Through its genoprotective, mitochondrial bioenergetic modulation, and antioxidant effects, Fucoxanthin and its metabolite minimize Ochratoxin A-induced nephrotoxicity in HK-2 huma... by Ekramy M. Elmorsy, Huda A. Al Doghaither, Ayat B. Al-Ghafari, Shaza A. Alyamani, Zakariya M. S. Mohammed, Neven A. Ebrahim, Gehad E. Elshopakey, Sameh M. Shabana

“…A significant deregulation of normal cellular pathways including genotoxicity (DNA damage percentage), mitochondrial bioenergetics disruption (PDH, α-KG, MCI and MCIII complexes activities, ATP levels and mitochondrial membrane potential), downregulation of some mitochondrial genes (ND1, ND5, CO-1 and ATP6/8) expression, mitophagy inhibition (PARK1 and parkin), Oxidative stress induction (ROS and TBARS), oxidative stress genes downregulation (HO-1 and Nrf2), antioxidant enzymatic activity reduction (ROS and CAT), and apoptotic mediator markers elevation (Caspases- 3, 8 and 9, and Bax/Bcl-2 ratio) were observed in OTA mono-treated cells compared to untreated control cells. …”
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Men of Color Health Awareness intervention: changes in adrenocortical activity assessed using fingernail cortisol by Jerrold S. Meyer, Jeffery Markham, Lamont Scott, Luis A. Valdez, Dean E. Robinson, David R. Buchanan

“…IntroductionA randomized controlled trial (#NCT03745703) assessed the efficacy of a tailored stress reduction intervention (Men of Color Health Awareness; MOCHA) aimed at improving the health of middle-aged African-American men. …”
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Annona squamosa (custard apple) leaves extract mitigates abemaciclib-induced liver injury (AILI) in male rats by Lashin S. Ali, Gamal Mohamed, Ahmed A. El-Mansy, Khaled S. El-Bayoumi, Mohammed Y. Sobhey, Abd El-Fattah B. M. El-Beltagy, Reham A. Ghanem

“…ALE effectively mitigated oxidative stress and inflammation in liver tissues induced by abemaciclib, evidenced by significant enhancements in liver antioxidant enzymes such as SOD, CAT, and GSH-GPx, as well as reductions in pro-inflammatory markers like IL-1β, IFN-γ, and iNOS. …”
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The Association of OLFM4 with the Progression and Cisplatin Resistance of Head and Neck Squamous Carcinoma by Xinlu He, Xi Yao, Keling Pang, Xulin Chen, Zhengbo Wei, Ying Xie

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Zinc toxicity induces intestinal cell death via inhibiting NAD+ synthesis in mice and IPEC-J2 cells by Lingjun Chen, Feifei Huang, Leilei Zhu, Xin Tian, Mohan Zhou, Jie Feng

“…The collective findings suggest NAD+ reduction is the primary factor contributing to intestinal Zn toxicity, although ROS also plays a role. …”
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Hepatic restorative potential of Portulaca oleracea ethanolic extract and/or metformin in type II diabetes mellitus model induced by high-fat diet and STZ by Naglaa Bahr, Amna H. M. Nour, Abd M. Abd El-KaderEl-Kader, Maha A. El Demellawy, Doaa A. Ghareeb

“…Results Rats treated with STZ exhibited notable elevations in tissue prooxidants (TBARS, XO, and NO), and inflammatory markers (TNF-α, IL-1β, and IFN-γ), with a parallel reduction in the activity of tissue antioxidants (SOD and GPx). …”
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Neuroprotective and anticonvulsant effect of trimetazidine in a PTZ-kindling model of mice through modulation of the IL-1β/IL-1R1 and HMGB-1/TLR-4 axis by Shahnawaz Ahmad, Mohammed Samim, Seema Jain, Divya Vohora, Nidhi

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Chloride-dependent plasma membrane hyperpolarization confers superior salinity tissue tolerance in wild rice Oryza coarctata by Ping Yun, Celymar Angela Solis, Babar Shahzad, Lana Shabala, Meixue Zhou, Gayatri Venkataraman, Zhong-Hua Chen, Sergey Shabala

“…The aim of this study was to understand the mechanistic basis of salinity tissue tolerance in the Oryza coarctata, a halophytic wild relative of cultivated rice Oryza sativa, to be then used as novel targets for improving salinity stress tolerance of O. sativa. Salinity led to ∼80% decline in mesophyll cell viability in cultivated rice, whereas only 15% reduction was observed in the wild rice. …”
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Parameters of lipid and oxidative-antioxidant status in persons aged 18-23 from radiation-contaminated areas under conditions of moderate physical activity by Vadym L. Sokolenko, Svitlana V. Sokolenko

