Cerebrospinal Fluid Aβ Biomarkers Predict Recurrent Hemorrhage and Identify Cerebral Amyloid Angiopathy in Patients With Lobar Hemorrhage by Philipp Arndt, Malte Pfister, Frank Schreiber, Valentina Perosa, Hendrik Mattern, Jose Bernal, Berkant Bay, Marc Dörner, Marwa Al‐Dubai, Vanessa Swiatek, Belal Neyazi, Erol Sandalcioglu, Cornelia Garz, Sven G. Meuth, Michael Goertler, Stefan Vielhaber, Katja Neumann, Stefanie Schreiber

“…Biomarker levels were compared between patients with and without recurrent hemorrhage, and optimal cutoff values were derived from receiver operating characteristic analysis to define high and low biomarker groups. …”
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Post-extrasystolic variation of ST segment and T wave as a mortality risk predictor after myocardial infarction by Ralf J. Dirschinger, Ralf J. Dirschinger, Alexander Müller, Petra Barthel, Alexander Steger, Michael Dommasch, Axel Bauer, Karl-Ludwig Laugwitz, Georg Schmidt, Daniel Sinnecker, Daniel Sinnecker

“…Optimal limits yielding a maximum area under the receiver-operating characteristics (ROC) curve were determined by systematic testing, covering the time window from the J point to the end of the T wave. …”
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Efficiency and safety of cannabinoid medical use: an analysis of discussions and observed trends on Instagram by Olena Litvinova, Olena Litvinova, Bikash Baral, Thomas Wochele-Thoma, Maima Matin, Nikolay T. Tzvetkov, Olga Adamska, Agnieszka Kamińska, Marcin Łapiński, Artur Stolarczyk, Atanas G. Atanasov, Atanas G. Atanasov

“…The analysis shows that English dominates the studied category (70.74% of posts), while German, French, Spanish, and other languages also occupy a significant place, emphasizing the importance of a multilingual approach in content analysis. …”
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Device‐therapy in chronic heart failure: Cardiac contractility modulation versus cardiac resynchronization therapy by Goekhan Yuecel, Leo Gaasch, Abbass Kodeih, Svetlana Hetjens, Babak Yazdani, Stefan Pfleger, Daniel Duerschmied, William T. Abraham, Ibrahim Akin, Juergen Kuschyk

“…Methods and results The Mannheim Cardiac Resynchronization Therapy Registry (MARACANA) and the Mannheim Cardiac Contractility Modulation Observational Study (MAINTAINED) included all patients who received CRTs or CCMs in our medical centre between 2012 and 2021. …”
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Construction of a risk prediction model for pulmonary infection in patients with spontaneous intracerebral hemorrhage during the recovery phase based on machine learning by Jixiang Xu, Yuan Li, Fumin Zhu, Fumin Zhu, Xiaoxiao Han, Liang Chen, Yinliang Qi, Yinliang Qi, Xiaomei Zhou, Xiaomei Zhou

“…Accurate prediction of PI risk is crucial for early intervention and optimized clinical management. The aim of this study was to develop a machine learning (ML) model for predicting PI risk in patients during the recovery phase of deep SICH and to investigate the contributions of individual risk factors through explainable artificial intelligence techniques.MethodsWe conducted a retrospective study involving 649 patients diagnosed with PI during the recovery phase of deep SICH between 2021 and 2023. …”
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Immunomodulatory gene networks predict treatment response and survival to de-escalated, anthracycline-free neoadjuvant chemotherapy in triple-negative breast cancer in the WSG-ADAP... by Darren Korbie, Clare Stirzaker, Oleg Gluz, Christine zu Eulenburg, Ulrike Nitz, Matthias Christgen, Sherko Kuemmel, Eva-Maria Grischke, Helmut Forstbauer, Michael Braun, Mathias Warm, John Hackmann, Christoph Uleer, Bahriye Aktas, Claudia Schumacher, Rachel Wuerstlein, Enrico Pelz, Hans Heinrich Kreipe, Susan J. Clark, Matt Trau, Monika Graeser, Nadia Harbeck

