Cutoff levels for newborn screening of 21-OH deficiency in a Brazilian metropolitan area by Kallianna Paula Duarte Gameleira, Juliana de Vasconcellos Thomas, Vitor Guilherme Brito de Araújo, Cláudia Vicari Bolognani, Sérgio Eduardo Soares Fernandes, Fábio Ferreira Amorim

“…Conclusion: The proposed 17OHP cutoff strategy effectively reduced false positives, improving specificity, LR+, PPV, and accuracy Thus, it optimized CAHNBS programs while minimizing unnecessary costs and parental distress.…”
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The heterogeneity of mortality burden of lower respiratory infection associated with ambient temperature and its drivers in China by Sujuan Chen, Jinlei Qi, Yulin Zhuo, Jianxiong Hu, Jiangmei Liu, Peng Yin, Tao Liu, Mengen Guo, Guanhao He, Ziqiang Lin, Fengrui Jing, Jinling You, Wenjun Ma, Maigeng Zhou

“…Abstract：: Ambient temperature is linked to an increased risk of lower respiratory infections (LRI) yet the evidence on the population and spatial heterogeneity of LRI mortality burden attributed to non-optimal temperatures and its socioeconomic drivers remain limited. …”
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Effects of albumin and weight-standardized hand grip strength on survival for cancer patients with frailty by Xiao-Man Xiong, Chu-Ying Zhang, Hong-Xia Xu, Ge-Ge Zhang, Saba Fida, Jiu-Wei Cui, Wei Li, Min Weng, Kun-Hua Wang, Fu-Xiang Zhou, Jun-Qiang Chen, Xiang-Hua Wu, Han-Ping Shi, Yan-Li Zhang, Chun-Hua Song

“…Objective:. While albumin and the weight-standardized hand grip strength (HGS/W) serve as valuable prognostic indicators for cancer patients, their correlation with the prognosis in frail cancer patients remains inadequately explored. …”
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Neoadjuvant chemoimmunotherapy versus neoadjuvant chemoradiotherapy in patients with borderline resectable esophageal squamous cell carcinoma by Jun-Peng Lin, Feng-Nian Zhuang, Wei-Jie Chen, Zhou Lin, Yu-Jie Chen, Xiao-Feng Chen, Hui Lin, Hao He, Peiyuan Wang, Hang Zhou, Wen-Wei Wei, Peng-Qiang Gao, Shuo-Yan Liu, Feng Wang

“…Abstract Background The optimal treatment strategy for patients with borderline resectable (cT3br) esophageal squamous cell carcinoma (ESCC) remains unclear. …”
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Multi-omics characterization of diabetic nephropathy in the db/db mouse model of type 2 diabetes by Liping Wang, Ran Zhou, Guanghui Li, Xiaodan Zhang, Yan Li, Yinchen Shen, Junwei Fang

“…Methods: Renal tissues from db/db mice underwent integrative multi-omics analysis, encompassing transcriptomics, metabolomics, and lipidomics. …”
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Dual targeting of BCMA and SLAMF7 with the CARtein system: chimeric antigen receptors with intein-mediated splicing elicit specific T cell activation against multiple myeloma by Noelia Moares, Noelia Moares, Pablo Gonzalez-Garcia, Pablo Gonzalez-Garcia, Wenjie Yi-He, Wenjie Yi-He, Juan P. Muñoz-Miranda, Juan P. Muñoz-Miranda, Antonio Gabucio, Antonio Gabucio, Rosa Luna-Espejo, Javier Ocaña-Cuesta, Ricardo Fernandez-Cisnal, Cecilia M. Fernandez-Ponce, Cecilia M. Fernandez-Ponce, Francisco Garcia-Cozar, Francisco Garcia-Cozar

“…The design of the intein-spliced CAR system (termed "CARtein") was further optimized through advanced protein structure prediction software.ResultsCells expressing the spliced CARtein constructs, engineered to target BCMA, SLAMF7, or both antigens simultaneously, demonstrated robust and highly specific activation in response to their respective antigens.DiscussionThese results suggest that the CARtein platform is a promising, versatile, and highly specific approach for the modular design and engineering of CARs, enabling multi-antigen targeting while maintaining structural and functional integrity. …”
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Clinical outcomes and therapeutic modalities in older Chinese patients with MCL: a multi-center real-world retrospective study by Yuan Yang, Ping Yang, Wei Zhang, Hui Liu, Xiuhua Sun, Xiubin Xiao, Jingwen Wang, Zhenling Li, Lihong Li, Shuye Wang, Juan He, Xiaoling Li, Qingqing Cai, Weilong Zhang, Jing Wang, Chunyuan Li, Yingtong Chen, Shuozi Liu, Hongmei Jing

