Mining, validating, and quantifying circular RNA transcriptome from total RNA as a biomarker or target by Tan Ze Wang, Raj Kumar Thapa, Frank Yu, Ayesha Warsi, Kassie Rong, Pious Jose, Tahereh Kashkoulinejad-Kouhi, Phyo Wei Win, Christina A. Castellani, Tina Mele, Xiufen Zheng

“…We sought to characterize the circRNA transcriptome from RNA-seq with total RNA from septic peripheral blood mononuclear cells (PBMCs), assess/compare commonly used aligners, and optimize validation methods, considering sepsis is the leading cause of death in intensive care units (ICU) and there is no effective treatment. …”
Get full text

Combined effects of quinic acid and isochlorogenic acid B on LPS-induced inflammation and pyroptosis in MAC-T cells and mouse mammary glands by Xiang Lv, Quan Long, Yuchen Kang, Tao Lin, Tao Lin, Caode Jiang

“…This study aims to examine the inhibitory effects and mechanisms of QA and ICAB combination on lipopolysaccharide (LPS)-induced inflammation and pyroptosis in bovine mammary epithelial cells (MAC-T) and mouse mammary tissue.MethodsThe optimal concentrations of QA and ICAB for treating MAC-T cells were determined using Cell Counting Kit-8 (CCK-8). …”
Get full text

Antithrombotic Treatment After Valve-in-Valve, Valve-in-Ring, and Valve-in-MAC Procedures: A Systematic Review and Meta-Analysis by Gonçalo Terleira Batista, Gonçalo Costa, Joana Delgado Silva, Lino Gonçalves

“…Introduction: While antithrombotic therapy following transcatheter valve implantation has been extensively studied in various clinical trials, there remains a notable gap in evidence regarding the optimal approach following valve-in-valve (ViV), valve-in-ring (ViR) and valve-in-mitral annular calcification (ViMAC) procedures, warranting further assessment. …”
Get full text

Effects of acupuncture versus moxibustion on functional dyspepsia: a randomized clinical trial by Yangke Mao, Pan Zhang, Zhaoxuan He, Yuke Teng, Zilei Tian, Sha Yang, Kuan Fang, Wei Zhang, Yuting Wang, Tao Yin, Fang Zeng

“…However, the differences of acupuncture and moxibustion in FD are unclear. Methods A total of 144 eligible FD patients were enrolled and randomly assigned to either the acupuncture or moxibustion group to receive 20 treatment sessions. …”
Get full text

Compliant buffer layer achieves native-like cartilage stress in talar prosthesis: a finite element analysis study by Yaokuan Ruan, Yi Liu, Zhende Jiang, Yifan Zhong, Lu Zheng, Nan Mei, Zhihui Qian, Fei Chang

“…Abstract Background Avascular necrosis (AVN) of the talus presents considerable clinical challenges and is frequently associated with poor treatment outcomes. While 3D-printed customized talar prosthesis has shown promising potential in total talar replacement (TTR), current materials create a hard–soft mismatch with native cartilage, increasing local stress, accelerating wear, and causing complications. …”
Get full text

Machine learning-based radiomics for differentiating lung cancer subtypes in brain metastases using CE-T1WI by Xueming Xia, Wei Du, Qiheng Gou

“…Among them, 173 individuals had NSCLC with 228 BMs, while 87 patients were diagnosed with SCLC with 142 BMs. …”
Get full text

Innovative Cardiac Rehabilitation: Effects of Adaptive Postural Balance Exercise on Coronary Artery Disease and Type 2 Diabetes by Qin D, Liu G, Zhang J, Lin S, Liu X, Zhao J, Zhang Q, Ma M, Wang S

“…Specifically, we compared the efficacy of APBCRE with aerobic exercise (AE) alone and irregular exercise (IE).Patients and Methods: This randomized controlled trial included 348 patients with CAD, comprising 261 patients with T2DM and 87 non-diabetic CAD patients as a control group. …”
Get full text

Six-month intervention effect of a digital movement behavior intervention on parent- and child intermediary outcomes—results from the Let’s Grow randomized controlled trial by Johanna Sandborg, Katherine L. Downing, Liliana Orellana, Rachael W. Taylor, Lisa M. Barnett, Valerie Carson, Kylie D. Hesketh

“…The aim of this study was to investigate the effect of a digital intervention, intended to help parents promote healthy movement behaviors in toddlers on these intermediary outcomes. Methods This study utilized data from the Let’s Grow trial (n = 1165). …”
Get full text

Is the Hip Keeping the Ankle Out of Work after Total Ankle Arthroplasty? by Frank DiLiberto PT, PhD, Maxine Olson MS, Finola Summerville, Stacey Meardon PhD, PT, Anand Vora MD

“…Therefore, our purpose was to determine the energetic response of the ankle, knee, and hip during multiple functional tasks in people after TAA in comparison to healthy controls. Methods: Ten people after TAA (69.6±8.6 years, 5 female, 45.4±9.2 months post TAA) and five healthy control participants (66.8±8.3 years, 2 female) have completed this ongoing case-control study. …”
Get full text

High-sensitivity c-reactive protein and cardiovascular disease risk assessment in a population of type 2 diabetes mellitus patients by Bruno Basil, Jamila Aminu Mohammed, Izuchukwu Nnachi Mba, Blessing Kenechi Myke-Mbata, Joseph Chizoba Akujieze

“…Serum hsCRP was measured by homogenous immunoassay, while 10-year CVD risk was estimated with the WHO CVD risk assessment chart validated for Western sub-Saharan Africa. …”
Get full text

