Characteristics and Outcomes of People With COPD Who Experience Exacerbations While on Inhaled Triple Therapy: Results of the SIRIUS I Cohort Study in the US (2015–2019) by Nordon C, Carstens D, Fagerås M, Müllerová H, Veeranki PS, Alves JA, Germack HD, Barnes TL, McCormack MC

“…During the 12-month follow-up, mean (SD) all-cause and COPD costs were $63,178 ($77,061) and $26,153 ($47,085), respectively.Conclusion: There is high mortality and considerable HCRU and healthcare costs incurred by people with COPD experiencing frequent moderate/severe exacerbations while on TT. Optimization of COPD management and new therapies are needed to reduce disease burden in this population.Keywords: COPD, burden of illness, exacerbation, inhaled triple therapy, mortality, healthcare resource utilization…”
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Congestion Influence on Optimal Bidding in a Competitive Electricity Market using Particle Swarm Optimization by OICC Press Authors

“…In this paper, the bidding strategy problem with congestion management is modeled as an optimization problem and solved using Particle Swarm Optimization (PSO).  …”
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Bayesian Optimization for Instruction Generation by Antonio Sabbatella, Francesco Archetti, Andrea Ponti, Ilaria Giordani, Antonio Candelieri

“…This study introduces BOInG (Bayesian Optimization for Instruction Generation), a method leveraging Bayesian Optimization (BO) to efficiently generate instructions while addressing the combinatorial nature of instruction search. …”
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Optimization of strutted beam parameters by A. K. Yusupov, H. M. Musеlеmov, T. O. Ustarhanov

“…The objective of the research is to design strutted beams that have optimal parameters for metal consumption.Methods. …”
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Preferential whole blood transfusion during the early resuscitation period is associated with decreased mortality and transfusion requirements in traumatically injured patients by John B Holcomb, Jeffrey David Kerby, Parker Hu, Jan O Jansen, Daniel Lammers, Omar Rokayak, Emily W Baird, Richard D Betzold, Zain Hashmi

“…Introduction Whole blood (WB) transfusion represents a promising resuscitation strategy for trauma patients. …”
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Statistical Assessment of The Implementation of Socio-Economic Development Strategies of The Republic of Uzbekistan in the Context of Digital Transformation by B. A. Begalov, I. E. Zhukovskaya

“…The main purpose of the article is to conduct a statistical assessment of the implementation of strategies for the socio-economic development of the Republic of Uzbekistan using an innovative methodology based on the use of digital technological solutions.Materials and methods. In the course of writing this article, the authors used the methods of system analysis, synthesis, statistical sampling and grouping, induction, deduction, methods of working with computer networks and digital platforms, special methods and tools necessary to optimize the work of the portal of the State Committee of the Republic of Uzbekistan on Statistics, as well as when working on this article, methods of working with digital technologies, specialized software products, web services were reflected.Results. …”
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Towards the Optimization of Apodized Resonators by Ana Valenzuela-Pérez, Carlos Collado, Jordi Mateu

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Entropy optimization for chemically reactive magnetized unsteady thin film hybrid nanofluid flow on inclined surface subject to nonlinear mixed convection and variable temperature by Aljohani Mashael A., Khan Arshad, Alfwzan Wafa F., Yasmin Humaira, Raizah Zehba, Abualnaja Khadijah M., Mahmoud Emad E.

