Evaluation of the hypercholesterolemia care cascade and compliance with NCEP-ATP III guidelines in Iran based on the WHO STEPS survey by Shirin Djalalinia, Sepehr Khosravi, Moein Yoosefi, Sarvenaz Salahi, Zahra Shokri Varniab, Ali Golestani, Nazila Rezaei, Ameneh Kazemi, Arezou Dilmaghani-Marand, Negar Rezaei, Erfan Ghasemi, Naser Ahmadi, Mohammad-Mahdi Rashidi, Yosef Farzi, Kamyar Rezaee, Maryam Nasserinejad, Sina Azadnajafabad, Elham Abdolhamidi, Rosa Haghshenas, Arefeh Alipour Derouei, Azadeh Momen Nia Rankohi, Farshad Farzadfar

“…Of those receiving treatment, 52.85% (females) and 53.93% (males) achieved optimal LDL, while 76.98% (females) and 81.06% (males) attained total cholesterol < 200 mg/dL. …”
Get full text

Analysis of nutritional quality and food digestibility in male Javan rhinoceros (Rhinoceros sondaicus) in Ujung Kulon National Park by Adhi Hariyadi

“…Overall energy consumption was related to the size of the animal, while the digestibility of plants consumed appeared to be influenced by individual age and habitat conditions. …”
Get full text

Trends in inpatient antibiotic use in Indonesia and the Philippines during the COVID-19 pandemic by Amara Z. Fazal, Olivia L. McGovern, Garrett W. Mahon, Fernanda C. Lessa, Maria Tarcela Gler, Jemelyn Garcia, Mark John Festin, Kuntaman Kuntaman, Ida Parwati, Cherry Siregar, Jay Christian D. Muere, Gina De Guzman Betito, Maya Montemayor, Arleen De Leon, Emmeline Borillo, Mark Ramon Victor Llanes, Regina Berba, Musofa Rusli, Mariyatul Qibtiyah, Bambang Pujo Semedi, Rosantia Sarassari, Leonardus Widyatmoko, Basti Andriyoko, Adhi Kristianto Sugianli MD, Dewi Kartika Turbawaty, Ivo Dhanitri Ranita, Franciscus Ginting, Rahmadania Marita Joesoef, Made Ananda Krisna, Twisha S. Patel

“…We assessed changes in AU during the COVID-19 pandemic in Indonesia and the Philippines. Methods: We evaluated hospital-wide AU over 36 months in six hospitals, 3 in Indonesia and 3 in the Philippines. …”
Get full text

What Changes are Mandatory in Breast Surgery Training? An International Survey and Recommendations of the French Academy of Surgery and the Senologic International Society by Tolga Ozmen, Caroline Bouche, Megane Buttignol, Bolivar Arboleda-Osorio, Mauricio Magalhaes Costa, Henry Coudane, Darius Dian, Xishan Hao, Shigeru Imoto, Olivier Jardé, Hubert Johanet, Esther Meka, Alexander Mundinger, Ruben Orda, Vahit Ozmen, Tadeusz Pienkowski, Schlomo Schneebaum, Charlotte Vaysse, Susie Brousse, Atilla Soran, Carole Mathelin

“…Most respondents (66%) had over 15 years of experience, and 75% were male. While 50% reported that breast surgery fellowships were not mandatory, countries with requirements often stipulated a one or two-year experience and a minimum cases number. …”
Get full text

