Optimizing Paediatric Hypospadias Surgical Repair: Pudendal Nerve Block Versus Caudal Block for Superior Analgesia by Hemachander Sridharan, Nikhil Kesarkar, Raylene Dias

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Optimizing Thermal Performance of Mini Heat Exchangers: An Experimental Analysis Using a Full Factorial Design by Sergio da Silva Franco, Álvaro Augusto Soares Lima, Alvaro Antonio Villa Ochoa, José Ângelo Peixoto da Costa, Gustavo de Novaes Pires Leite, Márcio Vilar, Kilvio Alessandro Ferraz, Paula Suemy Arruda Michima

“…The innovation of this study resides in the development and analysis of a mini heat exchanger optimized using chemometric methods to achieve efficient thermal dissipation. …”
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The use of linear programming approach in diet optimization among children under five: a scoping review by Yee Xuen Miow, Wilfred Kok Hoe Mok, Wan Ying Gan, Poh Ying Lim, Geeta Appannah, Siti Nur ‘Asyura Adznam

“…Abstract Background Adequate nutrition is crucial for optimal child growth and development, especially for children under five. …”
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Review of Low-Carbon Co-Optimization Research on Demand-Side Flexibility Resources for New Power Systems by HUA Haochen, ZHANG Zhouhe, ZOU Yiqun, YU Kun, GAN Lei, CHEN Xingying, LIU Di, LI Bing, ZHANG Chongbiao, Pathmanathan Naidoo

“…The reasonable design of the market operation mechanism， user behavior model， and price formation mechanism motivates massive demand-side flexibility resources to actively participate in low-carbon optimization. [Methods] This study explores flexible regulation capabilities on the demand side， focusing on key technologies for utilizing demand-side resources， and reviews existing research from four perspectives： 1） carbon emission measurement of flexible demand-side resources， 2） aggregation and adjustable potential assessment of these resources， 3） low-carbon optimization of new power systems incorporating flexible resources， and 4） participation of flexible resources in electricity-carbon coupled markets. …”
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A calculation revision method for maximum DG hosting capacity in distribution networks by ZHANG Haochong, LI Peiqiang, YANG Gexing

“…Then， improved comprehensive sensitivity indices for distribution networks are constructed， and a calculation revision method is subsequently developed to achieve more accurate maximum hosting capacity calculation while identifying potential weak points in the networks. …”
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Optimization of Controlled-Release Microspheres Containing Vitexin and Isovitexin Through Experimental Design and Evaluation of Their Hypoglycemic Effects by Nhu Huynh Mai, Hoang-Han Do, Phi Hoang Yen Tran, Cong-Phi Nguyen, Van-Ha Nguyen, Ngoc Phuc Nguyen Nguyen, Kien-Duc Ngo, Duc-Tuan Nguyen, Minh-Quan Le

“…<b>Methods</b>: Microspheres were prepared using alginate as the core matrix and a chitosan outer layer. …”
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Dasatinib Dose Optimization Based on Therapeutic Drug Monitoring in Patients with Chronic-Phase Chronic Myeloid Leukemia by Cheng F, Cui Z, Li Q, Wang L, Zhang Y, Li W

“…Fang Cheng,1,2 Zheng Cui,1,2 Qiang Li,1,2 Liu Wang,1,2 Yu Zhang,1,2 Weiming Li3 1Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan, 430022, People’s Republic of China; 3Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of ChinaCorrespondence: Yu Zhang, Email zhangwkp@163.com Weiming Li, Email lee937@126.comBackground: Although a dosage decrease regimen for chronic phase chronic myeloid leukemia (CML-CP) has been suggested, there is a marked lack of guidance on individualizing medication dosages for patients.Methods: Our aim was to explore the application of therapeutic drug monitoring (TDM) as a strategy for optimizing dasatinib dosage in patients with CML-CP.Results: It was observed that patients administered a dosage of 100 mg exhibited significantly higher concentrations than those given 50 mg, with no marked difference in concentration between branded and generic drugs. …”
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Nutritional status and barriers to optimal nutrition among pediatric patients with cancer in tanzania: a quantitative analysis by Deogratias M. Katabalo, Yadurshini Raveendran, Anthony Cuthbert Liwa, Benson R. Kidenya, Kristin Schroeder

“…Methods Two study populations were recruited: pediatric patients with cancer and their primary caregivers. …”
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Topical Nitroglycerin for Radial Access Optimization: Supporting Vascular Access in Patients at Risk for Acute Heart Failure by Adrian Sebastian Zus, Simina Crișan, Silvia Luca, Daniel Nișulescu, Mihaela Valcovici, Oana Pătru, Mihai-Andrei Lazăr, Cristina Văcărescu, Dan Gaiță, Constantin-Tudor Luca

