Current Trends and Future Directions in Pancreatic Cancer Management: Review by Wojciech Firlej, Michał Nowak, Barbara Ufnalska, Anna Konarska, Anna Machowiak, Artur Fabijański, Mateusz Janik, Justyna Lisiecka, Joanna Rychlewska-Duda, Adriana Dukacz

“…This review underscores the importance of integrating novel therapies with conventional approaches to optimize patient outcomes. …”
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Comparison of biodegradable and metal occluders in patients with PFO and migraine: study design and rationale of BioMetal Trial by Ziping Li, Jie Dong, Jing Dong, Yiming Yan, Manchen Gao, Fang Fang, Fengwen Zhang, Wenbin Ouyang, Shouzheng Wang, Chuangshi Wang, Xiangbin Pan, BioMetal investigators

“…Abstract Background The association between migraine and patent foramen ovale (PFO) has led to investigations into percutaneous PFO closure as a potential therapeutic avenue. While existing trials with metal occluders have shown promise in reducing migraine burden, concerns over long-term complications and the impact of metal devices on migraine exacerbation have prompted the development of biodegradable alternatives. …”
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Comparative outcomes of invasive versus conservative strategy in stable coronary artery disease patients: a risk-stratification-based hypothesis-generative study by Zizhao Qi, Miaohan Qiu, Ying Xu, Kai Xu, Haiwei Liu, Xiaozeng Wang, Jing Li, Bin Liu, Shaoliang Chen, Jiyan Chen, Yaling Han, Yi Li

“…The present study sought to evaluate the impacts of initial invasive versus conservative strategy on long-term clinical outcomes for patients with SCAD stratified by risk scores. Methods This was a sub-analysis of the multicenter, observational Optimal antiPlatelet Therapy for Chinese patients with Coronary Artery Disease (OPT-CAD) study. …”
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Long-term nitrogen management strategies based on straw return improve soil carbon and nitrogen fractions and nitrogen use efficiency of maize in the Tumochuan Plain Irrigation Dis... by Wenbo Li, Wenbo Li, Jiawei Qu, Jiawei Qu, Julin Gao, Julin Gao, Xiaofang Yu, Xiaofang Yu, Daling Ma, Daling Ma, Shuping Hu, Shuping Hu, Qinggeer Borjigin, Qinggeer Borjigin, Kexin Lu

“…The main plots included deep plowing with straw return (DPR) and no straw return (RT), while subplots comprised four N application rates (0, 210, 255, and 300 kg ha-1). …”
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The application of ketamine in pain management for sports injuries and other medical conditions - literature review by Katarzyna Nowicka, Wiktor Klimek, Marta Ignatiuk-Chilkiewicz, Monika Olszanska, Dominika Hakało, Joanna Kałuska, Tomasz Suprun, Aleksandra Sokół, Klaudia Mościszko, Maria Majewska

“…The pediatric population may particularly benefit from ketamine’s rapid, intranasal administration, though dosing and safety must be carefully considered. While early findings are encouraging, more research is needed to establish optimal protocols and to explore its role in managing sport-related injuries.  …”
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Monitoring of Nutrients, Metabolites, IgG Titer, and Cell Densities in 10 L Bioreactors Using Raman Spectroscopy and PLS Regression Models by Morandise Rubini, Julien Boyer, Jordane Poulain, Anaïs Berger, Thomas Saillard, Julien Louet, Martin Soucé, Sylvie Roussel, Sylvain Arnould, Murielle Vergès, Fabien Chauchard-Rios, Igor Chourpa

“…Real-time monitoring is necessary for optimizing culture conditions and ensuring consistent product quality. …”
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Emission Characteristics of Concrete Mixer Trucks Under Real-world Operating Conditions by Xinbo SHI, Yao CHEN, Jin LI, Peixuan LI, Zihang ZHOU, Bin WANG, Xue CHEN

