Unraveling the microbiome–aroma Nexus: a metagenomic and volatile compound analysis of Yunnan cigars by Jing Pan, Ming-Da Huang, Jin Wang, Jian-Xiong Zhao, Bin Yang, Hong-Hui Yang, Jin-Sheng Huang, Yu-Long Su, Xue-Ru Song, Wei-Guang Wang, Ling-Duo Bu

“…However, comparative studies examining the microbiome–aroma nexus across major cigar-producing regions remain limited.MethodsWe integrated high-throughput metagenomic sequencing with volatile organic compound (VOC) profiling to investigate microbial community structure and aroma compounds in four Yunnan cigars and two Cuban cigars.ResultsBacillus spp. was consistently dominant across all samples, while Yunnan cigars exhibited higher microbial diversity. …”
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Dual-Drug Delivery Systems Using Hydrogel–Nanoparticle Composites: Recent Advances and Key Applications by Moon Sup Yoon, Jae Min Lee, Min Jeong Jo, Su Jeong Kang, Myeong Kyun Yoo, So Yeon Park, Sunghyun Bong, Chan-Su Park, Chun-Woong Park, Jin-Seok Kim, Sang-Bae Han, Hye Jin Lee, Dae Hwan Shin

“…This review discusses representative fabrication methods, including physical embedding, covalent integration, and layer-by-layer assembly, to offer insights into practical implementation strategies. …”
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Artificial Intelligence‐Based Pathology to Assist Prediction of Neoadjuvant Therapy Responses for Breast Cancer by Juan Ji, Fanglei Duan, Qiong Liao, Hao Wang, Shiwei Liu, Yang Liu, Zongyao Huang

“…Artificial intelligence (AI) applied to image‐based omics offers potential to enhance pathological interpretation precision and consistency. Methods This review synthesizes existing literature on the application of AI in breast cancer pathology. …”
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Feasibility and long-term survival of proximal gastrectomy after neoadjuvant therapy for locally advanced proximal gastric cancer: A propensity-score-matched analysis by Tingfei Gu, Yinkui Wang, Zhouqiao Wu, Ning He, Yingai Li, Fei Shan, Ziyu Li, Jiafu Ji, Sihan Zhou, Xiuyuan Hao

“…However, there is a lack of evidence regarding the optimal extent of resection for locally advanced proximal GC after neoadjuvant therapy. …”
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Pregnancy probability prediction models based on 5 machine learning algorithms and comparison of their performance by REN Chao, REN Chao, YANG Huan, ZHOU Niya, ZHOU Niya

“…It is feasible to use machine-learning methods to predict human preconception outcomes through social-psychological-behavioral questionnaires. …”
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BOOTStrap-SCI: Beyond One option of treatment for spinal trauma and spinal cord injury: Consensus-based stratified protocols for pre-hospital care and emergency room (part I) by Nicolò Marchesini, Andreas K. Demetriades, Oscar Alves, Riya Mandar Dange, Harold Mauricio Choco, Edinson Dussan Lozada, Dumar Javier Figueredo Sanabria, Angélica Gamboa, Luz Llined Mendoza Victoria, Enoc Noscue Montealegre, Jonathan A. Pardo Carranza, Jonathan Velásquez Quintero, Andrès M. Rubiano

“…A pragmatic, resource-adapted approach may help optimize management in these contexts. Research question: This study aimed to develop resource-adapted protocols for pre-hospital and emergency room management of STx and SCI, addressing challenges specific to LMICs while supported by clinical evidence and expert based practices. …”
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Spatial patterns and key driving factors of wheat harvest index under irrigation and rainfed conditions in arid regions by Yongyu Chen, Yongyu Chen, Hengbati Wutanbieke, Dongdong Zhong, Dongdong Zhong, Jian Chen, Jian Chen, Zhen Huo, Zhen Huo, Hegan Dong, Hegan Dong

