Retrospective Review of Children Hospitalized for Epstein–Barr Virus-Related Infectious Mononucleosis by Shufeng Tian, Jinjun Zheng, Zhe Zhou, Qingluan Yang, Biao Sun, Yuxi Li, Zengrui Lin, Yuchun Long, Song Guan, Sen Wang, Jiexin Zhuang, Wenhong Zhang, Lingyun Shao, Jikui Deng

“…Objectives: Our objective was to investigate the clinical characteristics, complications, and treatment outcomes of Epstein–Barr virus (EBV)-related infectious mononucleosis (IM) in children and to identify risk factors associated with prolonged fever and abnormal liver function. Methods: This retrospective study included 3006 children admitted to Shenzhen Children’s Hospital from May 2009 to April 2024 with suspected EBV-related IM. …”
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From colorless to pink: Structural insights into vitamin B12-induced color change in monoclonal antibodies by Kai-feng He, Hao-dong Cui, Wen-hui Deng, Na Xing, Guo-jian Liu, Abdallah Iddy Chaurembo, Li-dan Fu, Yuan Li, Xin-yue Tong, Han-bin Lin, Chun-he Wang

“…Peptide analysis revealed distinct UV absorption at 360 nm for SP2, while SDS-PAGE indicated slight molecular weight differences. …”
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Two sides of the same coin: recruitment performance and perceived workload in primary care trials-insights from the AgeWell.de study by Linda Sanftenberg, Robert Philipp Kosilek, Lorenz Birnberger, Hannah Schillok, Felix Wittmann, Melanie Luppa, Anne Blawert, Melanie Boekholt, Christian Brettschneider, Hans-Helmut König, Alexander Bauer, Solveig Weise, Thomas Frese, Hanna Kaduszkiewicz, Juliane Döhring, Catharina Escales, Jochen René Thyrian, Birgitt Wiese, Steffi G. Riedel-Heller, Jochen Gensichen

“…The top 20% of recruiters (Q5) accounted for 42.1% of all participants, while the lowest quintile (Q1) recruited just 3.2%. …”
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External Validation of 3 Prediction Models for Mortality in Out‐of‐Hospital Cardiac Arrest Survivors: A Retrospective Multicenter Study by Chun‐Hsiang Huang, Edward Pei‐Chuan Huang, Cheng‐Yi Fan, Yi‐Chien Kuo, Chien‐Tai Huang, Ching‐Yu Chen, Chi‐Hsin Chen, Yi‐Ju Ho, Chun‐Ju Lien, Yun‐Chang Chen, Sih‐Shiang Huang, Tzu‐Hsueh Wang, Wen‐Chu Chiang, Wei‐Tien Chang, Chien‐Hua Huang, Chih‐Wei Sung

“…While CASS and FACTOR demonstrated similar sensitivity, specificity, and negative predictive value, mSARICA exhibited significantly higher sensitivity, lower specificity, and higher negative predictive value. …”
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Dissecting the genetic architecture of yield-related traits by QTL mapping in maize by Hao Zhang, Hao Zhang, Ting Li, Zhenyu Zhang, Jie Wang, Haoxiang Yang, Jiachen Liu, Wanchao Zhu, Wanchao Zhu, Jiquan Xue, Jiquan Xue, Shutu Xu, Shutu Xu

“…IntroductionMaize is a cornerstone of global agriculture, essential for ensuring food security, driving economic development, and meeting growing food demands. Yet, how to achieve optimal yield remains a multifaceted challenge influenced by biotic, environmental, and genetic factors whose comprehensive understanding is still evolving.MethodsQTL mapping of eight essential yield traits was conducted across four environments — Sanya (SY) in 2021, and Yangling (YaL), Yulin (YuL), and Weinan (WN) in 2022 — using two types of populations: a KA105/KB024 recombinant inbred line (RIL) population and two immortalized backcross populations (IB1 and IB2) derived from the RILs by crossing with their respective parents. …”
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Arginine depletion potentiates standard-of-care chemo-immunotherapy in preclinical models of high-risk neuroblastoma by Kimberley M. Hanssen, Jayne Murray, Ruby Pandher, Stephanie Alfred, Laura D. Gamble, Jennifer Brand, Erin Mosmann, Frances K. Kusuma, Crystal Mak, Adam Kearns, Alvin Kamili, Caroline Atkinson, Alexis Z. Minchaca, Jean Bertoldo, David S. Ziegler, Francis Mussai, Paul N. M. Cheng, Murray D. Norris, Jamie I. Fletcher, Michelle Haber

