Does Levosimendan hasten veno-arterial ECMO weaning? A propensity score matching analysis by Nicolas Paulo, Antoine Kimmoun, David Hajage, Pierre Hubert, David Levy, Marc Pineton de Chambrun, Juliette Chommeloux, Ouriel Saura, Grégoire Del Marmol, Quentin Moyon, Guillaume Hékimian, Melchior Gautier, Charles Edouard Luyt, Guillaume Lebreton, Bruno Levy, Alain Combes, Matthieu Schmidt

“…Patients receiving levosimendan while on VA-ECMO were matched to those not receiving levosimendan during the same period, based on pre-specified variables and time from ECMO initiation. …”
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Microbiological aspects and clinical impact of lower lung field tuberculosis: An observational cohort study in Peru by Qi Tan, Chuan-Chin Huang, Roger Calderon, Leonid Lecca, Milagros Mendoza, Gabriela Reyes Rocha, Karen Tintaya, Ximena Tovar, Jia-Yih Feng, Sheng-Wei Pan, Yen-Han Tseng, Jhong-Ru Huang, Zibiao Zhang, Megan B. Murray

“…We aimed to identify microbiological determinants of LLF TB and evaluate treatment responses to optimize care. Methods: We conducted an observational cohort study in Lima, Peru, enrolling adults with microbiologically confirmed pulmonary TB (PTB) diagnosed by GeneXpert MTB/RIF assay or sputum culture. …”
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Predictive Factors for Super Responder Status and Long-Term Effectiveness of Guselkumab in Psoriasis: A Multicenter Retrospective Study by Edoardo Mortato, Marina Talamonti, Lorenzo Marcelli, Matteo Megna, Annunziata Raimondo, Giacomo Caldarola, Nicoletta Bernardini, Anna Balato, Anna Campanati, Maria Esposito, Claudio Bonifati, Viviana Lora, Luca Potestio, Serena Lembo, Francesco Loconsole, Eleonora De Luca, Nevena Skroza, Dario Buononato, Tommaso Bianchelli, Maria Concetta Fargnoli, Nello Tommasino, Felice Primavera, Clara De Simone, Luca Bianchi, Marco Galluzzo

“…Methods A retrospective longitudinal study was conducted at ten Italian centers between January and October 2024. …”
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Medical care costs of cancer in the last year of life using national health insurance data in Korea. by Mihai Park, Inmyung Song

“…Efforts are needed to optimize EOL care for cancer patients.…”
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Unveiling nitrogen preferences in indica rice: a classification study of cultivars in South China by Chu-sheng Lu, Chu-sheng Lu, Chu-sheng Lu, Chu-sheng Lu, Jia-jun Lai, Jia-jun Lai, Jia-jun Lai, Jia-jun Lai, Xian-ting Fan, Xian-ting Fan, Xian-ting Fan, Xian-ting Fan, Kai-ming Liang, Kai-ming Liang, Kai-ming Liang, Yuan-hong Yin, Yuan-hong Yin, Yuan-hong Yin, Qun-huan Ye, Qun-huan Ye, Qun-huan Ye, Hong Shen, You-qiang Fu, You-qiang Fu, You-qiang Fu

“…Understanding this preference is key to optimizing nitrogen use efficiency in rice production. …”
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Data Governance Navigation for Advanced Operations in Healthcare Excellence by Vahideh Zarea Gavgani, Aniseh Pourrasmi

“…Data governance in the field of health care is an organized and standardized method for managing, analyzing, and sharing medical data in an ethical and transparent manner, all of which align with legal and ethical standards. …”
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Influence of Emergent Vegetation Layout on Flow Pattern in a Rectangular Shallow Basin by Junnan LYU, Yuxuan JIANG, Zhidong YAO, Chen YE, Xufeng YAN

“…However, a detailed quantitative analysis of the impact of vegetation’s spatial distribution remains unexplored, leaving room for optimizing vegetation layout for hydraulic efficiency and landscape beauty.Methods This study focuses on how various spatial arrangements of emergent aquatic vegetation affect the hydraulic performance of shallow basins, aiming to identify an optimal vegetation design. …”
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An artificial intelligence platform for predicting postoperative complications in metastatic spinal surgery: development and validation study by Weihao Jiang, Juan Zhang, Weiqing Shi, Xuyong Cao, Xiongwei Zhao, Bin Zhang, Haikuan Yu, Shengjie Wang, Yong Qin, Mingxing Lei, Yuncen Cao, Boyu Zhu, Yaosheng Liu

