Heavy metal biomarkers and their impact on hearing loss risk: a machine learning framework analysis by Ali Nabavi, Mohammad Kashkooli, Sara Sadat Nabavizadeh, Farimah Safari

“…Multiple machine learning algorithms, including Random Forest, XGBoost, Gradient Boosting, Logistic Regression, CatBoost, and MLP, were optimized and evaluated. Model performance was assessed using accuracy, area under the curve (AUC), sensitivity, and specificity, while SHAP (SHapley Additive exPlanations) elucidated feature contributions.ResultsThe CatBoost model demonstrated the strongest performance, achieving an accuracy of 74.9% and an AUC of 0.792 on test data. …”
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Analysis of Tumor and Tumor-Like Entities Tested on the Orthopaedic In-Training Examination From 2012 to 2023 by Sean Kelly, MD, Braden Goldberg, MD, Eli Bryk, MD, FAAOS, FAOA, FACS, Vincent Vigorita, MD

“…Bone tumor questions averaged nine per year, while soft tissue tumor questions averaged four. …”
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Coupling relationship between land use transition and rural transformation development: A case study of county-level regions in Jiangsu Province by GE Dazhuan, WANG Rumin, LU Xiaoxue

“…Rural trasformation development was the cause and driving force of for land use transition, while land use transition provided material basis and spatial support for rural transformation development. …”
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The influence of college students’ psychological resilience on problem solving: based on eye tracking technology by Zhenguo Xu, Zhenguo Xu, Wenxiu Du, Wenxiu Du, Huaiyan Zhao, Huaiyan Zhao, Qing Liu, Wanli Xie, Wanli Xie

“…IntroductionThe digital intelligence era has put forward new requirements for cultivating innovative talent, and problem solving ability is one of the key abilities for the cultivation of innovative talents.MethodsUsing eye tracking technology, this study explored the impact of college students’ psychological resilience on problem solving. …”
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Intestinal Failure in Pediatric Vascular Ehlers–Danlos Syndrome: A Case Series and Literature Review by Carolina Percul, Veronica Busoni, Carina Izquierdo, Pablo A. Lobos

“…Background: Vascular Ehlers–Danlos syndrome (vEDS) is a rare connective tissue disorder characterized by collagen type III deficiency, predisposing to spontaneous arterial, uterine, and intestinal ruptures. While intestinal complications are recognized in vEDS, intestinal failure (IF) secondary to these complications is a rare and potentially life-threatening occurrence. …”
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Watkins wheat landraces decode nitrogen-driven biomass trade-offs: GWAS exposes root-shoot dialectics and elite landraces for resilient agriculture by Abdul Waheed, Muhammad Shahid Iqbal, Zareen Sarfraz, Junliang Hou, Yanping Wei, Bo Song, Shifeng Cheng

“…Adaptive alleles of RALF33 in European landraces optimized root proliferation under LN, while Eurasian landraces exhibited shoot-root coordination under NN through TaNAR1 variants. …”
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Evaluating variant pathogenicity prediction tools to establish African inclusive guidelines for germline genetic testing by Kangping Zhou, Kazzem Gheybi, Pamela X. Y. Soh, Vanessa M. Hayes

“…Lack of ancestrally relevant genomic data perpetuated by African diversity has resulted in European-biased curated clinical variant databases and pathogenic prediction guidelines. While numerous variant pathogenicity prediction tools (VPPTs) exist, their performance has yet to be established within the context of African diversity. …”
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Treatment outcomes and considerations for topical immunotherapy in patients with alopecia totalis and alopecia universalis by Taiyo Hitaka, Sanehito Haruyama, Shun Ohmori, Natsuko Saito-Sasaki, Etsuko Okada, Motonobu Nakamura, Yu Sawada

“…Hair regrowth was observed within 4 months in 90% of cases, while peak therapeutic effects were achieved within 3 years. …”
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A Retrospective Analysis of CLL Patients in a Romanian Hematology Center by Ana-Maria IORDAN, Minodora Cezarina ONISAI, Anca RAITARU, Claudia DESPAN, Ionel GELATU, Silvia CIORTAN, Daniela GEORGESCU

“…Understanding real-world management and prognostic factors is essential for optimizing outcomes. Methods: We conducted a retrospective study of 112 CLL patients treated at "Colentina" Clinical Hospital, Bucharest, from January 2009 to June 2025. …”
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Digital technologies-enhanced older adults health management: developing a five-dimensional extension of social learning theory for community settings by Ting Liu, Yiming Taclis Luo, Patrick Cheong-Iao Pang

