Clinical and economic impact of the availability of innovative therapies for advanced lung cancer in men in Latin America: a population-based secondary data studyResearch in contex... by Andrés F. Cardona, Natalia Sánchez, Liliana Gutiérrez-Babativa, Leonardo Rojas, Jairo Zuluaga, Stella Martínez, Lucia Viola, Carlos Carvajal, Juliana Bogoya, Laura Prieto-Pinto, Daniel Samacá-Samacá, Antonio Robles, Joshua Kock, Claudio Martín, Luis Corrales, Luis E. Raez, Vladmir Cordeiro de Lima, Suraj Samtani, Oscar Arrieta

“…Accelerating the introduction of innovative therapies for advanced lung cancer in Latin America represents a significant opportunity to enhance survival rates, instilling hope and optimism while also avoiding substantial PL. Funding: This study was conducted as a research partnership between Roche and CTIC. …”
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Deep Learning-Based Cardiac Chamber Segmentation in Magnetic Resonance-Guided Adaptive Radiation Therapy by Xinru Chen, PhD, Yao Ding, PhD, Julius Weng, MD, Carol C. Wu, MD, Yao Zhao, PhD, Angela Sobremonte, BS, Mustefa Mohammedsaid, MS, Zhan Xu, PhD, Xiaodong Zhang, PhD, Joshua S. Niedzielski, PhD, Sanjay S. Shete, PhD, Laurence E. Court, PhD, Zhongxing Liao, MD, Jihong Wang, PhD, Ergys Subashi, PhD, Percy P. Lee, MD, Jinzhong Yang, PhD

“…Adaptive plan greatly reduced individual cardiac chamber dose while maintaining similar target coverage. Conclusions: This study demonstrated the feasibility of using bFFE-SPAIR and T1 mDixon sequences to accurately segment cardiac chambers on a 1.5-T MR-Linac. …”
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Bronchoalveolar lavage cell percentages as diagnostic markers of immune checkpoint inhibitor pneumonitis by Mahnoor Mir, Felipe Soto, Pedro Antonio Amezcua Gomez, Rodrigo Del Rio Arroyo, Adarsh Suresh, Amber Su, Qiong Gan, John Stewart, Roberto Adachi, Diwakar D. Balachandran, Lara Bashoura, Roberto F. Casal, Burton F. Dickey, George A. Eapen, Scott E. Evans, Horiana Grosu, Carlos A. Jimenez, Julie Lin, David E. Ost, Bruce F. Sabath, Vickie R. Shannon, Aung Naing, Jianjun Gao, Jia Wu, Karthik Suresh, Saadia A. Faiz, Mehmet Altan, Ajay Sheshadri

“…The AUROC for BAL lymphocytes to diagnose ICIP was 0.62 (95% CI 0.57–0.67, optimal cutoff 15.5%, sensitivity 69%, and specificity 52%) and the AUROC for eosinophils was 0.61 (95% CI 0.56–0.66, optimal cutoff 1%, sensitivity 58%, and specificity 62%). …”
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Re-use of Building Products in the Netherlands by Loriane Icibaci

“…Although the challenges to develop methods to efficiently process (remanufacture, resize, recondition) used components into new products while securing quality standards, safety requirements and economic viability exist; cascading reuse can help to overcome barriers related to public perception and consumption of used products. …”
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Effective cellular and neutralizing immunity against SARS-CoV-2 after mRNA booster vaccination is associated with pDC and B cell activation by Dorit Fabricius, Carolin Ludwig, Carolin Ludwig, Matthias Proffen, Matthias Proffen, Janina Hägele, Janina Hägele, Judith Scholz, Judith Scholz, Christiane Vieweg, Christiane Vieweg, Immanuel Rode, Immanuel Rode, Simone Hoffmann, Simone Hoffmann, Sixten Körper, Sixten Körper, Hubert Schrezenmeier, Hubert Schrezenmeier, Bernd Jahrsdörfer, Bernd Jahrsdörfer

“…This study aimed to elucidate the immune responses, including B cell, plasmacytoid dendritic cell (pDC), and T cell activation, following mRNA booster vaccination.MethodsIn a longitudinal cohort study, 136 individuals received three different vaccination regimens: homologous mRNA, heterologous vector-mRNA-mRNA, or heterologous vector-vector-mRNA vaccinations. …”
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Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement by Xinyu Wang, Qianye Chen, Jiping Sun, Zihan Huang, Zijian Zhang, Tingwei Lu, Xiangru Huang, Siyuan Sun, Yuanqi Liu, Houwen Pan, Li Mei, Paul R. Cooper, Qinggang Dai, Lei Shen, Lingyong Jiang

