A secure end-to-end communication framework for cooperative IoT networks using hybrid blockchain system by Suresh Babu Erukala, Dimitar Tokmakov, Anoosha Perumalla, Rajesh Kaluri, Anna Bekyarova-Tokmakova, Nevena Mileva, Slavi Lubomirov

“…Hence, the proposed framework improves over existing approaches regarding linear computing complexity, increased cryptographic methods, and a more efficient consensus process.…”
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Is the Existing Measles Vaccination Schedule in the Russian Federation Effective? by O. V. Tsvirkun, A. G. Gerasimova, N. V. Turaeva, N. T. Tikhonova, A. A. Melnikova, A. A. Vatolina

“…Children aged 6-11 months were more likely to get sick, accounting for an average of 75.98%, while the proportion of children with measles in the first five months averaged 24.02%. …”
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Design, synthesis, and anti-inflammatory potential of PROTAC drug molecules based on fondaparinux sodium by Ruoxuan Wu, Ruoxuan Wu, Ruoxuan Wu, Ruoxuan Wu, Tianji Zhang, Tianji Zhang, Siran Zhao, Siran Zhao, Marco Maccarana, Jin-Ping Li, Jin-Ping Li, Chao Li, Chao Li, Chao Li, Chao Li, Hui Cao, Hui Cao, Hui Cao, Hui Cao

“…IntroductionIn this study, we used an approach by conjugating Fondaparinux Sodium (FS) with selected drugs to generate proteolysis-targeting chimeras (PROTACs).MethodsBy applying bioprocess engineering principles, the direct amidation reaction was optimized –through precise control of pH, substrate ratios, and solvent selection –to reliably produce high‐purity (>99%) PROTAC molecules on a scalable platform. …”
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Effect of Bacillus Calmette-Guérin vaccination against Mycobacterium tuberculosis infection in children: an updated systematic review and meta-analysis by Shunli Cai, Qingyi Luo, Guozhong Zhou, Xin Guo, Yan Dong, Hongbo Chen, Shiqi Luo, Jian He, Yuan Xia, Hanse Li, Yingchen Zhou, Chao Song

“…Objectives: To update the understanding of the effectiveness of the Bacillus Calmette-Guérin (BCG) vaccine in preventing tuberculosis (TB) infection in children. Methods: PubMed, Web of Science, Cochrane, and Embase were searched from their inception to January 12, 2025. …”
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Quantification of rehabilitation for patients with Parkinson’s disease and related disorders using wearable devices; a proof of concept by Hikaru Kamo, Hikaru Kamo, Genko Oyama, Genko Oyama, Genko Oyama, Genko Oyama, Genko Oyama, Genko Oyama, Koichi Nagaki, Koichi Nagaki, Koichi Nagaki, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori

“…Therefore, this study aimed to quantify rehabilitation interventions and identify optimal approaches based on patient characteristics.MethodsParticipants diagnosed with PD or related disorders and residing in an elderly care facility received various rehabilitation therapies—including water stimulation bed, therapeutic massage, sit-to-stand training, gait training, cycle ergometer training, aerobic training using treadmill, stretching, balance training, calisthenics, and resistance training—while wearing a wearable device between April and May 2022. …”
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Integrated neural network framework for multi-object detection and recognition using UAV imagery by Mohammed Alshehri, Tingting Xue, Tingting Xue, Ghulam Mujtaba, Yahya AlQahtani, Nouf Abdullah Almujally, Ahmad Jalal, Ahmad Jalal, Hui Liu, Hui Liu, Hui Liu

“…Deep SORT is employed for efficient vehicle tracking, while CSRNet facilitates high-density vehicle counting. …”
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An Empirical Analysis of Herding Behavior in the Stock Market: Evidence from Various Economic and Social Conditions in Iran by Majid Aghaei

“…However, after experiencing intense currency fluctuations, while some indications of herding behavior persisted, they were not statistically significant. …”
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Integrating community perspectives to improve survey completion rates in public health research by refining controversial survey elements by Arleth A. Escoto, Angel Lomeli, Maria Linda Burola, Breanna Reyes, Ana Perez-Portillo, Scarlet Flores, Kayleigh Kornher, Norma Porras, Ariel Cohen, Linda Salgin, Borsika A. Rabin, Louise C. Laurent, Marva Seifert, Nicole A. Stadnick

