Revolutionizing total hip arthroplasty: The role of artificial intelligence and machine learning by Umile Giuseppe Longo, Sergio De Salvatore, Alice Piccolomini, Nathan Samuel Ullman, Giuseppe Salvatore, Margaux D'Hooghe, Maristella Saccomanno, Kristian Samuelsson, Rocco Papalia, Ayoosh Pareek

“…Abstract Purpose There has been substantial growth in the literature describing the effectiveness of artificial intelligence (AI) and machine learning (ML) applications in total hip arthroplasty (THA); these models have shown the potential to predict post‐operative outcomes using algorithmic analysis of acquired data and can ultimately optimize clinical decision‐making while reducing time, cost and complexity. …”
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Comparison of the application value of contrast-enhanced ultrasound and contrast-enhanced CT in puncture biopsy of peripheral pulmonary lesions by Gang Wang, Ji-cheng Zhang, Zhi-hua Wang, Bo Gou, Xiao-lin Liu, Gang Liu, Jian Liu

“…The average number of pleural punctures, puncture time, satisfaction with the first puncture specimen, diagnostic accuracy and complication rate were compared between the two guidance methods.Results① Compared with the CECT group, the CEUS-guided group required fewer pleural punctures (2.5 vs. 4.1 times) and shorter puncture time (24 minutes vs. 42 minutes) on average, and the difference was statistically significant (P<0.001). ② In terms of complications, the incidence of pneumothorax (3.1% vs. 8%) was lower in the CEUS group, while the incidence of bleeding (1.5% vs. 3.1%) had no significant difference between the two groups ③ When the diameter of the lesion is <3 cm, the specimen satisfaction and diagnostic accuracy of the CEUS group are lower than those of the CECT group (71.0% vs. 88.3%, 64.5% vs. 86.7%). …”
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Exploring Human Use of Monoclonal Antibodies Against Critical Bacteria: A Scoping Review of Clinical Trials by Marco Piscaglia, Giovanni Scaglione, Camilla Genovese, Fabio Borgonovo, Fabio Brivio, Flavia Rampichini, Renata Grifantini, Alessandra Bandera, Andrea Gori, Marta Colaneri, Emanuele Palomba

“…This review evaluates the clinical efficacy, safety, and limitations of mAbs targeting critical bacterial pathogens, analyzing factors influencing therapeutic outcomes, and proposing strategies to optimize their clinical application. Methods A comprehensive analysis of clinical trials investigating antibacterial mAbs was conducted. …”
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CircEPDR1 regulates proliferation and differentiation of goat skeletal muscle satellite cells through miR-345-3p/Akirin1 axis by Song Shi, Diansong Duan, Jing Luo, Zihao Zhao, Tao Ma, Dinghui Dai, Siyuan Zhan, Jiaxue Cao, Jiazhong Guo, Tao Zhong, Linjie Wang, Hongping Zhang, Li Li

“…Objective Circular RNAs (circRNAs) play pivotal roles in regulating the growth and development of mammalian skeletal muscle This study aims to provide new insights into the molecular regulatory network that underlies skeletal muscle development, presenting valuable targets to enhance and optimize livestock production performance. Methods In this study, we anchored a novel circRNA from previous circRNA sequencing data from goat skeletal muscle and named it circEPDR1, which was confirmed through en-zymatic digestion and Sanger sequencing. …”
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Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols by Walther Haenseler, Melanie Eschment, Melanie Eschment, Beth Evans, Marta Brasili, Marta Brasili, Joana Figueiro-Silva, Fee Roethlisberger, Fee Roethlisberger, Affef Abidi, Affef Abidi, Darcie Jackson, Martin Müller, Martin Müller, Sally A. Cowley, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu, Ruxandra Bachmann-Gagescu

“…Interestingly, we found that while GPR161 signal almost completely disappeared from cilia upon Sonic hedgehog (SHH) stimulation in NSCs and immature neurons, this was not the case in more mature neurons, suggesting a possible developmental time window for cilia-dependent SHH signaling.ConclusionTaken together, our results provide a systematic description of cilia in hiPSC-derived neuronal cells generated with different protocols, underscoring the importance of selecting the optimal model system and controls for investigating primary cilia in hiPSC-derived neuronal cells.…”
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Impacts of Ecological Restoration Projects on Ecosystem Carbon Storage of Tongluo Mountain Mining Area, Chongqing, in Southwest China by Lei Ma, Manyi Li, Chen Wang, Hongtao Si, Mingze Xu, Dongxue Zhu, Cheng Li, Chao Jiang, Peng Xu, Yuhe Hu

