<i>N</i>-Acetylcysteine Treatment Restores the Protective Effect of Heart Ischemic Postconditioning in a Murine Model in the Early Stages of Atherosclerosis by Tamara Zaobornyj, Virginia Perez, Georgina Ossani, Tamara Mazo, Eugenia Godoy, Jorge Godoy, Yohana Yanaje, Camila Musci-Ferrari, Mario Contin, Valeria Tripodi, Magali Barchuk, Gabriela Berg, Ricardo J. Gelpi, Martin Donato, Veronica D’Annunzio

“…The analysis indicates that animals subjected to I/R and IP protocols in conjunction with NAC show a tendency to reach basal values, thus suggesting a potential for the reduction in ROS. <b>Conclusions:</b> NAC treatment mitigates oxidative stress and restores the cardioprotective effect of ischemic postconditioning in a model of early-stage atherosclerosis. …”
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Associations Between Social Determinants of Health, Allostatic Load, and Anthracycline Cardiotoxicity in a Diverse Patient Population by Lili Zhang, Justin Song, Waqas Hanif, Rachel Clark, Magued Haroun, Mrunalini Dandamudi, Patricia Guia Simoza, Leandro Slipczuk, Mario J. Garcia, Min Pu, Carlos A. Gongora, Tomas G. Neilan, Della F. Makower, Earle C. Chambers, Carlos J. Rodriguez

“…Background Allostatic load (AL) is a measurement of physiological burden of chronic stress, operationalized using a composite score derived from biomarkers from multiple physiologic systems. …”
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Development and engineering application validation of alkali-activated full-component shield tunnel spoil regenerated solid-waste grouting material by Zhiran Yang, Yu Zhou, Li Wang, Shizhuo Zou, Jinfei Chai, Yufei Fang, Shichao Jiang, Hui Ma

“…This low-cement-content approach combined with solid waste recycling technology provides a practical solution for green construction, carbon reduction, and resource recycling in underground engineering.…”
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Phase-Resolved Functional Lung MRI Evaluation of Dynamic Hyperinflation Induced by Metronome-Paced Tachypnea in Patients with Chronic Obstructive Pulmonary Disease by R. A. Müller, F. Klimeš, A. Voskrebenzev, L. Behrendt, T. F. Kaireit, M. Wernz, M. Zubke, A. L. Kern, M. R. Prince, W. Shen, C. B. Cooper, R. G. Barr, J. M. Hohlfeld, J. Vogel-Claussen

“…MPT in combination with phase-resolved functional lung (PREFUL) MRI can be used to assess stress-driven ventilation dynamics globally and regionally. …”
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Gill transcriptome profiling reveals adaptation to brackish water in a selectively bred hybrid tilapia (Oreochromis niloticus x O. aureus) strain by Xiaofei Yu, July B. Ariñez, Priadi Setyawan, Zhitian Wu, Muhammad Hunaina Fariduddin Aththar, Mark Camara, Yang Fang, Martien A.M. Groenen, Hans Komen, John W.M. Bastiaansen, Hendrik-Jan Megens

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Natural variation of AcEGY3 mediates chloroplastic ROS homeostasis to confer kiwifruit thermotolerance by Chengcheng Ling, Jun Yang, Jiale Xu, Wei Tang, Yunyan Liu, Yingzhen Wang, Pengwei Li, Yan He, Zhiyin Ouyang, Shuqi Chen, Fei Xing, Xinxin Wang, Pu Liu, Yajing Liu, Runze Wang, Xiaofen Liu, Xueren Yin, Heqiang Huo, Dawei Li, Jan Smalle, Yongsheng Liu, Songhu Wang

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Epigenome profiling reveals distinctive regulatory features and cis-regulatory elements in pepper by Hongji Yang, Guorong Yu, Zhidong Lv, Tonghui Li, Xi Wang, Ying Fu, Zhangsheng Zhu, Guangjun Guo, Hang He, Ming Wang, Guochen Qin, Feng Liu, Zhenhui Zhong, Yan Xue