“…This study also responds to calls for culturally adaptable digital health frameworks by examining how Bandura’s SLT operates within Macao’s unique socio-cultural context while exploring transferability to low- and middle-income countries.Methods20 older adults were interviewed in semi-structured focus groups during four community health events in Macao. …”
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PXseg: automatic tooth segmentation, numbering and abnormal morphology detection based on CBCT and panoramic radiographs by Raokaijuan Wang, Fangyuan Cheng, Guangsheng Dai, Jiayu Zhang, Chengmin Fan, Jinghong Yu, Juan Li, Fulin Jiang

“…Abstract Objective PXseg, a novel approach for tooth segmentation, numbering and abnormal morphology detection in panoramic X-ray (PX), was designed and promoted through optimizing annotation and applying pre-training. Methods Derived from multicenter, ctPXs generated from cone beam computed tomography (CBCT) with accurate 3D labels were utilized for pre-training, while conventional PXs (cPXs) with 2D labels were input for training. …”
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Trends and forecasts of the prevalence and mortality of Alzheimer’s disease and other dementias in China by Mingxuan Hou, Mingxuan Hou, Ling Yang

“…Joinpoint regression was used to identify significant changes in trends, while Age–Period–Cohort (APC) models were applied to disentangle age, period, and cohort effects. …”
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Co-differentiation and enrichment of corneal endothelial cells and keratocytes from human pluripotent stem cells by Abhinav Reddy Kethiri, Pyry Grönroos, Ajai Suwaraj Chinnaiah Nagaraj, Heli Skottman

“…Using xeno-free, defined conditions, we differentiated both CK and CEnC from hPSC using a single protocol with further optimized enrichment methods for hPSC-CK and hPSC-CEnC purification, advancing cell differentiation techniques.…”
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Dynamic X-Ray Imaging and Its Role in Predicting Outcomes in Coccygectomy Patients: A Narrative Review by Mohannad W. Awwad, Musab Al Ageel, Abeer W. Awwad, Osama A. Alrehaili, Waleed Awwad

“… Background Chronic coccydynia is a debilitating condition often exacerbated by any activity that applies pressure to the coccygeal area. While diagnosis is primarily clinical, dynamic X-ray imaging has emerged as a valuable tool for identifying structural abnormalities like hypermobility or subluxation. …”
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Evaluation of the Patient Innovation Partner Role: Perceived Benefits, Structures, Supports, and Recommendations for Lived Experience Engagement in Healthcare Innovation Teams by Shoshana H. Bardach, Amanda Perry, Terry Sturke, Randy Stevens, Milan F. Satcher

“…ABSTRACT Background Patient engagement plays a valuable role in health research and quality improvement. While prior research highlights some principles and key considerations for patient involvement in these efforts, there is a limited understanding of how best to structure and support this engagement, especially from the patient perspective and for healthcare innovation projects. …”
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Exploring the social representations of breastfeeding among mothers and grandmothers in Uruguay using word association by Alejandra Girona, Lucia de Pena, Hugo Cristo Sant’Anna, Gastón Ares, Rita Heck

“…Health-related benefits were present in peripheral areas for both groups, while references to the mother’s well-being were largely absent. …”
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Research on ischemic stroke risk assessment based on CTA radiomics and machine learning by Zhi-Li Li, Hong-Yu Yang, Xiao-Xiao Lv, Ya-Kun Zhang, Xin-Yu Zhu, Yu-Rou Zhang, Li Guo

“…Through Lasso regression, nine optimal features were selected to construct the radiomics model. …”
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Structured Transformation of Unstructured Prostate MRI Reports Using Large Language Models by Luca Di Palma, Fatemeh Darvizeh, Marco Alì, Deborah Fazzini

“…Objectives: to assess the ability of high-performing open-weight large language models (LLMs) in extracting key radiological features from prostate MRI reports. Methods: Five LLMs (Llama3.3, DeepSeek-R1-Llama3.3, Phi4, Gemma-2, and Qwen2.5-14B) were used to analyze free-text MRI reports retrieved from clinical practice. …”
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Outcomes of liver transplantation in the era of modern antiviral therapy for hepatitis C by K. Yu. Kokina, Yu. O. Malinovskaya, Ya. G. Moysyuk

“…The patients were divided into 2 groups: Group 1 included 40 patients who received DAA therapy before LT, while Group 2 consisted of 9 patients who did not receive antiviral treatment while on the LT waiting list. …”
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Effects of external fixator-assisted acute angulation on arterial diameter: a cadaveric model by Akif Mirioglu, Kaan Ali Dalkir, Hakki Can Olke, Bugra Eraslan, Bugra Kundakci, Melih Bagir, Mehmet Ali Deveci

“…Conclusions The tibia demonstrated higher tolerance for varus angulation, while the femur allowed greater procurvatum and recurvatum before vascular compromise. …”
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