The application of ketamine in pain management for sports injuries and other medical conditions - literature review by Katarzyna Nowicka, Wiktor Klimek, Marta Ignatiuk-Chilkiewicz, Monika Olszanska, Dominika Hakało, Joanna Kałuska, Tomasz Suprun, Aleksandra Sokół, Klaudia Mościszko, Maria Majewska

“…The pediatric population may particularly benefit from ketamine’s rapid, intranasal administration, though dosing and safety must be carefully considered. While early findings are encouraging, more research is needed to establish optimal protocols and to explore its role in managing sport-related injuries.  …”
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Monitoring of Nutrients, Metabolites, IgG Titer, and Cell Densities in 10 L Bioreactors Using Raman Spectroscopy and PLS Regression Models by Morandise Rubini, Julien Boyer, Jordane Poulain, Anaïs Berger, Thomas Saillard, Julien Louet, Martin Soucé, Sylvie Roussel, Sylvain Arnould, Murielle Vergès, Fabien Chauchard-Rios, Igor Chourpa

“…Real-time monitoring is necessary for optimizing culture conditions and ensuring consistent product quality. …”
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Hyperfibrinolysis: a crucial phenotypic abnormality of posttraumatic fibrinolytic dysfunction by Kyosuke Takahashi, Kazuma Yamakawa, Anaar E. Siletz, Morihiro Katsura, John B. Holcomb, Charles E. Wade, Jessica C. Cardenas, Erin E. Fox, Morgan Schellenberg, Matthew Martin, Kenji Inaba, Kazuhide Matsushima

“…Objectives: To assess whether posttraumatic fibrinolysis phenotypes identified by TEG correlate with levels of key fibrinolysis-related serum markers and with risk of mortality and hospital complications. Methods: This is a secondary analysis of the Pragmatic, Randomized Optimal Platelet and Plasma Ratios trial. …”
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Comparative outcomes of invasive versus conservative strategy in stable coronary artery disease patients: a risk-stratification-based hypothesis-generative study by Zizhao Qi, Miaohan Qiu, Ying Xu, Kai Xu, Haiwei Liu, Xiaozeng Wang, Jing Li, Bin Liu, Shaoliang Chen, Jiyan Chen, Yaling Han, Yi Li

“…The present study sought to evaluate the impacts of initial invasive versus conservative strategy on long-term clinical outcomes for patients with SCAD stratified by risk scores. Methods This was a sub-analysis of the multicenter, observational Optimal antiPlatelet Therapy for Chinese patients with Coronary Artery Disease (OPT-CAD) study. …”
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Long-term nitrogen management strategies based on straw return improve soil carbon and nitrogen fractions and nitrogen use efficiency of maize in the Tumochuan Plain Irrigation Dis... by Wenbo Li, Wenbo Li, Jiawei Qu, Jiawei Qu, Julin Gao, Julin Gao, Xiaofang Yu, Xiaofang Yu, Daling Ma, Daling Ma, Shuping Hu, Shuping Hu, Qinggeer Borjigin, Qinggeer Borjigin, Kexin Lu

“…The main plots included deep plowing with straw return (DPR) and no straw return (RT), while subplots comprised four N application rates (0, 210, 255, and 300 kg ha-1). …”
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Emission Characteristics of Concrete Mixer Trucks Under Real-world Operating Conditions by Xinbo SHI, Yao CHEN, Jin LI, Peixuan LI, Zihang ZHOU, Bin WANG, Xue CHEN

“…Most existing studies have primarily focused on heavy-duty freight vehicles, such as tractors, transport trucks, and dump trucks, while comparatively less attention has been given to concrete mixer trucks, which frequently operate in urban areas and pose potential threats to human health. …”
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Clinical decision support for pharmacologic management of treatment-resistant depression with augmented large language models by Roy H. Perlis, Pilar F. Verhaak, Joseph Goldberg, Cristina Cusin, Michael Ostacher, Gin S. Malhi, Carlos A. Zarate, Richard C. Shelton, Dan V. Iosifescu, Mauricio Tohen, Manish Kumar Jha, Martha Sajatovic, Michael Berk

