Evaluation of a Machine Learning Model Based on Laboratory Parameters for the Prediction of Influenza A and B in Chongqing, China: Multicenter Model Development and Validation Stud... by Weiwei Hu, Yulong Liu, Jian Dong, Xuelian Peng, Chunyan Yang, Honglin Wang, Yong Chen, Shan Shi, Jin Li

“… BackgroundInfluenza viruses are major pathogens responsible for acute respiratory infections in humans, which present with symptoms such as fever, cough, sore throat, muscle pain, and fatigue. While molecular diagnostics remain the gold standard, their limited accessibility in resource-poor settings underscores the need for rapid, cost-effective alternatives. …”
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Metal ion-enhanced photosynthetic bacteria for bioplastic production from kitchen waste digestate: performance and mechanism by Wei Zhao, Huize Liu, Jingyi Li, Shiqi Liu, Xue Tao, Li Sun, Longyi Lv, Jinsong Liang, Guangming Zhang

“…All reactors were placed in a light-proof experimental chamber with a light intensity of 4,000 lx.ResultsThe optimal concentrations of 10 mg/L Fe3+ and 2 mg/L Mn2+ promoted PSB biomass and PHB accumulation, while excessive concentrations of metal ions inhibited them. …”
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Development of a postoperative recurrence prediction model for stage Ⅰ non-small cell lung cancer patients using multimodal data based on machine learning by ZHANG Di, WU Yi, XU Yu

“…Radiomic models were established based on extracted features from tumor-dominant regions of interest (ROI) on CT images, while clinical models were developed using demographic characteristics and preoperative laboratory examinations. …”
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Impact of Sagittal Spinal Balance on Functional Recovery After PLIF of L5‐S1 Isthmic Spondylolisthesis With Lumbar Spinal Stenosis by Jiaheng Lv, Quan Zhou, Wei He, Tianci Fang, Yujie Shen, Yulin Chen, Hao Liu, Huilin Yang, Yifei Zheng, Tao Liu

“…This study analyzes the influence of residual sagittal imbalanceon health‐related quality of life (HRQOL) after PLIF for L5‐S1 IS with LSS, aiming to optimize surgical correction and prognostic accuracy. …”
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PREDICTORS OF THE DEVELOPMENT OF HYPOXIC-ISHEMIC ENCEPHALOPATHY IN FULL-TERM AND PREMATURE INFANTS BORNFROM MOTHERS WITH METABOLIC SYNDROME IN THE EARLY NEONATAL PERIOD by А. Давиденко, В. Похилько, О. Ковальова, Ю. Чернявська, С. Цвіренко, Г. Соловйова

“…Furthermore, urinary nitrite concentration serves as an optimal biomarker for predicting HIE onset. …”
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Independent Association of Sleep Apnea-Specific Hypoxic Burden and Sleep Breathing Impairment Index with Thyroid Function in Obstructive Sleep Apnea: A Retrospective Study by Zhou Y, Shi Y, Zhu S, Cao Z, Xie Y, Lu C, Niu X, Ma L, Wang Z, Su Y, Xia Z, Yuan Y, Yang J, Lu R, Feng Y, Ren X, Hou W

“…Multiple linear regression analyzed the independent relationships between the AHI, SASHB, SBII, and thyroid function indicators while adjusting for potential confounders.Results: Significant intergroup differences were observed in thyroid function indicators under various grouping methods, with different trends. …”
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Evaluation of Olive Mill Waste Compost as a Sustainable Alternative to Conventional Fertilizers in Wheat Cultivation by Ana García-Rández, Silvia Sánchez Méndez, Luciano Orden, Francisco Javier Andreu-Rodríguez, Miguel Ángel Mira-Urios, José A. Sáez-Tovar, Encarnación Martínez-Sabater, María Ángeles Bustamante, María Dolores Pérez-Murcia, Raúl Moral

“…However, the OCP treatment reduced grain yield by only 15%, while improving soil microbial activity and enzymatic responses. …”
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Prognostic differences between persistent HFrEF and HFrecEF following acute myocardial infarction by Jeong Yoon Jang, Jae Myoung Lee, Yujin Shin, Yong-Lee Kim, Gain Yu, Jae Seok Bae, Yun-Ho Cho, Choong Hwan Kwak, Min Gyu Kang, Kye-Hwan Kim, Jeong Rang Park, Jin-Yong Hwang, Young-Hoon Jeong, Jong-Hwa Ahn