Pembrolizumab-axitinib versus nivolumab-cabozantinib as first-line therapy in patients with metastatic renal cell carcinoma: a retrospective real-world comparison (ARON-1) by Matteo Santoni, Giandomenico Roviello, Enrique Grande, Ugo De Giorgi, Ondrej Fiala, Emmanuel Seront, Javier Molina-Cerrillo, Renate Pichler, Zin W. Myint, Jakub Kucharz, Ravindran Kanesvaran, Thomas Büttner, Martin Pichler, Umberto Basso, Jindrich Kopecky, Maria T. Bourlon, Linda Cerbone, Tomas Buchler, Alvaro Pinto, Alfonso Gómez de Liaño, Caterina Gianni, Anca Zgura, Pasquale Rescigno, Jawaher Ansari, Orazio Caffo, Zsófia Küronya, Maria Giuseppa Vitale, Dipen Bhuva, Martina Catalano, Nuno Vau, Ray Manneh Kopp, Sebastiano Buti, Aristotelis Bamias, Camillo Porta, Kaisa Sunela, Francesco Massari

“…Abstract Background The optimal first-line therapy for metastatic renal cell carcinoma (mRCC) remains uncertain, despite recent advancements in immune-based combinations. …”
Get full text

VENETOCLAX-BASED VERSUS 7+3 INDUCTION THERAPY IN FIT YOUNGER ADULTS WITH NEWLY DIAGNOSED NON-CBF AML by Dmitrii Zhogolev, Nikita Pastukhov, Bella Aybova, Anna Smirnova, Ivan Moiseev, Sergey Bondarenko, Alexander Kulagin

“…Survival analysis was conducted using the Kaplan-Meier method and log-rank test. Cumulative incidences of relapse and NRM were assessed using competing risk models with Gray’s test. …”
Get full text

Safety and efficacy of PD-1 inhibitors plus tyrosine kinase inhibitors combination therapy in patients with advanced hepatocellular carcinoma combined with hyperbilirubinemia: a re... by Shida Pan, Shida Pan, Jianing Wang, Jianing Wang, Jiahe Tian, Jiahe Tian, Yilin Wang, Yilin Wang, Siyu Wang, Yingying Yu, Yingying Yu, Fengyi Li, Yan-Mei Jiao, Yingjuan Shen, Luo Yang, Xiaomeng Liu, Qin Qiu, Junqing Luan, Fu-Sheng Wang, Fu-Sheng Wang, Fu-Sheng Wang, Fu-Sheng Wang, Fanping Meng, Fanping Meng, Fanping Meng

“…The median overall survival (OS) for the entire cohort was 5.03 months, while the median progression-free survival (PFS) was 3.63 months. …”
Get full text

Efficacy test of a Mycoplasma hyorhinis mRNA-LNP vaccine candidate by Eszter Zsófia Nagy, Levente Szeredi, Hiromi Muramatsu, Noémi Nagy, Dénes Grózner, Zsuzsa Kreizinger, Kinga M. Sulyok, Bandana Pangabam, Lilla Tóth, Rachel H.J. Jun, Dorottya Földi, Enikő Wehmann, Miklós Tenk, Norbert Pardi, Miklós Gyuranecz

“…Therefore, the present study aimed to develop a M. hyorhinis mRNA-LNP vaccine candidate. Materials and methods: The selected antigens were highly conserved proteins involved in bacterial adhesion. …”
Get full text

Enhancing fermentation quality and fiber decomposition of Phragmites australis silage by introducing Bacillus subtilis and lactic acid bacteria consortia by Yong Liu, Songbai Zhang, Junrui Liao, Nazir Ahmad Khan, Shaoxun Tang, Chuanshe Zhou, Zhiliang Tan, Asmaa Elnagar, Ibrahim F. Rehan, Ibrahim F. Rehan, Ibrahim F. Rehan, František Zigo, Abdelfattah Z. M. Salem, Abdelfattah Z. M. Salem

“…Acetic and butyric acid concentrations were significantly reduced (p &lt; 0.05), while neutral detergent fiber (NDF) decreased by 5.9% compared to the Control. …”
Get full text

Expression characteristics and functional identification of PpD2 gene in peach (Prunus persica) by XIE Hefang, ZHANG Yajia, ZHANG Junjie, LIAN Xiaodong, ZHANG Haipeng, CHENG Jun, WANG Wei, HOU Nan, WANG Lei, ZHENG Xianbo, FENG Jiancan, WANG Xiaobei, TAN Bin

