A Novel Hypoxia-Related Gene Signature with Strong Predicting Ability in Non-Small-Cell Lung Cancer Identified by Comprehensive Profiling by Huajun Yang, Zhongan Wang, Ling Gong, Guichuan Huang, Daigang Chen, Xiaoping Li, Fei Du, Jiang Lin, Xueyi Yang

“…This study is aimed at identifying whether circRNAs could be used as the diagnostic biomarkers for NSCLC. Methods. The heterogeneity of samples in this study was assessed by principal component analysis (PCA). …”
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Sex differences in toxicity and outcomes in patients with sarcoma treated in the perioperative setting at a comprehensive cancer center by Ilaria Tortorelli, Ilaria Tortorelli, Benedetta Chiusole, Fabio Murtas, Fabio Murtas, Antonella Galiano, Maital Bolshinsky, Selma Ahcene-Djaballah, Chiara De Toni, Salvatore Vizzaccaro, Marco Maruzzo, Umberto Basso, Alberto Banzato, Marina Coppola, Sara Lonardi, Vittorina Zagonel, Antonella Brunello

“…Future studies should aim to better optimize drug dosing according to the sex, with the ultimate goal of increasing therapeutic benefit while limiting toxicity.…”
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Understanding the Interface Characteristics Between TiB₂(0001) and L1₂-Al₃Zr(001): A First-Principles Investigation by Xingzhi Pang, Loujiang Yang, Hang Nong, Mingjun Pang, Gaobao Wang, Jian Li, Zhenchao Chen, Wei Zeng, Zhihang Xiao, Zengxiang Yang, Hongqun Tang

“…This study employs first-principles calculation methods to explore the characteristics of the TiB₂(0001)/L1₂-Al₃Zr(001) interface, including the atomic structure, adhesion work, interfacial energy, and electronic structure of various interface models. …”
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Impact of Metastasectomy on Survival Outcomes in Colorectal Cancer: A Single Center Retrospective Study by Oğuzcan Kınıkoğlu, Yunus Emre Altıntaş, Goncagül Akdağ, Sedat Yıldırım, Hacer Şahika Yıldız, Akif Doğan, Uğur Özkerim, Sıla Öksüz, Alper Topal, Deniz Işık, Tuğba Başoğlu, Heves Sürmeli, Seval Ay, Hatice Odabaş, Nedim Turan

“…R0 resections were associated with improved OS (median: 69.6 months), while non-R0 resections had poorer outcomes. Synchronous metastases were linked to shorter OS than metachronous metastases, although the difference was not statistically significant (p=0.09). …”
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Standardization of epistemic trust/mistrust/credulity questionnaire: Examining validity and reliability among adolescents Standardization of ETMCQ among adolescents by Raziyeh Hashemi, Mehdi Reza Sarafraz, Habib Hadian Fard, Mohammad Reza Taghavi

“…Participants were selected through snowball sampling method. The questionnaire link was sent to 310 students via mobile phone. …”
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Effects of different Si content and Sr addition on microstructure characteristics and mechanical properties of cast Al-Si-Cu-Mg-Mn alloys by Xinxin Ma, Jiaqi Pei, Yanpeng Pan, Liwen Chen, Jinzhong Tian, Hua Hou, Jibo Hou, Yuhong Zhao

“…When the Si content reaches 7 wt%, the degree of solute polarization is the largest, while as the Si content continues to be increased, the degree of solute polarization is decreased instead. …”
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Optical properties of Gd3+ doped bismuth silicate crystals based on first principles by Yan Huang, Xuefeng Xiao, Yan Zhang, Jiashun Si, Shuaijie Liang, Qingyan Xu, Huan Zhang, Lingling Ma, Cui Yang, Xuefeng Zhang, Jiayue Xu, Tian Tian, Hui Shen

