A prospective, randomized, double-blind entropy-guided approach to evaluate the efficacy of different doses of dexmedetomidine with propofol versus fentanyl with propofol for ProSe... by Mahantesh Mudakanagoudar, Bhavana Koppad, Manjunath Shivapujimath, Meghana Hanagandi

“…PLMA insertion requires adequate jaw relaxation and depth of anesthesia while maintaining hemodynamic stability. Opioids including fentanyl and alpha-2 agonists like dexmedetomidine are increasingly being used with propofol for the same. …”
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Atypical Lipomatous Tumours vs. Lipomas: A Multimodal Diagnostic Approach by Wolfram Weschenfelder, Katharina Lucia Koeglmeier, Friederike Weschenfelder, Christian Spiegel, Amer Malouhi, Nikolaus Gassler, Gunther Olaf Hofmann

“…<b>Background/Objectives</b>: This study aimed to develop a reliable scoring system combining clinical and radiological parameters to distinguish atypical lipomatous tumours (ALTs) from lipomas, improving diagnostic accuracy and reducing expensive molecular pathology testing. <b>Methods</b>: A retrospective analysis of 188 patients who underwent surgery for lipomatous tumours was conducted. …”
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Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer by Carolina Martinez-Ciarpaglini, Tanja D de Gruijl, Daniela S Thommen, Nicole C T van Grieken, Joep Grootjans, Sarah Derks, Tessa S Groen-van Schooten, Rosalia Franco Fernandez, Emma N Bos, Jens Seidel, Job Saris, Tania C Fleitas

“…Furthermore, mature TLSs were characterized by overexpression of antitumor immune pathways such as B cell-related pathways, MHC class II antigen presentation while immature TLS were associated with protumor pathways, including T cell exhaustion and enhancement of DNA repair pathways in the corresponding cancer.Conclusion The observation that GC-derived peritoneal metastases often contain immature TLS which are associated with immune suppressive regulatory tumor-infiltrating leucocytes, is in keeping with the lack of response to immune checkpoint blockade and the poor prognostic features of peritoneal metastatic GC, which needs to be taken into account when optimizing immunomodulatory strategies for metastatic GC.…”
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Assessing the temporal transferability of machine learning models for predicting processing pea yield and quality using Sentinel-2 and ERA5-land data by Michele Croci, Manuele Ragazzi, Alessandro Grassi, Giorgio Impollonia, Stefano Amaducci

“…This ability, known as temporal transferability, is often overestimated by standard validation methods, creating a gap between theoretical performance and operational reliability. …”
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Chronic Endometritis: A Silent Contributor to Infertility and Reproductive Failure—A Comprehensive Review by Mihai Lucan, Mircea Sandor, Alin Bodog, Diana Mocuta, Cristina Daniela Aur, Liliana Sachelarie, Anca Huniadi

“…Histopathological assessment using CD138 immunostaining remains the gold standard for diagnosis, while hysteroscopy and molecular microbiological techniques provide complementary diagnostic value. …”
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Phenotyping of guar accessions from the VIR collection under irrigation and artificial drought conditions in Volgograd Province by M. A. Vishnyakova, E. A. Dzyubenko, N. V. Kocherina, M. M. Agakhanov, R A. Shaukharov

“…With optimal irrigation, a majority of guar accessions exhibited a tendency toward increased seed productivity, regardless of the group.…”
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Comparative analysis of the efficacy of seniprutug (BCD-180) and adalimumab in the treatment of active radiographic axial spondyloarthritis: results of a systematic review and matc... by A. M. Lila, T. V. Dubinina, D.  G. Tolkacheva, K. V. Sapozhnikov, N. A. Sableva, M. A. Morozova, P. S. Pukhtinskaia

“…The inclusion of the innovative domestic drug seniprutug into treatment paradigm of active r-axSpA will potentially reduce the socio-economic burden of this disease by providing an affordable, effective and safe therapy while optimizing healthcare costs…”
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Evaluation of Left Main Coronary Artery Using Optical Frequency Domain Imaging and Its Pitfalls by Vincent Roule, Idir Rebouh, Adrien Lemaitre, Mathieu Bignon, Pierre Ardouin, Rémi Sabatier, Fabien Labombarda, Katrien Blanchart, Farzin Beygui

“…Methods. We included 42 consecutive patients who underwent OFDI, including LM imaging. …”
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Virtual reality and mixed reality in the assessment of spatial memory by Sara Garcia-Navarra, Lucia Solares, Marta Mendez

“…Traditional assessment methods, such as paper-based tests and laboratory paradigms, often lack ecological validity and fail to capture the complexities of real-world navigation. …”
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ЕSTIMATION OF SOCIO-ECONOMIC BURDEN OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE FOR A 5-YEAR PERIOD: A REGIONAL ASPECT by E. A. Orlova, A. R. Umerova, I. P. Dorfman, M. A. Orlov, M. A. Abdullaev

“…The aim of the study was to estimate the economic damage by COPD, including direct medical and non-medical costs and indirect costs associated with premature deaths of working-age individuals.Materials and methods. First, estimation of the economic COPD burden in Astrakhan region (AR) was carried out using the clinical and economic analysis of the "cost of illness" (COI). …”
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Correlation and Comparative Evaluation of MOCART and MOCART 2.0 for Assessing Cartilage Repair by Felix Conrad Oettl, Louis Leuthard, Moritz Brunner, Vincent A. Stadelmann, Stefan Preiss, Michael Leunig, Gian M. Salzmann, Jakob Hax

