P57 | SELONSERTIB (ASK1 INHIBITOR) IN SKIN TISSUE REPAIR OF OBESE MICE

“… Obesity can impair skin wound healing due to an increase in the oxidative stress that activates apoptosis signal-regulating kinase 1 (ASK1), an enzyme involved in cell death pathways. …”
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Effect of dialysate glucose on synthesis of serum hepcidin in patients on maintenance hemodialysis by Hua Rui-xue, Zou Lu-xi, Wu Yu, Sun Ling

“…ObjectiveAs an important regulator of iron homeostasis，hepcidin participates in the pathophysiology of anemia and cardiovascular events in maintenance hemodialysis （MHD） patients.This study was designed to compare the effect of glucose-free versus glucose-containing dialysate on the synthesis of hepcidin-25 during hemodialysis （HD） and elucidate its potential mechanism in MHD patients.MethodsIn a self-before and after control study of 31 stable MHD non-diabetics，serum hepcidin-25 and plasma catecholamines （adrenaline，noradrenaline &amp; dopamine） were measured at pre-dialysis，intra-dialysis （120th min of HD） and post-dialysis using glucose-free dialysate and then switched to 5.5 mmol/L glucose-containing dialysate.One-way analysis of variance was utilized for identifying the effect of two dialysates on intra-dialysis%changes of serum hepcidin-25 and plasma catecholamines.Pearson/Spearman’s correlation coefficients were utilized for examining the relationships between serum hepcidin-25 and plasma catecholamines.ResultsGlucose-free dialysate achieved a greater reduction of serum hepcidin-25 than 5.5 mmol/L glucose-containing dialysate during a single HD ［（-8.45±18.46）% <italic>vs</italic> （0.37±17.24）%，<italic>P</italic>=0.0308］.Serum level of hepcidin-25 was positively associated with plasma levels of catecholamines at pre-，intra- and post-HD （<italic>r</italic>=0.34，0.25，0.62，<italic>P</italic>&lt;0.05）.ConclusionGlucose-containing dialysate may up-regulate hepcidin synthesis and/or secretion via an activation of sympathetic nervous system or oxidative stress，possibly due to elevated catecholamines.Adequately designed studies are still required for elucidating the mechanisms of dialysate glucose on hepcidin kinetics during HD.…”
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Herbo-Mineral Medicine, Cardiogrit Gold, Exhibits Protective Effects in Caenorhabditis elegans Model of Doxorubicin-Induced Cardiotoxicity by Acharya Balkrishna, Saurabh Bhatti, Meenu Tomer, Sudeep Verma, Rishabh Dev, Anurag Varshney

“…CG treatment rescued N2 C. elegans from doxorubicin-induced reduction in their growth, reproduction, locomotory behavior, pharyngeal pumping, feeding ability, and increased ROS generation. …”
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PHYSICAL ACTIVITY AND ITS IMPORTANCE FOR THE PREVENTION OF CARDIOVASCULAR DISEASES by S. S. Yakushin, E. V. Filippov

“…Further increase of the PA (its duration and/or intensity) leads to a further reduction of risks. PA should take most days of the week and have a duration of more than 10 minutes a day. …”
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AGE- MACULAR DEGENERATION AND GLAUCOMA. EPIDEMIOLOGICAL AND CLINIC-PATHOGENETIC ASPECTS by A. Z. Fursova, O. G. Gusarevich, M. S. Tarasov, M. A. Vasilyeva, N. V. Chubar, N. V. Litvinova

“…The vascular theory of pathogenesis related to the reduction of the perfusion of the head of the optic nerve, retina and chorioidea defines the diagnostic importance of the layer thickness parameters of the peripapillar nervous fibers and ganglion cell in differential diagnostics of this pathology. …”
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Numerical investigation of cooling enhancement in double-layer fractal-like microchannel disk heat sinks via layer shifting and tertiary channels by Hosein Akhtari, Ardalan Shafiei Ghazani

“…Angular shifting alone offers a modest reduction in thermal resistance; however, its combination with tertiary channels delivers substantial gains, significantly lowering thermal resistance. …”
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Study on Seismic Performance of Frame–Shear Wall Split-Foundation Structures with Shear Walls on Both Grounding Ends by Wusu Wang, Baolong Jiang, Yingmin Li, Yangyang Tang, Shuyan Ji

“…Shear-bending stiffness should be adopted in stiffness calculations to reflect the stiffness reduction effect of drop height on lower embedding shear walls. …”
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Efficacy of atorvastatin therapy in prevention of postoperative atrial fibrillation in patients with ischemic heart disease by O. A. Rubanenko

“…Our study has shown that atorvastatin therapy contributed to the reduction of number of new cases of AF after CABG in patients with IHD. …”
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Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19. by Al-kuraishy, Hayder M., Al-Gareeb, Ali Ismail, Mostafa-Hedeab, Gomaa, Keneth Iceland, Kasozi, Zirintunda, Gerald, Aslam, Akhmed, Allahyani, Mamdouh, Welburn, Susan Christina, Batiha, Gaber El-Saber