“…Arginase therapy has been proposed as a therapeutic approach for neuroblastoma treatment and has a favorable safety profile in pediatric cancer patients, however optimal therapeutic combinations remain unexplored. …”
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Outcomes of Implementing a Multidimensional Antimicrobial Stewardship Program in a Medical Ward in a Third-Level University Hospital in Northern Italy by Maria Mazzitelli, Daniele Mengato, Gianmaria Barbato, Sara Lo Menzo, Fabio Dalla Valle, Margherita Boschetto, Paola Stano, Cristina Contessa, Daniele Donà, Vincenzo Scaglione, Giacomo Berti, Elisabetta Mariavittoria Giunco, Tiziano Martello, Francesca Venturini, Ignazio Castagliuolo, Michele Tessarin, Paolo Simioni, Annamaria Cattelan

“…<b>Background/Objectives</b>: Antimicrobial stewardship programs (ASPs) optimize antimicrobial use, improving outcomes and reducing resistance. …”
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Gymnadenia conopsea orchid: a systematic review by Jing-Yi Wu, Jing-Yi Wu, Ruo-Nan Tang, Ruo-Nan Tang, Jia-Wen Wang, Jia-Wen Wang, Wan-Ying Chen, Wan-Ying Chen, Xing Liu, Ji-Wen Wang, Mei-Ya Li, Fu-Sheng Jiang, Fu-Sheng Jiang

“…For propagation, wild-simulated cultivation should be adopted for resource conservation, while optimizing symbiotic germination techniques is critical to overcome propagation bottlenecks, ultimately enabling sustainable utilization.…”
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The Extended Flexor Carpi Radialis Approach for Distal Radius Fracture Fixation: A Prospective Study by Sulaiman Alrefai, MD, Dionne Hsu, MD(c), Jonathan Persitz, MD, Atefeh Noori, PhD, Andrea Chan, MD, FRCSC, Ryan Paul, MD, FRCSC

“…This approach ensures optimal radial and dorsal exposure by releasing the radial septum and simplifies reduction by releasing deforming forces while providing access to the critical volar ulnar corner. …”
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Age-Onset-Related Particularities of Pediatric MS—Understanding the Spectrum: A Tertiary Center Experience by Alice Denisa Dică, Dana Craiu, Florentina Ionela Linca, Magdalena Budișteanu, Catrinel Iliescu, Carmen Sandu, Cristina Pomeran, Diana Bârcă, Niculina Butoianu, Carmen Burloiu, Ioana Minciu, Ina Ofelia Focșa, Dana Surlică, Oana Tarța-Arsene, Cristina Cazacu, Andreea Badea, Alexandru Stefan Niculae, Daniela Adriana Ion

“…Further multicenter studies with standardized imaging and cognitive assessment protocols are needed to optimize care for this vulnerable population.…”
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Impact of Storage Conditions on Bronchoalveolar Lavage Fluid Analysis: A Human Study by Yu Shionoya, Kanae Maruyama, Takeshi Kawasaki, Mayumi Ono, Yushi Murai, Ryutaro Hirama, Dai Horiuchi, Noriko Sakuma, Shinsuke Kitahara, Shun Sato, Kohei Takahashi, Yoshihito Ozawa, Takuji Suzuki

“…This study aimed to evaluate how different storage conditions impact BALF cell counts and differentials to guide optimal sample handling practices. <b>Methods</b>: Forty patients who underwent BAL at Chiba University Hospital from June to December 2024 were included. …”
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Impacts of Traditional Warm-Up and Post-Activation Potentiation on Muscle Endurance During the Back Squat: Response of Blood Lactate, Perceived Effort, and Time Under Tension by Taianda M. Amorim, Alexandre V. Gurgel, Viviane Faleiro, Thiago T. Guimarães, Estêvão R. Monteiro, Felipe G. Teixeira, Bruno Jotta, Tiago C. Figueiredo, Raquel C. Castiglione, Silvio R. Marques-Neto

“…Background: Warm-up strategies are essential for optimizing strength-training performance. Traditional warm-ups improve neuromuscular readiness, whereas post-activation potentiation (PAP) has been proposed to acutely enhance muscular output. …”
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Assessment of salt tolerance in peas using machine learning and multi-sensor data by Zehao Liu, Qiyan Jiang, Yishan Ji, Rong Liu, Hongquan Liu, Xiuxiu Ya, Zhenxing Liu, Zhirui Wang, Xiuliang Jin, Tao Yang

“…The results show that: 1) multi-source data fusion significantly improved the accuracy of AGB and SPAD estimation; 2) the CatBoost algorithm achieved the highest performance for AGB estimation (R² = 0.70, RMSE = 1.59 t/hm2, NRMSE = 13.94 %), while the LightGBM algorithm performed best for SPAD estimation (R² = 0.60, RMSE = 2.33, NRMSE = 14.53 %); and 3) The PSTS established based on the optimal estimation data exhibits a strong consistency with the ground-measured data. …”
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Clinical features of non-compaction cardiomyopathy across age groups: a retrospective study of 415 patients by Ying Li, Jimei Chen, Min Qiu, Miao Tian, Ziqin Zhou, Ruyue Zhang, Jiazichao Tu, Linjiang Han, Shuheng Zhou, Xinming Li, Jian Zhuang, Shusheng Wen

