The role of cut-off values for creatinine, blood urea nitrogen, and uric acid in prognostic assessment of chronic heart failure: a retrospective cohort study by Zheng Xu, Yuebing Yue, Manfei Xu, Liyan Qian, Liping Dou

“…Abstract Background Chronic heart failure (CHF) significantly harms patients and society, causing high mortality and reduced quality of life, straining healthcare systems; early identification and intervention are crucial for improving long-term prognosis. Methods This retrospective cohort study involved 297 CHF patients. …”
Get full text

Computed tomography-based radiomic features combined with clinical parameters for predicting post-infectious bronchiolitis obliterans in children with adenovirus pneumonia: a retro... by Li Zhang, Ling He, Guangli Zhang, Xiaoyin Tian, Haoru Wang, Fang Wang, Xin Chen, Yinglan Zheng, Man Li, Yang Li, Zhengxiu Luo

“…Multiple statistical methods were used to determine the best radiomic features. …”
Get full text

Prediction Value of Visceral Obesity Related Indices for Visceral Obesity in Chinese Patients with Type 2 Diabetes Mellitus by Tan Y, Li K, Ma J, Luo Z, Gong S, Mao J, Zhou Q, Zhou H, Gan S

“…Among the total population, WC had the best predictive performance for VO (AUC=0.8833, optimal cutoff =90.05). CVAI was the best predictor for males (AUC=0.8837, optimal cutoff =117.39), while WC performed best in females (AUC=0.8733, optimal cutoff=87.25). …”
Get full text

Multidose Dalbavancin Population Pharmacokinetic Analysis for Prolonged Target Attainment in Patients Requiring Long-Term Treatment by Giammarco Baiardi, Michela Cameran Caviglia, Silvia Boni, Antonello Di Paolo, Valeria Marini, Giuliana Cangemi, Alessia Cafaro, Emanuele Pontali, Francesca Mattioli

“…<b>Methods:</b> Pharmacokinetic analysis was based on a nonlinear mixed effects modelling approach performed in NONMEM v7.5/Pirana, while R was used for data management and graphical summaries. …”
Get full text

Development of machine learning algorithms to predict viral load suppression among HIV patients in Conakry (Guinea) by Degninou Yehadji, Degninou Yehadji, Geraldine Gray, Carlos Arias Vicente, Petros Isaakidis, Petros Isaakidis, Abdourahimi Diallo, Saa Andre Kamano, Thierno Saidou Diallo

“…Traditional research has focused on statistical analysis, but machine learning (ML) is gradually influencing HIV clinical care. While ML has been used in various settings, there’s a lack of research supporting antiretroviral therapy (ART) programs, especially in resource-limited settings like Guinea. …”
Get full text

Repositioning FDA-Approved Sulfonamide-Based Drugs as Potential Carbonic Anhydrase Inhibitors in <i>Trypanosoma cruzi</i>: Virtual Screening and In Vitro Studies by Eyra Ortiz-Pérez, Adriana Moreno-Rodríguez, Timoteo Delgado-Maldonado, Jessica L. Ortega-Balleza, Alonzo González-González, Alma D. Paz-González, Karina Vázquez, Guadalupe Avalos-Navarro, Simone Giovannuzzi, Claudiu T. Supuran, Gildardo Rivera

“…This study proposes the repositioning of sulfonamide-based drugs to identify new trypanocidal agents. <b>Method:</b> Ligand-based virtual screening and molecular docking analysis were performed on FDA-approved drugs targeting α-TcCA. …”
Get full text

Cost analysis of apple hybrid breeding by YANG Yingying, YU Meng, YANG Jing, ZHAO Zhengyang, YANG Yazhou

“…[Methods] A statistical analysis of the expenses incurred from pollination to the selection of superior lines in hybrid breeding is conducted. …”
Get full text

Spasticity and pain and the improvement of muscle strength in athletes with partial spinal cord injury by Dariusz Tadeusz SKALSKI, Kinga ŁOSIŃSKA, Magdalena PROŃCZUK, Alicja MARKIEL, Jarosław MARKOWSKI, Jan PILCH, Joanna MOTOWIDŁO, Petr STASTNY, Adam MASZCZYK

“…Robot-assisted gait training (RAGT) using the Lokomat has been proposed as an effective rehabilitation method to improve motor function and reduce these symptoms. …”
Get full text

Evaluation of the Effects of the Quaternary Ammonium Silane K21 on Zebrafish Viability, Toxicity, Growth, and Development by Surendra K. Rajpurohit, Devan Anmol S. Manhiani, Ashwin Ajith, Pragya Rajpurohit, Simran Hotwani, Sai Nasanally, Arsha Sreekumar, Keshu Bhat, Aiden Van Derhei, Rohan Pasi, Arishia Mishra, Kirk Kimmerling, Clifton M. Carey

“…This study explored potential applications of the K21 molecule in human health protection, disease prevention, and treatment using the zebrafish model. <b>Method</b>: A multi-dimensional approach was utilized to assess the toxicity, tolerance, and optimal dosage of K21 through serial dilutions at various concentrations. …”
Get full text

