Prevalence and Predictors of Diabetic Retinopathy in Saudi Arabia: Insights from a Systematic Review and Meta-Analysis by Ali Mohammed Alshahrani, Alaa Mohammed Alshahrani, Beshayer Abdullah H. Al-Boqami, Alwaleed Abdulhadi Alqahtani, Bassam Alzahrani, Yousef Bassi, Mohammed Yousef Almohaimeed, Abeer Mohammed Alalmaai, Ariana Saraiva, Bandar Naffaa Alhumaidi, Najla A. Albaridi, Maria João Lima, Conrado Carrascosa, António Raposo

“…Poor glycemic control and longer diabetes duration were consistently identified as significant predictors of DR, while other factors, such as obesity and hypertension, were also associated with an increased risk of DR. …”
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Longitudinal analysis of hsa-miR-3163, hsa-miR-124-3p, hsa-miR-548c-3p, and hsa-miR-27a-3p as prognostic biomarkers in HIV-infected patients by Ilker Inanç Balkan, Ilker Inanç Balkan, Ilker Inanç Balkan, Andleeb Shahzadi, Haktan Sönmez, Burhaneddin Oktan, Muhammad Ihtisham Umar, Bilgül Mete, Fehmi Tabak, Günnur Deniz, Umut Can Küçüksezer

“…RT-qPCR and ELISA techniques were used to analyze miRNA expression levels while immunological markers (CD4 count and ratio) were assessed by flow cytometry.ResultsmiR-27a-3p expression was significantly increased at 2nd and 6th months of ART (p<0.001). miR-548ac-3p was upregulated at 6th month compared to healthy individuals and ART-naive subjects (p<0.05). miR-124-3p expression was significantly elevated in ART-naive subjects in comparison with healthy controls (p<0.001). …”
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The effect of taurine supplementation on markers of muscle damage and muscle pain in an athletic population: A systematic review and meta-analysis of randomized controlled trials a... by Elaheh Dehghani, Fatemeh Naeini, Sakineh Shab Bidar, Mohammad Beba, Erfan Mortezapour, Ruhollah Nourian, Khashayar Danandeh, Zahra Gohari Dezfuli, Kurosh Djafarian

“…Conclusion: TS may support post-exercise muscle recovery by reducing CK and LDH levels, but its effect on muscle pain remains unclear. While it shows potential as a recovery aid for athletes, further research is needed to optimize dosing and practical applications in sports performance and rehabilitation.…”
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LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock by Marie Crandall, Lisa Jones, Faheem W Guirgis, Lauren Page Black, Martin Daniel Rosenthal, Morgan Henson, Jason Ferreira, Christiaan Leeuwenburgh, Colleen Kalynych, Lyle L Moldawer, Taylor Miller, Srinivasa T Reddy, Samuel S Wu, Frederick A Moore

“…Twenty-four patients will be randomised to one of two doses of the study drug, while 24 control group patients will receive no drug and will be followed during their hospitalisation. …”
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Combination of clinical factors predicts successful glucocorticoid withdrawal in systemic lupus erythematosus (SLE): results from a multicentre, retrospective cohort study by Alessandra Bortoluzzi, Marcello Govoni, Dimitrios T Boumpas, Antonis Fanouriakis, Prodromos Sidiropoulos, George Bertsias, Konstantinos Parperis, Argyro Repa, Ettore Silvagni, Myrto Nikoloudaki, Nestor Avgoustidis, Sofia Pitsigavdaki, Antonio Marangoni, Irini Flouri, Spyridon Katechis

“…Objective Glucocorticoid (GC) tapering and withdrawal to reduce damage represents a key aspect of the European Alliance of Associations for Rheumatology (EULAR) SLE recommendations. However, optimal strategies for relapse-free GC cessation remain ill-defined. …”
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Machine learning-driven model for predicting knowledge, attitudes, and practices regarding medication safety among residents in Hubei, China by Chao Mei, Chao Mei, San-Lan Wu, San-Lan Wu, Tao Zhou, Tao Zhou, Yong-Ning Lv, Yong-Ning Lv, Yu Zhang, Yu Zhang, Chen Shi, Chen Shi, Wei-Jing Gong, Wei-Jing Gong

