Are Cannabis-Based Medicines a Useful Treatment for Neuropathic Pain? A Systematic Review by Nawaf Almuntashiri, Basma M. El Sharazly, Wayne G. Carter

“…Hence, future RCTs will need to have larger numbers and be more extended studies that explore optimal dosing and delivery methods and identify patient subgroups that are most likely to benefit. …”
Get full text

Global, regional, and national burden of ischemic stroke in older adults (≥60 years) from 1990 to 2021 and projections to 2030 by Shuting Hua, Zexian Dong, Hui Wang, Tong Liu, Tong Liu, Tong Liu

“…The decline in disease burden was most pronounced in high-SDI regions, while low-SDI regions faced a significantly higher disease burden and exhibited notable regional disparities. …”
Get full text

Characterization and clustering of intra-day physical activity patterns using accelerometry among sexual and gender minority adults by David Lopez-Veneros, Billy A. Caceres, Kasey Jackman, Joseph A. Belloir, Yashika Sharma, Suzanne Bakken, Ipek Ensari

“…., discrimination), and could be reciprocally associated with physical activity (PA) behavior. While PA is a health-protective factor, research on PA patterns in SGM adults is limited. …”
Get full text

Comparative Analysis of Farm Yard Manure and NPK Fertilizer on Cabbage Yield: A Case Study of Kabale University. by Arinaitwe, Saul

“…Cabbage yield metrics, including average weight per cabbage head and total yield per plot, were recorded and analyzed using appropriate statistical methods to determine significant differences between the two treatments. …”
Get full text

Effects of different doses of remimazolam besylate on postoperative sedation, pain, and adverse reactions in patients undergoing hysteroscopic surgery by Linjiang Yang, Liang Zhong, Xu Deng, Hao Fang, Siqin Li, Yi Li

“…Remimazolam Besylate, a new ultra-short-acting benzodiazepine, offers potential for safe sedation, but the optimal dose for postoperative outcomes is unclear. …”
Get full text

Development of a single-center predictive model for conventional in vitro fertilization outcomes excluding total fertilization failure: implications for protocol selection by Hai Wang, Haojie Pan, Zitong Xu, Xianjue Zheng, Shuqi Xia, Jiayong Zheng

“…Abstract Objectives To develop a multidimensional clinical indicator-based prediction model for identifying high-risk patients with fertilization failure conventional in vitro fertilization (c-IVF) cycles, thereby optimizing therapeutic decision-making. Methods This retrospective single-center study analyzed 691 cycles (594 c-IVF, 97 rescue ICSI) from January 2019 to August 2024. …”
Get full text

Comparative efficacy of exercise interventions for cognitive health in older adults: A network meta-analysis by Jinhao Zhang, Wei Ye, Wang Li, Fan Zhang, Zhijian Wu

“…However, the most effective types of exercise, along with optimal frequency and duration of interventions, remain inadequately defined. …”
Get full text

Thrombospondin-1 induces immunogenic cell death in human mucoepidermoid carcinoma MC-3 cells via the PERK/eIF2α signaling pathway: potential implications for tumor immunotherapy by Yixuan Zhu, Kaizhi Cai, Lijuan Guo, Huan Zhang, Li Guan, Zongyao Zhang, Pengcheng Huang, Sen Yang

“…The CCK-8 assay was performed to determine the optimal seeding density, TSP-1 concentration, and treatment time. …”
Get full text

Dihydromyricetin attenuates age-related macular degeneration: pharmacological effects and exploration of putative targets by Hongyu Zhou, Jianhui Pang, Baiyang Wu, Yanan Zhuang, Shenjun Li, Jing Jiang, Jing Jiang

“…This study aimed to investigate the pharmacological effects of dihydromyricetin (DHM) on AMD and to identify its putative pharmacological targets through network analysis and molecular docking approaches.MethodsIn vitro experiments established an AMD model using sodium iodate (SI)-induced ARPE-19 cells, with CCK-8 assays determining 15 mM SI as the optimal modeling concentration and 100 μM DHM as the optimal treatment concentration. …”
Get full text

Support Vector Machine for Stratification of Cognitive Impairment Using 3D T1WI in Patients with Type 2 Diabetes Mellitus by Xu Z, Zhao L, Yin L, Cao M, Liu Y, Gu F, Liu X, Zhang G

“…After features selection, there were 11 optimal features to distinguish N and CI and 12 optimal features to MCI and DM. …”
Get full text

Neutrophil‐Lymphocyte Ratio as Predictor for Acute Infection After Primary Total Joint Arthroplasty in Rheumatoid Arthritis Patients by Yahao Lai, Jiaxuan Fan, Ning Lv, Xiaoyu Li, Wenxuan Zhao, Zeyu Luo, Zongke Zhou