“…This study aimed to evaluate the prognostic differences between persistent HFrEF and HFrecEF.MethodsThis prospective cohort study included AMI patients with reduced LVEF (<40%) at admission. …”
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CRISPR/Cas genome editing in soybean: challenges and new insights to overcome existing bottlenecks by Nayara Sabrina Freitas-Alves, Clidia E. Moreira-Pinto, Fabiano T.P.K. Távora, Bruno Paes-de-Melo, Fabricio B.M. Arraes, Isabela T. Lourenço-Tessutti, Stéfanie M. Moura, Antonio C. Oliveira, Carolina V. Morgante, Yiping Qi, Maria Fatima Grossi-de-Sa

“…To date, the efficiency of gRNAs has been validated using protoplasts and hairy root assays, while stable plant transformation relies on Agrobacterium-mediated and particle bombardment methods. …”
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Impact of CYP3A4 and ABCB1 genetic variants on tacrolimus dosing in Greek kidney transplant recipients by Anna Tsironi, Konstantinos Lazaros, Effrosyni Mendrinou, Marios Papasotiriou, Stavroula Siamoglou, Kyriaki Kydonopoulou, Anne John, Alexandra Gerou, Spyridon Gerou, Bassam R. Ali, Bassam R. Ali, Aristidis G. Vrahatis, George P. Patrinos, George P. Patrinos, George P. Patrinos, George P. Patrinos, George P. Patrinos

“…Its narrow therapeutic index requires precise management to achieve optimal dosing and to minimize adverse drug events (ADEs) while ensuring its therapeutic efficacy. …”
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Cutoff levels for newborn screening of 21-OH deficiency in a Brazilian metropolitan area by Kallianna Paula Duarte Gameleira, Juliana de Vasconcellos Thomas, Vitor Guilherme Brito de Araújo, Cláudia Vicari Bolognani, Sérgio Eduardo Soares Fernandes, Fábio Ferreira Amorim

“…Conclusion: The proposed 17OHP cutoff strategy effectively reduced false positives, improving specificity, LR+, PPV, and accuracy Thus, it optimized CAHNBS programs while minimizing unnecessary costs and parental distress.…”
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The heterogeneity of mortality burden of lower respiratory infection associated with ambient temperature and its drivers in China by Sujuan Chen, Jinlei Qi, Yulin Zhuo, Jianxiong Hu, Jiangmei Liu, Peng Yin, Tao Liu, Mengen Guo, Guanhao He, Ziqiang Lin, Fengrui Jing, Jinling You, Wenjun Ma, Maigeng Zhou

“…Abstract：: Ambient temperature is linked to an increased risk of lower respiratory infections (LRI) yet the evidence on the population and spatial heterogeneity of LRI mortality burden attributed to non-optimal temperatures and its socioeconomic drivers remain limited. …”
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Effects of albumin and weight-standardized hand grip strength on survival for cancer patients with frailty by Xiao-Man Xiong, Chu-Ying Zhang, Hong-Xia Xu, Ge-Ge Zhang, Saba Fida, Jiu-Wei Cui, Wei Li, Min Weng, Kun-Hua Wang, Fu-Xiang Zhou, Jun-Qiang Chen, Xiang-Hua Wu, Han-Ping Shi, Yan-Li Zhang, Chun-Hua Song

“…Objective:. While albumin and the weight-standardized hand grip strength (HGS/W) serve as valuable prognostic indicators for cancer patients, their correlation with the prognosis in frail cancer patients remains inadequately explored. …”
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Neoadjuvant chemoimmunotherapy versus neoadjuvant chemoradiotherapy in patients with borderline resectable esophageal squamous cell carcinoma by Jun-Peng Lin, Feng-Nian Zhuang, Wei-Jie Chen, Zhou Lin, Yu-Jie Chen, Xiao-Feng Chen, Hui Lin, Hao He, Peiyuan Wang, Hang Zhou, Wen-Wei Wei, Peng-Qiang Gao, Shuo-Yan Liu, Feng Wang