“…ObjectiveTo evaluate the current state and determinants of medication safety knowledge, attitudes, and practices (KAP) among residents in Hubei Province, and to offer guidance for targeted educational initiatives.MethodsA standardized questionnaire from the Science and Technology Development Center of the Chinese Pharmaceutical Association was utilized. …”
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Identification of HLA-B*13:01 allele in leprosy patients with dapsone hypersensitivity syndrome in Ambon, Indonesia by Sri Linuwih Susetyo Wardhani Menaldi, Mufqi Handaru Priyanto, Sandra Widaty, Yunia Irawati, Yulia Ariani Aswin, Dwi Anita Suryandari, Melani Marissa, Iwan Ariawan, Emiliana Kartika, Malika Sabrina Yunifananda, Hok Bing Thio

“…In Ambon, the capital city of Maluku Province, the prevalence is 8.27 per 10.000 persons, exceeding the national rate of 0.61. While multidrug therapy (MDT) including Dapsone remains the standard treatment for leprosy, it carries the risk of a severe adverse reaction known as Dapsone Hypersensitivity Syndrome (DHS). …”
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Prevalence and risk factors of postpartum depression among postnatal mothers with hypertensive disorders of pregnancy in a developing country by Wina Ivy Ofori Boadu, Enoch Odame Anto, Edmund Mintah Wiafe, Michael Nyantakyi, Joseph Frimpong, Emmanuel Ekow Korsah, Ezekiel Ansah, Afia Agyapomaa Kwayie, Elizabeth Aboagye, Christian Obirikorang, Emmanuel Timmy Donkoh, Kwame Ofori Boadu

“…Background: Postpartum depression is a public health issue affecting both maternal well-being and child development. While it is the most common mental health disorder following childbirth, data on its prevalence and associated risk factors in developing countries, including Ghana, remains limited. …”
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HPV-negative oropharyngeal carcinoma as a separate prognostkally unfavorable form of cancer, requiring new approaches to treatment (case report) by A. R. Gevorkov, A. V. Boyko, A. P. Polyakov, L. V. Bolotina, N. N. Volchenko, I. V. Rebrikova, A. М. Lemeshko, S. V. Shashkov

“…The study objective is to demonstrate the difficulties associated with treatment of HPV-negative oropharyngeal cancer.Material and methods. A 52-year-old male patient visited a doctor in P.A. …”
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Cerebrospinal Fluid Aβ Biomarkers Predict Recurrent Hemorrhage and Identify Cerebral Amyloid Angiopathy in Patients With Lobar Hemorrhage by Philipp Arndt, Malte Pfister, Frank Schreiber, Valentina Perosa, Hendrik Mattern, Jose Bernal, Berkant Bay, Marc Dörner, Marwa Al‐Dubai, Vanessa Swiatek, Belal Neyazi, Erol Sandalcioglu, Cornelia Garz, Sven G. Meuth, Michael Goertler, Stefan Vielhaber, Katja Neumann, Stefanie Schreiber

“…Biomarker levels were compared between patients with and without recurrent hemorrhage, and optimal cutoff values were derived from receiver operating characteristic analysis to define high and low biomarker groups. …”
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Post-extrasystolic variation of ST segment and T wave as a mortality risk predictor after myocardial infarction by Ralf J. Dirschinger, Ralf J. Dirschinger, Alexander Müller, Petra Barthel, Alexander Steger, Michael Dommasch, Axel Bauer, Karl-Ludwig Laugwitz, Georg Schmidt, Daniel Sinnecker, Daniel Sinnecker

“…Optimal limits yielding a maximum area under the receiver-operating characteristics (ROC) curve were determined by systematic testing, covering the time window from the J point to the end of the T wave. …”
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Efficiency and safety of cannabinoid medical use: an analysis of discussions and observed trends on Instagram by Olena Litvinova, Olena Litvinova, Bikash Baral, Thomas Wochele-Thoma, Maima Matin, Nikolay T. Tzvetkov, Olga Adamska, Agnieszka Kamińska, Marcin Łapiński, Artur Stolarczyk, Atanas G. Atanasov, Atanas G. Atanasov

“…The analysis shows that English dominates the studied category (70.74% of posts), while German, French, Spanish, and other languages also occupy a significant place, emphasizing the importance of a multilingual approach in content analysis. …”
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Device‐therapy in chronic heart failure: Cardiac contractility modulation versus cardiac resynchronization therapy by Goekhan Yuecel, Leo Gaasch, Abbass Kodeih, Svetlana Hetjens, Babak Yazdani, Stefan Pfleger, Daniel Duerschmied, William T. Abraham, Ibrahim Akin, Juergen Kuschyk

