Trajectories of α-fetoprotein and unresectable hepatocellular carcinoma outcomes receiving lenvatinib: a retrospective, multicenter cohort study by Yitao Zheng, Jingna Hu, Yingna Mei, Yanjun Xiang, Haofeng Lu, Jiuting Zhu, Kaile Pan, Shuqun Cheng, Yang Liu

“…The primary endpoint was overall survival (OS), while the secondary endpoint was progression-free survival (PFS). …”
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Scalp dosimetry as a predictor of radiation-induced alopecia in primary brain tumours: a retrospective study from a tertiary cancer centre in south India by Lalitha Nageshwari S, Govardhan HB, Ibrahim Khaleel, Vijayath BR, Akshay KT, Priyadarshini T, Sahana R

“…This study aims to evaluate the scalp as an organ at risk by defining dose constraints that minimize RIA while maintaining optimal target coverage. Materials and methods: A retrospective analysis was conducted on 70 patients with primary brain tumours who received focal cranial radiotherapy between January 2022 and December 2024. …”
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The anti-inflammatory and antioxidant effects of astaxanthin as an adjunctive therapy in community-acquired pneumonia: a randomized controlled trial by Fatma Makram Youssef, Hayam Ateyya, Amir Eskander Hanna Samy, Eman Mohamed Elmokadem

“…Although the ASX group had a shorter hospital stay than the placebo group, the difference was not statistically significant (P > 0.05).ConclusionASX supplementation as an adjunct to standard CAP treatment significantly reduced inflammation while improving disease severity scores. ASX was found to be safe and well-tolerated. …”
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Triglyceride-glucose index: a novel assessment tool for all-cause mortality in critical stroke patients—a retrospective analysis of the eICU-CRD database by Bo Wu, Wanli Yu, Gang Zhang, Haotian Jiang, Nan Wu

“…Abstract Background Stroke, a leading cause of death and disability, includes ischemic (IS), hemorrhagic (HS), and subarachnoid subtypes. While the triglyceride-glucose index (TyG) has been linked to cerebrovascular diseases, studies focus on single subtypes and lack ICU data. …”
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Gas Exchange and Mechanical Properties of the Lung in Miners with Severe Concomitant Injury by V. V. Moroz, Yu. A. Churlyaev, V. N Kiselev, P. G Sitnikov, L. Yu. Redkokasha

“…Objective: to study the specific features of pulmonary gas exchange and mechanical properties in various manifestations of respiratory failure in miners with severe concomitant injury, who have a service length of 10 years or more, in order to optimize respiratory support.Subjects and methods. …”
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Antihypertensive combination therapy effects on cardiac remodelling in elderly patients by L. Kh. Gadzhieva, K. A. Masuev, M. I. Ibragimova

“…To investigate potential regression of left ventricular (LV) remodelling in elderly patients receiving antihypertensive combination therapy. Materials and methods. The study included 80 patients (23 men, 57 women) with arterial hypertension (AH) and different levels of cardiovascular risk, aged 60–86 years (mean age 72,4±6,5 years; median age 72 years; interquartile range 69,5–76 years). …”
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Healthcare utilization associated with antimicrobial resistance at a tertiary hospital in Vietnam: A retrospective observational study from 2016 to 2021. by Nga Thi-Quynh Nguyen, Nhien Phan-Thuy Nguyen, Quynh Thuy Truong, Thao Phuong Huynh, Hong-Nguyen Tran-Thi, Minh Van Hoang, Hai-Yen Nguyen-Thi

“…<h4>Methods</h4>We conducted a retrospective observational study of patients hospitalized at the Hospital for Tropical Diseases from 2016-2021 with non-duplicate isolates of any ESKAPE pathogens from clinical specimens. …”
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Progression of tricuspid and pulmonary regurgitation following surgical repair of subarterial ventricular septal defect via different approaches: predictors and outcomes by Lai Li, Aijun Liu, Junwu Su

“…Preoperative TR grade was partially associated with lower TRP, while the trans-pulmonary approach was considered an independent risk factor for PRP. …”
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Changes in Health Education Literacy After Structured Web-Based Education Versus Self-Directed Online Information Seeking in Patients Undergoing Carpal Tunnel Release Surgery: Nonr... by Mariella Seel, Julian Alexander Mihalic, Stefan Mathias Froschauer, Bernhard Holzner, Jens Meier, Tobias Gotterbarm, Matthias Holzbauer

“…Carpal tunnel release (CTR) surgery, a common day-surgery procedure, necessitates effective patient education for optimal recovery and self-management. …”
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Are Cannabis-Based Medicines a Useful Treatment for Neuropathic Pain? A Systematic Review by Nawaf Almuntashiri, Basma M. El Sharazly, Wayne G. Carter

