Retrospective Review of Children Hospitalized for Epstein–Barr Virus-Related Infectious Mononucleosis by Shufeng Tian, Jinjun Zheng, Zhe Zhou, Qingluan Yang, Biao Sun, Yuxi Li, Zengrui Lin, Yuchun Long, Song Guan, Sen Wang, Jiexin Zhuang, Wenhong Zhang, Lingyun Shao, Jikui Deng

“…Objectives: Our objective was to investigate the clinical characteristics, complications, and treatment outcomes of Epstein–Barr virus (EBV)-related infectious mononucleosis (IM) in children and to identify risk factors associated with prolonged fever and abnormal liver function. Methods: This retrospective study included 3006 children admitted to Shenzhen Children’s Hospital from May 2009 to April 2024 with suspected EBV-related IM. …”
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From colorless to pink: Structural insights into vitamin B12-induced color change in monoclonal antibodies by Kai-feng He, Hao-dong Cui, Wen-hui Deng, Na Xing, Guo-jian Liu, Abdallah Iddy Chaurembo, Li-dan Fu, Yuan Li, Xin-yue Tong, Han-bin Lin, Chun-he Wang

“…Peptide analysis revealed distinct UV absorption at 360 nm for SP2, while SDS-PAGE indicated slight molecular weight differences. …”
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Two sides of the same coin: recruitment performance and perceived workload in primary care trials-insights from the AgeWell.de study by Linda Sanftenberg, Robert Philipp Kosilek, Lorenz Birnberger, Hannah Schillok, Felix Wittmann, Melanie Luppa, Anne Blawert, Melanie Boekholt, Christian Brettschneider, Hans-Helmut König, Alexander Bauer, Solveig Weise, Thomas Frese, Hanna Kaduszkiewicz, Juliane Döhring, Catharina Escales, Jochen René Thyrian, Birgitt Wiese, Steffi G. Riedel-Heller, Jochen Gensichen

“…The top 20% of recruiters (Q5) accounted for 42.1% of all participants, while the lowest quintile (Q1) recruited just 3.2%. …”
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External Validation of 3 Prediction Models for Mortality in Out‐of‐Hospital Cardiac Arrest Survivors: A Retrospective Multicenter Study by Chun‐Hsiang Huang, Edward Pei‐Chuan Huang, Cheng‐Yi Fan, Yi‐Chien Kuo, Chien‐Tai Huang, Ching‐Yu Chen, Chi‐Hsin Chen, Yi‐Ju Ho, Chun‐Ju Lien, Yun‐Chang Chen, Sih‐Shiang Huang, Tzu‐Hsueh Wang, Wen‐Chu Chiang, Wei‐Tien Chang, Chien‐Hua Huang, Chih‐Wei Sung

“…While CASS and FACTOR demonstrated similar sensitivity, specificity, and negative predictive value, mSARICA exhibited significantly higher sensitivity, lower specificity, and higher negative predictive value. …”
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Temporal trends in lipoprotein(a) testing among United States veterans from 2014 to 2023 by Sofia E. Gomez, Adam Furst, Tania Chen, Natasha Din, David J. Maron, Paul Heidenreich, Neil Kalwani, Shriram Nallamshetty, Jonathan H Ward, Anthony Lozama, Alexander Sandhu, Fatima Rodriguez

“…Practice guidelines increasingly recommend broad Lp(a) screening among various populations to optimize preventive care. Corresponding changes in testing rates and population-level detection of elevated Lp(a) in recent years has not been well described. …”
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Selection of therapeutically effective T-cell receptors from the diverse tumor-bearing repertoire by Yusuke Nakamura, Jun Huang, Matthias Leisegang, Thomas Blankenstein, Guoshuai Cao, Gerald Willimsky, Steven P Wolf, Hans Schreiber, Xinyi Feng, Vasiliki Anastasopoulou, Kimberley Drousch, Poh Yin Yew, Leonie Rosenberger, Leo Hansmann, Christina Moewes, Erlend Strønen, Taigo Kato, Naresha Saligrama, Johanna Olweus

“…Background The development of T-cell receptor (TCR)-based T-cell therapies is hampered by the difficulties in identifying therapeutically effective tumor-specific TCRs from the natural repertoire of a patient’s cancer-specific T cells.Methods Here, we mimic experimentally near-patient conditions to analyze the T-cell repertoire in euthymic tumor-bearing mice responding to the H-2Kb-presented neoantigen p68S551F (mp68). …”
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Dissecting the genetic architecture of yield-related traits by QTL mapping in maize by Hao Zhang, Hao Zhang, Ting Li, Zhenyu Zhang, Jie Wang, Haoxiang Yang, Jiachen Liu, Wanchao Zhu, Wanchao Zhu, Jiquan Xue, Jiquan Xue, Shutu Xu, Shutu Xu

