Targeting AKR1B1 inhibits metabolic reprogramming to reverse systemic therapy resistance in hepatocellular carcinoma by Qi Wang, Juan Liu, Ming Yang, Jun Zhou, Yaxuan Li, Jingjing Zheng, Hao Jia, Shuhua Yue, Yinpeng Le, Yuxin Su, Wenrui Ma, Ni An, Yunfang Wang, Jiahong Dong

“…The secretory nature of AKR1B1 not only underscores its predictive value but also facilitates the intercellular transmission of drug resistance. …”
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Specificity and Selectivity of Raman Spectroscopy for the Detection of Dose‐Dependent Heavy Metal Toxicities by Isaac D. Juárez, Nicholas Shepard, Cole Sebok, Sudip Biswas, Endang Septiningsih, Dmitry Kurouski

“…We found these changes were specific to each HM, reflecting the activation of distinct stress‐response mechanisms. We also performed ICP‐MS of harvested rice tissue, allowing us to build Raman‐based calibration curves for predicting the HM concentration within rice. …”
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Evaluation of constitutive modeling for dynamic plastic-fracture modeling of dual phase (DP590) steel sheets by F. Najafnia, H. Talebi-Ghadikolaee, A.H. Bamdad, E. Dorchepour, R. Hashemi

“…In contrast, the normalized Cockroft-Latham model shows significant errors at higher stress triaxialities, making it less suitable for precise fracture predictions. …”
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Investigation into the Rolling Process of 20CrNiMo/Incoloy 825 Composite Materials by Jie Liu, Hailian Gui, Peng Zhang, Chen Zhang, Hao Liu

“…The effects of rolling pass reduction and rolling speed on the warpage, interface strain difference, and stress of the 20CrNiMo/Incoloy 825 composite materials were evaluated, highlighting an ideal first-pass reduction of 30% and a rolling speed of 0.117 m/s. …”
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Influence of oral health status on absenteeism and presenteeism as indices of work productivity loss by Naoko Adachi, Kumiko Sugimoto, Hitomi Suzuki, Kayoko Shinada

“…Data on dental health and general health checkups were obtained from workers’ health records, and the workers responded to questionnaires on work productivity loss due to oral health problems, job stress, and oral health-related QOL. The odds ratio (OR) and 95% confidence interval (CI) for presenteeism and absenteeism were calculated using multiple logistic regression analyses of oral health status and oral health-related QOL adjusting with sex, age, educational background, occupation, job stress, current smoking, and hypertension. …”
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Topology Optimization of a Robot Gripper with nTopology by Beatriz Monteiro, Francisca Rocha, Jose Costa

“…Fusion360 static stress analysis showed a reduction of 43% in weight, keeping the safety factor above 3, and leading to a displacement of 0,0067 mm. …”
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Research on a PTSD Risk Assessment Model Using Multi-Modal Data Fusion by Youxi Luo, Yucui Shang, Dongfeng Zhu, Tian Zhang, Chaozhu Hu

“…The results show that the multi-modal data model is more accurate than the single data model, with significantly improved prediction ability. Zero-inflated Poisson models are prone to over-fitting when data is limited, while deep neural network models show superior performance in both training and prediction sets, especially the Hybrid LSTM-FCNN model, which not only has high accuracy but also strong generalization ability. …”
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CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF ADAMANTANE DERIVATIVE IN THERAPY OF ASTHENIC DISORDERS IN EARLY FORMS OF CHRONIC BRAIN ISCHEMIA by E. V. Davydova, A. V. Zurochka

“…When treating psychogenic asthenic syndrome in the veterans of recent  military  conflicts, an adamantane derivative  administered as a course  treatment, at a dose of 50 mg 2 times daily causes psychostimulant, anxiolytic, vegetotropic, antihypotymic, and hypnotic pharmacological effects, with reduction of main psychopathological and somatoneurological symptoms.A notable immunotropic effect  of the  drug  was revealed, being  expressed  as enhanced immunopoiesis; activation of innate defense  mechanisms; expansion of Treg lymphocyte population, suggestive for increased suppressor  effect  upon  the  mechanisms of autoimmune aggression;  implementation of cell differentiation/ proliferative effect; anti-apoptogenic properties; anti-inflammatory activity (reduction of TNFα, IL-8, hsCRP, along with IL-2  increase) associated with reduced functional activity of mononuclear cells; vasotropic action expressed  as normalized balance of vasoactive  factors  (nitric  oxide,  endothelin-1), decrease of nitrotyrosine concentration, suggesting  the  nitrosylation stress reduction. …”
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The Use of Germination Indices for Salinity Tolerance Classification of Pepper Cultivars by Gamze Kaya

