The effects of clinical crown length on the sagittal movement of maxillary central incisor in clear aligner treatment: a finite element exploration by Chen Zhou, Zhicai Feng, Jianhan Ren, Haotian Luo, Hio Cheng Ieong, Runze Li, Yangqiao Qing, Yuqing Guo, Bingyan Guo, Zichun Huang, Yang Cao, Weicai Wang

“…Labio-lingual attachment had the optimal effect in tipping and translational movement. …”
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Lower body mass index is associated with the achievement of target LDL in patients using PCSK9 inhibitors in Taiwan by Kuan-Chieh Tu, Wei-Ting Chang, Hui-Wen Lin, Po-Lin Lin, Yen-Wen Wu, Chao-Feng Lin, Hung-I. Yeh, Min-Ji Charng, Po-Hsun Huang, Tsung-Hsien Lin, Wei-Wen Lin, I.-Chang Hsieh, Feng-Yu Kuo, Ching-Pei Chen, Sheng-Hsiang Lin, Yi-Heng Li

“…These findings support personalized strategies for optimizing cholesterol management in statin-intolerant patients while further investigations are required. …”
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Increased autophagy activity regulated by LC3B gene promoter DNA methylation is associated with progression to active pulmonary tuberculosis disease by Yung-Che Chen, Ying-Tang Fang, Chao-Chien Wu, Tung-Ying Chao, Yi-Hsi Wang, Chia-Cheng Tseng, Sum-Yee Leung, Chiu-Ping Lee, Ting-Ya Wang, Po-Yuan Hsu, Jen-Chieh Chang, Meng-Chih Lin, Chang-Chun Hsiao

“…Conclusions Increased LC3B expression and LC3B gene promoter hypermethylation may serve as biomarkers for progression of M. tb infection, while use of de-methylation agent may be a potential approach to host-directed immunotherapy in active TB disease.…”
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Atrial Fibrillation Termination Success During Ablation: Insights From Pooled Clinical Studies by Changjian He, Wenchang Zhang, Feng Li, Huaiqiang Wang, Xiongyi Han, Zihan Zhao, Guojie Ye, Tengfei Liu, Da Zhang, Haiyan Liu, Jie Liu, Jingning Zhao, Chunhua Ding

“…Background: The optimal endpoint for ablation in persistent atrial fibrillation (pers-AF) remains unclear. …”
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Contribution of Human Resources for Health competence and skill mix on compliance with healthcare quality standards among Primary Healthcare Facilities in Tanzania: evidence from d... by Syabo M. Mwaisengela, Patricia A. Materu, Chrisogone J. German, Issa I. Mmbaga, Danny J. Temba, Raymond R. Kiwesa, Martin S. Mapunda, Erick S. Kinyenje, Nathanael Sirili, Pankras W. Luoga, Simon P. Ernest, Joseph M. Burra, Joseph C. Hokororo, Godfrey Kacholi, Ntuli A. Kapologwe, Mackfallen G. Anasel, Claud J. Kumalija, Michael Habtu, Grace E. Saguti, Janeth S. Masuma, Talhiya A. Yahya, Eliudi S. Eliakimu

“…Proportions of skill mix status and compliance with HCQS were compared by chi square test while Prevalence Ratios were estimated by Multivariable Poisson Regression with 95% Confidence Interval. …”
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Comparative Analysis of Gut Microbiota Diversity Across Different Digestive Tract Sites in Ningxiang Pigs by Wangchang Li, Xianglin Zeng, Lu Wang, Lanmei Yin, Qiye Wang, Huansheng Yang

“…Understanding the structure and function of tissue-specific microbial communities in Ningxiang pigs is essential for optimizing their growth, development, and nutritional efficiency. …”
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Impacts of Traditional Warm-Up and Post-Activation Potentiation on Muscle Endurance During the Back Squat: Response of Blood Lactate, Perceived Effort, and Time Under Tension by Taianda M. Amorim, Alexandre V. Gurgel, Viviane Faleiro, Thiago T. Guimarães, Estêvão R. Monteiro, Felipe G. Teixeira, Bruno Jotta, Tiago C. Figueiredo, Raquel C. Castiglione, Silvio R. Marques-Neto

“…Background: Warm-up strategies are essential for optimizing strength-training performance. Traditional warm-ups improve neuromuscular readiness, whereas post-activation potentiation (PAP) has been proposed to acutely enhance muscular output. …”
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Evaluating Maize Residue Cover Using Machine Learning and Remote Sensing in the Meadow Soil Region of Northeast China by Zhengwei Liang, Jia Du, Weilin Yu, Kaizeng Zhuo, Kewen Shao, Weijian Zhang, Cangming Zhang, Jie Qin, Yu Han, Bingrun Sui, Kaishan Song