“…Hence, future RCTs will need to have larger numbers and be more extended studies that explore optimal dosing and delivery methods and identify patient subgroups that are most likely to benefit. …”
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Global, regional, and national burden of ischemic stroke in older adults (≥60 years) from 1990 to 2021 and projections to 2030 by Shuting Hua, Zexian Dong, Hui Wang, Tong Liu, Tong Liu, Tong Liu

“…The decline in disease burden was most pronounced in high-SDI regions, while low-SDI regions faced a significantly higher disease burden and exhibited notable regional disparities. …”
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Characterization and clustering of intra-day physical activity patterns using accelerometry among sexual and gender minority adults by David Lopez-Veneros, Billy A. Caceres, Kasey Jackman, Joseph A. Belloir, Yashika Sharma, Suzanne Bakken, Ipek Ensari

“…., discrimination), and could be reciprocally associated with physical activity (PA) behavior. While PA is a health-protective factor, research on PA patterns in SGM adults is limited. …”
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Comparative Analysis of Farm Yard Manure and NPK Fertilizer on Cabbage Yield: A Case Study of Kabale University. by Arinaitwe, Saul

“…Cabbage yield metrics, including average weight per cabbage head and total yield per plot, were recorded and analyzed using appropriate statistical methods to determine significant differences between the two treatments. …”
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Effects of different doses of remimazolam besylate on postoperative sedation, pain, and adverse reactions in patients undergoing hysteroscopic surgery by Linjiang Yang, Liang Zhong, Xu Deng, Hao Fang, Siqin Li, Yi Li

“…Remimazolam Besylate, a new ultra-short-acting benzodiazepine, offers potential for safe sedation, but the optimal dose for postoperative outcomes is unclear. …”
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Development of a single-center predictive model for conventional in vitro fertilization outcomes excluding total fertilization failure: implications for protocol selection by Hai Wang, Haojie Pan, Zitong Xu, Xianjue Zheng, Shuqi Xia, Jiayong Zheng

“…Abstract Objectives To develop a multidimensional clinical indicator-based prediction model for identifying high-risk patients with fertilization failure conventional in vitro fertilization (c-IVF) cycles, thereby optimizing therapeutic decision-making. Methods This retrospective single-center study analyzed 691 cycles (594 c-IVF, 97 rescue ICSI) from January 2019 to August 2024. …”
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Comparative efficacy of exercise interventions for cognitive health in older adults: A network meta-analysis by Jinhao Zhang, Wei Ye, Wang Li, Fan Zhang, Zhijian Wu

“…However, the most effective types of exercise, along with optimal frequency and duration of interventions, remain inadequately defined. …”
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Thrombospondin-1 induces immunogenic cell death in human mucoepidermoid carcinoma MC-3 cells via the PERK/eIF2α signaling pathway: potential implications for tumor immunotherapy by Yixuan Zhu, Kaizhi Cai, Lijuan Guo, Huan Zhang, Li Guan, Zongyao Zhang, Pengcheng Huang, Sen Yang

“…The CCK-8 assay was performed to determine the optimal seeding density, TSP-1 concentration, and treatment time. …”
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Dihydromyricetin attenuates age-related macular degeneration: pharmacological effects and exploration of putative targets by Hongyu Zhou, Jianhui Pang, Baiyang Wu, Yanan Zhuang, Shenjun Li, Jing Jiang, Jing Jiang

“…This study aimed to investigate the pharmacological effects of dihydromyricetin (DHM) on AMD and to identify its putative pharmacological targets through network analysis and molecular docking approaches.MethodsIn vitro experiments established an AMD model using sodium iodate (SI)-induced ARPE-19 cells, with CCK-8 assays determining 15 mM SI as the optimal modeling concentration and 100 μM DHM as the optimal treatment concentration. …”
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Support Vector Machine for Stratification of Cognitive Impairment Using 3D T1WI in Patients with Type 2 Diabetes Mellitus by Xu Z, Zhao L, Yin L, Cao M, Liu Y, Gu F, Liu X, Zhang G

“…After features selection, there were 11 optimal features to distinguish N and CI and 12 optimal features to MCI and DM. …”
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Neutrophil‐Lymphocyte Ratio as Predictor for Acute Infection After Primary Total Joint Arthroplasty in Rheumatoid Arthritis Patients by Yahao Lai, Jiaxuan Fan, Ning Lv, Xiaoyu Li, Wenxuan Zhao, Zeyu Luo, Zongke Zhou

“…The neutrophil‐lymphocyte ratio showed diagnostic sensitivity of 92.6% and specificity of 43.3%, while the monocyte‐lymphocyte ratio showed sensitivity of 77.8% and specificity of 46.3%. …”
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