“…Results showed that germination percentage decreased with increasing NaCl levels while the highest germination percentage at 20 dS/m was 92% in BT Burdem with no significant reduction. Seedling growth of pepper cultivars was severely inhibited by increasing salinity stress. …”
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Fatigue Design Evaluation of Railway Bogie with Full-Scale Fatigue Test by Jung-Won Seo, Hyun-Moo Hur, Hyun-Kyu Jun, Seok-Jin Kwon, Dong-Hyeong Lee

“…Much study has been carried out in experimental and theoretical domains on the prediction of the structural integrity of the bogie frame. …”
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Energy absorption capacity of NiTi lattice structure (1st report: Evaluation of stiffness and strength of the structure by considering the effective length of the strand) by Yuji ATAGO, Kuniharu USHIJIMA, Koichi TSUCHIYA

“…In addition, for RD structures, accurate prediction can be ensured when the ratio of strand diameter d to the width of the unit-cell L satisfies d/L ≤ 0.2.…”
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Dual Cohort Insights Into Accelerometer‐Derived Weekend Warrior Physical Activity and Its Impact on Mortality by Rui Ren, Wenxu Wang, Qitong Liu, Xingyue Ye, Linze Xi, Ru Zhang, Liying Wang, Yao Zhang, Yanan Ma, Difei Wang

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State of the antioxidant system in mitochondria of skin cells during experimental B16/F10 melanoma growth with chronic neurogenic pain by E. M. Frantsiyants, I. V. Neskubina, E. I. Surikova, L. K. Trepitaki, L. A. Nemashkalova, I. V. Kaplieva, N. S. Lesovaya

“…The growth of В16/F10 melanoma together with chronic neurogenic pain restructures the antioxidant system of skin mitochondria towards generation of reductive stress under the influence of chronic pain, which can affect the growth and development of experimental melanoma.…”
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Improvement of depressive symptoms, after a suicide attempt, with dextromethorphan/bupropion combination treatment in a patient with treatment‐resistant depression and psychiatric... by Bruno Pedraz‐Petrozzi, Michael Deuschle, Maria Gilles

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Mathematical Simulation about Gas Transport in a Dual-Porosity Tight Gas Reservoir considering Multiple Effects by Jing Chen, Xinmin Song, Baozhu Li, Wuguang Li, Changlin Liao, Lei Yang

“…Threshold pressure gradient, gas slippage, and stress sensitivity have important effects on the production of a tight gas reservoir. …”
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Bacterial community composition and function in different habitats in Antarctic Fildes region revealed by high-throughput sequencing by Yi-He Zhang, Yi-He Zhang, Yong-Qiang Hu, Yin-Xin Zeng, Yin-Xin Zeng, Yin-Xin Zeng, Yin-Xin Zeng, Yin-Xin Zeng, Ting Hu, Wei Han, Yu Du, Zhong Hu, Shan-Shan Meng

“…., pmoA), nitrification (e.g., amoA and hao), reductive citrate cycle pathway (e.g., frdA), repair of DNA damage (e.g., lexA and uvrB), salt and osmotic stress tolerance (e.g., betB, gltB, and treS), and aromatic hydrocarbon degradation (e.g., bcrC and bssA) were detected in pristine and/or ornithogenic soils, whereas genes related to sulfur metabolism (e.g., soxY, fccB, dsrAB, and sat), nitrogen fixation (e.g., nifH), acetyl-CoA metabolism (e.g., acsB, cdhD, and cdhE), carbohydrate degradation (e.g., amyA and chiA), and cold adaptation (e.g., cspA, deaD and recQ) were in higher abundance in marine and/or intertidal sediments. …”
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Clinical Sports Medicine & Orthopedics by Hoffmann F, Heinz L, Mouton C, 2, Seil R, 2, 3, Nührenbörger C, 2

“…Therapeutically, load reduction with avoidance of high impact activities for at least 6 weeks is indicated initially, followed by dosed and progressive load increase. …”
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Unveiling the flexural strength of corroded prestressed self compacting concrete beams enhanced with M-sand and polypropylene fibres by Yamuna Bhagwat, Gopinatha Nayak

“…The presence of aggressive environmental conditions leads to a reduction in the efficiency of the structures by degradation. …”
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Lifestyle modification intervention among pregnant women with hypertension based on the self-determination theory using M-Health by Negar Heidari, Fatemeh Rajati, Paria Heidari, Mojgan Rajati

“…A mobile app was employed to deliver the educational intervention, addressing lifestyle factors such as nutrition, physical activity, and stress management. …”
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Mechanism and Control of Rockburst Induced by Draining Spatial Islands and Squaring by Yunhai Cheng, Fenghui Li, Xiufeng Zhang, Gangwei Li, Le Xu

“…A stress adjustment scheme was established, including overall hydraulic fracturing of the external roof of the drainage region, reduction of stoping speed, and pressure relief of large-diameter boreholes. …”
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