Abstract 015: Pioneering NaF‐PET/CT Imaging for Early Detection of Atherosclerosis: Potential Implications for Neurointerventional Surgery by Eric M Teichner, Robert C Subtirelu, Arjun B Ashok, Yvonne Su, Victoria A Anderson, Milo Writer, Omar Al‐Daoud, Miraziz Ismoilov, Chitra Parikh, William Y Raynor, Sahithi Talasila, Poul F Høilund‐Carlsen, Abass Alavi, Mona‐Elisabeth Revheim

“…Methods Our study participant is a 31‐year‐old male with atrial fibrillation, multiple cardiovascular risk factors, and class 2 obesity, enrolled in the Cardiovascular Molecular Calcification Assessed by 18F‐NaF PET/CT (CAMONA) study. …”
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PREDICTORS OF THE DEVELOPMENT OF HYPOXIC-ISHEMIC ENCEPHALOPATHY IN FULL-TERM AND PREMATURE INFANTS BORNFROM MOTHERS WITH METABOLIC SYNDROME IN THE EARLY NEONATAL PERIOD by А. Давиденко, В. Похилько, О. Ковальова, Ю. Чернявська, С. Цвіренко, Г. Соловйова

“…Furthermore, urinary nitrite concentration serves as an optimal biomarker for predicting HIE onset. …”
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Investigating the Efficiency of Different Cover Crops on Weed Populations and Yield and Yield Components of Soybean (Glycine max L.) by Ali Jafari, Behnam Kamkar, Asieh Siahmarguee, Javid Gherekhloo, Ebrahim Zeinali, Parisa Alizadeh Dehkordi

“…IntroductionPlanting cover crops, along with effective management practices, offers a sustainable alternative to conventional weed control methods. Beyond weed suppression, cover crops contribute positively by increasing organic matter, improving soil structure, enhancing water retention capacity, controlling soil-borne diseases, reducing soil erosion, and ultimately boosting crop yields. …”
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Evaluation of the pharmacological potential of N-((5-phenyl-6,11-dihydro-[1,2,4]triazolo[1’,5’:1,6]pyrido[3,4-b]indol-2-yl)methyl)benzamides by S. O. Fedotov

“…Early-stage computer-based prediction of toxicological and pharmacokinetic properties remains a key strategy for optimizing the screening process. The application of in silico methods allows timely assessment of the safety, ADME profile and biological potential of compounds prior to experimental investigations. …”
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Independent Association of Sleep Apnea-Specific Hypoxic Burden and Sleep Breathing Impairment Index with Thyroid Function in Obstructive Sleep Apnea: A Retrospective Study by Zhou Y, Shi Y, Zhu S, Cao Z, Xie Y, Lu C, Niu X, Ma L, Wang Z, Su Y, Xia Z, Yuan Y, Yang J, Lu R, Feng Y, Ren X, Hou W

“…Multiple linear regression analyzed the independent relationships between the AHI, SASHB, SBII, and thyroid function indicators while adjusting for potential confounders.Results: Significant intergroup differences were observed in thyroid function indicators under various grouping methods, with different trends. …”
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Exergame (ExerG)-Based Physical-Cognitive Training for Rehabilitation in Adults With Motor and Balance Impairments: Usability Study by Silvia Herren, Barbara Seebacher, Sarah Mildner, Yanick Riederer, Ulrike Pachmann, Nija Sonja Böckler, Stephan Niedecken, Sabrina Alicia Sgandurra, Leo Bonati, Isabella Hotz, Alexandra Schättin, Roman Jurt, Christian Brenneis, Katharina Lenfert, Frank Behrendt, Stefan Schmidlin, Lennart Nacke, Corina Schuster-Amft, Anna Lisa Martin-Niedecken

“…The findings will inform future optimizations. Future work will assess long-term impact.…”
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Evaluation of Olive Mill Waste Compost as a Sustainable Alternative to Conventional Fertilizers in Wheat Cultivation by Ana García-Rández, Silvia Sánchez Méndez, Luciano Orden, Francisco Javier Andreu-Rodríguez, Miguel Ángel Mira-Urios, José A. Sáez-Tovar, Encarnación Martínez-Sabater, María Ángeles Bustamante, María Dolores Pérez-Murcia, Raúl Moral