“…The methodology quantified carbon storage variations among engineered restoration (ER), natural recovery (NR), and unmanaged sites (CWR) while identifying optimal vegetation configurations for karst ecosystems. …”
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Reliable models for calculating the condensation heat transfer inside smooth helical tubes of different flow directions utilizing smart computational techniques by Chou-Yi Hsu, Nikunj Rachchh, T. Ramachandran, Aman Shankhyan, A. Karthikeyan, Ahmad Alkhayyat, Prabhat Kumar Sahu, Abhinav Kumar, Satvik Vats, F. Ranjbar

“…Abstract Condensers with helical tubes have received much attention in diverse industries. The optimal design of the mentioned equipment necessitates predictive tools for calculating the condensation heat transfer coefficient (HTC). …”
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Multimodal Feature-Driven Deep Learning for the Prediction of Duck Body Dimensions and Weight by Wenbo Xiao, Qiannan Han, Gang Shu, Guiping Liang, Hongyan Zhang, Song Wang, Zhihao Xu, Weican Wan, Chuang Li, Guitao Jiang, Yi Xiao

“…Accurate body dimension and weight measurements are critical for optimizing poultry management, health assessment, and economic efficiency. …”
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Adoptively transferred macrophages for cancer immunotherapy by Jennifer L Guerriero, Kyung Soo Park, Alexander P Gottlieb, Morgan E Janes, Supriya Prakash, Neha Kapate, Vineeth Chandran Suja, Lily Li-Wen Wang, Samir Mitragotri

“…Here, we demonstrate that adoptively transferred macrophages, with optimal activation prior to administration, act as a potent cellular cancer therapeutic platform against a murine melanoma model.Method The macrophage therapy was prepared from bone marrow-derived macrophages, pretreated ex vivo with an activation cocktail containing interferon-γ, tumor necrosis factor-α, polyinosinic:polycytidylic acid, and anti-CD40 antibody. …”
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Explainable machine learning model for predicting the transarterial chemoembolization response and subtypes of hepatocellular carcinoma patients by Yunjie Zhang, Songjian Tong, Junhui Yang, Jiawei Lin, Yifan Kong, Deyu Lu, Yan Chen, Yingchao Li, Linfeng Xu, Xiuyan Kong, Guoqing Zhu, Hao Zhang, Pixu Liu, Zhijie Yu, Jinglin Xia

“…We developed a Machine Learning (ML)-based model integrating routine clinical variables to preoperatively predict TACE efficacy, enabling tailored TACE candidate selection and optimized therapeutic decision-making. Methods This retrospective multicentre study enrolled treatment-naive HCC patients undergoing initial TACE from two independent cohorts: the First Affiliated Hospital of Wenzhou Medical University (training cohort) and Wenzhou Central Hospital (external validation cohort). …”
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The Effectiveness of Teaching Spiritual Concepts Based on Mention and Prayer on Moral Intelligence and Quality of Attachment in Students by سارا آقابابایی, Fateme Hekmatzade

“…The present study aimed to examine the effectiveness of spiritual concepts training centered around mention and prayer on moral intelligence and attachment quality of students. The research method was quasi-experimental with a pre-test, post-test, and follow-up design (for a period of 3 months) with a control group. …”
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Early hemodynamic impact of SGLT2 inhibitors in overweight cardiometabolic heart failure: beyond fluid offloading to vascular adaptation– a preliminary report by Nadia Salerno, Jessica Ielapi, Angelica Cersosimo, Isabella Leo, Assunta Di Costanzo, Giuseppe Armentaro, Salvatore De Rosa, Angela Sciacqua, Sabato Sorrentino, Daniele Torella