“…Abstract Background The optimal treatment strategy for patients with borderline resectable (cT3br) esophageal squamous cell carcinoma (ESCC) remains unclear. …”
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Multi-omics characterization of diabetic nephropathy in the db/db mouse model of type 2 diabetes by Liping Wang, Ran Zhou, Guanghui Li, Xiaodan Zhang, Yan Li, Yinchen Shen, Junwei Fang

“…Methods: Renal tissues from db/db mice underwent integrative multi-omics analysis, encompassing transcriptomics, metabolomics, and lipidomics. …”
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Clinical outcomes and therapeutic modalities in older Chinese patients with MCL: a multi-center real-world retrospective study by Yuan Yang, Ping Yang, Wei Zhang, Hui Liu, Xiuhua Sun, Xiubin Xiao, Jingwen Wang, Zhenling Li, Lihong Li, Shuye Wang, Juan He, Xiaoling Li, Qingqing Cai, Weilong Zhang, Jing Wang, Chunyuan Li, Yingtong Chen, Shuozi Liu, Hongmei Jing

“…The present study was performed to identify the prognostic factors and optimal treatment modalities in older Chinese MCL patients.Methods Patients (age ≥ 65 yrs) with MCL from 19 comprehensive hospitals in China were included. …”
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Population-based colorectal cancer risk prediction using a SHAP-enhanced LightGBM model by Guinian Du, Hui Lv, Yishan Liang, Jingyue Zhang, Qiaoling Huang, Guiming Xie, Xian Wu, Hao Zeng, Lijuan Wu, Jianbo Ye, Wentan Xie, Xia Li, Yifan Sun

“…This tool shows significant potential for optimizing early diagnosis and personalized risk assessment in CRC management.…”
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Formulation of zein nanoparticles for augmenting the anti-inflammatory activity of dexketoprofen by Mahmoud A. El Hassab, Mona H. Ibrahim, Sherif S. Abdel Mageed, Abdulla M. A. Mahmoud, Zainab Sabry Othman Ahmed, Zainab Sabry Othman Ahmed, Shaimaa Mosallam, Manar Adel Abdelbari, Eman F. Khaleel, Maram A. El Hasab, Asmaa Elsayyad, Asmaa Elsayyad, Shady Allam, Shady Allam, Moaz A. Eltabeeb, Ahmed T. Negmeldin, Ahmed T. Negmeldin, Wagdy M. Eldehna, Rofida Albash

“…IntroductionTopical delivery of anti-inflammatory drugs is an important strategy for enhancing therapeutic efficacy while minimizing systemic side effects. This study focuses on improving the anti-inflammatory activity of Dexketoprofen by developing zein nanoparticles (ZNs) as a novel topical carrier system, aiming to optimize drug delivery and patient outcomes.MethodsDexketoprofen-loaded ZNs were prepared using an ethanol injection technique and optimized via a 23 full factorial design. …”
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Explainable machine learning for predicting distant metastases in renal cell carcinoma patients: a population-based retrospective study by Zhao Hou, Zhao Hou, Peipei Wang, Peipei Wang, Dingyang Lv, Dingyang Lv, Huiyu Zhou, Huiyu Zhou, Zhiwei Guo, Zhiwei Guo, Jinshuai Li, Jinshuai Li, Mohan Jia, Mohan Jia, Hongyang Du, Hongyang Du, Weibing Shuang, Weibing Shuang

“…Hyperparameters were optimized using grid search and tenfold cross-validation. …”
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Electroacupuncture enhances mesenchymal stem cell therapy via improved perfusion and inflammation modulation in peripheral nerve injury: an IVIM-MRI study in rats by Junfeng Li, Qiuyi Chen, Jintong Pan, Jintong Pan, Fanqi Meng, Wensheng Huang, Yingying Liang, Xuewen Yu, Ruirui Qi, Peiyin Luo, Haodong Qin, Yueyao Chen, Xiaofeng Lin

“…By employing intravoxel incoherent motion (IVIM) MRI, the study monitored perfusion and explored how EA improves the regenerative environment to optimize stem cell transplantation outcomes.MethodsSeventy-two rats were randomly assigned to four groups: EA, EA + BMSCs, BMSCs, and PBS. …”
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