“…IntroductionMaize is a cornerstone of global agriculture, essential for ensuring food security, driving economic development, and meeting growing food demands. Yet, how to achieve optimal yield remains a multifaceted challenge influenced by biotic, environmental, and genetic factors whose comprehensive understanding is still evolving.MethodsQTL mapping of eight essential yield traits was conducted across four environments — Sanya (SY) in 2021, and Yangling (YaL), Yulin (YuL), and Weinan (WN) in 2022 — using two types of populations: a KA105/KB024 recombinant inbred line (RIL) population and two immortalized backcross populations (IB1 and IB2) derived from the RILs by crossing with their respective parents. …”
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Pharmacokinetics of Psilocybin: A Systematic Review by Shakila Meshkat, Huda Al-Shamali, Argyrios Perivolaris, Trusha Tullu, Richard J. Zeifman, Yanbo Zhang, Lisa Burback, Olga Winkler, Andrew Greenshaw, Muhammad Ishrat Husain, Amy C. Reichelt, Eric Vermetten, Manish K. Jha, Rakesh Jetly, Raimar Loebenberg, Venkat Bhat

“…Understanding the pharmacokinetics of psilocybin and its active metabolite psilocin is crucial for optimizing its clinical use and minimizing adverse effects. …”
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Arginine depletion potentiates standard-of-care chemo-immunotherapy in preclinical models of high-risk neuroblastoma by Kimberley M. Hanssen, Jayne Murray, Ruby Pandher, Stephanie Alfred, Laura D. Gamble, Jennifer Brand, Erin Mosmann, Frances K. Kusuma, Crystal Mak, Adam Kearns, Alvin Kamili, Caroline Atkinson, Alexis Z. Minchaca, Jean Bertoldo, David S. Ziegler, Francis Mussai, Paul N. M. Cheng, Murray D. Norris, Jamie I. Fletcher, Michelle Haber

“…Arginase therapy has been proposed as a therapeutic approach for neuroblastoma treatment and has a favorable safety profile in pediatric cancer patients, however optimal therapeutic combinations remain unexplored. …”
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PAROS: Multi-Component Robotic System and an Image-Guided Patient Alignment for Robot-Assisted Ophthalmic Surgery by Alireza Alikhani, Van Dai Nguyen, Satoshi Inagaki, Benjamin Busam, Koorosh Faridpooya, Mathias Maier, Peter Gehlbach, Iulian Iordachita, Nassir Navab, M. Ali Nasseri, Daniel Zapp

“…Patient alignment time has been identified as a key factor differentiating robot-assisted and manual surgeries in overall procedure duration, with robot preparation and patient alignment extending surgery time by an average of <inline-formula> <tex-math notation="LaTeX">$51\pm 6$ </tex-math></inline-formula> minutes compared to manual methods. To address these challenges, this paper introduces a multi-component robotic system combined with an image-guided patient alignment methodology designed to reduce preparation and alignment time in robotic eye surgery while maintaining surgical efficiency. …”
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An in-depth evaluation of the efficacy and safety of various treatment modalities for chronic thromboembolic pulmonary hypertension: A systematic review and network meta-analysis by Noha Rami Ismail, Hamdy A. Makhlouf, Atef Hassan, Ahmed Elshahat, Mohamed Abdelfatah Abdellatif, Abdelmoemen Esam Rezk, Abdelrahman Mady, Rashad G. Mohamed, Hanady Mohammad Elfeky, Ahmed Abdelaziz

“…Limited data is available on the optimal treatment of choice. We aimed to comprehensively assess the efficacy and safety of CTEPH targeted therapies and update the evidence. …”
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Outcomes of Implementing a Multidimensional Antimicrobial Stewardship Program in a Medical Ward in a Third-Level University Hospital in Northern Italy by Maria Mazzitelli, Daniele Mengato, Gianmaria Barbato, Sara Lo Menzo, Fabio Dalla Valle, Margherita Boschetto, Paola Stano, Cristina Contessa, Daniele Donà, Vincenzo Scaglione, Giacomo Berti, Elisabetta Mariavittoria Giunco, Tiziano Martello, Francesca Venturini, Ignazio Castagliuolo, Michele Tessarin, Paolo Simioni, Annamaria Cattelan

“…<b>Background/Objectives</b>: Antimicrobial stewardship programs (ASPs) optimize antimicrobial use, improving outcomes and reducing resistance. …”
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Exploring the role of community pharmacists in addressing obesity: a Saudi Arabian perspective by Othman AlOmeir, Mansour Almuqbil, Hanaa Ali Alhabshi, Maha Mahrab Saiel Alenazy, Saleha Mafareh Al-Jaro Masaod Hagwi, Walaa F. Alsanie, Walaa F. Alsanie, Abdulhakeem S. Alamri, Abdulhakeem S. Alamri, Majid Alhomrani, Majid Alhomrani, Amal F. Alshammary, Rafiulla Gilkaramenthi, Syed Mohammed Basheeruddin Asdaq, Syed Mohammed Basheeruddin Asdaq