“…By comparing the accuracy of these methods, the most accurate model was determined and applied to subsequent CRC estimation. …”
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Multi-omics dissection of metabolic dysregulation associated with immune recovery in people living with HIV-1 by Lin-Yu Wan, Sin Man Lam, Hui-Huang Huang, Wen-Jing Cao, Xiang-Yi Cao, Xue-Meng Li, Li-Ping Zhang, Jia-Min Gao, Chao Zhang, Xing Fan, Yan-Mei Jiao, Guanghou Shui, Fu-Sheng Wang, Jin-Wen Song

“…Abstract Background Despite the success of antiretroviral therapy (ART) in suppressing HIV-1 replication, some people living with HIV-1 (PLWH) fail to achieve an optimal recovery of CD4 T cells, and precise metabolic regulation underlying immune recovery remained poorly understood. …”
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Assessment of salt tolerance in peas using machine learning and multi-sensor data by Zehao Liu, Qiyan Jiang, Yishan Ji, Rong Liu, Hongquan Liu, Xiuxiu Ya, Zhenxing Liu, Zhirui Wang, Xiuliang Jin, Tao Yang

“…The results show that: 1) multi-source data fusion significantly improved the accuracy of AGB and SPAD estimation; 2) the CatBoost algorithm achieved the highest performance for AGB estimation (R² = 0.70, RMSE = 1.59 t/hm2, NRMSE = 13.94 %), while the LightGBM algorithm performed best for SPAD estimation (R² = 0.60, RMSE = 2.33, NRMSE = 14.53 %); and 3) The PSTS established based on the optimal estimation data exhibits a strong consistency with the ground-measured data. …”
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Clinical features of non-compaction cardiomyopathy across age groups: a retrospective study of 415 patients by Ying Li, Jimei Chen, Min Qiu, Miao Tian, Ziqin Zhou, Ruyue Zhang, Jiazichao Tu, Linjiang Han, Shuheng Zhou, Xinming Li, Jian Zhuang, Shusheng Wen

“…Notably, heart failure was most prevalent in adult patients (54.6%, n=53), while cardiac murmur was the primary presenting symptom in both infant and child/adolescent groups (19.5%, n=33 and 17.4%, n=26, respectively). …”
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Prevalence and Predictors of Diabetic Retinopathy in Saudi Arabia: Insights from a Systematic Review and Meta-Analysis by Ali Mohammed Alshahrani, Alaa Mohammed Alshahrani, Beshayer Abdullah H. Al-Boqami, Alwaleed Abdulhadi Alqahtani, Bassam Alzahrani, Yousef Bassi, Mohammed Yousef Almohaimeed, Abeer Mohammed Alalmaai, Ariana Saraiva, Bandar Naffaa Alhumaidi, Najla A. Albaridi, Maria João Lima, Conrado Carrascosa, António Raposo

“…Poor glycemic control and longer diabetes duration were consistently identified as significant predictors of DR, while other factors, such as obesity and hypertension, were also associated with an increased risk of DR. …”
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Longitudinal analysis of hsa-miR-3163, hsa-miR-124-3p, hsa-miR-548c-3p, and hsa-miR-27a-3p as prognostic biomarkers in HIV-infected patients by Ilker Inanç Balkan, Ilker Inanç Balkan, Ilker Inanç Balkan, Andleeb Shahzadi, Haktan Sönmez, Burhaneddin Oktan, Muhammad Ihtisham Umar, Bilgül Mete, Fehmi Tabak, Günnur Deniz, Umut Can Küçüksezer

“…RT-qPCR and ELISA techniques were used to analyze miRNA expression levels while immunological markers (CD4 count and ratio) were assessed by flow cytometry.ResultsmiR-27a-3p expression was significantly increased at 2nd and 6th months of ART (p<0.001). miR-548ac-3p was upregulated at 6th month compared to healthy individuals and ART-naive subjects (p<0.05). miR-124-3p expression was significantly elevated in ART-naive subjects in comparison with healthy controls (p<0.001). …”
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The effect of taurine supplementation on markers of muscle damage and muscle pain in an athletic population: A systematic review and meta-analysis of randomized controlled trials a... by Elaheh Dehghani, Fatemeh Naeini, Sakineh Shab Bidar, Mohammad Beba, Erfan Mortezapour, Ruhollah Nourian, Khashayar Danandeh, Zahra Gohari Dezfuli, Kurosh Djafarian