“…These challenges highlight the emergent need to optimize tree architecture and develop labor-saving cultivars to address the developmental bottlenecks in the peach industry. …”
Get full text

Rapid laboratory confirmation of the 2025 Sudan Virus Disease (Svd) index case in Uganda by Andrew Nsawotebba, Susan Nabadda, Valeria Nakintu, Isaac Ssewanyana, Misaki Wayengera, Jonathan Kabazzi, Stephen Balinandi, Godfrey Pimundu, Tonny Muyigi, Alisen Ayitewala, Samuel Gidudu, Morgan Otita, Ibrahim Mugerwa, Moses Rubangakene, Sulaiman Ikoba, Sam Kalungi, Rhoda Wanyenze, Kevin K. Ariën, Eunice Namboozo, Benedict Kanamwanji, Steven Ssekyondwa, Ronald Kasujja, Derrick Kitwe, Catherine Dambya, Innocent Morunyanga, Reginald Rony Bahatungire, Francis Kakooza, Moses Joloba, Atek Kagirita, Allan Muruta, Pontiano Kaleebu, Henry Kyobe, Charles Olaro, Diana Atwine, Jane Ruth Aceng

“…The 50 µL sample had the lowest Ct values for the Orthoebolavirus target, while the 30 µL sample had the lowest Ct values for the internal control target. …”
Get full text

Serum Concentrations of Matrix Metalloproteinase‐1 and Procollagen Type I Carboxy Terminal Propeptide Discriminate Infarct‐Like Myocarditis and Non−ST‐Segment−Elevation Myocardial... by Lucas Bacmeister, Ersin Cavus, Sebastian Bohnen, Enver Tahir, Hanna Wolf, Annette Buellesbach, Adrian Heidenreich, Virginia K. Haacke, Susanne Weber, Ingo Hilgendorf, Tanja Zeller, Francisco Ojeda, Ulf K. Radunski, Gunnar K. Lund, Gerhard Adam, Stefan Blankenberg, Dirk Westermann, Kai Muellerleile, Diana Lindner

“…Compared with healthy controls, subjects with myocarditis had higher serum concentrations of MMP‐1 and PICP, while no difference was observed in individuals with myocardial infarction. …”
Get full text

Discovery and validation of frameshift-derived neopeptides in Lynch syndrome: paving the way for novel cancer prevention strategies by Marta Pineda, Sabela Carballal, María Pellisé, Liseth Rivero, Francesc Balaguer, Fátima Marín, Leticia Moreira, Teresa Ocaña, Manel Juan, Daniel Benitez-Ribas, Georgina Flórez-Grau, Joaquín Castillo-Iturra, Cristina Bayó, Giancarlo Castellano, Hardeep Kumari, Maria Daca-Alvarez, Oswaldo Ortiz, Rebeca Moreira, Julia Canet-Hermida, Capella Gabriel

“…Background Lynch syndrome (LS), caused by germline pathogenic variants in the mismatch repair genes, leads to high rates of frameshift-derived neopeptide (FSDN) expression due to microsatellite instability (MSI). While colorectal cancer (CRC) prevention is effective, most LS-related tumors lack such strategies. …”
Get full text

Evaluation of Patient Benefits from the Superficial Circumflex Iliac Artery Perforator Flap in Elderly Patients by Hongmin Luo, Huining Bian, Zuan Liu, Chuanwei Sun, Hanhua Li, Lianghua Ma, Xiaoyan Wang, Zhifeng Huang, Xu Mu, Shenghua Chen, Yuyang Han, Lin Zhang, Shaoyi Zheng, Zeyang Yao, Wen Lai

“…These findings support the continued use of SCIP flaps in aging populations, emphasizing the need for individualized surgical approaches to optimize patient outcomes.…”
Get full text