“…Abstract Background Metastatic spinal disease often leads to significant morbidity, and accurate prediction of postoperative outcomes can help optimize patient management and resource allocation. …”
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Immune Microenvironment Characterization and Machine Learning-Guided Identification of Diagnostic Biomarkers for Ulcerative Colitis by Zheng Q, Wang L, Zhang Y, Peng J, Hou J, Wang H, Ma Y, Tang P, Li Y, Li H, Chen Y, Li J, Chen Y

“…Immune cell infiltration was assessed via the ImmuCellAI algorithm, while differential expression analysis and WGCNA were performed to identify key immune-related genes. …”
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Comparison of treatment regimens for unresectable stage III epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer by Xin Dai, Qian Xu, Lei Sheng, Xue Zhang, Miao Huang, Song Li, Kai Huang, Jiahui Chu, Jian Wang, Jisheng Li, Yanguo Liu, Jianyuan Zhou, Shulun Nie, Lian Liu, Jing Ni

“…We aimed to explore whether locally advanced inoperable patients with EGFR mutations benefit from tyrosine kinase inhibitors (TKIs) and the optimal treatment regimen. Methods:. We searched the PubMed, Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases from inception to December 31, 2022 and performed a meta-analysis based on a Bayesian framework, with progression-free survival (PFS) and overall survival (OS) as the primary endpoints. …”
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MRI-based pseudo-CT sequences as a radiation-free alternative to CT for obstetric pelvimetry: a proof-of-concept study by Caroline Chabot, Mathilde Haegeman, Eya Chaouch, Dana Dumitriu, Renaud Menten, Patricia Steenhaut, Pierre Bernard, Perrine Triqueneaux, Nicolas Michoux, Frédéric E. Lecouvet

“…This proof-of-concept study evaluates the reliability of these sequences and the agreement with CT for pelvimetry in a predominantly elderly population. Methods This retrospective study included 21 female patients who underwent 3-T whole-body MRI including ZTE and BB sequences and 18fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/CT with optimized low-dose whole-body CT. …”
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Data extraction from free-text stroke CT reports using GPT-4o and Llama-3.3-70B: the impact of annotation guidelines by Jonas Wihl, Enrike Rosenkranz, Severin Schramm, Cornelius Berberich, Michael Griessmair, Piotr Woźnicki, Francisco Pinto, Sebastian Ziegelmayer, Lisa C. Adams, Keno K. Bressem, Jan S. Kirschke, Claus Zimmer, Benedikt Wiestler, Dennis Hedderich, Su Hwan Kim

“…Abstract Background To evaluate the impact of an annotation guideline on the performance of large language models (LLMs) in extracting data from stroke computed tomography (CT) reports. Methods The performance of GPT-4o and Llama-3.3-70B in extracting ten imaging findings from stroke CT reports was assessed in two datasets from a single academic stroke center. …”
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Regional variations and trends in liver transplantation practices across Europe by Tommaso Di Maira, Valérie Cailliez, Beatriz Domínguez-Gil, Beatriz Mahíllo, Marina Álvarez, Luca Saverio Belli, René Adam, Constantino Fondevila, Giacomo Germani, Hermien Hartog, Marina Berenguer

“…This study reviews LT practices and trends in Europe to identify potential policies for improving outcomes. Methods: Data were extracted from the European Liver Transplant Registry and the Global Observatory on Donation and Transplantation. …”
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Tumor-agnostic transcriptome-based classifier identifies spatial infiltration patterns of CD8+T cells in the tumor microenvironment and predicts clinical outcome in early-phase and... by Cláudia S Ferreira, Konstanty Korski, Michael A Cannarile, Irina Klaman, Petra C Schwalie, Iakov I Davydov, Andreas Roller, Martha L Serrano-Serrano, Astrid Heller, Nicolas Staedler, Gabriele Dietmann, Alberto Valdeolivas