“…<i>Background and Objectives</i>: Radial artery spasm (RAS) is a frequent complication during invasive angiography using the transradial approach, leading to patient discomfort and procedural challenges. While intra-arterial nitroglycerine (NTG) effectively reduces RAS after sheath insertion, preprocedural prevention strategies are limited. …”
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Optimizing blood management in arthroplasty: a meta-analysis of carbazochrome sodium sulfonate and Tranexamic acid combination by Mohamed A. Alsaied, Omnia Samy El-Sayed, Shahd Alqato, Abdelrahman M. Elettreby, Ahmed A. Abo Elnaga

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Structural Optimization Design of the Dual-Layer CMUT with Low Power Consumption and High Ultrasonic Reception Performance by Jie Li, Zhaohui Xiao, Zutang Wu, Xiong Hu, Zhikang Li, Yihe Zhao, Min Li, Jiawei Yuan, Shaohui Qin, Libo Zhao

“…This design increases the total deflection and reduces the stiffness, making the membrane more susceptible to deformation under external forces, thereby achieving low power consumption and high reception performance. The finite element method (FEM) results showed that, compared with conventional CMUTs, the structural optimization design of the dual-layer CMUT had a 13.7% reduction in collapse voltage. …”
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Characterizing the Optimal Diversity Training Programs for Physicians: A Survey sponsored by Pacific Spine and Pain Society by Gendreau JL, Bauman MMJ, Brown NJ, Alfonzo Horowitz M, Chakravarti S, Mehkri Y, Grovey B, Lee E, Lee G, Cornidez E, Bhandal HS, Pope JE

“…In this paper, we attempt to describe trends in the Pacific Spine and Pain Society (PSPS) membership to help discover optimal diversity education paradigms for pain management providers by performing a survey on behalf PSPS.Methods: A survey was disseminated to all members of the PSPS at the 2022 annual meeting. …”
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Potency-optimized CD28-activating bispecific antibody for the targeted treatment of Nectin-4 positive cancers by Manpreet Kaur, Starlynn C Clarke, Katherine E Harris, Nathan D Trinklein, Elaine C Chen, Katja Rüger, Udaya S Rangaswamy, Laura M Davison, Sebastian Moreno Arteaga, Imani Smith, Ruth Chu, Soumili Chattopadhyay, Mathias Rickert, Shelley Force Aldred

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Optimizing blood-brain barrier permeability in KRAS inhibitors: A structure-constrained molecular generation approach by Xia Sheng, Yike Gui, Jie Yu, Yitian Wang, Zhenghao Li, Xiaoya Zhang, Yuxin Xing, Yuqing Wang, Zhaojun Li, Mingyue Zheng, Liquan Yang, Xutong Li

“…Our approach utilizes a variational autoencoder (VAE) generative model integrated with reinforcement learning for multi-objective optimization. This method specifically aims to enhance BBB permeability (BBBp) while maintaining high-affinity substructures of KRAS inhibitors. …”
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BBSNet: An Intelligent Grading Method for Pork Freshness Based on Few-Shot Learning by Chao Liu, Jiayu Zhang, Kunjie Chen, Jichao Huang

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Microbiological Assessment of the Different Hand Drying Methods and Washroom Environment Cross-Contamination by Fayza Kouadri

“…This research compared the effectiveness of three different hand drying methods—paper towels, the use of warm air dryers in stationary hands position, and the use of air drying while hand rubbing—and their potential for cross-contamination of other users and the surrounding environment. …”
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Practical and cost-effective method for the isolation of pollen grains from various sources by Ozge S. Kuddar, Benjamin J. Callahan, Christopher Bernhardt, Kelly A. Meiklejohn

“…Mock standards, with known concentrations and varied characteristics, when analyzed alongside unknown samples, can provide evaluation, optimization, and validation of scientific methods. Due to the scarcity of commercially available pollen grains, this study introduces a practical and cost-effective method for isolating pollen grains from various sources to be used in a mock pollen standard. …”
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Research on Lightweighting Methods for 3D Building Models Based on Semantic Constraints by J. Wu, T. Shen, L. Huo

“…Experimental results demonstrate that the proposed method significantly reduces the model's storage requirements while effectively preserving its semantic information.…”
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Development of Green Method for Trace Determination of Bendiocarb in Real Samples Using Emerson by Baghdad Science Journal

“…The most important parameters affecting the extraction and determination of BC are conducted via a classical optimization. Under the optimum conditions established , Beer’s law is obeyed in the range of 0.1-4 µg mL-1 while the optimum concentration ranges estimated by Ringbom’s plot was of 0.4-2.12 µg mL-1. …”
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Research on aerodynamic characteristics and control method of rigid-flexible variable camber wing by Tao Xin, Bin Li

“…In the wing configuration design, the optimal lift-to-drag ratio is used as the optimization objective, and the wing section mean line is parameterized to obtain the optimal rigid-flexible hybrid deformation configuration. …”
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