“…In contrast, for rainfed wheat, the order was: soil nutrient factors, Geographic-climatic factors, agronomic management factors, with total nitrogen (TN), available phosphorus(AP), total potassium(TK), and total phosphorus (TP) emerging as critical drivers of HI.DiscussionIrrigation significantly enhanced wheat HI (p < 0.01), and irrigated wheat demonstrated significantly higher HI, yield, and aboveground biomass (AGB) compared to rainfed wheat (p < 0.01). Optimizing phosphorus management could enhance HI in both systems, while irrigation infrastructure development remains vital for yield stability. …”
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Detecting Sleep Apnea with Smart-tech: Scientific Breakthrough or Overhyped Technology? by Aleksandra Głowacka, Paulina Grzeszczuk, Iwona Skorulska, Agnieszka Kalisz, Marta Ignatiuk-Chilkiewicz, Weronika Grywińska, Julia Kozakiewicz, Kamil Kościelecki, Klaudia Mączewska, Patrycja Długozima

“…Sleep disorders can severely impair cognitive functions such as concentration and memory, while also leading to chronic fatigue and emotional instability. …”
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Antiarrhythmic drug use in atrial fibrillation among different European countries – as determined by a physician survey by Espen Fengsrud, Carina Blomström-Lundqvist, A. John Camm, Andreas Goette, Peter R. Kowey, Jose L. Merino, Jonathan P. Piccini, Sanjeev Saksena, James A. Reiffel, Giuseppe Boriani

“…These findings indicate the need for more educational support for optimal AAD selection in AF management.…”
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Combination of immune checkpoint inhibitors and anthracyclines as a potential first-line regimen for dedifferentiated liposarcoma: systematic review and meta-analysis by Zhuang Aobo, Zhou Xiao, Xu Chengfei, Xi Zhe, Chen Yingxue, Zhang Chenhe, Xie Fuan, Yang Fan, Xiao Mengmeng, Ye Feng, Li Wengang

“…Methods We conducted a systematic meta-analysis to evaluate the efficacy of ICIs in treating patients with DDLPS. …”
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Geospatial impact evaluation of a low-cost agricultural intervention for enhancing environmental resilience by Pratap Khattri, Rachel Sayers, Kunwar K. Singh, Ryan Slapikas, Chet Bahadur Tamang, Dinee Tamang, Brad Sagara, Ariel BenYishay

“…However, while uptake was evident, the expected environmental outcomes, such as soil erosion control and riverbank stabilization, did not materialize. …”
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Valorization of Olive Mill Wastewater via <i>Yarrowia lipolytica</i>: Sustainable Production of High-Value Metabolites and Biocompounds—A Review by Amina Laribi, Bartłomiej Zieniuk, Doria Naila Bouchedja, Kahina Hafid, Lamia Elmechta, Samira Becila

“…Characterized by its dark color, high acidity, and rich composition of organic matter, phenolic compounds, and residual oils, OMW resists conventional degradation methods and poses significant environmental risks due to its phytotoxicity and microbial inhibition. …”
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Colorado Pediatric Airway Score (COPUR) as a Predictor of Intubation Difficulty in Children Aged 1-8 Years by Christopher Kapuangan, Aries Perdana, Fulki Fadhila, Andi Ade Wijaya Ramlan, Raihanita Zahra, Komang Ayu Ferdiana, Rahendra Rahendra

“…A COPUR score >7 was used to predict difficult intubation, while intubation difficulty was defined by an Intubation Difficulty Score (IDS) >5. …”
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Impact of Environmental Noise and Sleep Health on Pediatric Hypertension Incidence: ABCD Study by Augusto César F. De Moraes, Martin Y. Ma, Marcus V. Nascimento‐Ferreira, Ethan H. Hunt, Deanna M. Hoelscher