“…The neutrophil‐lymphocyte ratio showed diagnostic sensitivity of 92.6% and specificity of 43.3%, while the monocyte‐lymphocyte ratio showed sensitivity of 77.8% and specificity of 46.3%. …”
Get full text

Dynamic analysis of composition, insecticidal, and antifungal activities of Zanthoxylum armatum DC. at different harvesting periods by Yaqin Peng, Danping Xu, Wenkai Liao, Qianqian Qian, Junhao Wu, Tingjiang Gan, Zhihang Zhuo

“…Investigating the insect-repellent and antimicrobial effects of Zanthoxylum armatum DC. essential oils (EOs) at different harvest stages can optimize its harvest and utilization while also promoting the development of eco-friendly agents.MethodsThis study analyzed the changes in the composition and content of volatile compounds in Z. armatum EOs at different growth stages in Nanchong City using GC-MS.ResultsThe results indicate that the accumulation period of volatile compounds occurs before the t5 stage (August 4). …”
Get full text

Effects of phosphorus supply levels on the growth and nutrient utilization of Pinus massoniana lamb hybrid saplings by Wenyue Wang, Wenyue Wang, Jinguo Hua, Zhen Zhang, Zhen Zhang, Zhichun Zhou, Zhichun Zhou, Renchao Wu, Simin Qu, Xiuli Chu, Xiuli Chu

“…Understanding its response to fertilization is crucial for optimizing plantation management and growth.MethodsWe employed a two-factor randomized block design with three Pinus massoniana hybrid varieties (with shared male or female parents) and four phosphate fertilizer levels (0, 100, 250, 500 g·plant⁻¹). …”
Get full text

Improving nerve and muscle function: an exploration of targeted nerve function replacement following differential delay periods in a rat model by Chunxiao Tang, Yuanheng Li, Xinxian Fan, Jiamei Guo, Yifeng Lin, Yifan Gao, Lin Yang

“…Conclusion Timing critically influences TNFR outcomes, with immediate intervention yielding optimal restoration of both motor and sensory functions. …”
Get full text

Intensity vs. Volume in Professional Soccer: Comparing Congested and Non-Congested Periods in Competitive and Training Contexts Using Worst-Case Scenarios by Tom Douchet, Antoine Michel, Julien Verdier, Nicolas Babault, Marius Gosset, Benoit Delaval

“…<b>Background:</b> Understanding the balance between intensity and volume during training and competition is crucial for optimizing players’ performance and recovery in professional soccer. …”
Get full text

Importance of Spectral Information, Seasonality, and Topography on Land Cover Classification of Tropical Land Cover Mapping by Chansopheaktra Sovann, Stefan Olin, Ali Mansourian, Sakada Sakhoeun, Sovann Prey, Sothea Kok, Torbern Tagesson

“…Combining these variable selection methods with hyperparameter tuning optimized the classification, providing a more reliable LC product that outperforms existing LC products and proves valuable for deforestation monitoring, forest management, biodiversity conservation, and land use studies.…”
Get full text

Double-blind, non-inferiority, randomized controlled trial of dexamethasone 4, 5 and 6 mg for preventing adverse neonatal and maternal outcomes in very preterm to late preterm preg... by Saifon Chawanpaiboon, Punnanee Wutthigate, Sanitra Anuwutnavin, Sureelak Sutchritpongsa

“…By assessing efficacy and potential adverse outcomes, this study will provide critical insights for optimizing treatment protocols and improving neonatal care. …”
Get full text

Age-related distribution of human papillomavirus genotypes in women with cervical squamous cell carcinoma from Linyi, China, 2015–2023 by Yiming Wang, Haiyan Hou, Guanzheng Dong, Hanlin Zhang, Xiaohong Zhang, Yuxia Zhou, Mei Xue, Zhihui Wang, Jianxiang Geng, Lisai Liu

“…Abstract Background Understanding the regional HPV genotype profile is critical for informing targeted vaccination strategies and optimizing cervical cancer screening programs to enhance their effectiveness. …”
Get full text

DMSO-free cryopreservation of hiPSC-derived cardiomyocytes: low temperature characterization and protocol development by Akshat S. Mallya, Tessa Burrows, Jeanne Hsieh, Troy Louwagie, James R. Dutton, Brenda M. Ogle, Allison Hubel

“…A differential evolution (DE) algorithm was utilized to determine the optimal composition of a mixture of a sugar, sugar alcohol and amino acid to replace DMSO as the CPA. …”
Get full text

In-Memory Versus Disk-Based Computing with Random Forest for Stock Analysis: A Comparative Study by Chitra Joshi, Chitrakant Banchorr, Omkaresh Kulkarni, Kirti Wanjale

“…Background: The advancement of big data analytics calls for careful selection of processing frameworks to optimize machine learning effectiveness. Choosing the appropriate framework can significantly influence the speed and accuracy of data analysis, ultimately leading to more informed decision making. …”
Get full text