“…However, the OCP treatment reduced grain yield by only 15%, while improving soil microbial activity and enzymatic responses. …”
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Prognostic differences between persistent HFrEF and HFrecEF following acute myocardial infarction by Jeong Yoon Jang, Jae Myoung Lee, Yujin Shin, Yong-Lee Kim, Gain Yu, Jae Seok Bae, Yun-Ho Cho, Choong Hwan Kwak, Min Gyu Kang, Kye-Hwan Kim, Jeong Rang Park, Jin-Yong Hwang, Young-Hoon Jeong, Jong-Hwa Ahn

“…This study aimed to evaluate the prognostic differences between persistent HFrEF and HFrecEF.MethodsThis prospective cohort study included AMI patients with reduced LVEF (<40%) at admission. …”
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CRISPR/Cas genome editing in soybean: challenges and new insights to overcome existing bottlenecks by Nayara Sabrina Freitas-Alves, Clidia E. Moreira-Pinto, Fabiano T.P.K. Távora, Bruno Paes-de-Melo, Fabricio B.M. Arraes, Isabela T. Lourenço-Tessutti, Stéfanie M. Moura, Antonio C. Oliveira, Carolina V. Morgante, Yiping Qi, Maria Fatima Grossi-de-Sa

“…To date, the efficiency of gRNAs has been validated using protoplasts and hairy root assays, while stable plant transformation relies on Agrobacterium-mediated and particle bombardment methods. …”
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Impact of CYP3A4 and ABCB1 genetic variants on tacrolimus dosing in Greek kidney transplant recipients by Anna Tsironi, Konstantinos Lazaros, Effrosyni Mendrinou, Marios Papasotiriou, Stavroula Siamoglou, Kyriaki Kydonopoulou, Anne John, Alexandra Gerou, Spyridon Gerou, Bassam R. Ali, Bassam R. Ali, Aristidis G. Vrahatis, George P. Patrinos, George P. Patrinos, George P. Patrinos, George P. Patrinos, George P. Patrinos

“…Its narrow therapeutic index requires precise management to achieve optimal dosing and to minimize adverse drug events (ADEs) while ensuring its therapeutic efficacy. …”
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Cutoff levels for newborn screening of 21-OH deficiency in a Brazilian metropolitan area by Kallianna Paula Duarte Gameleira, Juliana de Vasconcellos Thomas, Vitor Guilherme Brito de Araújo, Cláudia Vicari Bolognani, Sérgio Eduardo Soares Fernandes, Fábio Ferreira Amorim

“…Conclusion: The proposed 17OHP cutoff strategy effectively reduced false positives, improving specificity, LR+, PPV, and accuracy Thus, it optimized CAHNBS programs while minimizing unnecessary costs and parental distress.…”
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The heterogeneity of mortality burden of lower respiratory infection associated with ambient temperature and its drivers in China by Sujuan Chen, Jinlei Qi, Yulin Zhuo, Jianxiong Hu, Jiangmei Liu, Peng Yin, Tao Liu, Mengen Guo, Guanhao He, Ziqiang Lin, Fengrui Jing, Jinling You, Wenjun Ma, Maigeng Zhou

“…Abstract：: Ambient temperature is linked to an increased risk of lower respiratory infections (LRI) yet the evidence on the population and spatial heterogeneity of LRI mortality burden attributed to non-optimal temperatures and its socioeconomic drivers remain limited. …”
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Effects of albumin and weight-standardized hand grip strength on survival for cancer patients with frailty by Xiao-Man Xiong, Chu-Ying Zhang, Hong-Xia Xu, Ge-Ge Zhang, Saba Fida, Jiu-Wei Cui, Wei Li, Min Weng, Kun-Hua Wang, Fu-Xiang Zhou, Jun-Qiang Chen, Xiang-Hua Wu, Han-Ping Shi, Yan-Li Zhang, Chun-Hua Song

“…Objective:. While albumin and the weight-standardized hand grip strength (HGS/W) serve as valuable prognostic indicators for cancer patients, their correlation with the prognosis in frail cancer patients remains inadequately explored. …”
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Neoadjuvant chemoimmunotherapy versus neoadjuvant chemoradiotherapy in patients with borderline resectable esophageal squamous cell carcinoma by Jun-Peng Lin, Feng-Nian Zhuang, Wei-Jie Chen, Zhou Lin, Yu-Jie Chen, Xiao-Feng Chen, Hui Lin, Hao He, Peiyuan Wang, Hang Zhou, Wen-Wei Wei, Peng-Qiang Gao, Shuo-Yan Liu, Feng Wang