“…Notably, jawbone MSCs not only exhibit a robust capacity for promoting hematopoietic regeneration but also offer therapeutic potential in infectious diseases.MethodsUsing an optimized enzymatic digestion protocol, we obtained a highly viable single‐cell suspension from mouse jawbone in vitro. …”
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Compartmentalization of High Infratemporal Fossa in Oral Cavity Squamous Cell Carcinomas and Its Impact on Clinical Outcome by Abhishek Mahajan, Ujjwal Agarwal, Renuka M. Ashtekar, Nivedita Chakrabarty, Richa Vaish, Vijay Maruti Patil, Vanita Noronha, Nandini Menon, Vasundhara Smriti, Jai Prakash Agarwal, Sarbani Ghosh-Laskar, Anil K. D’Cruz, Pankaj Chaturvedi, Prathamesh Pai, Asawari Patil, Munita Bal, Swapnil Rane, Neha Mittal, Kumar Prabhash

“…Previous studies have shown that the extent of ITF involvement influences management and outcomes. Therefore, to optimize management, T4b disease should be subclassified based on ITF involvement. …”
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從前瞻因應理論觀點探討翻轉教學策略應用 於退休準備課程在不同需求程度上之 教學成效 Exploring the Application of Flipped Teaching Strategies in Retirement Preparation Courses: An Analysis of Educational Effectiveness From... by 胡夢鯨 Menq-Jing Hwu, 施宇澤 Yu-Ze Shih, 劉霽瑈 Ji-Rou Liu, 陳雅雯 Ya-Wen Chen

“…Research demonstrates that adequate retirement planning reduces anxiety, enhances independence, and increases life satisfaction, while insufficient planning often results in financial and lifestyle challenges. …”
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Global, regional, and national burden of genitourinary cancers in 204 countries and territories, 1990–2021: a systematic analysis for the global burden of disease study 2021 by Zhiyong Zhang, Yingwei Xie, Lei Liu, Yongtao Wang, Shuang Li, Li Chen, Xiangbo Zeng, Yuanchao Zhu, Yishan Zhang, Yongyuan Xiao, Fengjin Zhao, Bihong Xu, Xiaocen Liu, Wenbin Guo, Ganping Wang, Wenlian Xie, Wanlong Tan, Hao Ping, Zaosong Zheng

“…The disease burdens of bladder, kidney, and prostate cancers were primarily distributed among older men, while testicular cancer mainly occurred in young men. …”
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Enhancing maize above-ground biomass estimation through multispectral, digital and LiDAR fusion on UAV platforms by Ziheng Feng, Zheqing Yang, Liunan Suo, Ke Wu, Zhiyao Ma, Haiyan Zhang, Jianzhao Duan, Wei Feng

“…Existing vegetation index (VI)-based maize AGB estimation methods using unmanned aerial platforms show limited generalizability due to insufficient integration of environmental and management factors. …”
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Efficacy of acupuncture as adjunctive therapy for patients with acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis by Guofeng Li, Jimin Liu, Guixian Yang, Jiajia Li, Yuan He, Xinru Fei, Lai Wei, Dongkai Zhao

“…The primary outcome was the effective rate, while secondary outcomes included lung function (FEV1%, FEV1/FVC%, FEV1), arterial blood gas analysis (PaO2, PaCO2, SaO2), the 6-min walk test (6MWT), COPD Assessment Test (CAT), modified Medical Research Council (mMRC) scale, and success rate of weaning. …”
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Clinical application value of intracavitary PRP infusion combined with IVF-FET in patients with chronic endometritis by ZHANG Xiaotong, HAO Xiaoyuan, FANG Rui, HU Shuyao, MA Linkun, ZHAO Yaqi, HAN Wei

“…[Objective] To evaluate the clinical application value of intrauterine perfusion with platelet-rich plasma (PRP) combined with in vitro fertilization-frozen-thawed embryo transfer (IVF-FET) in patients with chronic endometritis (CE). [Methods] A randomized controlled trial (RCT) was conducted, enrolling 60 CE patients undergoing artificial cycle frozen embryo transfer at our hospital from January 2022 to January 2024. …”
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Antibiotic stewardship in hematological patients with Escherichia coli and Klebsiella pneumoniae bloodstream infections: evaluating short-course and carbapenem-sparing strategies by Yuqing Cui, Xiaomeng Feng, Ling Pan, Qingsong Lin, Jieru Wang, Sisi Zhen, Yuping Fan, Xin Chen, Yizhou Zheng, Yingchang Mi, Fengkui Zhang, Xiaofan Zhu, Zhijian Xiao, Erlie Jiang, Mingzhe Han, Jianxiang Wang, Sizhou Feng

“…Among 1,105 patients in the antibiotic duration cohort, 48.96% (n = 541) received short-course therapy (median: 8 days, IQR: 7–9), while others received prolonged-course therapy (median: 14 days, IQR: 12–17). …”
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Growth factor independence 1 ameliorates osteoarthritis by inhibiting chondrocyte ferroptosis via inactivation of MAPK signaling pathway by Xiaoyu Jin, Xunhao Wang, Siyu Xu, Nuo Xu, Ziwei Wang, Chunqing Hu, Wei Liu, Zhaofeng Zhang, Xiyu Liu, Jingjing Fan, Ruiyang Jiang, Rui Wu, Zhongyang Lv, Dongquan Shi

