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  1. 581
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    Whole genome sequencing completes the molecular genetic testing workflow of patients with Lynch syndrome by Klaudia Horti-Oravecz, Anikó Bozsik, Tímea Pócza, Ildikó Vereczkey, Tamás Strausz, Erika Tóth, Tatiana Sedlackova, Diana Rusnakova, Tomas Szemes, István Likó, Edit Oláh, Henriett Butz, Attila Patócs, János Papp, Vince Kornél Grolmusz

    Published 2025-01-01
    “…Abstract Multigene panel tests (MGPTs) revolutionized the diagnosis of Lynch syndrome (LS), however noncoding pathogenic variants (PVs) can only be detected by complementary methods including whole genome sequencing (WGS). Here we present a DNA-, RNA- and tumor tissue-based WGS prioritization workflow for patients with a suspicion of LS where MGPT detected no LS-related PV. …”
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  3. 583

    Design and Optimization of an Uneven Wave-like Protrusion Channel in the Proton Exchange Membrane Electrolysis Cell Based on the Taguchi Design by Zhong-Liang Feng, Tian-Jun Zhou, Shen Xu, Guo-Liang Wang, Lu-Haibo Zhao, Bo Huang

    Published 2025-06-01
    “…This study introduces an innovative uneven wave-like protrusion channel structure for PEMECs, designed to optimize mass transfer and bubble removal while minimizing energy losses. …”
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  4. 584

    Cryotherapy and Whole Body Cooling: A Critical Review of Physiological Impacts on Elite Athletes by Wojciech Tokarczyk, Karol Demel, Monika Dziedzic, Adriana Potoczek, Justyna Talaska, Antoni Kantor, Krzysztof Pietrzak, Adrian Dyląg, Jakub Król, Kacper Raputa

    Published 2025-03-01
    “…Purpose: This review assesses physiological impacts of cryotherapy on key systems (cardiovascular, neuromuscular, immune) and evaluates benefits, risks, and protocol standardization needs. Methods: PubMed literature (2012-2023) was systematically analyzed using keywords "cryotherapy," "whole-body cooling," and "elite athletes." …”
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  5. 585

    Whole exome sequencing-based homologous recombination deficiency test for epithelial ovarian cancer by Ying-Cheng Chiang, Hsien-Neng Huang, Kuan-Ting Kuo, Wuh-Liang Hwu, Po-Han Lin

    Published 2025-01-01
    “…Methods We enrolled 40 patients with EOC in the training cohort and 23 in the validation cohort. …”
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  6. 586

    Evaluation of whole blood CD64 for identifying infection in neonates receiving hospital care by Naomi E. Spotswood, Naomi E. Spotswood, Naomi E. Spotswood, Peter A. Dargaville, Peter A. Dargaville, Leah Hickey, Leah Hickey, Leah Hickey, Michelle J. L. Scoullar, Michelle J. L. Scoullar, Riya Palchaudhuri, Riya Palchaudhuri, Shuning Zheng, Timothy Spelman, Suzanne M. Crowe, Suzanne M. Crowe, Hanumesh Kenchapla, James G. Beeson, James G. Beeson, David A. Anderson, David A. Anderson

    Published 2025-08-01
    “…Neonatal infections and sepsis in adults have been associated with increased CD64 expression on neutrophils. We investigated whole blood CD64 (wbCD64) and neutrophil elastase (NE) in neonates who were evaluated and treated for potential infection and evaluated the potential for these biomarkers as diagnostic tools.MethodsNeonates were prospectively recruited from two neonatal units. …”
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  7. 587
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    AUV path planning method based on improved sparrow search algorithm by Lijun TANG, Yunxia FAN, Xingyu ZHOU, Qian SUN

    Published 2025-06-01
    “…The ISSA also exhibits superior convergence speed, achieving near-optimal paths in approximately 20 iterations, while other algorithms require around 40 iterations to approach the global optimum. …”
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  9. 589