“…Melanoma and kidney cancers were among the strongest inflamed indications, while CD8-desert phenotypes were most abundant in liver metastases across all tumor types. …”
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Risk of disease progression after discontinuing immunotherapy in 105 patients with Merkel cell carcinoma who responded to PD-1 pathway blockade by Shailender Bhatia, Daniel S Hippe, Paul T Nghiem, Candice Church, Tomoko Akaike, Kristina Lachance, Lisa Tachiki, Thomas Pulliam, Song Y Park, Coley Doolittle-Amieva, Lisa Zaba, Nora A Alexander, Emily Gong, Lauren Zawacki, Allison J Remington, Yasman Moshiri, Alex Fu, Emily Huynh, Nikhil Harikrishnan, Marika Bierma

“…Background Immune checkpoint inhibitors (ICIs) are the preferred systemic therapy for most patients with advanced Merkel cell carcinoma (MCC). However, the optimal duration of treatment for patients responding to ICI is unclear. …”
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High-throughput screening of monoclonal antibodies against carbapenemases using a multiplex protein microarray platform by Sascha D. Braun, Sascha D. Braun, Martin Reinicke, Martin Reinicke, Celia Diezel, Celia Diezel, Elke Müller, Elke Müller, Katrin Frankenfeld, Thomas Schumacher, Hugo Arends, Stefan Monecke, Stefan Monecke, Ralf Ehricht, Ralf Ehricht, Ralf Ehricht

“…However, the development of such assays is often hindered by the time-consuming process of identifying high-affinity antibody pairs.MethodsTo accelerate this process, we evaluated a protein microarray platform as a high-throughput screening tool to identify optimal monoclonal antibody (mAb) pairs targeting the most clinically relevant carbapenemases. …”
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Microwave ablation vs. single-needle radiofrequency ablation for the treatment of HCC up to 4 cm: A randomized-controlled trial by Katsutoshi Sugimoto, Kento Imajo, Hidekatsu Kuroda, Go Murohisa, Kazue Shiozawa, Kentaro Sakamaki, Takuya Wada, Hirohito Takeuchi, Kei Endo, Tamami Abe, Takashi Matsui, Takahiro Murakami, Masato Yoneda, Atsushi Nakajima, Shigehiro Kokubu, Takao Itoi

“…Therefore, we evaluated and compared the effectiveness of MWA and RFA in managing HCC tumors up to 4 cm in size. Methods: In this multicenter randomized controlled trial conducted across five centers in Japan, eligible participants had up to 4 tumors, each up to 4 cm in size, and were not considered for surgery. …”
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Longitudinal assessment of changes in muscle composition using proton density fat fraction and T2* in patients with and without incidental vertebral compression fractures by Yannick Stohldreier, Yannik Leonhardt, Jannik Ketschau, Florian T. Gassert, Marcus R. Makowski, Jan S. Kirschke, Georg C. Feuerriegel, Philipp Braun, Benedikt J. Schwaiger, Dimitrios C. Karampinos, Nina Hesse, Alexandra S. Gersing, Alexandra S. Gersing

“…In multivariable linear regression models adjusted for sex, age and baseline BMD, PDFF values of the PSM increased significantly over 6 months in the VCF group (2.4 ± 2.8% vs. -1.0 ± 2.3%, p<0.001), while T2* values of the PSM showed a significant decrease (p ≤ 0.01). …”
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Self-monitoring of blood pressure following a stroke or transient ischaemic attack (TASMIN5S): a randomised controlled trial by R. J. McManus, A. Smith, E. Temple, L. M. Yu, J. Allen, R. Doogue, G. A. Ford, L. Glynn, B. Guthrie, P. Hall, L. Hinton, F. D. R. Hobbs, J. Mant, B. McKinstry, G. Mead, K. Morton, T. Rai, C. Rice, C. Roman, A. Stoddart, L. Tarassenko, C. Velardo, M. Williams, L. Yardley, on behalf of the TASMIN5S investigators

“…Methods Unblinded randomised controlled trial, comparing a BP telemonitoring-based intervention with control (usual care) for hypertension management in 12 primary care practices in England. …”
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Medicinal Melodies: A Scoping Review of Music In Medical Education by Rohan Sampy

“…Despite the promising evidence, challenges exist. Methods relying on musical skills might exclude non-musicians, and the effectiveness of listening-based approaches can vary with personal music preferences. …”
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