraarticular calcaneal fractures (DIACFs) remain a complex challenge in orthopedic practice due to their complexity and the intricate nature of surgical interventions. While surgical techniques have evolved, postoperative rehabilitation is equally crucial for achieving optimal outcomes. …”
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Navigating Pregnancy Testing in Chronic Pain Management for Women of Reproductive Age by Tamura S, Vardhan S, Breidenbach K, Shaparin N, Vydyanathan A, Gritsenko K

“…Despite national recommendations from organizations like the American College of Radiology (ACR), implementation of pregnancy screening in the pain management context remains limited.Methods: This review synthesizes current literature and practice guidelines to assess the gaps in pregnancy screening protocols within chronic pain management settings. …”
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Green-Synthesized Ag and ZnO Nanoparticles using Cassia fistula Leaf Extract: Biocompatibility and Growth Response in Early Plant Development by A.h.m. Maniruzzaman Rabbani, Syeda Nyema Jannat, Md. Shahed Al Shishir, Md. Shaheen Alam, Atiqur Rahman, Md. Shohidul Alam

“…These findings highlight that while green-synthesized nanoparticles hold agricultural potential, their use must be carefully optimized to avoid phytotoxic effects. …”
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Impact of the COVID-19 pandemic on lung cancer screening utilization and outcome: a health examination center retrospective study by Chi-Shen Chen, Cai-Sin Yao, Fu-Zong Wu

“…Future policies must prioritize high-risk individuals, optimize resources, and enhance early detection to improve outcomes and crisis preparedness.…”
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Exploring secular trends and types of tuberculosis burden in India over past three decades through insights from the Global Burden of Disease Study 2019 by Krittika Bhattacharyya, Ravi Prakash Jha, Deepak Dhamnetiya, Priyanka Patel, Neha Shri, Mayank Singh

“…Strengthening early detection, optimizing treatment strategies, and raising community awareness will be essential to curb the spread and impact of resistant TB forms, while mitigating the broader implications of AMR.…”
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Real-world safety profile of etelcalcetide in dialysis-related secondary hyperparathyroidism: a pharmacovigilance analysis of FAERS data by Cong Zou, Xing Wang, Ruizhen Huang, Honglin Hu

“…Purpose The real-world safety of etelcalcetide in the treatment of dialysis-related secondary hyperparathyroidism (SHPT) was evaluated by analyzing associated adverse events (AEs) and assessing their clinical significance.Methods Data from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) (2017–2024) were analyzed. …”
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Novel Approach for Evaluating the Effectiveness of Biological Drugs in Patients with Plaque Psoriasis: Real-World Experience of a Single-Centre Study in Poland by Kimak-Pielas A, Robak E, Zajdel R, Żebrowska A

“…Anti-IL-17AF therapy achieved complete remission (PASI-100) in the shortest time (53.8 days vs 101.7 days for a total population, p< 0.05). While treatment effectiveness did not differ between bio-naive and non-bio-naive patients overall, repeated exposures to anti-TNF and anti-IL-12/23 therapies were associated with a diminished clinical response.Conclusion: The study highlights the critical importance of strategic selection of the treatment to optimize long-term outcomes.Keywords: plaque psoriasis, biological drugs, effectiveness, psoriasis severity, PASI…”
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Development and Preclinical Evaluation of a Lyophilized Vaccine Against Equine Herpesvirus Type 4 (EHV-4) by Lespek Kutumbetov, Balzhan Myrzakhmetova, Aiganym Tussipova, Gulzhan Zhapparova, Talshyn Tlenchiyeva, Karina Bissenbayeva, Sergazy Nurabayev, Aslan Kerimbayev

“…Background/Objectives: Equine rhinopneumonia, caused by equine herpesvirus types 1 and 4 (EHV-1 and EHV-4), continues to be a significant health and economic concern in the global equine industry, particularly in Kazakhstan. While vaccines targeting EHV-1 are available, there is currently no licensed monovalent vaccine for EHV-4, and existing formulations offer limited protection against this serotype. …”
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Carbapenem De-escalation in urinary tract infections: prevalence and outcomes among hospitalized patients by Leedia Abuelshayeb, Rana Abu-Farha, Khawla Abu Hammour, Mohammed Zawiah

“…Abstract Objective To evaluate the prevalence and outcomes of carbapenem de-escalation among hospitalized urinary tract infection (UTI) patients at Jordan University Hospital from January 2022 to March 2024. Methods This retrospective study included adult patients who received carbapenems as empirical therapy and underwent urine culture testing. …”
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Effects of diet supplemented with water extracts of Artemisia annua L. on small intestinal immune and antioxidative indexes in lambs by Gen Gang, Ruiheng Gao, Huricha Zhao, Xiao Jin, Yuanyuan Xing, Lei Hong, Sumei Yan, Yuanqing Xu, Binlin Shi

“…Furthermore, expressions levels of Nrf2, GSH-Px and HO-1 in the small intestine increased quadratically (p < 0.05), while Keap1 expression levels exhibited a downward quadratic trend (p < 0.10).ConclusionIn summary, the optimal dietary addition of 1,000 mg/kg WEAA significantly enhanced intestinal immune function, antioxidant capacity, and the expression of related genes in the intestinal mucosa of lambs.…”
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Streamlining medical software development with CARE lifecycle and CARE agent: an AI-driven technology readiness level assessment tool by Steven N. Hart, Patrick L. Day, Christopher A. Garcia