“…Results: The expression of Gfi1 was significantly decreased, while 4-HNE, a typical lipid peroxidation product, was significantly increased both in damaged human and DMM surgery-induced mice OA cartilages. …”
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SBRT for bridging and downstaging HCC before transplant by Zhihao Li, Michael Yan, Marco P.A.W. Claasen, Luckshi Rajendran, Christian T.J. Magyar, Saheli Saha, Cameron Lee, Nazia Selzner, Elmar Jaeckel, Anand Ghanekar, Mark Cattral, Blayne A. Sayed, Markus Selzner, Ian McGilvray, Chaya Shwaartz, Trevor Reichman, Grainne M. O’Kane, Arndt Vogel, Robert C. Grant, Tae Kyoung Kim, Catherine Soo-Yee Naidoo, Ali Hosni, Rebecca Wong, Aruz Mesci, Jelena Lukovic, Aisling Barry, John Kim, Laura A. Dawson, Gonzalo Sapisochin

“…These findings are important for optimizing treatment strategies and providing patients with additional therapeutic options while awaiting transplantation. …”
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Application of a high-resolution melt assay for monitoring SARS-CoV-2 variants in Burkina Faso and Kenya by Caitlin Greenland-Bews, Sonal Shah, Morine Achieng, Emilie S. Badoum, Yaya Bah, Hellen C. Barsosio, Helena Brazal-Monzó, Jennifer Canizales, Anna Drabko, Alice J. Fraser, Luke Hannan, Sheikh Jarju, Jean-Moise Kaboré, Mariama A. Kujabi, Cristina Leggio, Maia Lesosky, Jarra Manneh, Tegwen Marlais, Julian Matthewman, Issa Nebié, Eric Onyango, Alphonse Ouedraogo, Kephas Otieno, Samuel S. Serme, Sodiomon Sirima, Ben Soulama, Brian Tangara, Alfred Tiono, William Wu, Emily R. Adams, Abdul Karim Sesay, Chris Drakeley, Feiko O. ter Kuile, Issiaka Soulama, Simon Kariuki, David J. Allen, Thomas Edwards

“…We show through comparison to sequencing that our assay can generate highly similar data on the different variants circulating in a population, therefore showing the effectiveness of our tool. While not a replacement for sequencing, we present a method of screening and prioritizing samples for further investigation and reduce overburdening sequencing capacity. …”
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Multicentre comparison of various microaxial pump devices as a bridge to durable assist device implantation by Marta L. Medina, Daniel Lewin, Hendrik Treede, Sebastian V. Rojas, Alexander Bernhardt, Michael Billion, Anna L. Meyer, Ivan Netuka, Janajade Kooij, Marina Pieri, Antonio Loforte, Mauro Rinaldi, Mariusz K. Szymanski, Adriaan O. Kraajieveld, Christian J.H. Moeller, Payam Akhyari, Khalil Jawad, Bastian Schmack, Gloria Färber, Assad Haneya, Daniel Zimpfer, Gaik Nersesian, Ilija Djordjevic, Diyar Saeed, Finn Gustafsson, Anna M. Scandroglio, Bart Meyns, Steffen Hofmann, Jan Belohlavek, Jan Gummert, Pia Lanmueller, Evgenij V. Potapov, Mehmet Oezkur

“…Methods and results A retrospective analysis was conducted across 19 high‐volume European centres. …”
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Experimental Study on Axial Compression Behaviour of Ultra-high-performance Concrete-filled Duplex Stainless Steel Tube Stub Rectangular Columns by TANG Hongyuan, WANG Huixiang, LIU Ye

“…The utilization of UHPC significantly improves the ultimate bearing capacity of stub columns while simultaneously satisfying the ductility requirement. …”
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Mechanism of exogenous methyl jasmonate mediated AsA-GSH cycle in Summer Black grape against low temperature stress by ZHANG Shaowei, ZHU Qianyan, ZHAO Xiaogai, ZHOU Bing, LI Peng, LI Guirong

“…[Conclusion] This study clarified the regulation effect of MeJA on AsA-GSH cycle of the Summer Black grape under low temperature stress, and screened out the optimal treatment concentration, which would provide theoretical basis and technical support for cold resistant cultivation of grape.…”
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DRG付费方式和临床路径管理对脑梗死患者住院费用影响的联合作用分析 Analysis of the Combined Effect of DRG Payment and Clinical Pathway Management on the Hospitalization Cost of Patients with Cerebral Infarction... by 王玲玲1，王晓楠1，王真明1，周道平2，张现格3，王文君1 (WANG Lingling1, WANG Xiaonan1, WANG Zhenming1, ZHOU Daoping2, ZHANG Xian’ge3, WANG Wenjun1 )

“…The DRG payment needs to be deeply integrated with clinical pathway management, and the balance point of the cost should be found according to the quality of different disease groups, which can serve as a benchmark for adjusting and optimizing the clinical pathway.…”
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