AEROfen: protocol for a phase I, open-label, randomised crossover study evaluating the efficiency of nebulised fentanyl in healthy volunteers – comparing facial versus intranasal a... by Muriel Quillard, André Gillibert, Florian Vallin, Nathalie Donnadieu, Sophie Ruault, Cassandre Follet, Audrey Dumont, Melanie Roussel, Cyprienne Boedard, Davis Nunes Ferreira, Tony Pereira, Luc-Marie Joly, Virginie Lvovschi, Thomas Duflot

“…The resulting data will be analysed using Monolix 2024R1 to model PK–PD relationships, perform Monte Carlo simulations and determine the optimal dosing and timing required to achieve a reduction of more than 30% in PUAL, while also evaluating safety, comfort and tolerance.Ethics and dissemination The study has been approved by the Ethic Committee Île-de-France VII (approval reference number: 000216, February 2024) and will be conducted in accordance with the Declaration of Helsinki. …”
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Predictive role of endogenous phase lags between target brain regions in dual-site transcranial alternating current stimulation by Osama Elyamany, Jona Iffland, Josef Bak, Cornelius Classen, Guido Nolte, Till R. Schneider, Gregor Leicht, Christoph Mulert

“…To address this gap, we explored the predictive value of endogenous phase lags in dual-site tACS to modulate interhemispheric connectivity during dichotic listening. Methods: Thirty healthy participants (16 females) completed a dichotic listening task while undergoing simultaneous electroencephalography and tACS, including four bitemporal verum conditions with varying phase lags (0°, 45°, 90°, and 180°), and a sham condition across five sessions. …”
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Impact of extraction techniques on phytochemical composition and bioactivity of natural product mixtures by Shicai Sun, Ying Yu, Yunju Jo, Jung Ho Han, Yingqi Xue, Minkyoung Cho, Sung-Jin Bae, Dongryeol Ryu, Wonyoung Park, Wonyoung Park, Wonyoung Park, Ki-Tae Ha, Ki-Tae Ha, Shiwei Zhuang

“…This review critically analyzes these techniques with a special focus on integrated (hybrid) strategies, revealing that while advanced methods like ultrasound-assisted extraction and microwave-assisted extraction offer improved efficiency, the greatest potential lies in the synergistic combination of methods to maximize yield and preserve bioactivity. …”
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Potential evaluation and development utilization technology of geothermal resources in the Jining Coalfield by Qipeng SHI, Jianguo FAN, Fengfeng SHI, Xuesen WANG, Huiming ZHENG, Jia MENG, Shuailiang SONG

“…Under the guidance of China’s “carbon peaking and carbon neutrality” goals, efforts are underway to optimize and adjust the national energy structure. …”
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Comparative Effects of Two Acupuncture Protocols in the Management of Chronic Insomnia: A Randomized Controlled Trial by Li L, Xia M, Chen X, Wang F, Li J, Zhao N, Liu Z, Chen Y

“…This highlights the urgent need for effective and safe therapeutic approaches that can target both nocturnal and daytime symptoms.Objective: To evaluate the clinical efficacy and safety of acupuncture in improving sleep quality and daytime functioning in patients with chronic insomnia, and to optimize its treatment protocol.Methods: This study was a single-blind, randomised, controlled trial. …”
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Investigation mechanical properties and on surface roughness during WEDM machining of nano Cr2C3-MoS2 hybrid metal matrix composites by Ramesh Vellaichamy, Pugazhenthi Rajagopal, A. Geetha Selvarani, Itha Veeranjaneyulu, J. Immanuel Durai Raj, E. Balaji, Mamdooh Alwetaishi, S. Baskar, Krishna Moorthy Sivalingam, P. V. Elumalai

“…The Taguchi method of experimental design was employed to optimize the process parameters. …”
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Reducing locomotive maintenance costs with intelligent software by Valeria A. Butusova, Yuriy A. Davydov, Alexey S. Kushniruk, Denis Yu. Drogolov

“…Materials and methods. Methods and Software Description: The software developed in this study employs a multi-stage analysis process to optimize the standards for inter-repair mileage of locomotives. …”
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BESW-YOLO: A Lightweight SAR Image Detection Model Based on YOLOv8n for Complex Scenarios by Xiao Tang, Kun Cao, Yunzhi Xia, Enkun Cui, Weining Zhao, Qiong Chen

“…However, traditional detection methods often suffer from false alarms and missed detections. …”
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Genomic architecture of purebred and crossbred Moghani lambs with Texel and Booroola sheep by Reza Talebi, Mohsen Mardi, Mehrshad Zeinalabedini, Tomasz Szmatoła, Mehrbano Kazemi Alamouti, Seyyedeh Azadeh Javadi Taklimi, Mohammad Reza Ghaffari

“…Taken together, these results highlight the need for improved breeding methods that prioritize trade-offs associated with reduced genetic diversity in crossbred populations. …”
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Experts' consensus over key components of online learning environments in medical education: a modified e-Delphi study by Noor-i-Kiran Naeem, Siti Nurma Hanim Hadie, Irwan Mahazir Ismail, Zil-e-Fatima Naeem, Ahmad Hassan Khan, Muhamad Saiful Bahri Yusoff