“…The leading equations have been solved through the homotopy analysis method in dimensionless form. It is observed that fluid motion is slowed down as the thickness factor, volumetric fraction of nanoparticles, and unsteadiness parameter increase, while it intensifies with higher values of mass and thermal Grashof numbers. …”
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Whole-body tumor segmentation from FDG-PET/CT: Leveraging a segmentation prior from tissue-wise projections by Sambit Tarai, Elin Lundström, Nouman Ahmad, Robin Strand, Håkan Ahlström, Joel Kullberg

“…One significant challenge is the risk for human error, leading to potential omission of especially small tumors and tumors with low FDG uptake.Purpose: In this study, we introduced an automated framework with segmentation prior, from a tissue-wise multi-channel multi-angled based approach, to enhance tumor segmentation in whole-body FDG-PET/CT.Method: The proposed framework utilized a segmentation prior generated from tumor segmentations in tissue-wise multi-channel projections of the standardized uptake value (SUV) from PET. …”
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Evaluation of biokinetics and dosimetry in [131I]-NaI therapies: whole-body images quantification versus lower limb region by Bianca Lemos Lima, Jamille da Silveira Almeida, Maria da Penha Albuquerque Potiens, Rogério Alexandre Pelissoni, Marcelo Tatit Sapienza, Carlos Alberto Buchpiguel, José Willegaignon

“…It has been observed that the absorbed dose values provided by thigh region dosimetry represent 87% of the absorbed dose value provided by whole-body dosimetry. Supposing the percentage difference between the values obtained by both dosimetric methods, it was possible to find a average correction factor that can be applied to the dosimetry data based on ROI in the thigh region, making dose values absorbed to become similar in the two dosimetric methods. …”
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Error Covariance Analyses for Celestial Triangulation and Its Optimality: Improved Linear Optimal Sine Triangulation by Abdurrahim Muratoglu, Halil Ersin Söken, Uwe Soergel

“…While current methods like Linear Optimal Sine Triangulation (LOST) provide statistically optimal solutions for position estimation using multiple celestial body observations, their performance can be compromised by suboptimal measurement pair selection. …”
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Molecular identification of haemoparasites in animals using blood lysate PCR: a quick and inexpensive alternative to purified whole genomic DNA by Binod Kumar, Nilima N. Brahmbhatt, Bhupendrakumar Thakre, Biswa Ranjan Maharana, Vijay L. Parmar, Manoj Kumar

“…Therefore, the currently developed and optimized blood lysate method could serve as a viable alternative to purified whole blood genomic DNA for molecular detection (PCR) of haemoparasites in animals particularly in resource-limited settings.…”
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An improved dung beetle optimizer based on Padé approximation strategy for global optimization and feature selection by Tianbao Liu, Lingling Yang, Yue Li, Xiwen Qin

“…Feature selection is a crucial data processing method used to reduce dataset dimensionality while preserving key information. …”
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Cyber-Physical Systems in Smart Grids Enhancing Energy Management and Distribution Efficiency by Ponnusamy Sivakumar, Gurugubelli Vanitha, G V Rambabu, Sheeba Adlin, Tiwari Mohit, T Saravanan

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An intelligent hybrid grey wolf-particle swarm optimizer for optimization in complex engineering design problem by Muhammad Suhail Shaikh, Haoyue Lin, Senlin Xie, Xiaoqing Dong, Yifan Lin, Chandan Kumar Shiva, Wulfran Fendzi Mbasso

“…The improvement in the average best optimal value varies across different cases, demonstrating the effectiveness of the proposed method. …”
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Enabling Stable Recycling of L-Arabinose Isomerase Through Whole-Cell Immobilization for Efficient and Cost-Effective D-Tagatose Production by Zepeng Li, Runmin Wang, Xiantai Lai, Wenyi Liao, Runfeng Liao, Zhuohong Wu, Guoyan Zhang, Xianghui Qi

“…This study presents a cost-effective and sustainable method for the production of D-tagatose using optimized whole-cell catalysis through immobilization, which paves the way to solve industrial challenges such as thermal instability and low substrate efficiency.…”
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Energy consumption optimization scheme in UAV-assisted MEC system based on optimal SIC order by Wei JI, Xuxin YANG, Fei LI, Ting LI, Yan LIANG, Yunchao SONG