“…Results: Of the 94 CDEs evaluated in the CIs, 20 (21.3%) were flagged by one or more interviewees. Nine (9.6%) English while fourteen (14.9%) Spanish CDEs were flagged by interviewees, with some overlap. …”
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From virtual to reality: application of a novel 3D printing hollow model for early-stage lung cancer in the clinical teaching of thoracoscopic sublobar resection by Di Yang, Di Yang, Yafei Miao, Yafei Miao, Linqian Li, Linqian Li, Linqian Li, Qing Yu, Qing Yu, Qiang Guo, Hefei Li, Xuguang Zhang, Shujie Cheng, Shujie Cheng, Jinghua Li, Jinghua Li, Ke Zhang, Ke Zhang, Ke Zhang, Ke Zhang

“…This study evaluates the educational efficacy of a 3DP lung cancer model optimized for surgery in teaching thoracoscopic sublobar resection.MethodsA total of 62 clinical interns were randomly assigned into two groups: a 3D visualization (3DV) model group and a 3DP model group. …”
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Robustness of Machine Learning Predictions for Determining Whether Deep Inspiration Breath-Hold Is Required in Breast Cancer Radiation Therapy by Wlla E. Al-Hammad, Masahiro Kuroda, Ghaida Al Jamal, Mamiko Fujikura, Ryo Kamizaki, Kazuhiro Kuroda, Suzuka Yoshida, Yoshihide Nakamura, Masataka Oita, Yoshinori Tanabe, Kohei Sugimoto, Irfan Sugianto, Majd Barham, Nouha Tekiki, Miki Hisatomi, Junichi Asaumi

“…<b>Results</b>: Our findings indicate that the decision tree (DT) model demonstrated consistently high robustness at 240 and 270 cGy, while the random forest model performed optimally at 300 cGy. …”
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Balancing accuracy and user satisfaction: the role of prompt engineering in AI-driven healthcare solutions by Mini Han Wang, Mini Han Wang, Mini Han Wang, Mini Han Wang, Mini Han Wang, Xudong Jiang, Xudong Jiang, Xudong Jiang, Xudong Jiang, Peijin Zeng, Peijin Zeng, Peijin Zeng, Xinyue Li, Kelvin Kam-Lung Chong, Guanghui Hou, Xiaoxiao Fang, Yang Yu, Xiangrong Yu, Junbin Fang, Yi Pan

“…These findings indicate a trade-off between accuracy and user satisfaction.DiscussionThe study highlights the critical role of prompt engineering in improving AI-based healthcare services. While enhanced accuracy is achievable, careful attention must be given to balancing response time and user satisfaction. …”
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Novel Approach to Proficiency Testing Reveals Significant Variations in Biomarker Practice Leading to Critical Differences in Lung Cancer Management by Kassandra R. Bisson, MHSc, Andrea Beharry, MLT, Normand Blais, MD, Michael D. Carter, MD, PhD, Parneet K. Cheema, MD, Patrice Desmeules, MD, John G. Garratt, RT, Barbara Melosky, MD, Bryan Lo, PhD, Stephanie Snow, MD, Basile Tessier-Cloutier, MD, Edwin Tio, MD, Stephen Yip, MD, PhD, Jennifer R. Won, PhD, Brandon S. Sheffield, MD

“…This study reports the results of the first end-to-end biomarker EQA challenge in NSCLC. Methods: Three challenge specimens were made using NSCLC tissue and paired with clinical vignettes mimicking referred-in cases. …”
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Stereotactic Radiation Therapy for the Treatment of Glandular Metastases From Renal Cell Carcinoma by Mihailo Miljanic, MD, Tidie Song, BS, Alana Christie, MS, Allen Yen, MD, Young Suk Kwon, MD, MPH, Aurelie Garant, MD, Todd A. Aguilera, MD, PhD, Zabihullah Wardak, MD, Hans Hammers, MD, Kevin Courtney, MD, PhD, Suzanne Cole, MD, James Brugarolas, MD, PhD, Robert Timmerman, MD, Raquibul Hannan, MD, PhD

“…Purpose: The optimal management strategies for glandular metastases in patients with metastatic renal cell carcinoma (mRCC) are currently unknown. …”
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Long-Term Outcomes of Patients Undergoing Conversion Surgery After Induction Chemotherapy: Turkish Oncology Group Study by Furkan Ceylan, Selin Aktürk Esen, Olçun Ümit Ünal, Ferit Aslan, İlknur Deliktaş Onur, Öztürk Ateş, Erkut Demirciler, İlkay Tuğba Ünek, Ahmet Gülmez, Esra Özen Engin, Semra Taş, Gamze Gököz Doğu, Melih Şimşek, Hacı Mehmet Türk, Ali İnal, Gökhan Şahin, Haydar Çağatay Yüksel, Ateş Kutay Tenekeci, Mutlu Hızal, Mehmet Ali Nahit Şendur, Doğan Uncu