“…Most existing studies have primarily focused on heavy-duty freight vehicles, such as tractors, transport trucks, and dump trucks, while comparatively less attention has been given to concrete mixer trucks, which frequently operate in urban areas and pose potential threats to human health. …”
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Evaluation of diabetes mellitus medication-taking behavior among first- and second-generation Australians of Chinese heritage: A nationwide cross-sectional study by Olumuyiwa Omonaiye, Alemayehu Mekonnen, Christopher Gilfillan, Rosemary Wong, Bodil Rasmussen, Elizabeth Holmes-Truscott, Kevin Mc Namara, Elizabeth Manias, Jerry Lai, Julie Considine

“…Conclusion: Medication beliefs play a role in sub-optimal medication-taking behavior among Chinese adults with T2DM. …”
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Clinical decision support for pharmacologic management of treatment-resistant depression with augmented large language models by Roy H. Perlis, Pilar F. Verhaak, Joseph Goldberg, Cristina Cusin, Michael Ostacher, Gin S. Malhi, Carlos A. Zarate, Richard C. Shelton, Dan V. Iosifescu, Mauricio Tohen, Manish Kumar Jha, Martha Sajatovic, Michael Berk

“…A sample of community clinicians identified the optimal treatment choice for 12/91 vignettes (13.2 %, 95 % CI: 7.7–21.6 %; Cohen’s kappa = 0.10, 95 % CI 0.03–0.18), while an additional group of expert psychopharmacologists identified optimal treatment for 9/140 (6.4 %, 95 %CI: 3.4–11.8 %; Cohen’s kappa = 0.03, 95 % CI 0.01–0.08). …”
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Silver nanoparticles as next-generation antimicrobial agents: mechanisms, challenges, and innovations against multidrug-resistant bacteria by Hazim O. Khalifa, Hazim O. Khalifa, Atef Oreiby, Atef Oreiby, Temesgen Mohammed, Mohamed A. A. Abdelhamid, Mohamed A. A. Abdelhamid, Essam Nageh Sholkamy, Hamada Hashem, Ragab M. Fereig, Ragab M. Fereig

“…Despite their potent antibacterial activity, concerns regarding bacterial adaptation, cytotoxicity, and non-specific interactions have prompted extensive research into innovative delivery systems to enhance AgNP efficacy while minimizing adverse effects. This review comprehensively explores the synthesis methods and physical properties of AgNPs, emphasizing their antimicrobial mechanisms and emerging resistance patterns. …”
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A machine learning approach to identifying key predictors of Peruvian school principals' job satisfaction by Luis Alberto Holgado-Apaza, Dany Dorian Isuiza-Perez, Nelly Jacqueline Ulloa-Gallardo, Yban Vilchez-Navarro, Ruth Nataly Aragon-Navarrete, Wilian Quispe Layme, Marleny Quispe-Layme, Danger David Castellon-Apaza, Remo Choquejahua-Acero, Jaime Cesar Prieto-Luna

“…SHAP analysis revealed that economic factors primarily influenced dissatisfied principals, while interpersonal factors were more important for highly satisfied principals, suggesting a hierarchical pattern of needs. …”
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Micheliolide Alleviates Hepatic Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via the TrxR1/2-Mediated ROS/MEK/ERK Pathway by Yi Liu, Ling Yao, Yuanyuan Liu, Yunheng Yang, Ailing Liang, Honglin He, Yao Lei, Wenfu Cao, Zhiwei Chen

“…<b>Background</b>: Hepatic fibrosis is a major global health issue without an optimal drug treatment, highlighting the urgent need to find effective therapies. …”
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Machine learning predicts improvement of functional outcomes in spinal cord injury patients after inpatient rehabilitation by Mohammad Rasoolinejad, Irene Say, Peter B. Wu, Xinran Liu, Yan Zhou, Yan Zhou, Nathan Zhang, Emily R. Rosario, Daniel C. Lu, Daniel C. Lu, Daniel C. Lu

“…The ability to accurately predict functional outcomes for SCI patients is essential for optimizing rehabilitation strategies, guiding patient and family decision making, and improving patient care.MethodsWe conducted a retrospective analysis of 589 SCI patients admitted to a single acute rehabilitation facility and used the dataset to train advanced machine learning algorithms to predict patients' rehabilitation outcomes. …”
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In how many patients urodynamics should be omitted? Data from a single-centre database on the basis of the upstream trial by Eleonora Rosato, Maria Cristina Mancini, Giorgio Cerrelli, Francesco Di Rocco, Luca Orecchia, Giuseppe Farullo, Andrea Turbanti, Simone Pletto, Yuri Cavaleri, Enrico Finazzi Agrò