“…The present study was performed to identify the prognostic factors and optimal treatment modalities in older Chinese MCL patients.Methods Patients (age ≥ 65 yrs) with MCL from 19 comprehensive hospitals in China were included. …”
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Population-based colorectal cancer risk prediction using a SHAP-enhanced LightGBM model by Guinian Du, Hui Lv, Yishan Liang, Jingyue Zhang, Qiaoling Huang, Guiming Xie, Xian Wu, Hao Zeng, Lijuan Wu, Jianbo Ye, Wentan Xie, Xia Li, Yifan Sun

“…This tool shows significant potential for optimizing early diagnosis and personalized risk assessment in CRC management.…”
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Explainable machine learning for predicting distant metastases in renal cell carcinoma patients: a population-based retrospective study by Zhao Hou, Zhao Hou, Peipei Wang, Peipei Wang, Dingyang Lv, Dingyang Lv, Huiyu Zhou, Huiyu Zhou, Zhiwei Guo, Zhiwei Guo, Jinshuai Li, Jinshuai Li, Mohan Jia, Mohan Jia, Hongyang Du, Hongyang Du, Weibing Shuang, Weibing Shuang

“…Hyperparameters were optimized using grid search and tenfold cross-validation. …”
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Electroacupuncture enhances mesenchymal stem cell therapy via improved perfusion and inflammation modulation in peripheral nerve injury: an IVIM-MRI study in rats by Junfeng Li, Qiuyi Chen, Jintong Pan, Jintong Pan, Fanqi Meng, Wensheng Huang, Yingying Liang, Xuewen Yu, Ruirui Qi, Peiyin Luo, Haodong Qin, Yueyao Chen, Xiaofeng Lin

“…By employing intravoxel incoherent motion (IVIM) MRI, the study monitored perfusion and explored how EA improves the regenerative environment to optimize stem cell transplantation outcomes.MethodsSeventy-two rats were randomly assigned to four groups: EA, EA + BMSCs, BMSCs, and PBS. …”
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Formulation of zein nanoparticles for augmenting the anti-inflammatory activity of dexketoprofen by Mahmoud A. El Hassab, Mona H. Ibrahim, Sherif S. Abdel Mageed, Abdulla M. A. Mahmoud, Zainab Sabry Othman Ahmed, Zainab Sabry Othman Ahmed, Shaimaa Mosallam, Manar Adel Abdelbari, Eman F. Khaleel, Maram A. El Hasab, Asmaa Elsayyad, Asmaa Elsayyad, Shady Allam, Shady Allam, Moaz A. Eltabeeb, Ahmed T. Negmeldin, Ahmed T. Negmeldin, Wagdy M. Eldehna, Rofida Albash

“…IntroductionTopical delivery of anti-inflammatory drugs is an important strategy for enhancing therapeutic efficacy while minimizing systemic side effects. This study focuses on improving the anti-inflammatory activity of Dexketoprofen by developing zein nanoparticles (ZNs) as a novel topical carrier system, aiming to optimize drug delivery and patient outcomes.MethodsDexketoprofen-loaded ZNs were prepared using an ethanol injection technique and optimized via a 23 full factorial design. …”
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Kinesiophobia and associated factors among patients after cardiac surgery under cardiopulmonary bypass: a cross-sectional study by Min You, Min You, Qianqian Mou, Qianqian Mou, Xiaotao Cao, Xiaotao Cao, Meng Luo, Meng Luo, Yi Song, Yi Song, Qingqing Li, Qingqing Li, Huiyun Hu, Huiyun Hu, Jianping Song

“…Healthcare providers should prioritize patients with the above risk profiles, while also establishing financial/emotional support systems, improving patient-family communication, optimizing acute pain management, implementing Enhanced Recovery After Cardiac Surgery protocols, and leveraging technology to design rehabilitation programs. …”
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Artificial intelligence in endoscopy and colonoscopy: a comprehensive bibliometric analysis of global research trends by Negin Letafatkar, Amr Ali Mohamed Abdelgawwad El-Sehrawy, KDV Prasad, KDV Prasad, Ahmad Alkhayyat, Ahmad Alkhayyat, Ahmad Alkhayyat, Ehsan Amini-Salehi, Maryam Hasanpour, Masoomeh Namdar Taleshani, Mohammad Hashemi, Hadi Alotaibi, Pegah Rashidian, Mohammad-Hossein Keivanlou, Soheil Hassanipour

