Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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Relationship between Professional Self-Concept with Intention to Leave, and Professional Quality of Life among Psychiatric Nurses by Sajjad Javanbakht, Mohammad Pourebrahimi, Mohammad Saatchi, Zahra Tamizi, Reza Ahmadi Jirandeh, Mobina Sanaeipour, Mohammadjavad Hosseinabadi-Farahani

“…Professional self-concept was the only predictor of compassion satisfaction and secondary trauma stress. Burnout was predicted by both professional self-concept and satisfaction with salary. …”
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Dicalcium Silicate Induced Proinflammatory Responses through TLR2-Mediated NF-κB and JNK Pathways in the Murine RAW 264.7 Macrophage Cell Line by Shixiang Lai, Liangjiao Chen, Wei Cao, Shiman Cui, Xingyang Li, Wenchao Zhong, Mingyu Ma, Qingbin Zhang

“…When we added siRNA-TLR2-1, a significant reduction was observed. These findings support the theory that C2S particles induce proinflammatory responses through the TLR2-mediated NF-κB and JNK pathways in the murine RAW 264.7 macrophage cell line.…”
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Exploring biochemical responses and cellular adaptations of Chlorella sorokiniana to polyethylene microplastic exposure by Jyoti Rawat, Pooja Bhatnagar, Abhilasha Mishra, Manisha Nanda, Prateek Gururani, Afzal Hussain, Mikhail S. Vlaskin, Sanjay Kumar, Monu Verma, Hyunook Kim, Vinod Kumar

“…Under the MP stress, reactive oxygen species (ROS) and phenolic levels were reduced, whereas flavonoid content increased. …”
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SLC44A2 negatively regulates mitochondrial fatty acid oxidation to suppress colorectal progression by blocking the MUL1-CPT2 interaction by Ying Yang, Longlong Zheng, Jiaxing He, Tao Wu, Haicheng Yang, Bo Zhang, Shuai Zhou, Yueyue Lu, Xianli He, Jibin Li, Nan Wang

“…In the present investigation, we observed a significant reduction in SLC44A2 expression in colorectal cancer (CRC), and low SLC44A2 expression was closely associated with poorer survival of CRC patients. …”
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Rheology of rock–ice avalanche in a periodic chute flow by Zhiping Sun, Zhibo Dong

“…Depth-resolved profiles of six key parameters—velocity, solid volume fraction, shear stress, normal stress, shear rate, and inertia number—were recorded during steady flow conditions. …”
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Assessment of geomechanical properties of Sakhalin shelf reservoirs based on modeling results by V. Yu. Kerimov, G. N. Potemkin, A. K. Shatyrov

“…This initiates the formation of a local stress field, launches changes in the degree of fracture openness, and determines the secondary porosity and permeability of rocks. 3D modeling allowed us to calculate predicted permeability for each stratigraphic horizon. …”
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The role of Cultural Socialization and Contextual Factors on the Subjective Well-Being of Immigrant Adolescent Girls at the Beginning and End of Adolescence: A life course perspect... by Elaheh Hejazi, Ahmad Baseri, Zahra Naghsh, simin ebrahimi

“…Hierarchical data analysis revealed that cultural socialization and speaking the mother tongue were significant predictors of subjective well-being, whereas educational level demonstrated a comparatively weaker predictive role. …”
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Gut microbiome and metabolome interactions in Crohn’s disease: mechanistic insights into exclusive enteral nutrition-induced remission by Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Quan Zhou, Quan Zhou, Mengli Xue, Mengli Xue, Mengli Xue, Mengli Xue, Xing Yu, Xing Yu, Xing Yu, Xing Yu, Xue’e Chen, Xue’e Chen, Xue’e Chen, Xue’e Chen, Jintong Chen, Jintong Chen, Jintong Chen, Jintong Chen, Chengdang Wang, Chengdang Wang, Chengdang Wang, Chengdang Wang

“…Importantly, EEN therapy was associated with a reduction in oxidative stress and an improvement in gut barrier function.ConclusionThis study comprehensively integrates microbiome and metabolome analyses, providing new insights into the mechanism of action of EEN therapy in CD. …”
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Effect of extreme pH levels on early larval stages of the Pacific abalone (Haliotis discus hannai Ino, 1953) by Dian Yuni Pratiwi, Irfan Zidni, Mi-Jin Choi, Young Dae Oh, Tae Min Kim, Han Kyu Lim

