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  4. 17164

    Integration of Network Pharmacology, Transcriptomics, and Metabolomics Strategies to Uncover the Mechanism of Chaihuang Qingfu Pill in Treating Sepsis-Induced Liver Injury by Zhang C, Chen F, Jiang Y, Deng J, Yan X, Yin X, Su B, Liu W

    Published 2025-06-01
    “…This study aims to systematically investigate the molecular basis of CHQF in the mitigation of sepsis-associated liver damage.Purpose: To explore the mechanism of CHQF for the treatment of sepsis-induced liver injury.Methods: A sepsis mouse model was established via cecal ligation and puncture (CLP). …”
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  5. 17165

    The impact of early vs. delayed surgery on outcomes in cervical spinal cord injury without fracture or dislocation by Sirui Xiao, Hui Yan, Beixi Bao, Yuxuan Wu, Xiaokang Cheng, Chunyang Xu, Jiaguang Tang

    Published 2025-08-01
    “…ObjectiveThis study aims to retrospectively analyze 104 patients diagnosed with cervical spinal cord injury without fracture or dislocation (CSCIwoFD) who underwent surgical treatment, in order to compare the effects of early vs. delayed surgical intervention on neurological functional recovery.MethodsPatients diagnosed with CSCIwoFD and treated surgically at our institution between August 2020 and January 2023 were retrospectively reviewed. …”
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  6. 17166

    Performance and Cost-Effectiveness of Computed Tomography Lung Cancer Screening Scenarios in a Population-Based Setting: A Microsimulation Modeling Analysis in Ontario, Canada. by Kevin Ten Haaf, Martin C Tammemägi, Susan J Bondy, Carlijn M van der Aalst, Sumei Gu, S Elizabeth McGregor, Garth Nicholas, Harry J de Koning, Lawrence F Paszat

    Published 2017-02-01
    “…Therefore, the objective of this study was to estimate the cost-effectiveness of lung cancer screening in a population-based setting in Ontario, Canada, and evaluate the effects of screening eligibility criteria.<h4>Methods and findings</h4>This study used microsimulation modeling informed by various data sources, including the Ontario Health Insurance Plan (OHIP), Ontario Cancer Registry, smoking behavior surveys, and the NLST. …”
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  7. 17167

    Cardiac Rehabilitation for Fontan Circulation Patients: A Systematic Review, and Meta-Analysis by Luna van de Ven, Ana Clara Félix, Joana Suarez, Jorge Dias, Fátima F. Pinto, Sérgio Laranjo

    Published 2024-11-01
    “…This systematic review and meta-analysis aimed to evaluate the safety, efficacy, and optimal exercise modalities for Fontan patients. <i>Materials and Methods:</i> A systematic search of PubMed, Scopus, Web of Science, and Cochrane Library was conducted on 24 August 2023. …”
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  8. 17168

    Final Fusion Strategies in Early-Onset Scoliosis: Does Implant Density Make a Difference After Magnetically Controlled Growing Rod Treatment? by Paolo Brigato, Leonardo Oggiano, Sergio De Salvatore, Davide Palombi, Sergio Sessa, Umile Giuseppe Longo, Andrea Vescio, Pier Francesco Costici

    Published 2025-05-01
    “…Background/Objectives: Early-onset scoliosis (EOS) frequently requires growth-friendly interventions, such as magnetically controlled growing rods (MCGRs), followed by definitive spinal fusion upon skeletal maturity. The optimal implant density (ID) for final posterior spinal fusion in these patients remains controversial. …”
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  9. 17169

    UMI-77 targets MCL-1 to activate mitophagy and ameliorate periodontitis in mice by Dalei Sun, Shu Ouyang, Xiaoxuan Xu, Jingjing Yan, Heqian Wang, Chenkai Lan, Wubin Ouyang, Liangjun Zhong, Jun Lin

    Published 2025-09-01
    “…Western blot confirmed downregulation of MCL-1 expression to near-normal levels in Group Ba, while TEM detected autolysosomes in both Group Ba and Group Ca, indicating mitophagy activation. …”
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  10. 17170

    A multi-dimensional performance evaluation of large language models in dental implantology: comparison of ChatGPT, DeepSeek, Grok, Gemini and Qwen across diverse clinical scenarios by Xing Wu, Guofei Cai, Bin Guo, Leizi Ma, Siqi Shao, Jun Yu, Yuchen Zheng, Linhong Wang, Fan Yang

    Published 2025-07-01
    “…Mixed-effects models showed Gemini-2.0-flash-thinking superiority over ChatGPT-o3-mini, while Qwen2.5-max exhibited a decline in performance. …”
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  11. 17171