“…A sample of community clinicians identified the optimal treatment choice for 12/91 vignettes (13.2 %, 95 % CI: 7.7–21.6 %; Cohen’s kappa = 0.10, 95 % CI 0.03–0.18), while an additional group of expert psychopharmacologists identified optimal treatment for 9/140 (6.4 %, 95 %CI: 3.4–11.8 %; Cohen’s kappa = 0.03, 95 % CI 0.01–0.08). …”
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Silver nanoparticles as next-generation antimicrobial agents: mechanisms, challenges, and innovations against multidrug-resistant bacteria by Hazim O. Khalifa, Hazim O. Khalifa, Atef Oreiby, Atef Oreiby, Temesgen Mohammed, Mohamed A. A. Abdelhamid, Mohamed A. A. Abdelhamid, Essam Nageh Sholkamy, Hamada Hashem, Ragab M. Fereig, Ragab M. Fereig

“…Despite their potent antibacterial activity, concerns regarding bacterial adaptation, cytotoxicity, and non-specific interactions have prompted extensive research into innovative delivery systems to enhance AgNP efficacy while minimizing adverse effects. This review comprehensively explores the synthesis methods and physical properties of AgNPs, emphasizing their antimicrobial mechanisms and emerging resistance patterns. …”
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The relationship between blood glucose and clinical outcomes after extracorporeal circulation: a retrospective cohort study by Li Li, Li Li, Rui Li, Yi-Jiang Liu, Zhan Wang, Xin Chen, Lin-Xi Xu, Lin-Xi Xu, Zhi-Huang Chen, Jia-Cheng Xu, Zhong-Gui Shan, Zhong-Gui Shan

“…BackgroundPostoperative blood glucose levels significantly impact outcomes in cardiac surgery patients undergoing extracorporeal circulation (ECC) auxiliary to open heart surgery. While hypoglycemia and hyperglycemia are known risk factors for adverse outcomes, the optimal glycemic range for patients undergoing ECC remains unclear. …”
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A machine learning approach to identifying key predictors of Peruvian school principals' job satisfaction by Luis Alberto Holgado-Apaza, Dany Dorian Isuiza-Perez, Nelly Jacqueline Ulloa-Gallardo, Yban Vilchez-Navarro, Ruth Nataly Aragon-Navarrete, Wilian Quispe Layme, Marleny Quispe-Layme, Danger David Castellon-Apaza, Remo Choquejahua-Acero, Jaime Cesar Prieto-Luna

“…SHAP analysis revealed that economic factors primarily influenced dissatisfied principals, while interpersonal factors were more important for highly satisfied principals, suggesting a hierarchical pattern of needs. …”
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Micheliolide Alleviates Hepatic Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via the TrxR1/2-Mediated ROS/MEK/ERK Pathway by Yi Liu, Ling Yao, Yuanyuan Liu, Yunheng Yang, Ailing Liang, Honglin He, Yao Lei, Wenfu Cao, Zhiwei Chen

“…<b>Background</b>: Hepatic fibrosis is a major global health issue without an optimal drug treatment, highlighting the urgent need to find effective therapies. …”
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Machine learning predicts improvement of functional outcomes in spinal cord injury patients after inpatient rehabilitation by Mohammad Rasoolinejad, Irene Say, Peter B. Wu, Xinran Liu, Yan Zhou, Yan Zhou, Nathan Zhang, Emily R. Rosario, Daniel C. Lu, Daniel C. Lu, Daniel C. Lu

“…The ability to accurately predict functional outcomes for SCI patients is essential for optimizing rehabilitation strategies, guiding patient and family decision making, and improving patient care.MethodsWe conducted a retrospective analysis of 589 SCI patients admitted to a single acute rehabilitation facility and used the dataset to train advanced machine learning algorithms to predict patients' rehabilitation outcomes. …”
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The Prevalence, Distribution, and Clinicopathological Features of Seven Lung Cancer Actionable Driver Mutations in Taiwan by Yu‐Ching Lin, Tsung‐Ming Yang, Ting‐Yao Wang, Yu‐Hung Fang, Ming‐Shian Lu, Chin‐Kuo Lin, Yuan‐Yuan Jiang, Chia‐Hung Han, Jrhau Lung, Ying‐Huang Tsai, Ming‐Szu Hung

“…While EGFR mutations in this cohort generally correlated with female sex, never‐smoking status, and adenocarcinoma histology, some mutation subtypes deviated from this trend. …”
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In how many patients urodynamics should be omitted? Data from a single-centre database on the basis of the upstream trial by Eleonora Rosato, Maria Cristina Mancini, Giorgio Cerrelli, Francesco Di Rocco, Luca Orecchia, Giuseppe Farullo, Andrea Turbanti, Simone Pletto, Yuri Cavaleri, Enrico Finazzi Agrò