Ultrasound-Guided Vacuum-Assisted Excision (VAE) in Breast Lesion Management: An Experimental Comparative Study of Two Different VAE Devices Across Various Aspiration Levels and Wi... by Serena Carriero, Maurizio Cè, Matilde Pavan, Mariassunta Roberta Pannarale, Giulia Quercioli, Sveva Mortellaro, Alessandro Liguori, Maria Cosentino, Maria Iodice, Marta Montesano, Giulia Querques, Carolina Lanza, Salvatore Alessio Angileri, Pierpaolo Biondetti, Filippo Pesapane, Gianpaolo Carrafiello, Sonia Santicchia

“…The Mammotome^® Elite 10G operates in a fixed mode, while the Mammotome^® Revolve EX 8G offers multiple aspiration levels and aperture windows for greater versatility. …”
Get full text

Immune and genomic biomarkers of immunotherapy response in cancer of unknown primary by Madhu Singh, Linda Mileshkin, Penelope Schofield, Bo Gao, Gary Richardson, Andrew Pattison, Rodney J Hicks, Niko Thio, Mark Warren, Colin Wood, Stephen B Fox, Anna DeFazio, Andrew Fellowes, Christopher Steer, David Bowtell, Nicholas Wilcken, Tharani Sivakumaran, Atara Posner, Dariush Etemadmoghadam, Krista Fisher, Samantha Webb, Christos S Karapetis, Ian M Collins, Narayan Karanth, Owen W J Prall, Richard William Tothill

“…Immune checkpoint inhibitors (ICIs) can be efficacious in some patients with CUP, but the optimal predictive biomarkers are unknown. We therefore assessed immune and genomic biomarkers as well as predicted TOO in patients with CUP, including a subset treated with ICIs.Methods Patients with CUP were subject to gene-expression profiling (GEP) and DNA panel sequencing. …”
Get full text

Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

“…These Nbs were formulated as tetravalent Nb-Fc fusion proteins for optimal CCR8 binding and blocking, containing either an antibody-dependent cell-mediated cytotoxicity (ADCC)-deficient or an ADCC-prone Fc region. …”
Get full text

Isolation and identification of strawberry anthracnose and fungicide screening in Henan province by SUN Wenbin, ZHANG Jingjing, SONG Yanhong, ZHAO Xia, LI Gang, ZHOU Houcheng, LIU Lifeng

“…Inoculated leaves with strain ZG-2 displayed rot after one week, while the lesion areas caused by the other strains were less than 50%, indicating a lower pathogenicity in comparison to ZG-2. …”
Get full text

Air-Outlet and Step-Number Effects on a Step-like Plenum Battery’s Thermal Management System by Olanrewaju M. Oyewola, Emmanuel T. Idowu, Morakinyo J. Labiran, Michael C. Hatfield, Mebougna L. Drabo

“…Optimizing the control of the battery temperature (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>T</mi></mrow><mrow><mi>b</mi></mrow></msub></mrow></semantics></math></inline-formula>), while minimizing the pressure drop (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>∆</mo><mi>P</mi></mrow></semantics></math></inline-formula>) in air-cooled thermal management systems (TMSs), is an indispensable target for researchers. …”
Get full text

Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8+ T cells by Kyungwha Lee, Jung-Yun Lee, Ji-Hyun Kim, Min Park, Junsik Park, Young Min Oh, Wonjae Lee, Myoung Ho Jang, Young Jun Koh, Sanghee Lee, Jisoo Kim, Kayoung Shin, Seoho Kim, Haejong Lee, Yuseong Lee, Chong Woo Park, Yaein Amy Shim, Young-Gyu Cho, Jongil Kim, Suyoun Park, Eun-Jin Lee, Hyuckjun Mok, Sung-Man Oh, Kook Hwan Kim

“…To optimize targeting to CD73-expressing cells and reinvigorate the antitumor effect of IL-2 in adenosine-rich microenvironment, we engineered a novel bifunctional GI-αCD73/IL-2v fusion protein. …”
Get full text