“…In order to further improve its performance, this study adopts a first principles calculation method based on density functional theory (DFT), selects Gd3+ as the dopant, and calculates and explores the changes in optical properties of BSO crystals after doping with 1/12, 1/6, and 1/3Gd3+. …”
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Calcium and silicon nanofertilizers improved morphological attributes and fatty acid composition in olive; an insight to synergistic interaction between these elements by Javad Erfani-Moghadam, Abdolkarim Zarei

“…The utilization of nano-fertilizers for targeted and controlled nutrient release represents a promising strategy to advance sustainable agricultural practices while minimizing environmental impact. Method The effects of foliar application of Ca and Si nanoparticles were investigated on the morphological attributes and fatty acid composition of olive tree cultivar ‘Zard’. …”
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Coal gangue image recognition model based on improved U−Net and top coal caving control by Yong YUAN, Zhenghan QIN, Yongqi XIA, Rang WU, Libao LI, Yong LI

“…The results substantiate that the FPN−ASPP−U−Net model delivers superior performance in coal gangue image segmentation, while also maintaining the lowest overall computational parameter count. …”
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Crash Performance of Additively Manufactured Tapered Tube Crash Boxes: Influence of Material and Geometric Parameters by Ahmed Saber, Mehmet Ali Güler, Erdem Acar, Omar Soliman ElSayed, Hussain Aldallal, Abdulrahman Alsadi, Yousef Aldousari

“…Additive manufacturing (AM), particularly Fused Deposition Modeling (FDM), has emerged as a promising method for their fabrication due to its design flexibility and continuous advancements in material development. …”
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Multiplex engineering using microRNA-mediated gene silencing in CAR T cells by Giulia Golinelli, Giulia Golinelli, John Scholler, Audrey Roussel-Gervais, Antonija Šakić, Sten Ilmjärv, Decheng Song, Khatuna Gabunia, Mei Ji, Ting J. Fan, Aasha Gupta, Mansi Deshmukh, Abdulla Berjis, Abdulla Berjis, Riccardo Cuoghi Costantini, Kimberly Apodaca, Neil C. Sheppard, Sven Kili, Massimo Dominici, Marco Alessandrini, Carl H. June, Carl H. June, Carl H. June, Bruce L. Levine

“…Targeted microRNAs (miRNAs) may provide a safer, functional, and tunable alternative for gene silencing without the need for DNA editing.MethodsAs a proof of concept for multiplex gene silencing, we employed an optimized miRNA backbone and gene architecture to silence T-cell receptor (TCR) and major histocompatibility complex class I (MHC-I) in mesothelin-directed CAR (M5CAR) T cells. …”
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Introduction of ultrasound-guided axillary vein approach for central venous catheterization in severely injured trauma patients: characteristics and concerns by Ruonan Gu, Ruonan Gu, Ruonan Gu, Ruonan Gu, Shanxiang Xu, Shanxiang Xu, Shanxiang Xu, Shanxiang Xu, Shouyin Jiang, Shouyin Jiang, Shouyin Jiang, Shouyin Jiang, Xiao Lu, Xiao Lu, Xiao Lu, Xiao Lu, Haizhen Wang, Haizhen Wang, Haizhen Wang, Haizhen Wang, Xiaogang Zhao, Xiaogang Zhao, Xiaogang Zhao, Xiaogang Zhao

“…This study aimed to characterize UAVC practices in a trauma intensive care unit (TICU) at a tertiary teaching hospital, specifically investigating optimal catheter positioning, procedure-related complications, and risk factors associated with catheter inaccurate placement and venous thromboembolism (VTE) development.MethodsA retrospective analysis was performed on trauma patients who underwent UAVC between October 2021 and April 2023. …”
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Characterizing anticoagulation reversal practices in Colombia: Initial insights from a national registry by Sebastián Seni-Molina, Santiago Posso Marín, Juan Esteban Masmela, María Camila Naranjo-Ramírez, Arturo D. Mora, Juliana María Gutiérrez-Posso, Julio Diez-Sepúlveda, Juan David Victoria-Salcedo, Ana Cristina Montenegro Arenas, Camilo Andrés Rueda Ortiz, Edgar David Gómez Lahitton, Hoover O. León-Giraldo, Juan Esteban Gómez-Mesa