    Risk factors of low bone mass in young patients with transfusion-dependent beta-thalassemia by Wei Zhang, Wei Zhang, Rongrong Liu, Rongrong Liu, Rongrong Liu, Siping He, Jihua Huang, Liting Wu, Cuifeng Huang, Yuzhen Liang, Yongrong Lai, Yongrong Lai, Yongrong Lai

    Published 2025-07-01
    “…ObjectiveTo determine the prevalence of low bone mass and associated risk factors among children and adolescents suffering from transfusion-dependent beta-thalassemia (TDT).MethodsIn this study, a total of 389 children and adolescents with TDT (236 males and 153 females), treated between January 2015 and December 2024 in the Department of Hematology at the First Affiliated Hospital of Guangxi Medical University, were selected. …”
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  12. 17172

    Clinical and histopathological features of lupus nephritis and the risk of long-term kidney outcomes in Indonesia by Ni Made Hustrini, Ni Made Hustrini, Endang Susalit, Monik Ediana Miranda, Meilania Saraswati, Y. K. Onno Teng, Merel van Diepen, Joris I. Rotmans

    Published 2025-06-01
    “…We examined the clinicopathological presentation and long-term kidney outcomes of lupus nephritis in Indonesia.MethodsThis was a retrospective cohort study conducted from 1 January 2011 to 31 December 2021 on biopsy-proven lupus nephritis patients, corresponding to the International Society of Nephrology/Renal Pathology Society 2018 classification. …”
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    Conservation of Verbascum sinaiticum Benth using innovative tissue culture technique and DNA barcoding by Mohamed Abdel-Shakur Ali, Nora Rabee Gowda, Mai A. Allam, Sayed A. Fayed

    Published 2025-07-01
    “…We have devised flexible methods for large-scale micropropagation that offer a sustainable and quick production strategy, even in the face of resource constraints. …”
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  14. 17174

    Development and external validation of machine learning models for the early prediction of malnutrition in critically ill patients: a prospective observational study by Yi Liu, Yehua Xu, Lixia Guo, Zhongbin Chen, Xueqin Xia, Feng Chen, Li Tang, Hua Jiang, Caixia Xie

    Published 2025-07-01
    “…Hyperparameters were optimized via 5-fold cross-validation on the training set, eliminating the need for a separate validation set while ensuring internal validation. …”
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  15. 17175

    Episiotomies and obstetric anal sphincter injuries following a restrictive episiotomy policy in France: An analysis of the 2010, 2016, and 2021 National Perinatal Surveys. by Raphaele Houlbracq, Camille Le Ray, Béatrice Blondel, Nathalie Lelong, Anne Alice Chantry, Thomas Desplanches, ENP2021 Study Group

    Published 2025-01-01
    “…We aimed to assess variations in the prevalence of both episiotomy and obstetric anal sphincter injury (OASI) from the 2010, 2016, and 2021 National Perinatal Surveys.<h4>Methods and findings</h4>A total of 29,750 women who had given birth to a live infant by vaginal delivery were included. …”
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  16. 17176

    A nomogram for predicting early bacterial infection after liver transplantation: a retrospective study by Jie Yu, Jie Yu, Jichang Jiang, Jichang Jiang, Caili Fan, Caili Fan, Jinlong Huo, Jinlong Huo, Tingting Luo, Tingting Luo, Lijin Zhao, Lijin Zhao

    Published 2025-04-01
    “…It can effectively identify the high-risk group for bacterial infection in the early postoperative period after liver transplantation, while simultaneously helping the transplant team dynamically monitor the key indicators and optimize perioperative management.…”
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    Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils by Yixiang Jiang, Ning Wang, Jingyi Liu, Haoran Ren, Wenkang Jiang, Yanting Lei, Xidan Fu, Miao Hao, Xiujuan Lang, Yumei Liu, Xijun Liu, Rui Li, Hulun Li

    Published 2025-02-01
    “…Abstract Background Stem cells utilized for ischemic stroke treatment often display unstable homing capabilities and diminished activity in vivo, limiting their neuroprotective efficacy. Furthermore, the optimal delivery route for stem cells remains undetermined. …”
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    An assessment of the level of knowledge about diabetes mellitus among diabetic patients in a primary healthcare setting by Lushendran M. Moodley, Viren Rambiritch

    Published 2007-12-01
    “…Section A investigated basic patient history (demographics and disease state), while section B was a basic knowledge test on diabetes mellitus. …”
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    Impact of Obesity on the Long-Term Outcomes of Advanced Therapies in IBD: A Real-World Study in Taiwan by Hsu WC, Lin SH, Kuo CJ, Chiu HY, Chen CM, Su MY, Chiu CT, Chang CW, Huang TY, Pan YB, Le PH

    Published 2025-06-01
    “…Future studies should explore optimal therapies for obese IBD patients.Keywords: inflammatory bowel disease, advanced therapies, drug persistence, overweight, obesity…”
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