“…Immune recruitment and viral defense gene networks were strongly associated with pCR, while metabolic pathways were associated with survival. …”
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Macular epiretinal membrane in high myopia: timing and prognosis of pars plana vitrectomy surgery by Yu-Tong Xia, Jia-Yun Ge, Zong-Chan Zhang, Li-Yue Zhang, Ying-Ying Wen, Ying Xie, Ye Shen, Jian-Ping Tong

“…AIM: To investigate the outcomes and prognosis of macular epiretinal membrane (ERM) after pars plana vitrectomy (PPV) in patients with high myopia (HM), focusing on the optimal timing of surgery and its impact on prognosis. …”
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Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

“…BackgroundDespite durable responses achieved with Immune Checkpoint Inhibitors (ICIs), data about optimal duration of treatment, especially in the context of adverse events, remain scarce.ObjectiveTo systematically review the evidence concerning the impact of treatment discontinuation with ICIs for reasons other than progressive disease (PD) on relapse rates and survival of melanoma patients.MethodsA systematic literature search was conducted in three electronic databases until July 2024. …”
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Myofascial pain syndrome in female patients with chronic nonspecific back pain: diagnosis and treatment by D. O. Rozhkov, O. E. Zinovyeva, A. N. Barinov, I. M. Vikhlyantsev, G. Z. Mikhailova, N. V. Penkov, A. M. Nosovsky

“…Objective: to elucidate the frequency and pathogenesis of myofascial pain syndrome (MFPS) in chronic nonspecific lower back pain (CNLBP) and to optimize the diagnosis and treatment of MFPS in CNLBP.Patients and methods. …”
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Navigating the complexities of end-stage kidney disease (ESKD) from risk factors to outcome: insights from the UK Biobank cohort by Debasish Kar, Richard Byng, Aziz Sheikh, Mintu Nath, Bedowra Zabeen, Shubharthi Kar, Shakila Banu, Mohammad Habibur Rahman Sarker, Navid Khan, Durjoy Acharjee, Shafiqul Islam, Victoria Allgar, José M. Ordóñez-Mena, Aya El-Wazir, Soon Song, Ashish Verma, Umesh Kadam, Simon de Lusignan

“…Abstract Background The global prevalence of end-stage kidney disease (ESKD) is increasing despite optimal management of traditional risk factors such as hyperglycaemia, hypertension, and dyslipidaemia. …”
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Subnational introduction of the RTS,S/AS01E malaria vaccine into routine immunization: experience and lessons from the three pilot countries by Rose Jalang’o, Kwame Amponsa-Achiano, Mike Chisema, Keziah Malm, Lydiah Khalayi, Brenda Mhone, Wahjib Mohammed, Franklin Asiedu-Bekoe, Adam Haji, Josephine Njoroge, Boston Zimba, Esther Chirwa, Peter O. Tweneboah, Jackson Sillah, Mgaywa G. M. D. Magafu, Cynthia Bergstrom, Tracey Goodman, Jenny Walldorf, Kristen Kelleher, Eliane Pellaux-Furrer, Mary J. Hamel, Michael R. Adjei, Rafiq N. A. Okine

“…RTS,S was initially introduced in randomly selected areas, while other areas served as comparators until the four-dose schedule vaccine was scaled up following the WHO recommendation in 2021. …”
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Association of bioelectrical impedance phase angle and nutritional status in patients undergoing pancreaticoduodenectomy by Jialing Li, Defu Hu, Yu Yan, Mengyu Yu, Hexing Hang, Hexing Hang, Yudong Qiu, Yudong Qiu, Dayu Chen, Xu Fu

“…Therefore, PhA may serve as a potential biomarker for preoperative nutritional assessment. While PhA shows utility in nutritional evaluation, it exhibited limited clinical significance for predicting most surgical complications in our cohort.…”
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Effect of repetitive transcranial magnetic stimulation with different stimulation parameters on post-stroke dysphagia: a systematic review and meta-analysis of randomized controlle... by Xu-Miao Peng, Xu-Miao Peng, Cheng Gong, Mei-Xia Xiao, Liang-Sheng Chen, Liang-Sheng Chen, Yi Li, Yi Li, Jie Chen, Mao-Yuan Wang, Mao-Yuan Wang, Mao-Yuan Wang, Yun Luo, Yun Luo, Yun Luo

