ЕSTIMATION OF SOCIO-ECONOMIC BURDEN OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE FOR A 5-YEAR PERIOD: A REGIONAL ASPECT by E. A. Orlova, A. R. Umerova, I. P. Dorfman, M. A. Orlov, M. A. Abdullaev

“…The aim of the study was to estimate the economic damage by COPD, including direct medical and non-medical costs and indirect costs associated with premature deaths of working-age individuals.Materials and methods. First, estimation of the economic COPD burden in Astrakhan region (AR) was carried out using the clinical and economic analysis of the "cost of illness" (COI). …”
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Correlation and Comparative Evaluation of MOCART and MOCART 2.0 for Assessing Cartilage Repair by Felix Conrad Oettl, Louis Leuthard, Moritz Brunner, Vincent A. Stadelmann, Stefan Preiss, Michael Leunig, Gian M. Salzmann, Jakob Hax

“…<i>Material and Methods</i>: This study included 111 patients (age: 35 ± 10, 35% female) who underwent cartilage repair surgery of the knee between September 2015 and March 2022. …”
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Association Between Cardiometabolic Index and Mortality Among Patients with Atherosclerotic Cardiovascular Disease: Evidence from NHANES 1999–2018 by Duo Yang, Wei Li, Wei Luo, Yunxiao Yang, Jiayi Yi, Chen Li, Hai Gao, Xuedong Zhao

“…There was a nonlinear J-shaped relationship between CMI and all-cause mortality, while the risk of cardiovascular mortality increased linearly with increasing CMI. …”
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A Novel Temozolomide-Myricetin Drug-Drug Cocrystal: Preparation, Characterization, Property Evaluations by Hai-Xin Qin, Jie Wang, Jia-Hui Peng, Xia-Lin Dai, Cai-Wen Li, Tong-Bu Lu, Jia-Mei Chen

“…The goal of the present study is to obtain novel drug-drug cocrystals involving two anti-glioma agents, temozolomide (TMZ) and myricetin (MYR). <b>Methods</b>: The novel TMZ-MYR cocrystal was prepared via slurry and solvent evaporation techniques and characterized by X-ray diffraction, thermal analysis, infrared spectroscopy, and dynamic vapor sorption measurements. …”
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Study on risk contagion between rare earth and new energy-related metals markets from the perspective of co-production and co-consumption by Renrui Zheng, Renrui Zheng, Hao Nong, Qishen Chen, Liuguo Shao, Liuguo Shao, Hongtao Zhang, Yanfei Zhang, Yanfei Zhang

“…Understanding these dynamics is crucial due to the growing interdependence of these markets and their susceptibility to policy shifts and extreme events.MethodsUsing higher-order moment risk measures, time-domain spillover indexes, and frequency-domain spillover indexes, we analyze return, volatility, skewness, and kurtosis risk spillovers across metal markets from 2014 to 2024. …”
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Framing financial incentives to promote hypertension care among rural primary doctors in Shandong Province, China: study protocol of a randomized field trial by Yue Zhong, Pengyang Fan, Jialong Tan, Elizabeth Maitland, Stephen Nicholas, Yiwei Qiao, Dejian Kou, Zehua Meng, Jian Wang

“…Insufficient financial incentives may explain the sub-optimal long-term treatment behavior by rural doctors. …”
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Genotypic and Environmental Impacts on Vicine and Convicine Concentrations in Faba Beans by Pankaj Maharjan, Aaron C. Elkins, Jason Brand, Samuel C. Catt, Simone J. Rochfort, Joe F. Panozzo

“…High concentrations of vicine and convicine (v-c) in faba beans can trigger favism in susceptible humans, posing a significant barrier to the broader adoption of faba beans as a food source. While plant breeding and various post-harvest processing methods have been adopted to reduce v-c levels, there is limited understanding of how agronomic practices may assist in reducing v-c levels. …”
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Growth Assessment and Nutritional Status in Children with Congenital Adrenal Hyperplasia—A Cross-Sectional Study from a Vietnamese Tertiary Pediatric Center by Thi Thuy Hong Nguyen, Khanh Minh Le, Thi Anh Thuong Tran, Khanh Ngoc Nguyen, Thi Bich Ngoc Can, Phuong Thao Bui, Dat Tien Tran, Chi Dung Vu

“…<b>Results</b>: Stunting was present in 16.4% of children, while 53.3% were overweight or obese. Bone age advancement occurred in 51.7% of cases. …”
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Donor – recipient selection using epitope mismatches in kidney transplantation by A. V. Vatazin, A. B. Vatazin, V. A. Stepanov

“…In the routine practice of a transplantation center with a short waiting list of its own, it might be possible to improve the kidney transplant survival as a result of considering epitope mismatches, thus  reducing the risk of developing donor-specific anti-HLA antibodies and ensuring a higher graft survival rate. This method can be used for additional ranking of transplantation candidates depending on the number of epitope mismatches within the fixed number of HLA-mismatches and thus select the optimal one. …”
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Rethinking Radiation Therapy for Perineural Invasion in Oral Cancer: Does More Coverage Improve Outcomes? by Sarbani Ghosh Laskar, Anuj Kumar, Ashwini Adhau, Shwetabh Sinha, Samarpita Mohanty, Munita Bal, Neha Mittal, Swapnil Rane, Asawari Patil, Ashwini Budrukkar, Monali Swain, Pallavi Rane, Gouri Pantvaidya, Sudhir Nair, Deepa Nair, Anuja Deshmukh, Shivakumar Thiagarajan, Richa Vaish, Vidisha Tuljapurkar, Chandrashekhar Dravid, Poonam Joshi, Rathan Shetty, Arjun Singh, Pankaj Chaturvedi