“…Conclusion: TS may support post-exercise muscle recovery by reducing CK and LDH levels, but its effect on muscle pain remains unclear. While it shows potential as a recovery aid for athletes, further research is needed to optimize dosing and practical applications in sports performance and rehabilitation.…”
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LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock by Marie Crandall, Lisa Jones, Faheem W Guirgis, Lauren Page Black, Martin Daniel Rosenthal, Morgan Henson, Jason Ferreira, Christiaan Leeuwenburgh, Colleen Kalynych, Lyle L Moldawer, Taylor Miller, Srinivasa T Reddy, Samuel S Wu, Frederick A Moore

“…Twenty-four patients will be randomised to one of two doses of the study drug, while 24 control group patients will receive no drug and will be followed during their hospitalisation. …”
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Combination of clinical factors predicts successful glucocorticoid withdrawal in systemic lupus erythematosus (SLE): results from a multicentre, retrospective cohort study by Alessandra Bortoluzzi, Marcello Govoni, Dimitrios T Boumpas, Antonis Fanouriakis, Prodromos Sidiropoulos, George Bertsias, Konstantinos Parperis, Argyro Repa, Ettore Silvagni, Myrto Nikoloudaki, Nestor Avgoustidis, Sofia Pitsigavdaki, Antonio Marangoni, Irini Flouri, Spyridon Katechis

“…Objective Glucocorticoid (GC) tapering and withdrawal to reduce damage represents a key aspect of the European Alliance of Associations for Rheumatology (EULAR) SLE recommendations. However, optimal strategies for relapse-free GC cessation remain ill-defined. …”
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Machine learning-driven model for predicting knowledge, attitudes, and practices regarding medication safety among residents in Hubei, China by Chao Mei, Chao Mei, San-Lan Wu, San-Lan Wu, Tao Zhou, Tao Zhou, Yong-Ning Lv, Yong-Ning Lv, Yu Zhang, Yu Zhang, Chen Shi, Chen Shi, Wei-Jing Gong, Wei-Jing Gong

“…ObjectiveTo evaluate the current state and determinants of medication safety knowledge, attitudes, and practices (KAP) among residents in Hubei Province, and to offer guidance for targeted educational initiatives.MethodsA standardized questionnaire from the Science and Technology Development Center of the Chinese Pharmaceutical Association was utilized. …”
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Identification of HLA-B*13:01 allele in leprosy patients with dapsone hypersensitivity syndrome in Ambon, Indonesia by Sri Linuwih Susetyo Wardhani Menaldi, Mufqi Handaru Priyanto, Sandra Widaty, Yunia Irawati, Yulia Ariani Aswin, Dwi Anita Suryandari, Melani Marissa, Iwan Ariawan, Emiliana Kartika, Malika Sabrina Yunifananda, Hok Bing Thio

“…In Ambon, the capital city of Maluku Province, the prevalence is 8.27 per 10.000 persons, exceeding the national rate of 0.61. While multidrug therapy (MDT) including Dapsone remains the standard treatment for leprosy, it carries the risk of a severe adverse reaction known as Dapsone Hypersensitivity Syndrome (DHS). …”
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Prevalence and risk factors of postpartum depression among postnatal mothers with hypertensive disorders of pregnancy in a developing country by Wina Ivy Ofori Boadu, Enoch Odame Anto, Edmund Mintah Wiafe, Michael Nyantakyi, Joseph Frimpong, Emmanuel Ekow Korsah, Ezekiel Ansah, Afia Agyapomaa Kwayie, Elizabeth Aboagye, Christian Obirikorang, Emmanuel Timmy Donkoh, Kwame Ofori Boadu

“…Background: Postpartum depression is a public health issue affecting both maternal well-being and child development. While it is the most common mental health disorder following childbirth, data on its prevalence and associated risk factors in developing countries, including Ghana, remains limited. …”
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HPV-negative oropharyngeal carcinoma as a separate prognostkally unfavorable form of cancer, requiring new approaches to treatment (case report) by A. R. Gevorkov, A. V. Boyko, A. P. Polyakov, L. V. Bolotina, N. N. Volchenko, I. V. Rebrikova, A. М. Lemeshko, S. V. Shashkov

“…The study objective is to demonstrate the difficulties associated with treatment of HPV-negative oropharyngeal cancer.Material and methods. A 52-year-old male patient visited a doctor in P.A. …”
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