“…The top contributing country was China, with 399 publications, while the United States led in centrality with a score of 0.27, indicating its key position in research collaborations. …”
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Insights into the role of MSLN-positive circulating tumor cell as an auxiliary diagnostic biomarker in epithelial ovarian cancer by Hang Xu, Min Wang, Shuting Wu, Qinke Li, Jinlong Wang, Siying Zhang, Qiongming Liu, Mengting Wang, Ruifang Li, Zhiyuan Hu, Zhiyuan Hu, Yi Liu, Zhu Yang

“…This study aimed to identify and validate novel auxiliary diagnostic markers for EOC.MethodsThrough integrated analysis of transcriptome sequencing data and single-cell RNA sequencing from public databases, we identified mesothelin (MSLN) as an EOC-specific target. …”
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High healthcare utilization and associated costs in the year prior to both primary reverse and anatomic shoulder arthroplasty: a study of 2393 patients from a private insurance dat... by Jason Corban, MD, Krishna Mandalia, BS, Darren Nin, PhD, Ya-Wen Chen, MD, MPH, Yutung Lan, MD, MPH, Ruijia Niu, MPH, David Chang, PhD, MPH, MBA, Eric Smith, MD, Kaley Beall, MPH, Sarav Shah, MD

“…This will allow payors and surgeons to critically appraise nonoperative modalities and direct their use to optimize efficacy while providing value-based care.…”
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Contingency-based flexibility mechanisms through a reinforcement learning model in adults with attention-deficit/hyperactivity disorder and obsessive-compulsive disorder by Rocío Rodríguez-Herrera, José Juan León, Pilar Fernández-Martín, Ana Sánchez-Kuhn, Miguel Soto-Ontoso, Laura Amaya-Pascasio, Patricia Martínez-Sánchez, Pilar Flores

“…Interhemispheric rsFC posterior parietal cortex could be important for optimal learning of the task.…”
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Quantification of Subsurface Hydrological Connectivity Using Wavelet Coherence Analysis by REN Ruijie, Fan Bihang, ZHANG Yaling, WANG Erqing, YANG Ruxin, HAN Xiaole, LIU Jintao, GUO Li

“…ObjectiveSubsurface hydrological connectivity governs the rainfall-runoff transformation relationship in headwater catchments and serves as a critical foundation for describing runoff generation and concentration mechanisms and simulating hillslope hydrological processes. While quantitative methods for subsurface structural connectivity have been developed, characterizing subsurface process connectivity remains a major challenge in hillslope hydrology research. …”
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Proactive Therapeutic Drug MONiToring to Guide Suppressive Antibiotic Therapy with DALBAvaNcin ( > 12 weeks) in Osteoarticular Infections (MONTALBANO) by C. Mariani, C. Mariani, M. Passerini, M. Passerini, L. Galli, L. Galli, A. Covizzi, M. Colaneri, M. Colaneri, M. Offer, M. Faenzi, S. Merli, S. Landonio, M. Fusi, M. Fusi, A. Dolci, A. Dolci, A. Gori, A. Gori, A. Gori, D. Cattaneo

“…This study evaluated the pharmacological efficacy of proactive therapeutic drug monitoring (TDM) to optimize dalbavancin administration. <strong>Methods</strong>: This single-center, retrospective study included adult OAI patients treated with <span class="inline-formula">≥4</span> doses of dalbavancin from July 2022 to October 2024. …”
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Effect of different photoperiods on growth indices of female sterlet sturgeon, Acipenser ruthenus by Bahman Meknatkhah, Masoud Sattari, Bahram Falahatkar, Samaneh Poursaeid

“…The highest specific growth rate (SGR) was observed in the 16L:8D, while the lowest was found in the constant darkness. …”
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Impact of cytomegalovirus DNAemia detected by next-generation sequencing on short-term prognosis after lung transplantation by Zhongping Xu, Yujiao Zhang, Dapeng Wang, Chenhao Xuan, Zhiyu Li, Hongyang Xu

“…Future research should determine optimal timing for preemptive antiviral strategies guided by mNGS.…”
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