“…Future work will focus on optimizing retrieval strategies and expanding validation across diverse clinical applications.…”
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Clustering and Interpretability of Residential Electricity Demand Profiles by Sarra Kallel, Manar Amayri, Nizar Bouguila

“…The results show that soft clustering methods effectively capture inter-cluster characteristics, leading to better cluster separation, whereas intra-cluster characteristics exhibit similar behavior across all clustering approaches. …”
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Tracking Long-Term Ozone Pollution Dynamics in Chinese Cities with Meteorological and Emission Attribution by Hongrui Li, Xiaoyong Liu, Zijian Liu, Mengyang Li, Tong Wu, Peicheng Li, Peng Zhou

“…Here, we develop a novel framework that couples Kolmogorov–Zurbenko (KZ) filtering with an optimized random forest (RF) regression model to examine daily maximum 8 h average ozone (O₃-8h) in 372 Chinese cities from 2013 to 2023. …”
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Sarcopenia in patients with metastatic breast cancer: A systematic review and meta-analysis by Min Kyeong Jang, Sungwon Park, Chang Park, Rebecca Raszewski, Seho Park, Sue Kim

“…Conclusions: Sarcopenia is prevalent and clinically meaningful in metastatic breast cancer. While its direct role in survival remains inconclusive, early assessment of sarcopenia by molecular subtype and treatment timing is crucial for optimizing care.…”
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The effect of social support on learning engagement among Chinese nursing interns: the mediating role of self-efficacy by Liping Wu, Yan Chen, Meiqin Xue, Weiyi Zhu, Wei Wang

“…Abstract Objective While perceived social support is recognized as crucial for nursing interns’ development, its psychological pathways influencing learning engagement remain unclear. …”
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Acute on chronic heart failure—Which variations on B‐type natriuretic peptide levels? by Paulo Bettencourt PhD, Inês Chora, Filipa Silva, Patrícia Lourenço, W. Frank Peacock

“…However, B‐type natriuretic peptide (BNP) level represents a single snapshot in time, while changes relative to a patient's baseline may be useful in risk stratification. …”
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Leaky Dams as Nature-Based Solutions in Flood Management Part II: Mechanisms, Effectiveness, Environmental Impacts, Technical Challenges, and Emerging Trends by Umanda Hansamali, Randika K. Makumbura, Upaka Rathnayake, Hazi Md. Azamathulla, Nitin Muttil

“…Leaky dams have become essential nature-based solutions for flood management, providing sustainable alternatives to traditional engineered flood control methods. This review delves into the mechanisms by which leaky dams operate, including the regulation of water flow through velocity reduction and distribution across floodplains, effective sediment trapping and soil quality enhancement, and the facilitation of groundwater recharge and water table stabilization. …”
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Determination of the minimal level of neutralizing antibodies elicited following vaccination able to protect rabbits against virulent cowpox virus by Muratbay Mambetaliyev, Alina Alieva, Yergali Abduraimov, Aralbek Rsaliyev, Kuandyk Zhugunissov

“…Based on these findings, 25 TCID50 was selected as the optimal dose for future VNT. Following cowpox virus challenge, rabbits with neutralizing titers ≥1:16 were protected from skin necrosis, while non-immunized animals developed characteristic lesions.ConclusionThese results suggest that a low-dose (25 TCID50) VNT improves the sensitivity and that a titer of 1:16 can be considered a protective threshold. …”
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A Study on the Spatial Perception and Inclusive Characteristics of Outdoor Activity Spaces in Residential Areas for Diverse Populations from the Perspective of All-Age Friendly Des... by Biao Yin, Lijun Wang, Yuan Xu, Kiang Chye Heng

“…By integrating multi-group perception data, standardizing experimental environments, and applying intelligent data mining, this study achieves multi-modal data fusion and in-depth analysis, providing theoretical and methodological support for precisely optimizing outdoor activity spaces in residential areas and advancing the development of all-age friendly communities.…”
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Diastereoselective Synthesis and Biological Evaluation of Spiro[chromane-2,4′-pyrimidin]-2′(3′<i>H</i>)-ones as Novel Antimicrobial and Antioxidant Agents by Alena S. Karandeeva, Natalia A. Bogdanova, Mariya V. Kabanova, Sergey I. Filimonov, Zhanna V. Chirkova, Anna A. Romanycheva, Valeria A. Panova, Anton A. Shetnev, Nurila A. Togyzbayeva, Saken A. Kanzhar, Nurbol O. Appazov, Kyrill Yu. Suponitsky

“…This study reports an improved diastereoselective synthesis of substituted spiro[chromane-2,4′-pyrimidin]-2′(3′<i>H</i>)-ones via the acid-catalyzed condensation of 6-styryl-4-aryldihydropyrimidin-2-ones with resorcinol, 2-methylresorcinol, and pyrogallol. The optimized method allows for the isolation of diastereomerically pure products, with stereoselectivity controlled by varying acid catalysts (e.g., methanesulfonic acid vs. toluenesulfonic acid) and solvent conditions. …”
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