“…Notably, heart failure was most prevalent in adult patients (54.6%, n=53), while cardiac murmur was the primary presenting symptom in both infant and child/adolescent groups (19.5%, n=33 and 17.4%, n=26, respectively). …”
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Longitudinal analysis of hsa-miR-3163, hsa-miR-124-3p, hsa-miR-548c-3p, and hsa-miR-27a-3p as prognostic biomarkers in HIV-infected patients by Ilker Inanç Balkan, Ilker Inanç Balkan, Ilker Inanç Balkan, Andleeb Shahzadi, Haktan Sönmez, Burhaneddin Oktan, Muhammad Ihtisham Umar, Bilgül Mete, Fehmi Tabak, Günnur Deniz, Umut Can Küçüksezer

“…RT-qPCR and ELISA techniques were used to analyze miRNA expression levels while immunological markers (CD4 count and ratio) were assessed by flow cytometry.ResultsmiR-27a-3p expression was significantly increased at 2nd and 6th months of ART (p&lt;0.001). miR-548ac-3p was upregulated at 6th month compared to healthy individuals and ART-naive subjects (p&lt;0.05). miR-124-3p expression was significantly elevated in ART-naive subjects in comparison with healthy controls (p&lt;0.001). …”
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The effect of taurine supplementation on markers of muscle damage and muscle pain in an athletic population: A systematic review and meta-analysis of randomized controlled trials a... by Elaheh Dehghani, Fatemeh Naeini, Sakineh Shab Bidar, Mohammad Beba, Erfan Mortezapour, Ruhollah Nourian, Khashayar Danandeh, Zahra Gohari Dezfuli, Kurosh Djafarian

“…Conclusion: TS may support post-exercise muscle recovery by reducing CK and LDH levels, but its effect on muscle pain remains unclear. While it shows potential as a recovery aid for athletes, further research is needed to optimize dosing and practical applications in sports performance and rehabilitation.…”
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Cerebrospinal Fluid Aβ Biomarkers Predict Recurrent Hemorrhage and Identify Cerebral Amyloid Angiopathy in Patients With Lobar Hemorrhage by Philipp Arndt, Malte Pfister, Frank Schreiber, Valentina Perosa, Hendrik Mattern, Jose Bernal, Berkant Bay, Marc Dörner, Marwa Al‐Dubai, Vanessa Swiatek, Belal Neyazi, Erol Sandalcioglu, Cornelia Garz, Sven G. Meuth, Michael Goertler, Stefan Vielhaber, Katja Neumann, Stefanie Schreiber

“…Biomarker levels were compared between patients with and without recurrent hemorrhage, and optimal cutoff values were derived from receiver operating characteristic analysis to define high and low biomarker groups. …”
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Macular epiretinal membrane in high myopia: timing and prognosis of pars plana vitrectomy surgery by Yu-Tong Xia, Jia-Yun Ge, Zong-Chan Zhang, Li-Yue Zhang, Ying-Ying Wen, Ying Xie, Ye Shen, Jian-Ping Tong

“…AIM: To investigate the outcomes and prognosis of macular epiretinal membrane (ERM) after pars plana vitrectomy (PPV) in patients with high myopia (HM), focusing on the optimal timing of surgery and its impact on prognosis. …”
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Subnational introduction of the RTS,S/AS01E malaria vaccine into routine immunization: experience and lessons from the three pilot countries by Rose Jalang’o, Kwame Amponsa-Achiano, Mike Chisema, Keziah Malm, Lydiah Khalayi, Brenda Mhone, Wahjib Mohammed, Franklin Asiedu-Bekoe, Adam Haji, Josephine Njoroge, Boston Zimba, Esther Chirwa, Peter O. Tweneboah, Jackson Sillah, Mgaywa G. M. D. Magafu, Cynthia Bergstrom, Tracey Goodman, Jenny Walldorf, Kristen Kelleher, Eliane Pellaux-Furrer, Mary J. Hamel, Michael R. Adjei, Rafiq N. A. Okine

“…RTS,S was initially introduced in randomly selected areas, while other areas served as comparators until the four-dose schedule vaccine was scaled up following the WHO recommendation in 2021. …”
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Modification of the Cardiac Renal Angina Index for Predicting Adverse Kidney Events After Pediatric Cardiac Surgery by Katherine F. Melink, Natalja L. Stanski, Emily Gorrell, Jeffrey A. Alten, Kevin A. Pettit, Stuart L. Goldstein, Huaiyu Zang, Nicholas J. Ollberding, Rajit K. Basu, Shina Menon, Megan SooHoo, Katja M. Gist

“…Patients who were cRAI positive had worse outcomes, while the composite outcome was effectively ruled out in patients who were cRAI negative. …”
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