“…Adjuvant radiotherapy (RT) is recommended for PNI‐positive OSCC, but optimal RT target volume remains uncertain. Methods This study retrospectively analysed 103 patients with histopathologically confirmed PNI‐positive OSCC treated between January 2017 and December 2023. …”
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Chromosomal Instability in Various Generations of Human Mesenchymal Stem Cells Following the Therapeutic Radiation by Majid Sadeghi Moghadam, Hosein Azimian, Jalil Tavakol Afshari, Mohammad Taghi Bahreyni Toossi, Najmeh Kaffash Farkhad, Seyed Hamid Aghaee-Bakhtiari

“…This study demonstrated significant nuclear alterations in the 10 days postirradiation due to the RIGIs that they inherited from their irradiated ancestral cells. While chromosomal instability is a prevalent event in malignant cells, so it seems necessary to optimize radiotherapy treatment protocols for tissues that contain stem cells, especially with IMRT, which delivers a low dose to a larger volume of tissues.…”
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Ensuring Sustainability in Pharmaceutical Care: A Retrospective Analysis of Administrative Databases on the Utilization, Costs, and Switching Patterns of Biological Therapies in th... by Renata Maria Bianca Langfelder, Roberto Langella, Cinzia D’Angelo, Claudia Panico, Sarah Cattaneo

“…<b>Background</b>: Biosimilars represent a fundamental advancement in global healthcare, offering significant cost containment while maintaining both therapeutic efficacy and safety in the management of chronic diseases. …”
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Correlation of serum apolipoprotein B with the Framingham Risk Score among a group of Iraqi subjects: a cross-sectional study by Israa Nather Ahmed, Fatimatuzzahra’ Abd Aziz, Raid Dhia Hashim

“…Correlation analysis between apoB and FRS was performed using Spearman’s test, while group comparisons were conducted via Kruskal–Wallis and Mann–Whitney tests. …”
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Long-Term Protection in Atlantic Salmon (<i>Salmo salar</i>) to Pancreas Disease (PD) Can Be Achieved Through Immunization with Genetically Modified, Live Attenuated Salmonid Alpha... by Stine Braaen, Øystein Wessel, Håvard Bjørgen, Espen Rimstad

“…Future efforts should optimize vaccine candidates to balance attenuation, immunogenicity, and minimal side effects.…”
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Determinants of developmental outcomes for children under 3 years in a rural setting, Kenya by Beatrice A. Oyugi, Silas O. Onyango, Henry Athiany, Gideon M. Kikuvi

“…Setting: Siaya County, Kenya. Methods: A cross-sectional study of children under 3 years and their caregivers, attending Child Welfare Clinic (CWC) at tier 3 health facilities in a rural setting in Kenya, was conducted. …”
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Ocular damages inflicted by criminal injuries by T. V. Gavrilova, N. A. Sobyanin, A. V. Patrushev, M. V. Chereshneva

“…The prevailing conditions were contusions (46.9%), while the most common traumatizing factor was first punch (79.6%). …”
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Cardiologists’ perceptions on telehealth practices and limitations during and following the COVID-19 pandemic by Jennifer Miao, Claire S Duvernoy, Paul D Varosy, Paul Theriot, Anne Rzeszut, S Elissa Altin

“…Background While telehealth utilization has decreased following the COVID-19 pandemic, the incorporation of remote visits into ambulatory cardiology practice guidelines remains a necessity. …”
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Association Between Human Embryo Culture Conditions, Cryopreservation, and the Potential Risk of Birth Defects in Children Conceived Through Assisted Reproduction Technology by Romualdo Sciorio, Luca Tramontano, Giuseppe Gullo, Steven Fleming

“…Key factors such as pH, temperature, osmolality, and gas concentrations are crucial for establishing optimal embryo development and implantation potential. …”
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The uterine cavity state in older reproductive age patients by V. N. Lokshin, A. N. Rybina, A. T. Abshekenova, E. Askar, Sh. K. Karibaeva, R. K. Valiev

“…Office hysteroscopy is recommended prior to ART initiation in this population to optimize outcomes.…”
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Biomechanical effects of digitally constructed titanium, modified polyetheretherketone, and polyetherketoneketone subperiosteal implants on atrophied maxilla: a finite element anal... by Mohammed A. El-Sawy, Basin El-Khatib, Hesham S. Borg, Mohamed T. Khater

“…Abstract Aim This study aimed to evaluate how different combinations of subperiosteal and superstructure framework materials—titanium, modified PEEK, and PEKK—affect stress distribution on bone in atrophic maxillae, using finite element analysis (FEA). Methods A three-dimensional finite element model of an atrophic maxilla was created from CT data and processed through CAD and ANSYS software. …”
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