“…However, at 30 hpf, a significant reduction in the oxygen consumption rate was observed only at pHs 9 and 10 (p &lt; 0.05). …”
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<i>Colletotrichum capsici</i>-Induced Disease Development in Postharvest Pepper Associated with Cell Wall Metabolism and Phenylpropanoid Metabolism by Yunfen Liu, Qian Song, Feilong Yin, Yuanli Liang, Mubo Song, Meiying He, Liang Shuai

“…These insights highlight the need for early intervention strategies to mitigate postharvest losses by targeting pathogen-induced stress responses and cell wall integrity preservation.…”
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Implications of thermal stratification and radiative heat flux in blood-based ternary and dihybrid nanomaterial flow through a stretchable cylinder by Muzher Saleem, Ghada A. Khouqeer, Fazal Haq, Naglaa AbdelAll, Arshad Hussain, Mohammed Sallah

“…A reduction of 4 % in the skin friction coefficient of THNF compared to HNF is noticed. …”
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Impacts of diffusion and chemical reaction on heat transfer in Casson nanofluids flow over a flat plate with accretion by J. Jayaprakash, Vediyappan Govindan

“…Conversely, more chemical reactions reduce the heat transfer rate. Concentration reduction can inhibit convective heat and mass transfer, which can reduce the efficiency of systems. …”
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A randomized cross-over study of the acute effects of running 5 km on glucose, insulin, metabolic rate, cortisol and Troponin T. by Boris Keselman, Marta Vergara, Sofia Nyberg, Fredrik H Nystrom

“…<h4>Conclusions</h4>Relatively short running-races can apparently induce a reduction in insulin sensitivity that is not fully compensated by concomitantly increased insulin secretion intended to ensure euglycemia. …”
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Psychodrama: implementation, study design and effectiveness: a systematic review by Jesús Maya, Miriam Pérez-Berbel, Laura Giraldo-Arroyave, Irene Hurtado

“…In relation to the effectiveness of psychodrama, positive and significant results were found, for example, in the reduction of post-traumatic stress levels, the empowerment of women in vulnerable situations, improvement in the quality of life and symptoms of patients with schizophrenia, or improvement in antisocial behavior in adolescents. …”
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Role of early increase in vascular endothelial growth factor-A levels after coronary stenting in the development of drug-eluting in-stent restenosis by V. V. Tishko, E. I. Senkina, M. E. Meshkova, A. N. Shishkevich, I. A. Menkova, S. E. Bednova, V. V. Tyrenko

“…The introduction of drug-eluting stents (DES) into clinical practice has led to a significant reduction in the incidence of in-stent restenosis (ISR) compared to implantation of bare metal stents. …”
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Factors influencing the performance of cardiopulmonary resuscitation by lay rescuers: A qualitative study based on the Theory of Planned Behavior. by Zhikang Zhong, Weiwei Li, Lin Zhou, Liang Liu

“…To improve intervention rates, it is crucial to target emotional barriers (virtual reality (VR)-based anxiety reduction) and address systemic constraints (AED availability and simplified Good Samaritan laws) while leveraging artificial intelligence tools to reinforce positive norms. …”
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Hydrogen-Rich Water Consumption for Acute and Residual Fatigue After Simulated Football Matches: Protocol for a Randomized, Double-Blinded, Placebo-Controlled, Parallel Trial by Michal Hruby, Karel Hulka, David Bernatik

“…The potential positive effects of molecular hydrogen, such as attenuation of oxidative stress, reduction in muscle damage markers, and accelerated neuromuscular recovery, may contribute to faster restoration of functional capacities. …”
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Shexiang Baoxin Pill Alleviates the Atherosclerotic Lesions in Mice via Improving Inflammation Response and Inhibiting Lipid Accumulation in the Arterial Wall by Li Lu, Yating Qin, Xinxin Zhang, Chen Chen, Xiangyu Xu, Chingwen Yu, Xiaomei Guo

“…Biochemical analyses indicated that SBP gavage improved oxidative stress in vivo, as seen by the level elevation of SOD, CAT, and GSH and the level reduction of MDA, H2O2, and MPO. …”
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Seeds of success: seed biology and germination response of Gazania weed in Australia by Muhammad Adnan, Babar Shahzad, Marisa Collins, Ali Ahsan Bajwa

“…Population 1 was more tolerant to salinity than Pop-3 with a 50% reduction in germination occurring at 268 and 252 mM NaCl, respectively. …”
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