“…<i>Material and Methods</i>: This study included 111 patients (age: 35 ± 10, 35% female) who underwent cartilage repair surgery of the knee between September 2015 and March 2022. …”
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Association Between Cardiometabolic Index and Mortality Among Patients with Atherosclerotic Cardiovascular Disease: Evidence from NHANES 1999–2018 by Duo Yang, Wei Li, Wei Luo, Yunxiao Yang, Jiayi Yi, Chen Li, Hai Gao, Xuedong Zhao

“…There was a nonlinear J-shaped relationship between CMI and all-cause mortality, while the risk of cardiovascular mortality increased linearly with increasing CMI. …”
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A Novel Temozolomide-Myricetin Drug-Drug Cocrystal: Preparation, Characterization, Property Evaluations by Hai-Xin Qin, Jie Wang, Jia-Hui Peng, Xia-Lin Dai, Cai-Wen Li, Tong-Bu Lu, Jia-Mei Chen

“…The goal of the present study is to obtain novel drug-drug cocrystals involving two anti-glioma agents, temozolomide (TMZ) and myricetin (MYR). <b>Methods</b>: The novel TMZ-MYR cocrystal was prepared via slurry and solvent evaporation techniques and characterized by X-ray diffraction, thermal analysis, infrared spectroscopy, and dynamic vapor sorption measurements. …”
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Study on risk contagion between rare earth and new energy-related metals markets from the perspective of co-production and co-consumption by Renrui Zheng, Renrui Zheng, Hao Nong, Qishen Chen, Liuguo Shao, Liuguo Shao, Hongtao Zhang, Yanfei Zhang, Yanfei Zhang

“…Understanding these dynamics is crucial due to the growing interdependence of these markets and their susceptibility to policy shifts and extreme events.MethodsUsing higher-order moment risk measures, time-domain spillover indexes, and frequency-domain spillover indexes, we analyze return, volatility, skewness, and kurtosis risk spillovers across metal markets from 2014 to 2024. …”
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Framing financial incentives to promote hypertension care among rural primary doctors in Shandong Province, China: study protocol of a randomized field trial by Yue Zhong, Pengyang Fan, Jialong Tan, Elizabeth Maitland, Stephen Nicholas, Yiwei Qiao, Dejian Kou, Zehua Meng, Jian Wang

“…Insufficient financial incentives may explain the sub-optimal long-term treatment behavior by rural doctors. …”
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Genotypic and Environmental Impacts on Vicine and Convicine Concentrations in Faba Beans by Pankaj Maharjan, Aaron C. Elkins, Jason Brand, Samuel C. Catt, Simone J. Rochfort, Joe F. Panozzo

“…High concentrations of vicine and convicine (v-c) in faba beans can trigger favism in susceptible humans, posing a significant barrier to the broader adoption of faba beans as a food source. While plant breeding and various post-harvest processing methods have been adopted to reduce v-c levels, there is limited understanding of how agronomic practices may assist in reducing v-c levels. …”
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Growth Assessment and Nutritional Status in Children with Congenital Adrenal Hyperplasia—A Cross-Sectional Study from a Vietnamese Tertiary Pediatric Center by Thi Thuy Hong Nguyen, Khanh Minh Le, Thi Anh Thuong Tran, Khanh Ngoc Nguyen, Thi Bich Ngoc Can, Phuong Thao Bui, Dat Tien Tran, Chi Dung Vu

“…<b>Results</b>: Stunting was present in 16.4% of children, while 53.3% were overweight or obese. Bone age advancement occurred in 51.7% of cases. …”
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Donor – recipient selection using epitope mismatches in kidney transplantation by A. V. Vatazin, A. B. Vatazin, V. A. Stepanov

“…In the routine practice of a transplantation center with a short waiting list of its own, it might be possible to improve the kidney transplant survival as a result of considering epitope mismatches, thus  reducing the risk of developing donor-specific anti-HLA antibodies and ensuring a higher graft survival rate. This method can be used for additional ranking of transplantation candidates depending on the number of epitope mismatches within the fixed number of HLA-mismatches and thus select the optimal one. …”
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Chromosomal Instability in Various Generations of Human Mesenchymal Stem Cells Following the Therapeutic Radiation by Majid Sadeghi Moghadam, Hosein Azimian, Jalil Tavakol Afshari, Mohammad Taghi Bahreyni Toossi, Najmeh Kaffash Farkhad, Seyed Hamid Aghaee-Bakhtiari

“…This study demonstrated significant nuclear alterations in the 10 days postirradiation due to the RIGIs that they inherited from their irradiated ancestral cells. While chromosomal instability is a prevalent event in malignant cells, so it seems necessary to optimize radiotherapy treatment protocols for tissues that contain stem cells, especially with IMRT, which delivers a low dose to a larger volume of tissues.…”
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Ensuring Sustainability in Pharmaceutical Care: A Retrospective Analysis of Administrative Databases on the Utilization, Costs, and Switching Patterns of Biological Therapies in th... by Renata Maria Bianca Langfelder, Roberto Langella, Cinzia D’Angelo, Claudia Panico, Sarah Cattaneo

“…<b>Background</b>: Biosimilars represent a fundamental advancement in global healthcare, offering significant cost containment while maintaining both therapeutic efficacy and safety in the management of chronic diseases. …”
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