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Alleviating Effect of <i>Lactiplantibacillus plantarum</i> HYY-S10 on Colitis in Mice Based on an Analysis of the Immune Axis in the Intestine by Mengna Li, Xintong Liu, Weijian Chen, Haoyue Xu, Fang Huang, Qingbo Yao, Xiangze Jia, Yanyan Huang

“…Additionally, the strain enhanced intestinal antioxidant capacity by increasing GSH-Px activity, which collectively contributed to the reduction in intestinal inflammation. Furthermore, HYY-S10 demonstrated multifaceted protective effects by ameliorating oxidative stress through the restoration of redox homeostasis and modulation of gut microbial ecology. …”
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Palmitic acid reduces LDLR-dependent uptake of macrophage-derived extracellular vesicles by hepatoma cells by Bootsakorn Boonkaew, Nantawat Satthawiwat, Bianca C. Pachane, Lucy M. Brett, Pisit Tangkijvanich, Chaiyaboot Ariyachet

“…Compared with control Huh7 cells, PA-treated Huh7 cells presented a reduction in the expression of macrophage-derived microRNA-223 (miR-223) after co-culture, accompanied by an increase in the expression of miR-223 target genes. …”
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Combining mindfulness intervention and open-label placebo treatment for chronic pain: a protocol for a feasibility study by Chung Jung Mun, Estrella Contreras, Yushu Xiao, Ryan Eckert, Alexandra Harting, Sathvika Damera, Iosef Perez, Hemant K. Pandey, Aram S. Mardian, Frank LoVecchio, Luana Colloca, Kelly E. Dunn, Michael Todd, Roger B. Fillingim, Mary C. Davis

“…Abstract Background Mindfulness-based interventions, such as mindfulness-based stress reduction (MBSR), are efficacious mind–body treatments for chronic pain, though their modest effect sizes suggest room for improvement. …”
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Applying neural network algorithms to ascertain reported experiences of violence in routine mental healthcare records and distributions of reports by diagnosis by Ava J. C. Mason, Vishal Bhavsar, Vishal Bhavsar, Riley Botelle, David Chandran, Lifang Li, Aurelie Mascio, Jyoti Sanyal, Giouliana Kadra-Scalzo, Angus Roberts, Marcus Williams, Marcus Williams, Robert Stewart, Robert Stewart

“…Males were significantly less likely to have reported recorded violence victimisation (0.44, 0.42-0.45) than females.DiscussionWe thus demonstrate the successful deployment of machine learning based NLP algorithms to ascertain important entities for outcome prediction in mental healthcare. The observed distributions highlight which sex, ethnicity and diagnostic groups had more records of violence victimisation. …”
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The Influence of Beryllium Incorporation into an Al-5wt.%Cu-1wt.%Si Alloy on the Solidification Cooling Rate, Microstructural Length Scale, and Corrosion Resistance by Joyce Ranay Santos, Milena Poletto Araújo, Talita Vida, Fabio Faria Conde, Noé Cheung, Amauri Garcia, Crystopher Brito

“…An experimental growth law, λ₂ = 26<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msup><mrow><mover accent="true"><mrow><mi mathvariant="normal">T</mi></mrow><mo>˙</mo></mover></mrow><mrow><mo>−</mo><mn>1</mn><mo>/</mo><mn>3</mn></mrow></msup></mrow></semantics></math></inline-formula>, was established, confirming the influence of Be and the cooling rate on dendritic size reduction. The final microstructure was characterized by an α-Al dendritic matrix with eutectic compounds (α-Al + θ-Al₂Cu + Si + Fe-rich phase) confined to the interdendritic regions. …”
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Laser directed energy deposition of heteroarchitected Ti6Al4V composites: In-situ TiB/TiC network engineering for multi-mechanistic strength-ductility synergy by Shenghao Hu, Chengfang Chai, Shuai Guo, Fengxian Li, Yichun Liu, Jianhong Yi, Jie Yu, Jürgen Eckert