“…Bleeding was the primary indication for reversal (92.4%), while surgical needs accounted for 7.6% of cases. …”
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Tranexamic acid in total hip arthroplasty: Nationwide evidence for reducing blood transfusions and post-operative complications by Hidetatsu Tanaka, Kunio Tarasawa, Yu Mori, Kazuyoshi Baba, Ryuichi Kanabuchi, Yasuaki Kuriyama, Hiroaki Kurishima, Hideki Fukuchi, Hiroki Kawamata, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

“…Future studies should clarify optimal dosing strategies tailored to Japanese populations.…”
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Effect of doped elements X (B, Al, Sn, Co) on binding performance of IDB-X/Diamond interface by Xiaogang JIAN, Wenshan YAO, Yi ZHANG, Xiaowei LIANG, Jibo HU, Zhe CHEN, Maolin CHEN

“…It provides a theoretical reference and basis for further optimizing the formulation of drill bit substrates and improving the interfacial bonding strength between the film and substrate.MethodsThis article uses the CASTEP module of the quantum mechanics computing software Materials Studio to study the influence mechanism of X (X = B, Al, Sn, Co) elements commonly used in IDB on the interfacial bonding performance of CVD diamond coatings on IDB from a microscopic perspective. …”
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Enhancing Typhoon Doksuri (2023) Forecasts via Radar Data Assimilation: Evaluation of Momentum Control Variable Schemes with Background-Dependent Hydrometeor Retrieval in WRF-3DVAR by Xinyi Wang, Feifei Shen, Shen Wan, Jing Liu, Haiyan Fei, Changliang Shao, Song Yuan, Jiajun Chen, Xiaolin Yuan

“…These findings highlight the importance of optimizing control variables and assimilation methods to enhance the prediction of TCs.…”
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Scopus-based bibliometric analysis of research trends in silage feed and its impact on rumen fermentation in ruminants by Tri Rachmanto Prihambodo, Randi Mulianda, Wulandari Wulandari, Santika Anggrahini, Novia Qomariyah, Andi Ella, Erna Winarti, Yenni Yusriani, Suyatno Suyatno, Jhon Firison, Deni Fitra, Anwar Efendi Harahap, Dinda Ayu Permata Sari, Taufik Hidayat, Anuraga Jayanegara

“…Collaboration network analysis revealed strong regional clusters, with North America and Europe forming central hubs, while Asia and South America showed growing but less integrated networks. …”
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Does Levosimendan hasten veno-arterial ECMO weaning? A propensity score matching analysis by Nicolas Paulo, Antoine Kimmoun, David Hajage, Pierre Hubert, David Levy, Marc Pineton de Chambrun, Juliette Chommeloux, Ouriel Saura, Grégoire Del Marmol, Quentin Moyon, Guillaume Hékimian, Melchior Gautier, Charles Edouard Luyt, Guillaume Lebreton, Bruno Levy, Alain Combes, Matthieu Schmidt

“…Patients receiving levosimendan while on VA-ECMO were matched to those not receiving levosimendan during the same period, based on pre-specified variables and time from ECMO initiation. …”
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Medical care costs of cancer in the last year of life using national health insurance data in Korea. by Mihai Park, Inmyung Song

“…Efforts are needed to optimize EOL care for cancer patients.…”
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An artificial intelligence platform for predicting postoperative complications in metastatic spinal surgery: development and validation study by Weihao Jiang, Juan Zhang, Weiqing Shi, Xuyong Cao, Xiongwei Zhao, Bin Zhang, Haikuan Yu, Shengjie Wang, Yong Qin, Mingxing Lei, Yuncen Cao, Boyu Zhu, Yaosheng Liu

“…Abstract Background Metastatic spinal disease often leads to significant morbidity, and accurate prediction of postoperative outcomes can help optimize patient management and resource allocation. …”
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