“…Abstract Background The optimal treatment strategy for patients with borderline resectable (cT3br) esophageal squamous cell carcinoma (ESCC) remains unclear. …”
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Epidemiology and Treatment Patterns of Fistulizing Crohn’s Disease in a Large, Real-World Australasian Cohort by Jack McNamara, William Wilson, Joseph L. Pipicella, Simon Ghaly, Jakob Begun, Ian C. Lawrance, Richard Gearry, Jane M. Andrews, Susan J. Connor

“…This study explores demographic, disease and treatment factors in a real-world Australasian cohort. Methods: A large real-world cohort of people with inflammatory bowel disease under routine care was interrogated in August 2023. …”
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Process Development for GMP-Grade Full Extract Cannabis Oil: Towards Standardized Medicinal Use by Maria do Céu Costa, Ana Patrícia Gomes, Iva Vinhas, Joana Rosa, Filipe Pereira, Sara Moniz, Elsa M. Gonçalves, Miguel Pestana, Mafalda Silva, Luís Monteiro Rodrigues, Anthony DeMeo, Logan Marynissen, António Marques da Costa, Patrícia Rijo, Michael Sassano

“…The study underscores the importance of monitoring the extraction and purification processes to optimize the cannabinoid content and sensory characteristics in cannabis preparations.…”
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Multi-omics characterization of diabetic nephropathy in the db/db mouse model of type 2 diabetes by Liping Wang, Ran Zhou, Guanghui Li, Xiaodan Zhang, Yan Li, Yinchen Shen, Junwei Fang

“…Methods: Renal tissues from db/db mice underwent integrative multi-omics analysis, encompassing transcriptomics, metabolomics, and lipidomics. …”
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Dual targeting of BCMA and SLAMF7 with the CARtein system: chimeric antigen receptors with intein-mediated splicing elicit specific T cell activation against multiple myeloma by Noelia Moares, Noelia Moares, Pablo Gonzalez-Garcia, Pablo Gonzalez-Garcia, Wenjie Yi-He, Wenjie Yi-He, Juan P. Muñoz-Miranda, Juan P. Muñoz-Miranda, Antonio Gabucio, Antonio Gabucio, Rosa Luna-Espejo, Javier Ocaña-Cuesta, Ricardo Fernandez-Cisnal, Cecilia M. Fernandez-Ponce, Cecilia M. Fernandez-Ponce, Francisco Garcia-Cozar, Francisco Garcia-Cozar

“…The design of the intein-spliced CAR system (termed "CARtein") was further optimized through advanced protein structure prediction software.ResultsCells expressing the spliced CARtein constructs, engineered to target BCMA, SLAMF7, or both antigens simultaneously, demonstrated robust and highly specific activation in response to their respective antigens.DiscussionThese results suggest that the CARtein platform is a promising, versatile, and highly specific approach for the modular design and engineering of CARs, enabling multi-antigen targeting while maintaining structural and functional integrity. …”
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Large-scale analysis highlights obesity as a risk factor for chronic, non-communicable inflammatory diseases by Sadegh Mousavi, Katja Bieber, Henner Zirpel, Artem Vorobyev, Henning Olbrich, Cristian Papara, Cristian Papara, David A. De Luca, David A. De Luca, Diamant Thaci, Enno Schmidt, Gabriele Riemekasten, Peter Lamprecht, Matthias Laudes, Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Ralf J. Ludwig, Ralf J. Ludwig

“…For 12 diseases, increased risks were confirmed to one of the two sensitivity analyses, while for 10 diseases, results were discordant. No increased risk was observed for one disease. …”
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Clinical outcomes and therapeutic modalities in older Chinese patients with MCL: a multi-center real-world retrospective study by Yuan Yang, Ping Yang, Wei Zhang, Hui Liu, Xiuhua Sun, Xiubin Xiao, Jingwen Wang, Zhenling Li, Lihong Li, Shuye Wang, Juan He, Xiaoling Li, Qingqing Cai, Weilong Zhang, Jing Wang, Chunyuan Li, Yingtong Chen, Shuozi Liu, Hongmei Jing

“…The present study was performed to identify the prognostic factors and optimal treatment modalities in older Chinese MCL patients.Methods Patients (age ≥ 65 yrs) with MCL from 19 comprehensive hospitals in China were included. …”
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