    Comparison of methods of optimal cut-point selection for biomarkers in diagnostic medicine: a simulation study with application of clinical data in health informatics by Mojtaba Hassanzad, Karimollah Hajian-Tilaki, Zinatossadat Bouzari, Shahla Yazdani

    Published 2025-04-01
    “…While, with high AUC, the Youden may produce less bias and MSE, but for moderate and low AUC, Euclidean has less bias and MSE than other methods. …”
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  10. 590

    Mathematical Models and Algorithms of Optimal Load Management of Electricity Consumers by I. U. Rakhmonov, K. M. Reymov

    Published 2019-11-01
    “…Therefore, it is advisable to use administrative measures in conditions of shortage of power and electricity in the power system. Optimal planning of short-term regimes of power systems according to rigid load profile received after alignment can be carried out by traditional methods. …”
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  11. 591

    Battery Sizing Method for Microgrids—A Colombian Application Case by Andres Felipe Zamora-Muñoz, Martha Lucia Orozco-Gutierrez, Dany Mauricio Lopez-Santiago, Jhoan Alejandro Montenegro-Oviedo, Carlos Andres Ramos-Paja

    Published 2025-05-01
    “…Thus, a reduction of 83.33% in the number of batteries is obtained. This optimized size reduces operational costs while maintaining technical reliability. …”
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    Optimization of bulk carrier hull design through CAD modelling and FEM structural analysis – a case study by Alexandru Pintilie, Mihaela-Greti Manea, Daniel Mărăşescu, Ovidiu Cristea, Paul Burlacu, Cătălin-Paul Clinci, Nicolae Silviu Popa

    Published 2025-06-01
    “…Recording of frequent structural damage to the hull of bulk carriers (some of it serious) motivates the need to use the concept of computer-based rational design through advanced analysis methods. The aim of this paper was to optimize - through structural and dimensional modeling - the mid ship section of the 165,000 dwt bulk carriers, under the effect of general combined stresses (longitudinal-vertical bending, transverse-vertical bending and longitudinal torsion) also considering specific local stresses. …”
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  15. 595

    Artificial neural networks-based multi-objective optimization of immersion cooling battery thermal management system using Hammersley sampling method by Muhammed Donmez, Mehmet Ihsan Karamangil

    Published 2024-12-01
    “…Using the Hammersley method, various module designs are generated. Multi-objective optimization, using ANN-based multi objective genetic algorithms, is conducted on a 16S1P configuration at 4C discharge and 0.008 kg/s. …”
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  16. 596

    Estimation of Discharge Energy of Lithium-ion Battery for Different Temperatures by FOX-Bidirectional Recurrent Neural Network Method by Göksu Taş

    Published 2024-12-01
    “…For this reason, in this study, the discharge energy of lithium-ion batteries under different temperature conditions was estimated using bidirectional-based deep learning methods. In addition, the hyperparameter values of the BiRNN method were determined with FOX optimization, and the FOX-BiRNN method was proposed. …”
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    A Continuous Space Path Planning Method for Unmanned Aerial Vehicle Based on Particle Swarm Optimization-Enhanced Deep Q-Network by Le Han, Hui Zhang, Nan An

    Published 2025-02-01
    “…This method divides the agent’s surrounding space into discrete and continuous action spaces. …”
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    Enhanced extraction of bioactive compounds from date seeds using a green pH-shift method: modeling, optimization, and characterization by Anuj Niroula, Aya Sayed Ali, Ahmad Rabbani, Jennifer Osamede Airouyuwa, Sajid Maqsood, Akmal Nazir

    Published 2024-12-01
    “…Cinnamic acid derivatives were most abundant at pH 6, and alkaline pH enhanced all polyphenolic categories, while acidic pH had a limited effect. These results highlight the effectiveness of the pH-shift method, particularly in alkaline conditions, for optimizing date seed bioactive extraction for applications in multiple disciplines including but not limited to foods, cosmetics, pharmaceuticals, agriculture, and biomedicine.…”
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