“…Factors associated with shorter PFS included advanced tumor stage (ypT3-T4), lymph node metastasis, and multiple metastases, while shorter OS was linked to advanced tumor stage and lack of objective response. …”
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Insights from metagenomics on microbial biosynthesis of vitamins B and K2 in chicken gut microbiota by Hai-Long Yu, Hai-Long Yu, Xin-Wen Hou, Ji-Xin Zhao, Guo-Hua Liu, Jin-Xin Meng, Jin-Xin Meng, Yong-Jie Wei, Yanan Cai, Jian Liu, Kai-Meng Shang, Hong-Bo Ni, Rui Liu, He Ma, Fu-Long Nan, Xiao-Xuan Zhang, Bei-Ni Chen, Xing Yang

“…Genomic analysis revealed that a mere 8.2% of genomes were capable of producing five or more vitamins, while almost half were limited to synthesizing just one. …”
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Retrospective Review of Children Hospitalized for Epstein–Barr Virus-Related Infectious Mononucleosis by Shufeng Tian, Jinjun Zheng, Zhe Zhou, Qingluan Yang, Biao Sun, Yuxi Li, Zengrui Lin, Yuchun Long, Song Guan, Sen Wang, Jiexin Zhuang, Wenhong Zhang, Lingyun Shao, Jikui Deng

“…Objectives: Our objective was to investigate the clinical characteristics, complications, and treatment outcomes of Epstein–Barr virus (EBV)-related infectious mononucleosis (IM) in children and to identify risk factors associated with prolonged fever and abnormal liver function. Methods: This retrospective study included 3006 children admitted to Shenzhen Children’s Hospital from May 2009 to April 2024 with suspected EBV-related IM. …”
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From colorless to pink: Structural insights into vitamin B12-induced color change in monoclonal antibodies by Kai-feng He, Hao-dong Cui, Wen-hui Deng, Na Xing, Guo-jian Liu, Abdallah Iddy Chaurembo, Li-dan Fu, Yuan Li, Xin-yue Tong, Han-bin Lin, Chun-he Wang

“…Peptide analysis revealed distinct UV absorption at 360 nm for SP2, while SDS-PAGE indicated slight molecular weight differences. …”
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Two sides of the same coin: recruitment performance and perceived workload in primary care trials-insights from the AgeWell.de study by Linda Sanftenberg, Robert Philipp Kosilek, Lorenz Birnberger, Hannah Schillok, Felix Wittmann, Melanie Luppa, Anne Blawert, Melanie Boekholt, Christian Brettschneider, Hans-Helmut König, Alexander Bauer, Solveig Weise, Thomas Frese, Hanna Kaduszkiewicz, Juliane Döhring, Catharina Escales, Jochen René Thyrian, Birgitt Wiese, Steffi G. Riedel-Heller, Jochen Gensichen

“…The top 20% of recruiters (Q5) accounted for 42.1% of all participants, while the lowest quintile (Q1) recruited just 3.2%. …”
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External Validation of 3 Prediction Models for Mortality in Out‐of‐Hospital Cardiac Arrest Survivors: A Retrospective Multicenter Study by Chun‐Hsiang Huang, Edward Pei‐Chuan Huang, Cheng‐Yi Fan, Yi‐Chien Kuo, Chien‐Tai Huang, Ching‐Yu Chen, Chi‐Hsin Chen, Yi‐Ju Ho, Chun‐Ju Lien, Yun‐Chang Chen, Sih‐Shiang Huang, Tzu‐Hsueh Wang, Wen‐Chu Chiang, Wei‐Tien Chang, Chien‐Hua Huang, Chih‐Wei Sung

“…While CASS and FACTOR demonstrated similar sensitivity, specificity, and negative predictive value, mSARICA exhibited significantly higher sensitivity, lower specificity, and higher negative predictive value. …”
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Dissecting the genetic architecture of yield-related traits by QTL mapping in maize by Hao Zhang, Hao Zhang, Ting Li, Zhenyu Zhang, Jie Wang, Haoxiang Yang, Jiachen Liu, Wanchao Zhu, Wanchao Zhu, Jiquan Xue, Jiquan Xue, Shutu Xu, Shutu Xu

“…IntroductionMaize is a cornerstone of global agriculture, essential for ensuring food security, driving economic development, and meeting growing food demands. Yet, how to achieve optimal yield remains a multifaceted challenge influenced by biotic, environmental, and genetic factors whose comprehensive understanding is still evolving.MethodsQTL mapping of eight essential yield traits was conducted across four environments — Sanya (SY) in 2021, and Yangling (YaL), Yulin (YuL), and Weinan (WN) in 2022 — using two types of populations: a KA105/KB024 recombinant inbred line (RIL) population and two immortalized backcross populations (IB1 and IB2) derived from the RILs by crossing with their respective parents. …”
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