“…Respiratory manifestations of SARS-CoV-2 infection such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) leads to hypoxia, oxidative stress, and sympatho-activation and in severe cases leads to sympathetic storm (SS). …”
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Adherence to Clinical Quidelines on Preoperative Assessment and Correction of Cardiovascular Risk in Non-cardiac Surgery by M. D. Nigmatkulova, E. B. Kleymenova, L. P. Yashina, V. A. Otdelenov, S. A. Payushchik, O. D. Konova, D. A. Sychev

“…Electrocardiography (ECG), echocardiography and non-invasive stress tests were performed according to clinical guidelines in 100%, 77.8% and 25% of cases, respectively. …”
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Growth Differentiation Factor-15 (GDF-15) is a Biological Marker in Heart Failure by A. M. Alieva, E. V. Reznik, T. V. Pinchuk, R. A. Arakelyan, R. K.  Valiev, A.  M. Rakhaev, A. S. Tikhomirova, I. G. Nikitin

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The interlinked trajectories of interpersonal attachment and maladaptive behaviors among Chinese adolescents—a latent growth modeling approach by He Xiao, Pei Chen, Huiyi Xiao, Peizhi Zhong, Jiajie He, Yangang Nie

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Accurate mapping of Spartina alterniflora in Fujian Province using phenological traits derived from Landsat time series by Qingyue Zhang, Wenting Wu, Shurong Guo, Lei Wu, Tongchao Le, Xiaocheng Zhou, Lihua Wang

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NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies by Keyi Zhang, Keyi Zhang, Ming Wen, Ming Wen, Xinyue Nan, Xinyue Nan, Shuaizhu Zhao, Shuaizhu Zhao, Hao Li, Hao Li, Yanping Ai, Yanping Ai, Houze Zhu, Houze Zhu

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Top-dressing nitrogen fertilizer rate contributes to decrease culm physical strength by reducing structural carbohydrate content in japonica rice by Wu-jun ZHANG, Long-mei WU, Yan-feng DING, Fei WENG, Xiao-ran WU, Gang-hua LI, Zheng-hui LIU, She TANG, Cheng-qiang DING, Shao-hua WANG

“…Further histochemical staining analysis revealed that high N treatments decreased the lignin deposition rapidly in the sclerenchyma cells of mechanical tissue, large vascular bundle and small vascular bundle region, which were consistent with reduction of bending stress, especially for W3668 and thus, resulted in poor stem strength and higher lodging index. …”
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Multiscale microstructure-based constitutive modeling of high-temperature creep rupture in post-irradiated ODS steels by Xiaobao Fu, Zhenyu Zhao, Zeyuan Yan, Yuntao Zhong, Dengke Chen, Ruiqian Zhang, Bin Liu, Qihong Fang, Jia Li

“…Considering the irradiation-induced microstructure, a modified thermal creep rate model is proposed, and the thermal creep rate and creep strain of irradiated ODS steel are predicted at different temperatures. The results show that the thermal creep rate reaches 3 × 10−5 s−1 at the temperature of 500 °C and stress of 200 MPa, while the thermal creep strain does not exceed 3 % at the temperature of 800 °C. …”
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Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism by Liuying Chen, Zhongwei Yin, Luorui Shang, Hang Yuan, Wenkang Gao, Shuhan Wang, Shuyan Wang, Xiaohua Hou, Shenglan Yang, Huikuan Chu

“…Results The loss of intestinal epithelial Fut2 exacerbates alcohol‐related hepatic oxidative stress damage, and this effect is dependent on gut bacteria. …”
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Exposure to persistent organic pollutants and sarcopenia: Revealing associations, mediated modifications, and potential mechanisms by Jinlong Tao, Jinchan Zhai, Jiaqi Yang, Qiang Niu, Yunhua Hu, Yizhong Yan

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Investigating the psychometric properties of the Premenstrual Symptoms Screening Tool (PSST) among Bangladeshi adolescent girls by Md. Saiful Islam, Maliha Khan Majlish, Md Saif Mahabub, Mahmudur Rahman, Md. Shefatul Islam, Md. Salim Uddin, Marc N. Potenza, Kamrun Nahar Koly

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Smoking cessation behavior, nicotine addiction, and mental health among current smokers in Klang Valley, Malaysia– a cross-sectional questionnaire survey by G. Sri Yogaprita Gunasegran, Palanisamy Sivanandy, Pravinkumar Vishwanath Ingle, Priya Manirajan, Chandrashekhar T. Sreeramareddy

“…The participants exhibited varying levels of stress, anxiety, and depression, with 22.3% (n = 88) experiencing severe stress, 37.7% (n = 149) extreme anxiety, and 32.9% (n = 130) moderate depression. …”
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