Treatment of total hip arthroplasty between two surgical access routes associated chronic pain, function and biomechanical parameters in older after osteoporotic femur fracture: co... by Marco Antônio Leite Pereira Pinto, Giovanna Truyts Biscardi Pinto, Mariana Afonso Ribeiro Sarquis Ude, Claudia Aparecida de Morais, Ana Paula Ribeiro

“…These findings are clinically relevant as they indicate that this approach not only provides significant pain relief but also improves the patients' quality of life by restoring hip functionality and mobility, while reducing the risk of falls and complications related to postural imbalance. …”
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Evaluation of Large Language Models in Tailoring Educational Content for Cancer Survivors and Their Caregivers: Quality Analysis by Darren Liu, Xiao Hu, Canhua Xiao, Jinbing Bai, Zahra A Barandouzi, Stephanie Lee, Caitlin Webster, La-Urshalar Brock, Lindsay Lee, Delgersuren Bold, Yufen Lin

“…Future research should integrate expert feedback, additional prompt engineering strategies, and specialized training data to optimize content accuracy and accessibility.…”
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Perioperative factors influencing post-appendectomy outcomes in adults: a single-center prospective study in the North of Palestine by Alaa Zayed, Khaled Demyati, Abdulsalam Alkaiyat, Alaa Omari, Eliana Masri, Zain Saqfalhait, Yazan.N.A.Abdallah, Obayda Darawsha, Mohammed Hajhamad

“…Abstract Background Acute appendicitis is one of the most common surgical emergencies, predominantly affecting young adults who form the backbone of the workforce. While its diagnosis and treatment are well-studied, limited research exists on the perioperative factors affecting post-operative outcomes and health-related quality of life in resource-limited settings like Palestine. …”
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Nutritional status and practices among Chinese marathon runners: data from the China marathon nutrition survey (CMNS) by Yan Chen, Xueyuan Zhao, Xiangxin Li, Wei Wen, Jingyi Zhang, Zhihui Lu, Yiheng Liang, Chengnan Zhang, Junqiang Qiu

“…Background The increasing popularity of marathon running in China highlights the need to better understand the dietary habits and nutritional needs of marathon runners to optimize performance and health outcomes. The study aimed to assess the dietary behaviors, nutritional knowledge, and running-specific nutritional practices of Chinese marathon runners as part of the China Marathon Nutrition Survey (CMNS).Methods This nationwide cross-sectional survey was conducted between January and December 2024. …”
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Efficacy and safety of stem cells in the treatment of glaucoma: systematic review and meta-analysis based on animal experiments by Danning Wu, Yanjing Liu, Xia Zhang, Ruixuan Zhang, Shaopeng Wang, Hui Lu, Tao Yue

“…PurposeGlaucoma, characterized by progressive retinal ganglion cell (RGC) degeneration and optic nerve atrophy, remains a leading global cause of irreversible blindness, despite advancements in clinical management. While current therapies predominantly focus on lowering intraocular pressure (IOP), neuroprotective strategies to preserve visual function remain an unmet clinical need. …”
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PD-1/PD-L1 inhibitors monotherapy vs. combination therapy in elderly advanced NSCLC: a real-world study and nomogram for survival prognosis by Yunye Mao, An Wang, Xiangwei Ge, Jinzhao Zhai, Yi Hu, Jinliang Wang

“…Abstract Background Immunotherapy with PD-1/PD-L1 inhibitors has transformed advanced non-small cell lung cancer (NSCLC) treatment, yet optimal strategies for elderly patients remain uncertain. …”
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Muscular and Renal Safety of Ticagrelor with High-Intensity Statins: Retrospective Cohort Findings by Alshammari AS, Shalwala AA, Alnuhait MA, Alhazmi AY, Fagieha RE, Hallabi NB, Alandijani EA, Aloufi MA, Alharbi MS, Alzahrani RS, Elkholy EM, Elrggal ME, Alotaibi AS

“…Although a trend toward increased AKI incidence was observed in the combination therapy group, this difference did not reach statistical significance.Conclusion: This study highlights potential safety concerns related to the co-administration of ticagrelor and high-intensity statins, particularly the increased risk of muscle-related complications. While the findings on AKI were inconclusive, the results support the need for cautious use of this combination and call for larger prospective studies to further evaluate its safety profile and optimize treatment strategies.Keywords: ticagrelor, atorvastatin, rosuvastatin, statin-associated muscle symptoms, acute kidney injury…”
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Application of continuous renal replacement therapy (CRRT) in patients with severe acute pancreatitis: an analytical study by Yiru Weng, Zhouzhou Dong, Gongjie Ye, Linhui Shi, Panpan Liu, Tingting Zhou, Honghua Ye

“…Conclusions CRRT serves as an independent protective factor against poor outcomes (discharge against medical advice (death within 24 h post-discharge (against medical advice)) /death) in SAP patients, while simultaneously reducing hospitalization duration and vasopressor requirements without increasing financial burden. …”
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Costs and Outcomes of a Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy: Multicenter Observational Study by Zareen Abbas Khan, Jørn Heggelund, Stian Lydersen, Kristian Kidholm, Henrik Pedersen, Imre Janszky, Tine Nordgreen, Vidar Halsteinli

“…Generic health-related quality of life (HRQoL) was measured with the EQ-5D-5L, while work and social functioning were measured with the Work and Social Adjustment Scale (WSAS) and sick leave days. …”
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Effect of low-intensity resistance training at different levels of blood flow restriction on pain, proprioception and muscle strength in patients with knee osteoarthritis: a random... by Yongjie Li, Shenyu Fu, Dakuan Zhang, Mengling Liu, Hongju Liu