“…The specific interaction between noise and sleep health in causing hypertension still needs to be explored. Methods and Results We analyzed data from 3320 participants of the ABCD (Adolescent Brain Cognitive Development) study, recruited across 21 US cities and monitored from 2018 to 2020 through 2020 to 2022. …”
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Comparing the potential of tree-based and area-based forest height metrics for aboveground biomass estimation in complex forest landscapes by Weiyan Liu, Yuling Chen, Haitao Yang, Guangcai Xu, Shiyu Yan, Lingjun Li, Ling Chen, Qinghua Guo

“…These findings provide critical insights for optimizing AGB estimation methods, supporting carbon stock assessments, forest monitoring, and management strategies.…”
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Engineered circular RNA-based DLL3-targeted CAR-T therapy for small cell lung cancer by Jingsheng Cai, Zheng Liu, Shaoyi Chen, Jingwei Zhang, Haoran Li, Xun Wang, Feng Yang, Shaodong Wang, Xiao Li, Yun Li, Kezhong Chen, Jun Wang, Ming Sun, Mantang Qiu

“…Electroporation conditions were then optimized for the efficient delivery of circRNA into human primary T cells. …”
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Enhanced Recovery After Surgery (ERAS) consensus recommendations for opioid-minimising pharmacological neonatal pain management by David de Beer, Mary E Brindle, Michael Scott, Megan A Brockel, Andrew Franklin, Mehul V Raval, Tyara Marchand, Mercedes Pilkington, Brandon Pentz, Kristin Short, Saffa Aziz, Jennifer Y Lam, Adam Spencer, Scott Else, Duncan McLuckie

“…There is a need to provide evidence-based consensus recommendations to manage neonatal pain perioperatively to ensure adequate analgesia while minimising harmful side effects.Methods Following a stakeholder needs assessment, an international guideline development committee (GDC) was established. …”
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SKIN AVILABLE MASTOID AREA ON THE STAGE OF ITS STRAIN by D.S. Avetikov, D.V. Steblovskii, I.I. Starchenko

“… According to the latest statistics in the scientific journals abnormal scarring and negative results of plastic surgery occur in 5-6% of the total. Therefore, an optimal aesthetic scar and maximum results after cosmetic otoplasty are obtained and lower rhytidectomy remains a challenge in plastic and reconstructive surgery and rehabilitation. …”
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Preliminary research indicates that mechanical force through Pioze1 enhances local immunity during NPWT treatment for spinal infections by Hao Xing, Junlin Pan, Huan Liu, Yanan Wang, Zhengqi Chang

“…Postoperatively, CRP, ESR, and VAS all significantly improved compared to preoperative levels (all p&lt;0.05), which was superior to traditional treatment methods. Following NPWT intervention, the expression of Piezo1 protein at the lesion site significantly increased (0.03 ± 0.11 vs. 0.27 ± 0.22; p&lt;0.05), while the expression levels of IL-1β, IL-6, IL-8, and TNF-α in the local immune microenvironment of the infected lesion significantly decreased (0.26 ± 0.11 vs. 0.16 ± 0.09, 0.27 ± 0.12 vs. 0.15 ± 0.67, 0.26 ± 0.18 vs. 0.10 ± 0.12, 0.35 ± 0.21 vs. 0.15 ± 0.11; p&lt;0.05).ConclusionClinical results demonstrate that NPWT treatment for spinal infections exhibits remarkable efficacy, accompanied by a notable augmentation in local Piezo1 protein consistency. …”
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Accuracy of photorespiration and mitochondrial respiration in the light fitted by CO2 response model for photosynthesis by Zhengwen Niu, Zi-Wu-Yin Ye, Qi Huang, Chunju Peng, Huajing Kang

“…Current CO2-response models exhibit limitations in estimating these parameters, hindering predictions of crop responses under future climate scenarios.MethodsLow-oxygen treatments and gas exchange measurements, calculating CO2 recovery/inhibition ratio in of wheat (Triticum aestivum L.) and bean (Glycine max L.) were employed to elucidate the biological significance and interrelationships of Rp and Rd. …”
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