“…This study aimed to explore the beliefs, practices, and barriers encountered by community pharmacists in Saudi Arabia regarding weight management.MethodsA cross-sectional survey was conducted among community pharmacists to gather data on their perceptions, practices, and barriers related to obesity management. …”
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Gymnadenia conopsea orchid: a systematic review by Jing-Yi Wu, Jing-Yi Wu, Ruo-Nan Tang, Ruo-Nan Tang, Jia-Wen Wang, Jia-Wen Wang, Wan-Ying Chen, Wan-Ying Chen, Xing Liu, Ji-Wen Wang, Mei-Ya Li, Fu-Sheng Jiang, Fu-Sheng Jiang

“…For propagation, wild-simulated cultivation should be adopted for resource conservation, while optimizing symbiotic germination techniques is critical to overcome propagation bottlenecks, ultimately enabling sustainable utilization.…”
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The Extended Flexor Carpi Radialis Approach for Distal Radius Fracture Fixation: A Prospective Study by Sulaiman Alrefai, MD, Dionne Hsu, MD(c), Jonathan Persitz, MD, Atefeh Noori, PhD, Andrea Chan, MD, FRCSC, Ryan Paul, MD, FRCSC

“…This approach ensures optimal radial and dorsal exposure by releasing the radial septum and simplifies reduction by releasing deforming forces while providing access to the critical volar ulnar corner. …”
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Age-Onset-Related Particularities of Pediatric MS—Understanding the Spectrum: A Tertiary Center Experience by Alice Denisa Dică, Dana Craiu, Florentina Ionela Linca, Magdalena Budișteanu, Catrinel Iliescu, Carmen Sandu, Cristina Pomeran, Diana Bârcă, Niculina Butoianu, Carmen Burloiu, Ioana Minciu, Ina Ofelia Focșa, Dana Surlică, Oana Tarța-Arsene, Cristina Cazacu, Andreea Badea, Alexandru Stefan Niculae, Daniela Adriana Ion

“…Further multicenter studies with standardized imaging and cognitive assessment protocols are needed to optimize care for this vulnerable population.…”
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Galactomannan detection in sputum samples of patients with chronic obstructive pulmonary disease: A promising marker for diagnosis of chronic pulmonary aspergillosis? by Sabrieh Asadi Shahi Sarae, Masoud Aliyali, Vida Mortezaee, Hamidreza Jamaati, Hossein Asgarian Omran, Siavash Abedi, Hossein Mehravaran, Jamshid Yazdani Charati, Maryam Sadat Mirenayat, Mihan Pourabdollah, Kosar Najmi, Sabah Mayahi, Mona Ghazanfari, Ahmed Al-Harrasi, Mahdi Abastabar, Mohammad T. Hedayati, Abdullah M.S. Al Hatmi

“…Background and purpose: Diagnosing chronic pulmonary aspergillosis (CPA) is challenging due to nonspecific symptoms, variable radiological findings, and limited mycological evidences. While galactomannan (GM) testing has been validated in serum and bronchoalveolar lavage fluid (BAL) for invasive pulmonary aspergillosis (IPA), its usefulness in sputum samples for CPA remains unclear. …”
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Impact of Storage Conditions on Bronchoalveolar Lavage Fluid Analysis: A Human Study by Yu Shionoya, Kanae Maruyama, Takeshi Kawasaki, Mayumi Ono, Yushi Murai, Ryutaro Hirama, Dai Horiuchi, Noriko Sakuma, Shinsuke Kitahara, Shun Sato, Kohei Takahashi, Yoshihito Ozawa, Takuji Suzuki

“…This study aimed to evaluate how different storage conditions impact BALF cell counts and differentials to guide optimal sample handling practices. <b>Methods</b>: Forty patients who underwent BAL at Chiba University Hospital from June to December 2024 were included. …”
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Cost analysis of four surgical techniques for pediatric inguinal hernia repair in a Dutch hospital by Roxanne Eurlings, Merel L. Kimman, Lloyd Brandts, Ruben G.J. Visschers, Wim G. van Gemert

“…Introduction: Pediatric inguinal hernia repair (IHR) can be performed using open repair, laparoscopic approaches such as percutaneous internal ring suture (PIRS) or conventional laparoscopic IHR (LIHR) with N-/Z-suture, and robot-assisted IHR (RIHR). While extensive literature on clinical outcomes exists, cost data remain scarce. …”
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Factors influencing nutrition literacy in patients of colorectal cancer: a cross-sectional study by Jing Zhang, Jing Zhang, Dan Li, Dan Li, Dan Li, Jiai Yan, Jiai Yan, Ju Yang, Ju Yang, Jing Sun, Jing Sun, Jing Sun, Yiran Liu, Yiran Liu, Yanping Xia, Yanping Xia, Yanping Xia, Hong Cao, Hong Cao, Hong Cao, Jiao Hua, Feng Zhang, Feng Zhang, Feng Zhang, Yingyu Wang, Yingyu Wang

“…This study aims to evaluate the level of NL in colorectal cancer patients and identify key factors influencing NL.MethodsA total of 245 colorectal cancer patients participated in this study. …”
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