“…Sodium-glucose cotransporter-2 inhibitors (SGLT2i) reduce HF hospitalizations and cardiovascular mortality across ejection fraction (EF) categories, yet their early hemodynamic effects in cardiometabolic HF, and with preserved ejection fraction (HFpEF) in particular, remain underexplored. Methods A prospective, single-center study included 20 consecutive HF patients receiving SGLT2i alongside optimized therapy. …”
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Study of the influence of ultra-high molecular weight polyethylene and high-density polyethylene on the properties and structure of ethylene propylene diene monomer rubber by M. D. Sokolova, A. R. Khaldeeva, M. L. Davydova, A. F. Fedorova, N. V. Shadrinov

“…Rubbers modified with UHMWPE, in comparison with HDPE, exhibit enhanced resistance to wear, oil, and frost, while maintaining their elastic and strength properties. …”
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Effects of blood flow restriction combined with high-load training on muscle strength and sports performance in athletes: a systematic review and meta-analysis by Chentianlei Su, Zhenglong Zhang, Bin Liang, Sicen Zhou, Xingyu Long

“…Short-term, high-frequency interventions (≤6 weeks, ≥3 sessions/week) using absolute pressure appear optimal for performance enhancement, while individualized pressure protocols may better balance safety and effectiveness in clinical settings.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD42025636274, identifier [CRD42025636274 (PROSPERO)].…”
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Prevalence of iron deficiency in acute and chronic heart failure according to different clinical definitions by Lukas Lanser, Gerhard Pölzl, Moritz Messner, Maria Ungericht, Marc‐Michael Zaruba, Jakob Hirsch, Stefan Hechenberger, Stefan Obersteiner, Bernhard Koller, David Haschka, Hanno Ulmer, Guenter Weiss

“…Absolute ID prevalence was highest when applying cardiology compared with gastroenterology guidelines and general definition (AHF: 44.7% vs. 20.4% vs. 7.0%; CHF: 34.1% vs. 13.4% vs. 7.2%), while frequency of combined ID was almost equally distributed. …”
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Integrating O-RADS US v2022, CEUS, and CA125 to enhance the diagnostic differentiation of ovarian masses: development of the OCC-US model by Zhuolin Jiang, Wei Pu, Xinyi Luo, Jie Zhang, Shijun Jia, Guonan Zhang, Yi Zhu

“…Conclusion The OCC-US model enhances diagnostic specificity while maintaining high sensitivity, optimizing risk stratification and surgical decision-making. …”
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Psychopathological Comorbidities in Children and Adolescents with Feeding and Eating Disorders: An Italian Clinical Study by Maria Califano, Jacopo Pruccoli, Oliviero Cavallino, Alessandra Lenzi, Antonia Parmeggiani

“…Future research should further investigate these transdiagnostic mechanisms to optimize clinical care.…”
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Hybrid fuzzy logic approach for enhanced MPPT control in PV systems by Mustapha Melhaoui, Mohammed Rhiat, Mohammed Oukili, Ilias Atmane, Kamal Hirech, Badre Bossoufi, Mishari Metab Almalki, Thamer A. H. Alghamdi, Mohammed Alenezi

“…While conventional algorithms are widely used, their performance is limited under fluctuating conditions. …”
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Construction of PMoV/rGO/Pt nanocomposite with photoreduced graphene oxide for efficient quantification of vanillic acid by Shixu Chen, Na Li, Cong Zhang, Haiyan Zhao, Min Cui, Bao Sun

“…In particular, PMoV/rGO/Pt composite was prepared and identified using various methods. Under optimal conditions, the limit of detection of the synthesized electrochemical sensor was estimated to be 0.9 μM at vanillic acid concentrations of 50–1350 μM. …”
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Comparative analysis of CDR3 length-dependent patterns in VHHs by Lu Zhang, Tianyu Yang, Yao Zhang, Jiahui Yan, Jiaguo Li, Wenfeng Xu, Weimin Zhu, Xinhao Wang

“…The CDR3 region in VHHs, which plays a crucial role in antigen binding, exhibits significant diversity and varies among species.MethodThis study systematically examined CDR3 length dependent patterns by analyzing NGS sequences from the PBMCs of Alpacas, Llamas and Bactrians, in conjunction with VHH structure data from the public database.ResultsVHHs from Alpacas and Llamas exhibited similar CDR3 length distributions, while Bactrian VHHs displayed significantly longer but narrower length distribution. …”
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