“…Results:: Among 212 patients analysed, 38.2% met all criteria for good surgical outcomes, while 61.8% exhibited at least one unfavourable criterion. …”
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<i>Lactobacillus rhamnosus</i> Sepsis in a Preterm Infant Following Probiotic Administration: Challenges in Diagnosis by Ilaria Farella, Maria Fortunato, Domenico Martinelli, Carmela De Carlo, Eleonora Sparapano, Stefania Stolfa, Federica Romanelli, Vittoriana De Laurentiis, Stefano Martinotti, Loredana Capozzi, Stefano Castellana, Antonio Parisi, Giuseppe Latorre

“…Probiotic administration has become common practice in neonatal intensive care units (NICUs) to prevent necrotizing enterocolitis (NEC) and promote gut health in preterm infants. While probiotics are generally considered safe, rare cases of probiotic-related sepsis have been reported. …”
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Research trends and hotspots of acupuncture for knee osteoarthritis from 2004 to 2024: a bibliometric analysis by Jun Zhou, Jun Zhou, Jun Zhou, Kuayue Zhang, Fanying Zhao, Xueyan Liu, Xueyan Liu, Jiarun Zhang, Fang Yuan, Lu Liu, Lu Liu, Lu Liu, Bin Li, Bin Li, Bin Li

“…The journal Medicine published the most papers, while Osteoarthritis and Cartilage was the most cited (470 times). …”
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Ultra-sensitive in situ detection of intracellular Mycobacterium tuberculosis with CRISPR/Cas12a by Zhiqiang Lin, Zhe Song, Hong Yu, Yang Zhou, Yang Zhou, Deliang Liu, Peize Zhang, Li Wei, Guiqin Dai, Guangyan Liang, Zhuojun He, Xiaorong Hu, Yuying Chen, Yuying Chen, Pengfei Zhao, Hongzhou Lu, Mingbin Zheng, Mingbin Zheng

“…The diagnostic performance was further validated using bronchoalveolar lavage fluid (BALF) samples from clinical participants, achieving a sensitivity of 94%, which surpassed conventional methods such as culture (67%) and Xpert (78%), while maintaining a specificity of 100%. …”
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Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studies by M. Camila Melo-Narvaez, Fee Gölitz, Eshita Jain, Janine Gote-Schniering, Mircea Gabriel Stoleriu, Wilhelm Bertrams, Bernd Schmeck, Ali Önder Yildirim, Ursula Rauen, Timo Wille, Mareike Lehmann

“…Moreover, TiProtec downregulated pathways associated with cell death, inflammation, and hypoxia while activating pathways protective against oxidative stress. …”
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Comparison of efficacy and adverse effects of CD19/20 CART versus CD19 single-target CART in R/R DLBCL: a single-center retrospective study by Bin Xue, Bin Xue, Yifan Liu, Bing Li, Yan Lu, Lili Zhou, Shiguang Ye, Huina Lu, Xiu Luo, Aibin Liang, Aibin Liang, Ping Li

“…However, a subset of patients fails to achieve optimal outcomes with CD19-targeted CAR T-cells alone. …”
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Options for postoperative radiation therapy in patients with de novo metastatic breast cancer by Chaofan Li, Yusheng Wang, Biyun Fang, Mengjie Liu, Shiyu Sun, Jingkun Qu, Shuqun Zhang, Chong Du

“…Background: Although meta-analyses have demonstrated survival benefits associated with primary tumor resection in MBC, guidelines lack consensus on the survival benefit of postoperative radiation therapy (RT). Methods: In this study, we included 1392 patients with de novo metastatic breast cancer (dnMBC) by integrating data from the SEER database (2010–2019) to systematically assess the efficacy of postoperative RT and develop a machine learning-driven prognostic tool. …”
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