“…With strong expert agreement, it ensures adaptability in hybrid education while paving the way for future research and innovation.…”
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Effects of air pollution and noise exposure on occupational hearing loss in oil workers: a prospective cohort study by Zheng Li, Haoruo Zhang, Nan Wang, Shangmingzhu Zhang, Zhenghao Luo, Xiaoqing Xuan, Mingyue Liu, Xinyang Chen, Xiaoming Li, Ling Xue, Jianhui Wu

“…Air pollution exposure (PM2.5, PM10, SO2, NO2, CO, and the Air Quality Comprehensive Index, AQCI) was assessed using monitoring station data, while cumulative noise exposure (dB(A)-year) was calculated from workplace measurements. …”
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The impact of online educational modules on learning musculoskeletal anatomy for health professionals. A systematic review by Nikita Bandekar, K.G. Mohandas Rao, Aithal P. Ashwini, K. Anniesmitha, Bincy M. George

“…The pandemic accelerated the adoption of online anatomy education, with many studies demonstrating that digital platforms successfully replaced traditional methods while achieving comparable educational outcomes. …”
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Binder Jetting for Functional Testing of Ceramic Sanitaryware by Cristina Fabuel, María Pilar Gómez-Tena, Arnaldo Moreno, Fernando González-Juárez, Verónica Rico-Pérez, Jordi Balcells

“…The results indicate that compositions containing calcined alumina exhibited lower pyroplastic deformation, while optimized gelling agent concentrations improved green strength and dimensional accuracy. …”
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Comparative efficacy of dietary interventions for glycemic control and pregnancy outcomes in gestational diabetes: a network meta-analysis of randomized controlled trials by Jiaoyang Di, Jingjing Fan, Fangxu Ma

“…The DASH diet showed favorable trends in improving glycemic control, while both diets appeared to reduce the risks of cesarean delivery and macrosomia. …”
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Comparison of Trunk and Hip Extensor Activation According to Various Applications of Elastic Bands During Nordic Hamstring Exercise by Jongsu Yun, Duk-hyun An, Won-gyu Yoo, Jae-seop Oh

“…During NHE, the ankles are fixed in a kneeling position, while the upper body falls forward as the knee extends, maximizing hamstring activation. …”

Correlation of safety and efficacy of atezolizumab therapy across indications by Jarushka Naidoo, Guru Sonpavde, Mark A Socinski, Rajat Mohindra, Corey Carter, Laurent Essioux, Gonzalo Durán-Pacheco, G Scott Chandler, Vidya Maiya, Javier Puente, Jose Vicente Cardona

“…Low-grade irAEs are significantly associated with improved OS, while specific high-grade irAEs are associated with poorer OS, underscoring the importance of early recognition and management of toxicity to optimize benefit/risk balance.…”
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Immunogenic cell death-related genes as prognostic biomarkers and therapeutic insights in uterine corpus endometrial carcinoma: an integrative bioinformatics analysis by Tianfei Yi, Zhenglun Yang, Peng Shen, Yan Huang

“…IntroductionImmunogenic cell death (ICD) is the phenomenon in which tumor cells undergo the transition from a non-immunogenic state to an immunogenic state upon their demise as a result of external stimuli. While ICD systems have been widely adopted in oncological research, their specific utilization for Uterine Corpus Endometrial Carcinoma (UCEC) investigations has received comparatively little attention.MethodsThe ICD score was assessed using single-sample gene set enrichment analysis (ssGSEA). …”
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Food safety practice and its associated factors among food handlers working in food and drinking establishments in Hargeisa, Somaliland by Mohamed Mussa Abdilahi, Jonah Kiruja, Abdisamad Shukri Ismail, Soheir H. Ahmed, Faisal Nooh, Ayanle Suleiman Ahmed, Abdiqathar Rashid Kulmie

“…Additionally, it is estimated that upto 30% of people in developed countries experience food-borne illnesses annually, while developing countries suffer around 2 million deaths from these diseases each year. …”
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Improving genomic prediction accuracy for methane emission and feed efficiency in sheep: integrating rumen microbial PCA with host genomic variation using neural network GBLUP (NN-... by Setegn Worku Alemu, Timothy P. Bilton, Patricia L. Johnson, Benjamin J. Perry, Hannah Henry, Ken G. Dodds, John C. McEwan, Suzanne J. Rowe

“…Conclusions Principal Component Analysis reduced the dimensionality of rumen microbiome data while preserving essential biological information. …”
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Surgical vs. Medical Management of Infective Endocarditis Following TAVR: A Systematic Review and Meta-Analysis by Dimitrios E. Magouliotis, Serge Sicouri, Massimo Baudo, Francesco Cabrucci, Yoshiyuki Yamashita, Basel Ramlawi

“…Methods: We conducted a systematic review and meta-analysis of studies comparing the surgical and medical management of TAVR-IE. …”
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