“…Abstract Background Low-intensity resistance training(LIRT) combined with blood flow restriction(BFR) has significant potential for promoting functional recovery in patients with knee osteoarthritis(KOA). However, the optimal level of BFR that works most effectively in combination with LIRT remains unclear. …”
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Temporal trends in the incidence of adverse effects of medical treatment in BRICS countries from 1990 to 2021: an age-period cohort analysis by Xingmin Wei, Xingmin Wei, Lu Jiang, Zhidong Zhang, Longjian Shang, Kun Liu, Xiaoang Qin, Gaoheng Ding, Lu Liu, Jianjun Wu

“…Brazil experienced the most substantial increase, rising from 23.06 per 100,000 to 75.09 per 100,000 (AAPC +3.88%), while Russia’s incidence grew less markedly, from 153.97 to 188.67 cases per 100,000 (AAPC +0.65%). …”
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Effectiveness of Topic-Based Chatbots on Mental Health Self-Care and Mental Well-Being: Randomized Controlled Trial by Alan C Y Tong, Kent T Y Wong, Wing W T Chung, Winnie W S Mak

“…Chatbots have emerged as promising tools by providing accessible, evidence-based support. While chatbots have shown promise in delivering mental health interventions, most studies have only focused on clinical populations and symptom reduction, leaving a critical gap in understanding their preventive potential for self-care and mental health literacy in the general population. …”
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Cardiac Indices Parameters on the Ultrasonic Cardiac Output Monitor as Potential Indicators to Predict the Ultrafiltration Endpoint Success in Acute Heart Failure Treatment by Yiou Li, Jiajia Chen, Jianye Bian, Fangyuan Chen, Qianli Wan, Fang Yuan

“…Methods: In this single-anonymized, randomized controlled trial, acute decompensated heart failure patients were randomly assigned to UF (U, n = 20) and USCOM+UF (UU, n = 20) groups at a ratio of 1:1. …”
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Long-Term Surgical Outcome of Trabeculectomy with Mitomycin C: A Comparison Between Primary and Secondary Glaucoma in Thailand by Arampinyokul P, Rojananuangnit K

“…After 8 years, about 75% of primary glaucoma patients had successful results, while only 47% of secondary glaucoma patients did. …”
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Effects of six traditional Chinese mind-body exercises on obesity and cardiovascular risk factors in middle-aged and elderly hypertensive patients: a network Meta-Analysis of 49 RC... by Haojie Li, Xinyu Lin, Xie Wu, Rui Huang

“…Tai Chi effectively lowers blood pressure and reduces abdominal obesity, while Baduanjin improves BMI. Personalized interventions with culturally adapted protocols could optimize adherence and global adoption.…”
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Treatment Planning Strategies for Interstitial Ultrasound Ablation of Prostate Cancer by Pragya Gupta, Tamas Heffter, Muhammad Zubair, I-Chow Hsu, E. Clif Burdette, Chris J. Diederich

“…This involves the integration with a FDA 510(k) cleared catheter-based ultrasound interstitial applicators and delivery system. Methods: A 3D generalized “prostate” model was developed to generate temperature and thermal dose profiles for different applicator operating parameters and anticipated perfusion ranges. …”
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A secure end-to-end communication framework for cooperative IoT networks using hybrid blockchain system by Suresh Babu Erukala, Dimitar Tokmakov, Anoosha Perumalla, Rajesh Kaluri, Anna Bekyarova-Tokmakova, Nevena Mileva, Slavi Lubomirov

“…Hence, the proposed framework improves over existing approaches regarding linear computing complexity, increased cryptographic methods, and a more efficient consensus process.…”
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Is the Existing Measles Vaccination Schedule in the Russian Federation Effective? by O. V. Tsvirkun, A. G. Gerasimova, N. V. Turaeva, N. T. Tikhonova, A. A. Melnikova, A. A. Vatolina

“…Children aged 6-11 months were more likely to get sick, accounting for an average of 75.98%, while the proportion of children with measles in the first five months averaged 24.02%. …”
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Design, synthesis, and anti-inflammatory potential of PROTAC drug molecules based on fondaparinux sodium by Ruoxuan Wu, Ruoxuan Wu, Ruoxuan Wu, Ruoxuan Wu, Tianji Zhang, Tianji Zhang, Siran Zhao, Siran Zhao, Marco Maccarana, Jin-Ping Li, Jin-Ping Li, Chao Li, Chao Li, Chao Li, Chao Li, Hui Cao, Hui Cao, Hui Cao, Hui Cao

“…IntroductionIn this study, we used an approach by conjugating Fondaparinux Sodium (FS) with selected drugs to generate proteolysis-targeting chimeras (PROTACs).MethodsBy applying bioprocess engineering principles, the direct amidation reaction was optimized –through precise control of pH, substrate ratios, and solvent selection –to reliably produce high‐purity (>99%) PROTAC molecules on a scalable platform. …”
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Effect of Bacillus Calmette-Guérin vaccination against Mycobacterium tuberculosis infection in children: an updated systematic review and meta-analysis by Shunli Cai, Qingyi Luo, Guozhong Zhou, Xin Guo, Yan Dong, Hongbo Chen, Shiqi Luo, Jian He, Yuan Xia, Hanse Li, Yingchen Zhou, Chao Song

“…Objectives: To update the understanding of the effectiveness of the Bacillus Calmette-Guérin (BCG) vaccine in preventing tuberculosis (TB) infection in children. Methods: PubMed, Web of Science, Cochrane, and Embase were searched from their inception to January 12, 2025. …”
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