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Behavioral moderators of In-utero superstorm sandy exposure and fronto-limbic cortical development—potential role of adaptiveness in clinical intervention strategies, a pilot study... by A. Duke Shereen, Donato DeIngeniis, Donato DeIngeniis, Tingting Wu, Md. Shafiur Rahman, Md. Shafiur Rahman, Melissa Blum, Jeffrey H. Newcorn, Yoko Nomura, Yoko Nomura, Yoko Nomura, Yoko Nomura

“…IntroductionPrenatal maternal stress may predispose a child to alterations in neurodevelopment and future psychopathology. …”
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A psychometric evaluation of the parent version of the children’s revised impact of event scale (CRIES): screening for post-traumatic stress disorder in Dutch children aged 3 to 7... by Mia P. Kösters, Eva Verlinden, Maj R. Gigengack, Hans M. Koot

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hucMSC Conditioned Medium Ameliorate Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Oxidative Stress and Inflammation via Nrf2/NF-κB Signaling Pathway by Yue Tang, Fengxia Ding, Chun Wu, Bo Liu

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The Sixth Edition of the WHO laboratory manual for the examination and processing of human semen: is everything new a well-forgotten old? by Yu. V. Olefir, I. V. Vinogradov, M. A. Rodionov, A. R. Zhyvulko, D. M. Popov, D. M. Monakov

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Factors associated with the dietary total antioxidant capacity of pregnant Brazilian women by Roberta Rejane Santos de Carvalho, Poliana Cristina de Almeida Fonseca Viola, Sandra Patrícia Crispim, Ana Karina Teixeira da Cunha França, Anderson Marliere Navarro, Bruno Feres de Souza, Franciane Rocha de Faria, Naiara Sperandio, Nathalia Pizato, Mariana de Souza Macedo, Renata Junqueira Pereira, Sylvia do Carmo Castro Franceschini, Carolina Abreu de Carvalho, Anderson Marliere Navarro, Carolina Abreu de Carvalho, Danielle Góes da Silva, Franciane Rocha de Faria, Naiara Sperandio, Jorge Gustavo Velásquez Meléndez, Míriam do Carmo Rodrigues Barbosa, Nathalia Pizato, Mariana de Souza Macedo, Renata Junqueira Pereira, Sandra Patrícia Crispim, Silvia Eloiza Priore, Sylvia do Carmo Castro Franceschini

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Deciphering sevoflurane-induced neurotoxicity: from isolated targets to intricate regulatory networks by Yue Shu, Liang Bai, Shouyang Yu, Yulan Li, Yulan Li

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Genetic variation and genome-wide association analysis of nitrogen use efficiency-related traits under combined heat and nitrogen-deficient stress in an Aegilops tauschii-derived w... by Amir Ibrahim Ismail Emam, Amir Ibrahim Ismail Emam, Izzat Sidahmed Ali Tahir, Izzat Sidahmed Ali Tahir, Nasrein Mohamed Kamal, Nasrein Mohamed Kamal, Yasir Serag Alnor Gorafi, Yasir Serag Alnor Gorafi, Hisashi Tsujimoto, Takayoshi Ishii, Takayoshi Ishii, Takayoshi Ishii

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Verbenone prevents cyclophosphamide-induced oxidative stress, inflammation, fibrosis, and cellular changes in the kidneys of Swiss albino mice by targeting NF-ĸB/TGF-β signaling pa... by Mohd Wasim, Syed Ali, Syed Haque

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An overview of molecular mechanisms and QTLs associated with arsenic tolerance in rice by Seyedeh Soheila Zarbafi, Amir Forghani Saravani, Jong Hyun Ham

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<i>Origanum majorana</i> Extracts: A Preliminary Comparative Study on Phytochemical Profiles and Bioactive Properties of Valuable Fraction and By-Product by Simone Bianchi, Rosaria Acquaviva, Claudia Di Giacomo, Laura Siracusa, Leeyah Issop-Merlen, Roberto Motterlini, Roberta Foresti, Donata Condorelli, Giuseppe Antonio Malfa

“…Both extracts (20 µg/mL) fully restored oxidative balance in hemin-stressed AC16 cardiomyocytes, without altering the expression of catalase, heme-oxygenase 1, superoxide dismutase 2, or ferritin. …”
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TRAP1 Improves Diabetic Retinopathy by Preserving Mitochondrial Function by Li Y, Xu W, Zhao G, Guo Y, Wang L, Du Q, Fei Y, Hu X, Hu H, Chen L, Xu Y

“…This study confirmed TRAP1’s critical role in the pathogenesis of DR.Results: Our findings elucidate a significant reduction in TRAP1 expression in diabetic rat retinas, particularly in the pigment epithelium. …”
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