“…However, consensus on optimal clinical protocols for rTMS remains unclear. …”
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Modification of the Cardiac Renal Angina Index for Predicting Adverse Kidney Events After Pediatric Cardiac Surgery by Katherine F. Melink, Natalja L. Stanski, Emily Gorrell, Jeffrey A. Alten, Kevin A. Pettit, Stuart L. Goldstein, Huaiyu Zang, Nicholas J. Ollberding, Rajit K. Basu, Shina Menon, Megan SooHoo, Katja M. Gist

“…Patients who were cRAI positive had worse outcomes, while the composite outcome was effectively ruled out in patients who were cRAI negative. …”
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Prevalence of Plasmodium spp. in humans and cattle: Implications for zoonotic malaria transmission in Indonesia by Hamzah Hasyim, Babucarr Jassey, Ririh Yudhastuti, Misnaniarti Misnaniarti, Iche Andriyani Liberty, Elvi Sunarsih, Langgeng Priyanto, Dalilah Dalilah, Yusri Yusri, Fadhilah Eka Maharani, Lukman Hakim, Siti Herlinda, Fildzah Hashifah Taufiq

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Integration of Network Pharmacology, Transcriptomics, and Metabolomics Strategies to Uncover the Mechanism of Chaihuang Qingfu Pill in Treating Sepsis-Induced Liver Injury by Zhang C, Chen F, Jiang Y, Deng J, Yan X, Yin X, Su B, Liu W

“…This study aims to systematically investigate the molecular basis of CHQF in the mitigation of sepsis-associated liver damage.Purpose: To explore the mechanism of CHQF for the treatment of sepsis-induced liver injury.Methods: A sepsis mouse model was established via cecal ligation and puncture (CLP). …”
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The impact of early vs. delayed surgery on outcomes in cervical spinal cord injury without fracture or dislocation by Sirui Xiao, Hui Yan, Beixi Bao, Yuxuan Wu, Xiaokang Cheng, Chunyang Xu, Jiaguang Tang

“…ObjectiveThis study aims to retrospectively analyze 104 patients diagnosed with cervical spinal cord injury without fracture or dislocation (CSCIwoFD) who underwent surgical treatment, in order to compare the effects of early vs. delayed surgical intervention on neurological functional recovery.MethodsPatients diagnosed with CSCIwoFD and treated surgically at our institution between August 2020 and January 2023 were retrospectively reviewed. …”
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Performance and Cost-Effectiveness of Computed Tomography Lung Cancer Screening Scenarios in a Population-Based Setting: A Microsimulation Modeling Analysis in Ontario, Canada. by Kevin Ten Haaf, Martin C Tammemägi, Susan J Bondy, Carlijn M van der Aalst, Sumei Gu, S Elizabeth McGregor, Garth Nicholas, Harry J de Koning, Lawrence F Paszat

“…Therefore, the objective of this study was to estimate the cost-effectiveness of lung cancer screening in a population-based setting in Ontario, Canada, and evaluate the effects of screening eligibility criteria.<h4>Methods and findings</h4>This study used microsimulation modeling informed by various data sources, including the Ontario Health Insurance Plan (OHIP), Ontario Cancer Registry, smoking behavior surveys, and the NLST. …”
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Cardiac Rehabilitation for Fontan Circulation Patients: A Systematic Review, and Meta-Analysis by Luna van de Ven, Ana Clara Félix, Joana Suarez, Jorge Dias, Fátima F. Pinto, Sérgio Laranjo

“…This systematic review and meta-analysis aimed to evaluate the safety, efficacy, and optimal exercise modalities for Fontan patients. <i>Materials and Methods:</i> A systematic search of PubMed, Scopus, Web of Science, and Cochrane Library was conducted on 24 August 2023. …”
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Final Fusion Strategies in Early-Onset Scoliosis: Does Implant Density Make a Difference After Magnetically Controlled Growing Rod Treatment? by Paolo Brigato, Leonardo Oggiano, Sergio De Salvatore, Davide Palombi, Sergio Sessa, Umile Giuseppe Longo, Andrea Vescio, Pier Francesco Costici

“…Background/Objectives: Early-onset scoliosis (EOS) frequently requires growth-friendly interventions, such as magnetically controlled growing rods (MCGRs), followed by definitive spinal fusion upon skeletal maturity. The optimal implant density (ID) for final posterior spinal fusion in these patients remains controversial. …”
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