“…Results:: Among 212 patients analysed, 38.2% met all criteria for good surgical outcomes, while 61.8% exhibited at least one unfavourable criterion. …”
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<i>Lactobacillus rhamnosus</i> Sepsis in a Preterm Infant Following Probiotic Administration: Challenges in Diagnosis by Ilaria Farella, Maria Fortunato, Domenico Martinelli, Carmela De Carlo, Eleonora Sparapano, Stefania Stolfa, Federica Romanelli, Vittoriana De Laurentiis, Stefano Martinotti, Loredana Capozzi, Stefano Castellana, Antonio Parisi, Giuseppe Latorre

“…Probiotic administration has become common practice in neonatal intensive care units (NICUs) to prevent necrotizing enterocolitis (NEC) and promote gut health in preterm infants. While probiotics are generally considered safe, rare cases of probiotic-related sepsis have been reported. …”
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Research trends and hotspots of acupuncture for knee osteoarthritis from 2004 to 2024: a bibliometric analysis by Jun Zhou, Jun Zhou, Jun Zhou, Kuayue Zhang, Fanying Zhao, Xueyan Liu, Xueyan Liu, Jiarun Zhang, Fang Yuan, Lu Liu, Lu Liu, Lu Liu, Bin Li, Bin Li, Bin Li

“…The journal Medicine published the most papers, while Osteoarthritis and Cartilage was the most cited (470 times). …”
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Ultra-sensitive in situ detection of intracellular Mycobacterium tuberculosis with CRISPR/Cas12a by Zhiqiang Lin, Zhe Song, Hong Yu, Yang Zhou, Yang Zhou, Deliang Liu, Peize Zhang, Li Wei, Guiqin Dai, Guangyan Liang, Zhuojun He, Xiaorong Hu, Yuying Chen, Yuying Chen, Pengfei Zhao, Hongzhou Lu, Mingbin Zheng, Mingbin Zheng

“…The diagnostic performance was further validated using bronchoalveolar lavage fluid (BALF) samples from clinical participants, achieving a sensitivity of 94%, which surpassed conventional methods such as culture (67%) and Xpert (78%), while maintaining a specificity of 100%. …”
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The Effect of Systemic Inflammation and Clinicopathologic Features on Survival in Malignant Pleural Mesothelioma: A Multicenter Analysis by Nadiye Sever, Sedat Yıldırım, Ali Fuat Gurbuz, Delyadil Karakaş Kılıç, Esra Zeynelgil, Yunus Emre Altintaş, Berivan Deniz Çimik, Yeşim Ağyol, Ali Kaan Güren, Pınar Erel, Erkam Kocaaslan, Burak Paçacı, Mustafa Alperen Tunç, Abdussamet Çelebi, Nazım Can Demircan, Selver Işık, Rukiye Arıkan, Murat Araz, Serdar Karakaya, Murat Sarı, Osman Köstek, İbrahim Vedat Bayoğlu

“…<i>Materials and Methods:</i> This retrospective, multicenter study included 217 patients diagnosed with MPM between January 2009 and March 2024. …”
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Evaluation of diabetes mellitus medication-taking behavior among first- and second-generation Australians of Chinese heritage: A nationwide cross-sectional study by Olumuyiwa Omonaiye, Alemayehu Mekonnen, Christopher Gilfillan, Rosemary Wong, Bodil Rasmussen, Elizabeth Holmes-Truscott, Kevin Mc Namara, Elizabeth Manias, Jerry Lai, Julie Considine

“…Conclusion: Medication beliefs play a role in sub-optimal medication-taking behavior among Chinese adults with T2DM. …”
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The Positive Effects of Soil Organic Carbon on European Cereal Yields Level Off at 1.4% by Ana Campos‐Cáliz, Enrique Valencia, César Plaza, Gina Garland, Anna Edlinger, Chantal Herzog, Marcel G. A. van derHeijden, Samiran Banerjee, Matthias C. Rillig, Sara Hallin, Aurélien Saghaï, Fernando T. Maestre, David S. Pescador, Laurent Philippot, Ayme Spor, Sana Romdhane, Pablo García‐Palacios

“…MAOC dominated the SOC pool, and was significantly related to relative yield up to an optimal level that varied with soil depth. Soil microbial diversity and nutrient availability emerged as main drivers of the SOC‐yield relationship, while water retention did not exhibit a notable influence. …”
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