Adherence to Atrial Fibrillation (AF) Better Care (ABC) pathway and adverse clinical outcomes in patients with atrial fibrillation by Mohammad Ammar Hakim Osman, Izzati Abdul Halim Zaki, Sahimi Mohamed, Muhammad Asyraf Harun, Raja Ezman Faridz Raja Shariff, Long Chiau Ming, Hanis Hanum Zulkifly

“…Only 90 (28 %) patients were managed according to the ABC pathway while 232 (72 %) patients were non-adherent to the ABC pathway. …”
Get full text

Well-Being in Psoriasis: Weighting its Components Using Best-worst Scaling Methodology by Esteban Daudén, Isabel Belinchón, Elena Colominas-González, Pablo Coto, Pablo de la Cueva, Fernando Gallardo, Jose Luis Poveda, Esther Ramírez, Sandra Ros, Ricardo Ruíz-Villaverde, Isabel Cabezas, Luis Lizán

“…Well-being was defined as a multi-dimensional concept that includes achieving emotional balance, having adequate overall health and control of the disease, enjoying positive social relationships, and being satisfied with disease care. However, while these components are recognized as integral to the concept, their relative contribution to achieving optimal well-being remains unclear. …”
Get full text

Eradication of Helicobacter pylori: challenges and advances by Yousra Sbibih, Abderrazak Saddari, Ilham Alla, Said Ezrari, Elmostapha Benaissa, Yassine Ben Lahlou, Mostafa Elouennass, Adil Maleb

“…Future research should focus on optimizing treatment protocols while preserving beneficial gut flora. …”
Get full text

Microbial Valorization of Sunflower Husk for Sustainable Biohydrogen and Biomass Production by Liana Vanyan, Akerke Toleugazykyzy, Kaisar Yegizbay, Ayaulym Daniyarova, Lyudmila Zuloyan, Gayane Mikoyan, Anait Vassilian, Anna Poladyan, Kairat Bekbayev, Karen Trchounian

“…Various pretreatment methods for the valorization of sunflower husks (SHs) for H₂ gas generation through fermentation by <i>Escherichia coli</i> were investigated. …”
Get full text

Comparing the Diagnostic Efficacy of Different Calcitonin Stimulation Tests for Sporadic Medullary Thyroid Carcinoma: Calcium Gluconate vs. Calcium Chloride by Jovan Ilic, Katarina Tausanovic, Goran Zoric, Milan Jovanovic, Matija Buzejic, Sara Ivanis, Milan Parezanovic, Milan Marinkovic, Nemanja Karamarkovic, Ana Petakov, Vladan Zivaljevic

“…<b>Background:</b> Medullary thyroid carcinoma (MTC) is a rare malignancy derived from parafollicular C-cells, with calcitonin (Ct) as its key biomarker. While basal Ct (bCt) levels above 100 pg/mL strongly suggest MTC, intermediate elevations (10–100 pg/mL) may reflect C-cell hyperplasia (CCH) or other benign conditions, making diagnostics challenging. …”
Get full text

The effect of early childhood material hardship mitigation on adolescent success by Bria McKenzie, Frances Shofer

“…The absence of MH at age 3 was significantly associated with optimal English GPA, optimal schoolwork perseverance and optimal overall perseverance (Table 1). …”
Get full text

The Art (and Science) of Individualized Selection of Non-Invasive Prenatal Screening (NIPS) by Hsieh V, Sherer DM, Davydovych K, Kheyman M, Dalloul M

“…Through continued research and progress for more methods of utilizing cfDNA technology in a variety of situations, there are now complexities in the selection of the optimal cfDNA screening approach depending on the clinical scenario. …”
Get full text

Enhancing surgical safety in lateral calcaneal plating: a cadaveric study on screw placement and fluoroscopic optimisation by Mahmut Kalem, Merve Dursun Savran, Mehmet Yilmaz, Ercan Şahin, Halil İbrahim Acar

“…Methods Thirty-three fresh-frozen cadaveric specimens were used. …”
Get full text

Insight into structural, Opto-electronic and elastic properties of lead-free double perovskites Cs2TlInX6 (X = Cl, Br and I) for optoelectronic applications: A first principles cal... by Nimra Ehsan, Tasawer Shahzad Ahmad, Mian HR Mahmood, Salhah Hamed Alrefaee, Naseem Akhter, Tatyana Orlova, Vineet Tirth, Ali Algahtani, Amnah Mohammed Alsuhaibani, Moamen S. Refat, Abid Zaman

Get full text

Expectation Confirmation and Technology Acceptance: A Study of the Public's Attention to Accept the Government's Digital Human Avatar by Jinghao CHEN, Feng JIA, Qianxi LIU

“…In particular, high levels of perceived quality and intelligence significantly increase satisfaction and acceptance, while convenience and attractiveness also play an important role. …”
Get full text

Study of rheumatoid arthritis in older patients: a cross-sectional study by Ramesh Kumar Sah, A. B. Dey, P. Chatterjee, A. Chakrawarty, Uma Kumar, S. N. Dwivedi, C. J. Das

“…ROC curve determined optimal cut-off value for 14-3-3η. Results This study reported an average age of 63.67 years with a high female-to-male ratio of 4:1 in the RA cohort, while in the OA cohort, the mean age was 65.5 years with a low female-to-male ratio of 2:1 overall. …”
Get full text