FPG Score: A Rapid Admission‐Based Tool for Predicting In‐Hospital Mortality in Elderly Hip Fracture Patients by Marcello Covino, Guido Bocchino, Maria Beatrice Bocchi, Chiara Barbieri, Benedetta Simeoni, Antonio Gasbarrini, Francesco Franceschi, Giulio Maccauro, Raffaele Vitiello

“…Early identification of high‐risk patients is crucial to guide clinical decision‐making, optimize resource allocation, and improve outcomes. …”
Get full text

Development of a questionnaire to evaluate the management of gestational diabetes mellitus patients among obstetric nurses by Yongyan Zhu, Yongyan Zhu, Yumin Ren, Jing Ma, Feifei Wan, Feifan Liu, Fangfang Du, Weili Li, Tian Tian, Xiaoqian Liu, Lili Li, Zhumin Jia

“…The Cronbach’s α coefficients for the four dimensions ranged from 0.793 to 0.928, while the overall Cronbach’s α coefficient of the questionnaire was 0.970. …”
Get full text

A study of the relationship between social support, caregiving experience and depressed mood of family caregivers of home-dwelling older adults with disability- - a cross-sectional... by Qianqian Yu, Lingfeng Xu, Lifang Zhou, XiaoLi Jiang, Na Xu, Zihan Lang, Yixuan Wu, Chengliang Yin

“…This study investigates the relationships among social support, caregiving experiences, and depressed mood in family caregivers of home-dwelling older adults with disabilities, aiming to provide theoretical guidance for enhancing caregivers’ physical and mental well-being and optimizing home-based care services. Methods A random sample of 494 family caregivers from three districts in a specified city was surveyed. …”
Get full text

Forecasting antimicrobial resistance in China using a hybrid ARIMA-GM(1,1) model by Feng Liu, Caixia Dang, Hengliang Lv, Ziqian Zhao, Sijin Zhu, Yang Wang, Hongbin Song, Yuanyong Xu, Hui Chen

“…Abstract Objective To evaluate the application value of the ARIMA-GM(1,1) combined model in predicting the resistance rates of key drug-resistant bacteria in China, providing a scientific basis for optimizing antimicrobial management strategies. Methods Based on data from the China Antibacterial Resistance Surveillance Network from 2014 to 2023, we selected six types of key drug-resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and cefotaxime/ceftriaxone-resistant Klebsiella pneumoniae (CTX/CRO-R-KP), to construct the ARIMA-GM(1,1) combined model. …”
Get full text

Long-term clinical comparison of three different femoral stems in Total Hip Arthroplasty with femoral shortening in patients with high-riding hips by Kutalmis Albayrak, Yakup Alpay, Ozgur Ismail Turk, Muhammed Mert, Deniz Akbulut, Akif Albayrak

“…Group 3 had significantly higher final HHS compared to Group 1 (p = 0.0002), while no significant differences were observed between Group 1 and Group 2 (p = 0.1947) or Group 2 and Group 3 (p = 0.0723). …”
Get full text

A Comparative Study of Esketamine-Propofol and Sufentanil-Propofol for Analgesia and Sedation During Breast Minimally Invasive Rotary Resection with Local Anesthesia: A Randomized... by Li N, Qi X, Bao J, Gu Y, Zhou X, Wang T, Jiang N, Wang Y, Ye Q

“…This study aims to compare the safety and efficacy of esketamine versus sufentanil as adjuncts to propofol for analgesia and sedation during breast MIRR.Patients and Methods: A total of 90 patients undergoing elective breast MIRR were randomly assigned to receive either sufentanil-propofol or esketamine-propofol for analgesia and sedation. …”
Get full text

Functional prognosis analysis of glioma resection in the left middle precentral gyrus and posterior middle frontal gyrus by WANG Yi-jie, HU Rui-ping, ZHOU Yu-yao, LU Jun-feng

“…Objective To investigate the functional outcomes for patients undergoing glioma resection in the left middle precentral gyrus and posterior middle frontal gyrus, and evaluate the efficacy of current surgical strategies. Methods A retrospective analysis was performed on the data of 7 patients who underwent glioma resection in the left middle precentral gyrus and posterior middle frontal gyrus in Huashan Hospital, Fudan University from January 2013 to July 2024. …”
Get full text

Computational Risk Stratification of Preclinical Alzheimer’s in Younger Adults by Oriehi Anyaiwe, Nandini Nataraj, Bhargava Sai Gudikandula

“…Furthermore, the framework supports retrospective disease trajectory analysis, offering clinicians insights into optimal intervention windows even after symptom onset. …”
Get full text

Scoping Review of Adult Emergency Department Discharge Interventions by Mary-Kate Gorlick, Shriman Balasubramanian, Gregory Han, Andy Hickner, Pranita Talukder, Peter AD Steel, Lynn Jiang

“…Introduction: The discharge process is a crucial component of the emergency department (ED) encounter, with poor discharge quality often leading to negative patient outcomes. While numerous interventions have been implemented to improve this process, a comprehensive review of these interventions has not been conducted. …”
Get full text

Healing Heels: A Meta-analysis of Platelet-rich Plasma vs Corticosteroid Injections in Plantar Fasciitis Treatment by Clevio Desouza, Vijay Shetty

“…Introduction: Plantar fasciitis (PF) is a common cause of heel pain, particularly affecting individuals involved in running sports and those with prolonged standing activities. While various nonoperative treatments are available, there is no consensus on the optimal therapy. …”
Get full text