“…Methods and results The Mannheim Cardiac Resynchronization Therapy Registry (MARACANA) and the Mannheim Cardiac Contractility Modulation Observational Study (MAINTAINED) included all patients who received CRTs or CCMs in our medical centre between 2012 and 2021. …”
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Construction of a risk prediction model for pulmonary infection in patients with spontaneous intracerebral hemorrhage during the recovery phase based on machine learning by Jixiang Xu, Yuan Li, Fumin Zhu, Fumin Zhu, Xiaoxiao Han, Liang Chen, Yinliang Qi, Yinliang Qi, Xiaomei Zhou, Xiaomei Zhou

“…Accurate prediction of PI risk is crucial for early intervention and optimized clinical management. The aim of this study was to develop a machine learning (ML) model for predicting PI risk in patients during the recovery phase of deep SICH and to investigate the contributions of individual risk factors through explainable artificial intelligence techniques.MethodsWe conducted a retrospective study involving 649 patients diagnosed with PI during the recovery phase of deep SICH between 2021 and 2023. …”
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Macular epiretinal membrane in high myopia: timing and prognosis of pars plana vitrectomy surgery by Yu-Tong Xia, Jia-Yun Ge, Zong-Chan Zhang, Li-Yue Zhang, Ying-Ying Wen, Ying Xie, Ye Shen, Jian-Ping Tong

“…AIM: To investigate the outcomes and prognosis of macular epiretinal membrane (ERM) after pars plana vitrectomy (PPV) in patients with high myopia (HM), focusing on the optimal timing of surgery and its impact on prognosis. …”
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Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

“…BackgroundDespite durable responses achieved with Immune Checkpoint Inhibitors (ICIs), data about optimal duration of treatment, especially in the context of adverse events, remain scarce.ObjectiveTo systematically review the evidence concerning the impact of treatment discontinuation with ICIs for reasons other than progressive disease (PD) on relapse rates and survival of melanoma patients.MethodsA systematic literature search was conducted in three electronic databases until July 2024. …”
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Myofascial pain syndrome in female patients with chronic nonspecific back pain: diagnosis and treatment by D. O. Rozhkov, O. E. Zinovyeva, A. N. Barinov, I. M. Vikhlyantsev, G. Z. Mikhailova, N. V. Penkov, A. M. Nosovsky

“…Objective: to elucidate the frequency and pathogenesis of myofascial pain syndrome (MFPS) in chronic nonspecific lower back pain (CNLBP) and to optimize the diagnosis and treatment of MFPS in CNLBP.Patients and methods. …”
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Navigating the complexities of end-stage kidney disease (ESKD) from risk factors to outcome: insights from the UK Biobank cohort by Debasish Kar, Richard Byng, Aziz Sheikh, Mintu Nath, Bedowra Zabeen, Shubharthi Kar, Shakila Banu, Mohammad Habibur Rahman Sarker, Navid Khan, Durjoy Acharjee, Shafiqul Islam, Victoria Allgar, José M. Ordóñez-Mena, Aya El-Wazir, Soon Song, Ashish Verma, Umesh Kadam, Simon de Lusignan

“…Abstract Background The global prevalence of end-stage kidney disease (ESKD) is increasing despite optimal management of traditional risk factors such as hyperglycaemia, hypertension, and dyslipidaemia. …”
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Subnational introduction of the RTS,S/AS01E malaria vaccine into routine immunization: experience and lessons from the three pilot countries by Rose Jalang’o, Kwame Amponsa-Achiano, Mike Chisema, Keziah Malm, Lydiah Khalayi, Brenda Mhone, Wahjib Mohammed, Franklin Asiedu-Bekoe, Adam Haji, Josephine Njoroge, Boston Zimba, Esther Chirwa, Peter O. Tweneboah, Jackson Sillah, Mgaywa G. M. D. Magafu, Cynthia Bergstrom, Tracey Goodman, Jenny Walldorf, Kristen Kelleher, Eliane Pellaux-Furrer, Mary J. Hamel, Michael R. Adjei, Rafiq N. A. Okine

“…RTS,S was initially introduced in randomly selected areas, while other areas served as comparators until the four-dose schedule vaccine was scaled up following the WHO recommendation in 2021. …”
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Association of bioelectrical impedance phase angle and nutritional status in patients undergoing pancreaticoduodenectomy by Jialing Li, Defu Hu, Yu Yan, Mengyu Yu, Hexing Hang, Hexing Hang, Yudong Qiu, Yudong Qiu, Dayu Chen, Xu Fu

“…Therefore, PhA may serve as a potential biomarker for preoperative nutritional assessment. While PhA shows utility in nutritional evaluation, it exhibited limited clinical significance for predicting most surgical complications in our cohort.…”
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