Abnormal lipid metabolism and atherosclerosis: a new perspective on organelle function regulation and ferroptosis by Xize Wu, Yuxi Huang, Jiaqi Ren, Xue Pan, Qiuying Wu, Qicheng Cai, Ruiying Wang, Teng Feng, Shan Gao, Bo Wang, Meijia Cheng, Meijia Cheng, Yue Li, Lihong Gong

“…A nomogram for predicting AS risk was constructed incorporating the expression levels of these five validated Hub genes. …”
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The Data Drill: An Opportunity for Researchers to Practice Accessing and Interpreting Data by Sandi Caldrone, Yali Feng

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Insights on the neurocognitive mechanisms underlying hippocampus-dependent memory impairment in COVID-19 by Patric Meyer, Ann-Kathrin Zaiser

“…This impairment remained statistically significant after controlling for potential confounding factors (i.e., age, gender, education, depressiveness, anxiety, and stress). This finding, derived indirectly from behavioral performance, suggests compromised hippocampal neurogenesis following infection, which may contribute to COVID-related memory deficits. …”
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Role of probiotics in prevention and treatment of diarrhea and disbiosis in infants by S. G. Gribakin

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Addressing the psychological impact of climate-induced disasters on young people in Africa: Challenges and pathways forward by Usoro Udousoro Akpan, Ibrahim Khalil Ja’Afar, Sinclair Chidera Eke

“…It explores how climate stresses compound existing societal issues, affecting young people’s well-being. …”
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An analysis of knowledge, attitude and practice gaps in scientific buffalo husbandry. by Gururaj Makarabbi, Aiswarya Sabu, Navneet Saxena, Madan Lal Sharma

“…Chi-square tests confirmed education (OR=3.4, p < 0.001) and herd size (OR=2.4, p < 0.01) as the strongest KAP predictors, with logistic regression underscoring income's pivotal role (OR=4.3 for practices). …”
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Gangguan Bermain Game Selama Pandemi Covid-19: Sebuah Tinjauan Pustaka Sistematis by Astaf Aji Pranaya, Dini Kumalawati Sarjani, Fanny Rosalia, Rahma Mesi Shabrina

“…In addition, changes in the education system where schools are held online give students a lot of free time, resulting in increased aggressive behavior among them. …”
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Role of mesenchymal stromal cells and their secretory products in kidney regeneration by O. V. Payushina, D. A. Tsomartova, E. V. Chereshneva, M. Yu. Ivanova, T. A. Lomanovskaya, S. L. Kuznetsov

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Revitalising terraced landscapes: Co-production of ecosystem services for sustainable futures by Christos Zoumides, Adriana Bruggeman, Hakan Djuma

“…We examine the use of advanced biophysical assessments, mapping tools, and stakeholder-driven approaches to enhance field assessment, monitoring capabilities and tackle management challenges under changing socio-economic conditions. We stress the urgent need for education and capacity-building initiatives to counteract indigenous knowledge loss and sustain traditional practices. …”
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Inhibition of NA+/H+ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats by Peng Li, Geng-Rong Chen, Fu Wang, Ping Xu, Li-Ying Liu, Ya-Ling Yin, Shuang-Xi Wang

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Myopia Progression Risk: Seasonal and Lifestyle Variations in Axial Length Growth in Czech Children by Stepan Rusnak, Vaclav Salcman, Lenka Hecova, Zdenek Kasl

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Emotional Exhaustion in University Teachers: Contributing Aspects and Mediating Mechanisms by Alejandra Trillo, David Ortega-Jiménez, Karina Ocampo-Vásquez, Marina R. Ramírez, Tatiana Mansanillas, Francisco D. Bretones

“…Nowadays, employees in the higher education sector are faced with an increasingly demanding environment, which can lead to high levels of stress and emotional exhaustion. …”
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Caregiving for people with dementia in a rural context in South Africa by Thavanesi Gurayah

“…Services that would alleviate caregiver burden are education, caregiver training, a financial grant and respite care. …”
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Psychiatric aspects of spondyloarthritis by T. A. Lisitsyna, D. Yu. Veltishchev, E. L. Nasonov, A. M. Lila

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M.U.P.S (Medically Unexplained Physical Symptoms): Is the Accurate Diagnosis Necessary for the Rehab-Team? by Avi Ohry, Atzmon Tsur

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Laser powder bed fusion of a novel high-strength Al–Mg–Er–Zr-Sc alloy: Process, microstructure, and performance by Zhengjiang Gao, Hui Li, Teng Ma, Huan Yang, Wei Wang, Wu Wei, Hui Huang, Shengping Wen, Zuoren Nie

“…Both of keyholes caused by excessive energy input and unfused defects caused by insufficient energy input will decrease alloy density and induce stress concentration, resulting in a reduction in elongation. …”
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Low-Dose Ribavirin Treatments Attenuate Neuroinflammatory Activation of BV-2 Cells by Interfering with Inducible Nitric Oxide Synthase by Iva Bozic, Danijela Savic, Marija Jovanovic, Ivana Bjelobaba, Danijela Laketa, Nadezda Nedeljkovic, Mirjana Stojiljkovic, Sanja Pekovic, Irena Lavrnja

“…Our results imply that low-dose ribavirin may alleviate nitrosative stress during neuroinflammation.…”
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Restoration of 3-dimensional aortic hemodynamics after the Ross procedure for unicuspid aortic valve disease using 4-dimensional flow magnetic resonance imagingCentral MessagePersp... by Andrew Zbihley, BA, Anthony Maroun, MD, Justin J. Baraboo, BS, Ethan Johnson, PhD, Meilynn Shi, BA, Bradley D. Allen, MD, Michael Markl, PhD, S. Chris Malaisrie, MD, Christopher K. Mehta, MD

“…Systolic peak velocity (PV), wall shear stress, and viscous energy loss (EL) of each MRI were assessed and compared. …”
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THE ROLE OF GENETICALLY DETERMINED BODY RESISTANCE OF WARM-BLOODED ANIMALS TO HYPOXIA IN THE REALIZATION OF EFFECTOR FUNCTIONS OF NEUTROPHILS IN THE MODEL OF ADJUVANT-INDUCED RHEUM... by Elena Georgievna Pukhaeva, Alibek Kirilovich Badtiev, Fatima Elbrusovna Salamova, Stanislav Georgievich Dzgoev, Alina Muratbekovna Kupeeva

“…Given that human and animal populations are genetically heterogeneous in terms of the body's resistance to oxygen deficiency, the modern approach to predicting and treating diseases associated with impaired immune regulation requires taking into account the role of hypoxia in the implementation of pathogenetic mechanisms of inflammation. …”
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Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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