“…Microstructural characterization reveals that increasing B4C content (0–1 wt%) induced microstructural hierarchy through dual-phase (α+β) matrix refinement (α-lath reduction: 7.79 → 6.89 μm) and reinforcement architecture optimization, achieving 96.2 % high-angle grain boundaries and ceramic network continuity. …”
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Abiotic and biotic factors mediate the decomposition of crop straw in saline farmland soils by Chong Tang, Jingsong Yang, Lu Zhang, Wenping Xie, Rongjiang Yao, Xiangping Wang, Ruoyu Wang, Tao Li

“…In the future, organic C regulation in saline farmland should consider N management and salinity reduction.…”
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Clinical results of autologous fat transfer for basal thumb arthritis with a minimum of three years’ follow-up by Elisabeth M. Haas-Lützenberger, Iana Emelianova, Moritz C. Bader, Sinan Mert, Nicholas Moellhoff, Wolfram Demmer, Ursula Berger, Riccardo Giunta

“…Aims: In the treatment of basal thumb osteoarthritis (OA), intra-articular autologous fat transplantation has become of great interest within recent years as a minimally invasive and effective alternative to surgical intervention with regard to pain reduction. This study aims to assess its long-term effectiveness. …”
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Conditional diffusion-generated super-resolution for myocardial perfusion MRI by Changyu Sun, Changyu Sun, Neha Goyal, Yu Wang, Darla L. Tharp, Senthil Kumar, Talissa A. Altes

“…Our results showed significant image quality improvements, with a 5.1% reduction in nRMSE, a 1.1% increase in PSNR, and a 2.2% boost in SSIM compared to GAN-based super-resolution method (P &lt; 0.05 for all metrics using paired t-test) in retrospective study. …”
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Study of toxicological parameters in laboratory animals under the influence of hypochloritic acid in a chronic experiment by O. M. Brezvyn, I. Ya. Kotsiumbas, A. F. Obrazhei, O. B. Velichenko, O. B. Shmychkova, T. V. Luk'yanenko, D. V. Hyrenko, L. V. Dmitrikova

“…At the same time, using a concentration of 300 mg/l caused a slight reduction in the physical capabilities of the experimental animals; namely, the swimming time decreased by 18.2 % compared to animals of the control group. …”
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Neuroprotective properties of GABA and its derivatives in diabetic encephalopathy in old animals by I. N. Tyurenkov, D. A. Bakulin, A. V. Smirnov, M. R. Ekova, A. I. Bisinbekova, G. L. Snigur, Yu. I. Velikorodnaya, E. I. Morkovin, D. V. Verkholyak, O. S. Vasilyeva

“…These effects may be due to higher levels of the Klotho proteins, Nrf2 and BDNF, as well as lower levels of NF-κB, which may underlie the suppression of the oxidative stress, the reduction of MDA and inflammation (TNF-α).Conclusion. …”
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Weizmannia coagulans Ameliorate High-sucrose Diet-Induced Damage in Caenorhabditis elegans by Regulating Lipid Metabolism Pathways by Longfei HAN, Ying WU, Qiuxia FAN, Li CAO, Huawei NIU, Xuan LI, Lina ZHAO, Shaobin GU

“…Additionally, triglyceride levels were decreased by up to 56.25% (P<0.05) by CGMCC 9951, and a significant reduction in lipid accumulation was revealed by Oil Red O staining. …”
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Addressing the Stigma of Mental Illness in Black Families and Communities in Ontario, Canada: Protocol for a Mixed Methods Study by Joseph Adu, Josephine P H Wong, Priscilla Boakye, Sebastian Gyamfi, Egbe B Etowa, Mark Fordjour Owusu

“…We will use online self-reported surveys with Black individuals (335/431) to assess depression, anxiety, stress, mental health knowledge, racial discrimination, and mental health stigma. …”
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