“…In uplink non-orthogonal multiple access (NOMA)-based unmanned aerial vehicle (UAV)-assisted mobile edge computing (MEC) system, the successive interference cancellation (SIC) order of NOMA became a bottleneck limiting the transmission performance of task offload in uplink link.To reduce the energy consumption of the system, the SIC order was discussed and the optimal SIC order based on channel gain and task delay constraint was proposed.The optimization problem of minimizing the system energy consumption was proposed based on the optimal SIC order while satisfying the constraints of the given task delay of the device, the maximum transmit power constraint of the device, and the UAV trajectory.Since the problem was a complex non-convex problem, an alternating optimization method was adopted to solve the optimization problem to achieve power allocation and UAV trajectory optimization.A low-complexity algorithm based on matching theory was proposed to obtain the optimal device grouping in different time slots.Simulation results show that the optimal SIC order can realize smaller system energy consumption under the same task delay constraint compared with other SIC order, the proposed low-complexity device grouping algorithm can obtain the optimal device grouping.…”
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Energy consumption optimization scheme in UAV-assisted MEC system based on optimal SIC order by Wei JI, Xuxin YANG, Fei LI, Ting LI, Yan LIANG, Yunchao SONG

“…In uplink non-orthogonal multiple access (NOMA)-based unmanned aerial vehicle (UAV)-assisted mobile edge computing (MEC) system, the successive interference cancellation (SIC) order of NOMA became a bottleneck limiting the transmission performance of task offload in uplink link.To reduce the energy consumption of the system, the SIC order was discussed and the optimal SIC order based on channel gain and task delay constraint was proposed.The optimization problem of minimizing the system energy consumption was proposed based on the optimal SIC order while satisfying the constraints of the given task delay of the device, the maximum transmit power constraint of the device, and the UAV trajectory.Since the problem was a complex non-convex problem, an alternating optimization method was adopted to solve the optimization problem to achieve power allocation and UAV trajectory optimization.A low-complexity algorithm based on matching theory was proposed to obtain the optimal device grouping in different time slots.Simulation results show that the optimal SIC order can realize smaller system energy consumption under the same task delay constraint compared with other SIC order, the proposed low-complexity device grouping algorithm can obtain the optimal device grouping.…”
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Multi strategy Horned Lizard Optimization Algorithm for complex optimization and advanced feature selection problems by Marwa M. Emam, Mosa E. Hosney, Reham R. Mostafa, Essam H. Houssein

“…These findings affirm the potential of mHLOA as a powerful optimization framework for advanced feature selection and complex optimization problems.…”
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OPTIMIZATION OF IMID-BASED THERAPIES by Murat Çınarsoy

“…In this case, it is clear that multiple myeloma treatment optimization cannot be achieved by considering multiple myeloma treatment only as applying the appropriate drug combination.In order to ensure the optimization of IMID-based therapies, it is necessary to take a broad perspective.This perspective should include the correct selection of the patient to be treated with IMID, the development and implementation of IMID forms that will increase patient compliance, the use of techniques to predict the development of resistance, side effect management during treatment, preventing the increase in disease burden with appropriate maneuvers by following the disease burden after treatment, and drug-free follow-up.It is recommended to avoid thalidomide in the presence of peripheral neuropathy, to prefer other agents instead of lenalidomide in the presence of renal function loss, and to avoid pomalidomide in patients with COPD.Nex-20, a once-monthly subcutaneous formulation of lenalidomide, is expected to be an important breakthrough in improving patient compliance.Prediction of which patients will develop resistance will be very useful in order to have the best treatment outcomes.Calculation of miRNA risk scores, measurement of lenalidomide metabolite levels in urine, measurement of cereblon levels in blood, or immunohistochemical detection of cereblon levels are some of the methods currently being tried to predict disease resistance.Patients who develop anemia should be treated with erythropoietin, skin reactions should be treated with steroids and antihistamines, diarrhea should be treated with loperamide and colestyramine, and in general, the drug should be discontinued and the same dose or a lower dose should be insisted upon.An important part of treatment is maintenance therapy with lenalidomide. …”
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